Hub : Genes

SLC22A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1273	0.0393	3.5e-06	0.026	0.039	0.024	0.038	0.029	7.9e-05	1.3e-06	0.00014	1.7e-06	2.8e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.0406	0.0205	1.2e-02	-0.001	0.008	-0.002	0.011	-0.002	5.3e-01	2.9e-02	0.67000	1.3e-02	9.9e-01
3	TCGA	Breast Invasive Carcinoma	0.0425	0.0179	1.5e-04	0.010	0.012	0.014	NA	0.013	3.0e-03	1.5e-03	0.00052	NA	7.2e-04
4	TCGA	Colon Adenocarcinoma	0.1180	0.0560	1.3e-03	0.017	0.017	0.000	NA	0.000	3.4e-02	3.4e-02	0.34000	NA	3.0e-01
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0317	0.0159	5.0e-03	-0.001	0.010	0.003	NA	0.000	4.2e-01	2.5e-02	0.12000	NA	3.3e-01
6	TCGA	Lung Adenocarcinoma	0.0758	0.0361	4.4e-03	0.012	0.019	0.023	NA	0.012	1.4e-02	2.3e-03	0.00082	NA	1.2e-02
7	TCGA	Prostate Adenocarcinoma	0.0390	0.0202	3.4e-03	0.004	0.023	0.007	NA	0.009	1.1e-01	1.6e-03	0.05500	NA	3.8e-02
8	TCGA	Thyroid Carcinoma	0.0630	0.0250	3.0e-04	0.020	0.047	0.021	NA	0.024	4.1e-03	2.3e-05	0.00360	NA	1.9e-03
9	TCGA	Uterine Corpus Endometrial Carcinoma	0.2030	0.1050	9.8e-03	-0.003	0.055	0.010	NA	0.005	4.0e-01	1.2e-02	0.17000	NA	2.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	1.1	1.8	6.1	2.0	-2.5	0.3	0.4	-0.3	1.1	-0.7	1.7	1.1
Bipolar Disorder or Schizophrenia	0.3	0.6	4.0	0.3	-2.0	-0.8	-0.2	0.5	0.7	0.1	0.1	0.2
Depressed Affect (Nagel 2018)	1.9	4.0	10.2	-2.4	0.8	-2.5	-2.5	1.1	-1.2	0.5	-3.2	-2.0
Depression (Nagel 2018)	2.9	4.4	9.8	-3.1	-1.5	-1.9	-2.6	1.3	-1.1	0.7	-3.1	-2.0
Intelligence (Savage-Jansen 2018)	0.6	2.0	8.0	-1.3	-0.8	0.4	-1.4	-1.2	1.1	-1.2	-1.1	2.8
Neuroticism (Nagel 2018)	2.5	5.9	16.4	-2.6	0.1	-4.0	-2.8	1.8	-1.7	0.9	-3.3	-2.2
Schizophrenia (2018)	0.3	0.7	1.6	-1.2	-0.5	-1.1	-0.5	0.9	-0.0	0.7	-1.3	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.9	0.1	0.4	0.2	-0.0	-0.4	-1.0	-0.8	-0.5	0.4
Worry (Nagel 2018)	2.0	4.2	13.8	-2.2	-1.9	-3.7	-2.3	1.0	-1.6	0.0	-2.4	-0.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.0	0.4	0.4	-0.0	-0.2	-0.7	0.0	-0.2	-0.3
Alzheimer’s Disease (in father)	0.5	0.6	1.3	-0.2	-0.5	1.1	1.0	-0.6	0.8	0.5	0.7	1.1
Alzheimer’s Disease (including proxy)	0.2	0.4	1.0	-0.2	0.0	1.0	0.5	-0.7	-0.2	0.5	0.3	1.0
Crohns Disease (2017)	0.5	1.0	2.8	-1.2	-1.7	-1.5	-0.9	0.1	-0.8	0.5	-0.7	0.6
Irritable Bowel Disease (IBD)	0.2	0.6	1.8	-1.3	-0.0	-0.9	-0.6	-0.4	0.7	0.6	-0.4	1.1
Ulcerative Colitis (UC)	0.5	0.9	2.8	-0.7	1.5	-0.5	0.4	0.0	1.7	1.3	0.4	0.8
