Best TWAS P=1.84e-10 · Best GWAS P=1.48e-08 conditioned to 0.537
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPP6C | 0.03 | 0.01 | bslmm | 315 | 0.01 | 2.2e-02 | 5.4 | -6.4 | 1.8e-10 | -0.84 | 0.02 | 0.85 | TRUE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | PPP6C | 0.08 | 0.06 | lasso | 4 | 0.05 | 7.8e-04 | 5.6 | -5.6 | 2.6e-08 | -0.99 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | PPP6C | 0.11 | 0.10 | lasso | 5 | 0.09 | 9.1e-08 | 5.5 | -5.4 | 5.1e-08 | -0.96 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | RABEPK | 0.07 | 0.05 | lasso | 4 | 0.05 | 6.3e-05 | 5.4 | -5.5 | 4.9e-08 | -0.98 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RABEPK | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.4e-04 | 5.4 | -5.4 | 5.2e-08 | -0.99 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPP6C | 0.05 | 0.06 | lasso | 3 | 0.05 | 1.1e-03 | 5.6 | -5.3 | 1.3e-07 | -0.98 | 0.01 | 0.91 | FALSE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PPP6C | 0.17 | 0.06 | enet | 5 | 0.09 | 2.0e-04 | 5.5 | -5.4 | 6.6e-08 | -0.99 | 0.01 | 0.79 | FALSE |