TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Medication: Cholesterol lowering
:
←
→
chr6:159,820,779-161,213,047
Best TWAS P=3.47e-10 · Best GWAS P=3.32e-18 conditioned to 2.17e-10
159.8M
160M
160.2M
160.4M
160.6M
160.8M
161M
161.2M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
SLC22A1
0.04
0.01
enet
17
0.01
5.2e-04
4.1
-6.3
3.5e-10
-0.59
0.01
0.94
TRUE
1
GTEx
Artery Tibial
RP11-288H12.3
0.17
0.01
lasso
8
0.06
2.3e-05
3.0
5.4
6.8e-08
0.14
0.23
0.05
TRUE
2
GTEx
Thyroid
RP11-288H12.3
0.14
0.07
enet
10
0.08
8.3e-07
-3.1
5.4
5.8e-08
0.23
0.49
0.20
FALSE