Major Depression (MDD)	0.8	1.0	5.2	-0.4	-2.3	-0.8	-1.1	-0.5	0.5	-0.6	-0.7	0.1
Reaction Time	0.4	0.7	4.3	0.7	-2.1	0.8	0.2	-0.1	-0.5	0.3	0.6	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	-0.9	0.2	-0.0	-1.0	-0.3	0.4	-0.3	-1.3	0.7
Breast Cancer	0.2	0.4	2.0	-0.2	0.2	-1.4	-0.4	0.2	-1.0	0.1	-0.3	-0.2
Ovarian Cancer	0.3	0.4	1.7	-0.4	-0.9	0.3	0.3	1.3	0.7	0.2	-0.3	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.3	2.7	-0.4	1.6	-1.5	-1.4	0.2	-1.6	-0.6	-1.3	-0.5
Bipolar Disorder (2011)	0.9	0.8	2.8	1.7	-0.9	0.7	1.2	-0.5	-0.3	-0.0	1.3	-0.3
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	-1.5	0.9	-1.0	-0.3	1.3	0.5	1.0	-0.4	-0.0
Coronary Artery Disease (CAD)	2.1	2.5	17.7	-0.7	-4.2	-1.4	0.1	-0.7	0.4	-0.6	-0.5	1.1
Crohns Disease (2012)	1.0	1.6	2.9	-1.4	-1.6	-1.7	-0.4	1.1	-1.6	1.4	-0.9	0.5
Mean Putamen Volume	1.2	1.4	3.5	1.9	1.1	-0.5	1.6	-1.1	0.6	-0.7	1.5	-0.4
Fasting Glucose	0.8	1.0	3.8	-1.3	-1.9	0.5	-0.2	-0.1	1.3	0.9	-0.3	0.6
HbA1C	0.6	0.7	2.5	1.2	-1.6	0.4	-0.2	0.0	0.8	0.0	0.7	0.8
HDL Cholesterol	0.9	1.5	4.3	-0.3	1.2	0.4	1.1	1.8	-0.7	2.1	0.9	-1.2
LDL Cholesterol	4.5	7.0	29.2	1.7	-1.2	-0.3	1.1	-5.4	0.7	-4.7	0.5	2.4
Lupus	0.7	1.0	2.6	-0.2	-0.9	-0.5	-1.3	-0.9	0.7	-1.3	-0.8	1.6
Neuroticism (2016)	1.2	1.7	4.0	-2.0	0.7	-1.6	-0.4	1.9	0.4	1.7	-0.9	-0.5
Primary Biliary Cirrhosis	0.8	1.1	3.3	-0.5	-0.4	-0.6	-1.3	-0.8	-1.3	-0.9	-1.8	-1.1
Rheumatoid Arthritis	1.3	1.8	7.0	0.7	0.6	2.3	1.0	-0.1	2.6	-0.4	1.2	0.0
Schizophrenia (2014)	0.5	1.1	4.0	0.2	-1.5	-0.9	0.5	0.9	2.0	0.7	0.4	1.0
Triglycerides	2.1	3.4	8.9	2.3	-1.7	0.9	-0.4	-3.0	1.5	-2.8	0.5	1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.0	0.2	0.5	0.8	-0.6	-1.4	-1.0	-1.1	0.1	0.4
Ulcerative Colitis	0.9	1.4	3.9	-2.0	0.3	-1.3	-1.2	-0.6	-1.3	-0.8	-1.5	0.1
Blood Eosinophil Count	0.1	0.7	2.5	-0.3	-1.5	-0.0	0.7	0.3	0.7	-0.1	-0.4	1.6
Blood Platelet Count	0.3	3.8	11.0	-1.1	-2.6	0.2	-0.2	3.3	0.3	3.2	-1.1	-2.0
Blood Red Count	0.1	0.9	1.8	1.1	0.7	1.3	0.5	1.3	1.3	0.5	0.8	0.1
Blood White Count	0.3	1.9	5.3	-1.1	-1.5	-1.0	1.2	2.3	-0.7	1.9	0.2	-1.3
Heel T-Score	0.6	5.1	16.3	-0.1	0.8	2.0	1.6	3.8	2.3	4.0	1.8	0.1
BMI	0.3	1.8	5.7	-2.1	1.9	-0.8	-0.5	0.8	2.4	0.3	-0.6	0.8
Height	0.5	9.5	20.2	-4.2	2.5	-1.6	-2.3	4.5	3.5	4.2	-1.7	-1.0
Waist Hip Ratio (WHR)	1.1	5.1	36.8	1.1	-6.1	1.1	-0.2	0.3	-2.3	0.1	-0.5	-1.0
Systolic Blood Pressure	1.6	8.0	24.2	-4.0	-4.9	-3.4	-2.7	0.9	-2.0	-0.3	-2.8	0.2
Smoking Status	1.9	4.4	10.1	-1.6	-1.6	-3.2	-1.8	2.6	0.2	1.7	-2.4	-2.5
Allergy or Eczema	0.9	2.4	10.9	0.8	-2.3	-1.0	-0.6	-0.4	-3.3	-0.8	-1.3	-0.6
