Best TWAS P=6.89e-08 · Best GWAS P=4.71e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Skin Not Sun Exposed Suprapubic | NTN5 | 0.19 | 0.07 | lasso | 5 | 0.08 | 2.5e-05 | 5.3 | 5.1 | 2.8e-07 | 0.93 | 0.02 | 0.98 | FALSE |
2 | METSIM | Adipose | NTN5 | 0.13 | 0.10 | bslmm | 450 | 0.14 | 3.2e-20 | 5.3 | 5.3 | 1.5e-07 | 0.68 | 0.01 | 0.99 | FALSE |
3 | The Cancer Genome Atlas | Colon Adenocarcinoma | FUT2 | 0.18 | 0.22 | enet | 12 | 0.18 | 6.8e-11 | 5.3 | -5.3 | 1.3e-07 | -0.95 | 0.01 | 0.99 | FALSE |
4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NTN5 | 0.05 | 0.04 | lasso | 2 | 0.02 | 6.7e-04 | 5.3 | 5.3 | 1.1e-07 | 0.97 | 0.01 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FUT2 | 0.05 | 0.08 | lasso | 2 | 0.08 | 6.7e-09 | 5.2 | -5.3 | 1.1e-07 | -0.96 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FUT2 | 0.08 | 0.12 | lasso | 4 | 0.11 | 2.5e-05 | 5.3 | -5.3 | 1.2e-07 | -0.92 | 0.01 | 0.97 | FALSE |
7 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FUT2 | 0.26 | 0.28 | lasso | 10 | 0.22 | 5.2e-06 | 5.3 | -5.3 | 1.1e-07 | -0.96 | 0.01 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FUT2 | 0.14 | 0.16 | lasso | 8 | 0.14 | 4.9e-10 | 5.3 | -5.4 | 6.9e-08 | -0.96 | 0.01 | 0.99 | TRUE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | NTN5 | 0.11 | 0.07 | blup | 43 | 0.09 | 2.6e-09 | 5.5 | 5.1 | 2.8e-07 | 0.89 | 0.01 | 0.99 | FALSE |