[Hub]/) : Traits : Medication: Cholesterol lowering : ←

chr20:62,008,975-62,912,463

Best TWAS P=1.07e-09 · Best GWAS P=1.76e-08 conditioned to 0.779

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	-5.5	-6.1	1.1e-09	-0.90	0.00	1.00	TRUE
21	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	5.6	6.0	1.8e-09	0.92	0.00	1.00	FALSE
7	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	5.4	-6.0	2.3e-09	-0.93	0.01	0.99	FALSE
20	GTEx	Vagina	RGS19	0.39	0.08	lasso	8	0.03	7.5e-02	5.4	-5.9	3.0e-09	-0.91	0.01	0.86	FALSE
11	GTEx	Esophagus Muscularis	RGS19	0.22	0.10	lasso	4	0.10	1.6e-06	-5.5	-5.9	4.7e-09	-0.80	0.00	1.00	FALSE
23	YFS	Blood	OPRL1	0.07	0.07	lasso	5	0.09	5.0e-27	-5.5	5.8	6.1e-09	0.82	0.00	1.00	FALSE
17	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	-5.5	-5.8	7.0e-09	-0.95	0.00	1.00	FALSE
19	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	5.4	-5.8	7.2e-09	-0.92	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS19	0.07	0.05	blup	48	0.07	1.1e-07	-5.4	-5.8	8.1e-09	-0.79	0.01	0.99	FALSE
16	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	5.4	-5.8	8.2e-09	-0.93	0.00	1.00	FALSE
9	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	-5.5	-5.8	8.7e-09	-0.91	0.00	1.00	FALSE
4	GTEx	Brain Cerebellar Hemisphere	OPRL1	0.27	0.14	lasso	7	0.17	4.4e-05	-5.5	-5.7	9.0e-09	-0.77	0.01	0.91	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	OPRL1	0.07	0.08	lasso	4	0.08	7.8e-09	-5.4	-5.7	1.3e-08	-0.68	0.01	0.99	FALSE
2	GTEx	Artery Tibial	OPRL1	0.10	0.10	lasso	2	0.06	1.1e-05	-5.5	-5.6	1.8e-08	-0.88	0.00	1.00	FALSE
5	GTEx	Brain Cerebellum	RGS19	0.28	0.22	lasso	4	0.18	7.2e-06	-5.5	-5.6	2.1e-08	-0.81	0.00	0.98	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	RGS19	0.51	0.28	enet	28	0.32	4.3e-18	-5.5	-5.5	2.9e-08	-0.80	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	C20orf201	0.03	0.01	lasso	4	0.01	2.3e-03	-5.4	5.5	2.9e-08	0.61	0.01	0.96	FALSE
10	GTEx	Esophagus Muscularis	OPRL1	0.17	0.14	lasso	1	0.13	4.7e-08	-5.5	-5.5	3.4e-08	-0.84	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	OPRL1	0.03	0.02	lasso	1	0.01	3.5e-02	-5.5	-5.5	3.4e-08	-0.84	0.00	0.95	FALSE
18	GTEx	Stomach	RGS19	0.18	0.25	lasso	2	0.25	2.2e-12	-5.5	-5.5	3.6e-08	-0.84	0.00	1.00	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	C20orf201	0.10	0.09	enet	9	0.10	9.9e-13	-5.4	5.5	3.7e-08	0.68	0.01	0.99	FALSE
1	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	-5.5	-5.5	4.3e-08	-0.80	0.00	1.00	FALSE
12	GTEx	Muscle Skeletal	RGS19	0.26	0.16	lasso	4	0.16	5.1e-15	5.4	-5.4	5.1e-08	-0.94	0.01	0.99	FALSE
8	GTEx	Colon Sigmoid	RGS19	0.27	0.07	enet	33	0.09	3.8e-04	-5.2	-5.4	7.2e-08	-0.61	0.01	0.98	FALSE
3	GTEx	Artery Tibial	RGS19	0.12	0.07	lasso	2	0.07	2.8e-06	5.4	-5.4	7.7e-08	-0.95	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS19	0.05	0.02	blup	48	0.02	1.1e-03	4.4	-5.4	8.4e-08	-0.75	0.01	0.97	FALSE
13	GTEx	Nerve Tibial	OPRL1	0.20	0.15	lasso	3	0.14	3.3e-10	-5.5	-5.3	1.1e-07	-0.82	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS19	0.06	0.06	blup	47	0.05	1.4e-06	-5.5	-5.3	1.5e-07	-0.80	0.00	1.00	FALSE
6	GTEx	Cells Transformed fibroblasts	OPRL1	0.25	0.07	enet	13	0.12	5.5e-09	4.9	-5.2	1.8e-07	-0.72	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS19	0.09	0.04	enet	4	0.04	2.8e-03	-4.9	-5.1	2.9e-07	-0.59	0.02	0.92	FALSE