Cardiovascular Disease	4.2	14.0	40.7	-2.3	-6.4	-5.5	-3.1	-2.1	-1.9	-3.3	-2.6	3.6
Hypothyroidism (self reported)	1.0	2.4	5.2	1.2	0.3	1.1	2.0	0.7	2.3	0.9	2.2	1.7
Respiratory disease	0.3	0.6	2.4	-0.1	1.5	0.0	0.4	-1.1	0.5	-0.3	0.5	1.1
Type 2 Diabetes (T2D) (2018)	1.4	2.6	15.2	0.4	-3.9	1.1	1.3	1.0	-0.5	0.3	1.0	1.6
Lung FEV1/FVC ratio	0.2	0.9	3.5	1.9	-0.4	0.9	0.9	-0.9	-0.5	-1.0	0.8	-0.1
Lung FVC	0.3	1.6	6.0	1.2	-1.4	1.0	-0.2	-1.6	-0.8	-2.5	-0.0	0.4
Neuroticism	2.1	5.0	14.1	-2.4	-0.1	-3.8	-3.1	1.1	-1.3	0.0	-3.4	-1.2
Chronotype (morning person)	0.3	0.8	2.5	-1.6	-1.6	-1.0	-0.4	-0.4	0.0	0.4	-0.7	0.0
Hair Pigment	0.1	2.4	6.5	-0.5	0.4	-1.3	-2.4	-0.5	-0.9	-1.0	-2.2	-2.5
Tanning	0.0	0.5	3.3	-0.2	1.8	-0.1	0.3	-0.3	0.8	0.7	-0.3	-0.1
Hand grip strength (left)	1.2	3.1	11.4	-0.2	1.7	-1.0	0.3	2.7	-0.8	3.4	-0.5	-2.1
Number of treatments/medications taken	1.6	3.0	15.5	-0.8	-3.9	-2.6	-0.6	-0.2	-0.0	0.1	-0.6	1.6
Average weekly spirits intake	0.5	0.7	2.0	-1.4	-0.4	-0.5	0.6	1.4	-0.2	1.1	0.2	0.3
Sensitivity / hurt feelings	0.4	0.7	2.3	-1.0	1.5	-1.0	-0.5	0.6	-0.9	0.1	-0.7	-0.6
Frequency of depressed mood in last 2 weeks	1.3	1.8	5.9	-1.5	-0.9	-1.0	-1.1	1.4	-0.7	0.7	-1.5	-2.4
Hearing difficulty/problems: Yes	1.3	2.0	8.0	-0.0	-1.2	-0.9	-1.1	-1.2	-2.1	-2.8	-0.4	0.7
Relative age of first facial hair	0.5	1.1	6.2	1.5	2.5	0.5	0.0	-0.0	0.4	0.7	0.4	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.4	0.1	-0.7	-0.1	0.9	-1.0	-0.0	-0.6	-0.7
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.3	-0.8	0.7	-1.8	-1.2	0.4	1.1	0.7	-1.7	-1.2
Ever had hysterectomy (womb removed)	0.5	0.6	3.5	1.9	0.1	0.6	0.1	-0.6	0.5	-0.4	0.8	-0.2
Systolic blood pressure, automated reading	1.5	4.3	12.2	-3.5	-2.7	-1.5	-2.9	0.0	-0.1	-0.5	-2.8	0.2
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	9.2	0.4	-3.0	0.6	1.3	-0.6	0.3	-0.7	1.1	2.7
Angina	6.7	8.8	27.6	-1.0	-4.8	-5.3	-1.7	-1.6	-2.9	-2.3	-1.3	2.7
Medication for hormone replacement therapy	0.6	0.6	2.1	-1.0	0.6	-1.2	0.4	0.5	0.4	1.5	-0.4	0.1
Vitamin and mineral supplements	0.9	1.3	3.5	0.1	1.7	1.9	0.9	-0.7	1.0	-0.4	1.4	0.7
Supplements: Zinc	1.0	1.1	4.1	2.0	-1.5	0.6	0.6	0.1	0.2	-0.6	0.9	1.3
Medication: Co-codamol	0.6	0.7	2.2	0.9	-0.2	0.1	0.1	-0.9	-1.5	-1.2	0.2	-1.2
Medication: Metformin	0.8	1.1	5.4	0.5	-2.3	0.4	0.8	0.2	0.0	0.0	1.2	1.5
Diabetes (father)	0.7	0.8	2.0	0.2	-1.0	0.4	1.0	1.2	1.1	1.4	0.5	0.6
Diabetes (mother)	0.6	0.8	2.3	1.5	-0.7	0.0	1.1	-0.3	0.8	-0.4	1.1	1.1
Severe depression (siblings)	0.7	0.8	2.7	-0.8	1.4	-1.6	-0.3	0.6	-0.6	0.7	-0.8	-0.2
Pack years adult smoking proportion	0.6	0.9	2.6	-1.1	-0.6	-0.5	-1.2	-0.3	-0.1	-0.7	-1.6	-1.3
Impedance of leg (right)	0.4	1.8	8.2	2.9	0.1	1.5	1.6	-0.9	-0.2	-0.3	1.4	0.3
Leg fat-free mass (left)	0.7	3.7	11.5	-3.4	1.7	-1.1	-0.8	2.0	2.5	2.3	-1.3	0.2
Trunk fat percentage	0.5	2.1	8.6	-0.6	2.9	0.6	0.2	-1.0	2.8	-0.3	0.2	0.5
Hand grip strength (right)	1.8	4.9	17.6	-0.7	2.0	-1.5	-0.4	3.6	-0.6	4.2	-0.9	-2.4
Townsend deprivation index at recruitment	0.5	0.7	1.2	0.2	0.3	0.9	-0.5	-1.1	-1.1	-1.1	-0.4	-1.1
Current tobacco smoking	1.2	2.0	7.8	-1.2	-0.2	-1.3	-1.4	0.8	-1.0	0.4	-2.0	-2.8
Average weekly fortified wine intake	0.4	0.5	2.3	-0.7	-1.0	0.1	-0.1	-0.2	-1.5	-0.3	-0.5	0.2
Maternal smoking around birth	0.4	0.5	2.3	-0.3	1.5	0.1	-1.2	0.0	0.0	0.8	-0.4	-0.4
Fed-up feelings	0.5	0.8	2.0	-1.4	1.0	0.6	-1.4	0.3	0.3	0.1	-1.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.9	-2.3	-0.5	-0.5	-2.4	0.9	-0.1	0.6	-2.2	-1.5
Relative age voice broke	0.7	1.1	2.4	1.5	0.8	1.6	0.6	0.7	1.5	0.7	1.0	0.2
Taking other prescription medications	0.7	1.2	5.5	-1.0	-2.4	0.0	0.3	1.2	0.6	0.8	0.6	1.0
Age when periods started (menarche)	0.8	1.9	4.6	-0.4	0.1	-1.9	-1.6	-0.1	-2.1	-2.0	-0.7	-1.3
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	7.2	-0.6	-0.2	-0.8	-2.3	0.8	-0.3	-0.1	-1.8	-2.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	9.7	0.8	-0.1	0.9	1.2	3.0	2.1	3.1	0.5	-0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	0.4	-1.1	0.9	-0.7	-0.2	0.5	-0.7	-0.1	0.4
Qualifications: CSEs or equivalent	0.4	0.5	1.0	0.5	-1.0	-0.0	-0.5	-1.0	-0.4	-0.8	-1.0	0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.9	0.7	-1.3	-0.0	-0.7	-1.4	-0.3	-0.9	-0.4	1.0
High blood pressure	1.4	4.0	13.1	-2.3	-3.6	-1.8	-2.3	-0.5	-0.6	-1.1	-2.1	1.7
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.5	0.4	-1.6	-1.1	-0.3	-0.3	-2.3	-0.1	-1.3	-0.5
Multivitamins +/- minerals	0.9	1.2	3.4	-0.3	-1.9	-1.7	-0.5	0.9	-1.2	0.5	-0.9	-0.6
Stomach or abdominal pain in last month	1.2	1.5	3.3	-0.1	-1.0	-1.3	-1.4	-1.2	-1.8	-1.8	-1.0	-0.3
Supplements: Glucosamine	0.8	1.0	1.7	-0.7	-1.0	-1.0	-1.0	0.4	-0.9	-1.2	-1.3	-1.2
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	10.0	2.6	-0.5	1.4	1.4	-2.3	1.1	-1.6	2.8	3.2
Medication: Atenolol	2.5	3.1	7.2	-2.7	-2.6	-2.5	-0.5	1.1	1.2	1.2	-0.6	1.8
Medication: Levothyroxine sodium	0.7	1.1	3.2	0.6	-0.3	0.5	0.7	0.4	1.8	0.4	1.4	1.8
Sitting height	0.7	4.8	9.4	-2.8	2.4	-1.6	-1.0	2.4	3.0	3.1	-1.4	0.3
Chronic bronchitis/emphysema (father)	1.1	1.3	3.3	-0.1	1.8	1.4	0.7	1.0	1.4	1.6	0.4	-0.6
High blood pressure (mother)	0.7	0.9	2.2	-1.0	0.2	-1.5	-0.2	1.5	1.0	1.1	-0.7	0.2
Body mass index (BMI)	0.2	0.8	2.9	-1.1	1.2	0.1	-0.2	-0.6	1.7	-0.6	-0.2	0.8
Impedance of leg (left)	0.2	1.1	4.8	2.2	0.1	1.4	1.1	-0.8	0.3	-0.1	1.0	0.0
Leg predicted mass (left)	0.7	3.9	11.8	-3.4	1.8	-1.2	-0.8	2.1	2.5	2.4	-1.3	0.2
Trunk fat mass	0.5	2.1	8.2	-1.6	2.7	0.1	-0.2	-0.2	2.9	0.5	-0.4	0.4
Waist circumference	0.1	0.3	1.0	-0.6	-0.7	0.7	-0.2	-0.5	1.0	-0.2	-0.4	0.5
Number of incorrect matches in round	0.1	0.2	0.4	-0.5	-0.0	0.6	0.6	-0.6	-0.3	-0.2	-0.1	0.3
Past tobacco smoking	0.7	1.3	6.8	0.4	1.0	2.6	0.4	-1.3	-0.5	-0.8	0.9	0.1
Alcohol usually taken with meals	0.5	0.8	2.0	-0.8	-0.4	-0.5	-0.1	1.4	0.7	1.4	-0.6	-1.2
Nervous feelings	0.8	1.6	5.1	-2.0	-0.2	-0.8	-2.3	0.4	-0.5	-0.3	-1.8	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	7.6	-2.8	0.5	-1.0	-2.3	0.3	-0.2	0.6	-2.1	-2.3
Hearing difficulty/problems with background noise	1.5	2.4	9.2	0.3	-0.9	-1.6	-0.6	-1.7	-1.6	-3.0	-0.4	1.6
Hair/balding pattern: Pattern 2	1.0	1.2	2.7	0.6	-1.6	-0.9	-1.3	0.1	-1.2	-0.6	-1.0	-1.6
Had menopause	1.1	1.4	2.7	-0.9	1.2	0.1	-1.6	-1.6	0.1	-1.4	-1.5	-1.0
Had other major operations	0.6	0.7	3.4	-0.1	-0.8	-0.3	0.1	-1.8	0.0	-1.4	-0.4	0.5
Forced vital capacity (FVC)	0.1	0.6	2.3	0.6	-0.2	0.5	-0.1	1.5	0.4	1.4	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	9.2	0.2	-0.2	0.5	1.3	3.0	2.7	3.0	0.9	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.7	-0.7	-1.2	-1.6	-1.0	0.2	-0.4	0.0	-1.3	0.2
Qualifications: None of the above	0.4	0.8	3.5	-0.3	0.1	-1.5	-0.9	0.4	-0.4	0.0	-0.6	-1.9
Financial difficulties in last 2 years	0.6	0.8	2.1	-0.8	-0.6	-0.6	-1.0	-1.0	1.5	-1.0	-0.8	0.1
Mouth/teeth dental problems	1.2	1.9	6.5	0.2	0.5	1.1	2.3	1.3	0.7	2.6	1.1	-0.1
Heart attack	7.1	9.1	28.4	-1.7	-3.8	-5.3	-2.8	-1.2	-3.4	-2.0	-3.0	1.4
Allergy	0.4	0.9	2.9	0.0	0.7	1.2	0.8	0.1	1.7	-0.1	1.3	0.8
Pain all over the body in last month	0.6	0.6	2.3	-0.9	-0.5	-0.3	-0.0	0.5	0.5	1.1	-1.5	-0.5
Diabetes (self-reported)	1.8	2.7	16.6	0.1	-4.1	0.5	1.4	0.8	-0.2	0.7	1.3	1.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	0.9	-0.3	-0.9	0.2	-0.2	-1.3	-1.0	0.3	-0.0
Medication: Ramipril	3.2	4.0	15.5	-0.2	-3.9	-1.9	-2.2	-1.0	-1.8	-2.2	-1.6	0.8
Medication: Simvastatin	3.0	4.4	16.4	0.0	-4.0	-3.5	-0.7	-1.8	-0.1	-1.5	-0.6	2.1
Fluid intelligence score	0.3	0.5	2.8	-0.1	1.1	0.5	-0.1	-0.0	1.7	0.6	-0.1	0.5
Illnesses of siblings	2.3	3.2	7.7	0.3	2.5	1.5	1.7	2.0	2.8	1.6	1.9	0.1
Neuroticism score	1.6	3.3	7.2	-2.2	-0.0	-2.7	-2.6	1.0	-0.8	0.5	-2.7	-1.5
Weight	0.5	2.4	8.0	-2.4	1.9	-0.2	-0.7	1.0	2.8	1.3	-0.8	0.4
Impedance of arm (right)	0.4	1.8	6.2	2.5	1.9	1.3	1.2	-0.2	0.2	0.1	1.2	-1.2
Arm fat percentage (right)	0.3	1.1	5.2	0.1	2.3	0.7	0.6	-0.9	1.6	-0.6	0.5	0.0
Trunk fat-free mass	0.8	4.7	14.1	-3.8	0.2	-1.3	-1.6	3.1	1.7	2.7	-1.9	-0.2
Hip circumference	0.5	2.1	8.4	-1.1	2.7	1.0	-0.4	-0.3	2.9	0.4	-0.3	0.7
Time employed in main current job	0.4	0.5	2.1	0.6	0.8	1.4	0.3	-0.1	-0.5	0.2	0.6	-0.7
Alcohol intake versus 10 years previously	1.1	1.6	4.1	-0.2	-2.0	1.1	-0.8	-1.8	-0.3	-1.6	-1.4	-0.8
Father’s age at death	1.0	1.4	8.2	-0.1	1.2	2.9	0.6	0.8	0.5	0.0	1.1	-0.6
Worrier / anxious feelings	2.0	3.7	9.1	-1.8	-1.0	-3.0	-2.1	0.7	-2.0	0.7	-2.3	-2.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.3	-1.2	0.1	-0.5	-1.2	0.2	0.3	0.6	-1.5	-1.3
Falls in the last year	0.6	0.8	3.5	0.4	-0.5	-0.3	-1.1	-1.9	-0.1	-1.0	-0.6	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.8	0.6	0.3	0.8	0.5	-0.2	-0.0	0.5	0.9
Number of live births	0.5	0.7	1.8	1.2	0.2	-0.6	0.3	-0.6	1.4	-1.1	0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.0	1.4	0.0	1.0	0.7	0.4	0.2	0.6	0.8	0.8
Pulse rate	2.6	4.3	14.1	1.7	0.9	3.8	1.1	-3.1	1.9	-2.0	1.4	0.3
Happiness	1.3	1.5	4.0	-1.6	-1.6	-0.4	-2.0	-0.2	-0.7	-0.2	-2.0	0.2
Noisy workplace	0.2	0.3	0.7	0.4	-0.2	0.8	0.7	0.5	-0.6	0.1	0.8	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	4.6	-1.2	-0.2	-0.0	-0.2	0.3	1.1	0.6	-0.2	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	4.8	2.2	-0.2	1.2	1.7	-0.0	0.3	-0.2	1.6	1.1
Mouth/teeth dental problems: Dentures	1.2	2.0	6.1	-0.5	-0.0	-2.2	-2.5	-0.7	-0.5	-1.2	-2.0	-1.1
Asthma	0.3	0.7	2.4	0.5	1.6	0.9	0.6	-1.0	-0.0	-0.3	0.6	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.4	-0.1	1.8	0.2	1.9	0.7	2.1	1.9	1.1	1.3
Medication: Cholesterol lowering	7.5	11.7	39.4	-1.7	-5.0	-6.3	-1.4	-2.9	-2.1	-3.4	-2.1	2.7
Depression (self-reported)	0.8	0.9	2.6	-0.5	-1.4	-1.2	-1.6	0.4	0.1	0.4	-1.3	0.3
Medication: Lansoprazole	1.2	1.4	8.9	0.5	-3.0	-0.1	-1.3	-0.2	-0.4	-1.0	-0.7	-0.4
Prospective memory result	0.7	0.9	2.4	-0.4	-0.3	0.5	-1.6	-1.4	0.1	-1.1	-1.1	-0.9
Lung cancer (father)	0.5	0.5	1.9	-1.2	1.4	0.7	-0.7	0.3	0.1	-0.7	-0.2	-0.2
Illnesses of mother	1.7	2.1	7.0	1.3	1.9	2.6	1.1	-0.2	0.3	0.9	1.5	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	1.1	-0.7	0.8	0.3	0.5	-0.5	0.1	0.1	0.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.7	-0.6	-0.8	0.8	-0.4	-0.2	0.0	-0.6	-0.3	-0.0
Impedance of arm (left)	0.3	1.5	5.3	2.3	2.0	0.9	1.0	-0.1	0.4	0.4	1.1	-1.1
Arm fat mass (right)	0.3	1.3	5.3	-1.3	2.1	0.0	-0.1	-0.0	2.3	0.4	-0.3	0.3
Trunk predicted mass	0.8	4.6	13.8	-3.7	0.2	-1.2	-1.5	3.1	1.9	2.7	-1.8	-0.1
Standing height	0.7	6.9	18.4	-3.2	2.0	-0.7	-1.2	3.8	3.1	4.3	-1.5	-0.9
Length of working week for main job	0.4	0.4	1.6	-0.6	-0.8	-0.2	1.2	0.7	-0.5	0.7	0.2	0.4
Exposure to tobacco smoke at home	0.5	0.5	2.4	0.2	-0.5	1.5	-0.1	-1.0	-0.9	-0.3	0.3	-0.2
Breastfed as a baby	1.1	1.4	6.6	-2.6	0.4	-1.7	-0.8	0.1	-0.0	-0.3	-0.9	1.1
Tense / ‘highly strung’	0.3	0.4	1.5	-1.2	-0.6	-1.0	-0.7	0.1	-0.0	-0.0	-0.6	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.8	-0.2	-1.4	-1.3	-0.6	0.6	0.9	1.1	-0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.4	1.5	-1.2	1.2	-0.2	0.1	-0.4	0.1	0.4	0.1	-0.3
Birth weight of first child	1.2	2.2	6.1	-0.3	0.4	2.1	1.5	-1.1	1.4	-0.7	1.7	2.5
Peak expiratory flow (PEF)	0.5	1.2	4.9	0.8	-1.0	0.4	1.1	0.1	0.7	0.2	1.4	2.2
Pulse wave reflection index	1.5	1.8	10.8	-0.2	3.3	0.7	0.5	1.4	0.1	1.5	-0.2	-0.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	5.1	-2.2	0.3	-1.4	-1.1	0.0	-0.0	0.4	-1.1	-0.1
Loud music exposure frequency	1.2	1.3	7.9	0.5	-2.8	-1.0	0.9	-0.0	-0.0	-0.0	0.9	0.9
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	7.1	-0.2	1.3	1.4	0.1	-0.9	2.7	-0.6	0.4	2.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-0.0	-1.3	-1.2	-1.0	0.2	-1.4	-1.0	-0.4	0.5
Blood clot in the leg (DVT)	0.3	0.4	2.2	-1.1	0.1	-0.5	-0.2	0.4	1.5	-0.3	0.2	0.2
Medication: Paracetamol	0.6	0.9	5.5	-0.6	-0.4	-0.5	-0.3	0.9	0.4	2.3	-0.3	-1.1
Headache pain in last month	0.5	0.8	3.3	-0.2	0.7	0.5	1.8	-0.3	0.0	0.9	1.3	-0.5
Medication for cholesterol, blood pressure or diabetes	4.3	7.1	23.3	1.6	4.4	4.8	1.2	1.5	2.6	1.7	2.0	-1.3
Glaucoma (self-reported)	0.7	0.8	1.8	0.4	0.3	1.2	1.2	0.4	1.1	1.0	1.4	0.2
Gout (self-reported)	0.9	1.2	4.2	0.7	-0.0	0.3	-0.1	-1.9	-2.1	-1.4	0.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.5	0.8	-0.6	1.1	1.2	1.0	2.1	1.4	1.5	1.1
Medication: Amlodipine	0.9	1.3	4.7	0.1	-0.5	-1.0	-0.4	-2.2	0.9	-1.4	0.2	1.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	0.2	-0.4	0.8	0.3	-0.9	-0.7	-0.5	-0.0	0.1
Birth weight	0.7	1.5	6.6	-2.6	-0.7	0.5	-1.7	1.1	-0.4	0.8	-1.2	-0.6
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.0	-0.2	1.4	1.3	-0.5	-1.6	1.7	-1.1	0.1	2.0
High blood pressure (siblings)	0.5	0.6	1.8	0.1	-1.3	-0.7	-0.1	-0.3	-1.3	0.8	-1.0	0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	1.8	0.4	-0.9	0.6	-0.0	1.3	-0.1	0.9	-0.4	0.4
Body fat percentage	0.4	1.5	5.8	-0.4	2.4	0.7	0.5	-1.3	2.1	-0.7	0.3	0.5
Leg fat percentage (right)	0.3	1.1	3.5	0.2	1.2	1.1	0.5	-1.9	0.8	-1.4	0.5	0.7
Arm fat-free mass (right)	0.9	4.4	17.2	-4.2	0.5	-1.7	-1.6	2.0	2.3	1.9	-1.9	0.7
Exposure to tobacco smoke outside home	0.4	0.6	1.9	-1.4	0.3	-1.2	0.3	0.4	-0.6	1.0	-0.6	-0.2
Comparative body size at age 10	0.9	2.5	6.9	-0.3	2.6	1.7	-1.2	-1.6	-1.9	-1.3	-1.7	-0.9
Number of full brothers	0.5	0.6	1.8	0.6	-0.4	0.2	-0.2	-1.0	-1.2	-1.3	-0.2	-0.2
Worry too long after embarrassment	1.2	2.1	4.4	-1.7	1.5	-2.1	-1.5	1.7	0.1	0.9	-1.5	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	4.4	-0.6	-2.1	-0.6	-0.9	0.6	-0.6	0.3	0.0	1.4
Wheeze or whistling in the chest in last year	0.1	0.2	1.1	-1.0	0.4	0.2	-0.3	0.2	0.1	0.3	-0.7	0.1
Number of children fathered	0.9	1.0	3.5	1.9	1.0	-0.4	1.4	0.4	-0.4	0.3	1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	4.5	-0.3	-0.5	-2.1	-0.6	0.4	-0.2	0.6	-0.8	-1.0
Age at first live birth	0.5	0.9	3.6	-0.2	-1.2	0.1	-0.8	-1.1	0.0	-1.0	0.1	1.9
Pulse wave peak to peak time	0.2	0.3	0.9	0.3	0.7	-0.8	0.2	0.4	0.3	0.9	0.1	0.1
Health satisfaction	0.5	0.7	3.0	-0.8	-1.7	-1.0	-0.5	0.4	-0.3	0.1	-0.8	0.4
Shortness of breath walking on level ground	0.7	0.9	5.4	0.4	0.4	0.1	0.4	-2.3	-0.0	-0.5	0.5	1.3
Qualifications: College or University degree	1.0	3.0	8.2	1.0	0.6	0.9	2.8	-0.7	-0.0	0.5	2.8	2.9
Eye problems/disorders: None of the above	1.2	1.4	4.3	0.8	2.1	1.6	1.0	-0.8	-0.1	-0.7	1.6	0.0
Mouth/teeth dental problems: Loose teeth	1.4	1.7	6.5	-0.6	-2.5	-0.1	-0.1	-0.9	0.6	-1.0	0.6	2.4
Emphysema/chronic bronchitis	0.8	0.9	3.7	-0.3	0.4	-1.4	-1.9	-0.1	0.2	-0.7	-1.3	-0.3
Medication for pain relief, constipation, heartburn	1.7	2.9	10.8	1.0	1.7	3.3	0.5	-2.0	-0.1	-2.5	0.8	0.3
Neck or shoulder pain in last month	0.7	1.0	3.8	-1.4	-2.0	-0.8	-0.5	0.0	-0.7	-0.2	-1.2	-0.8
Medication: Blood pressure	3.2	5.6	13.1	-2.5	-2.8	-3.6	-2.3	0.1	-2.5	-0.7	-3.1	-1.0
Angina (self-reported)	7.5	9.9	29.9	-1.3	-5.1	-5.5	-2.0	-1.6	-3.0	-2.2	-1.7	2.7
Migraine (self-reported)	0.9	1.1	5.4	-0.1	2.3	0.4	1.6	-0.3	-0.1	-0.2	1.2	0.6
Medication: Ibuprofen	1.8	2.2	5.5	-0.0	2.3	0.9	1.8	0.7	1.6	2.3	1.1	0.3
Medication: Allopurinol	0.8	1.1	4.8	0.5	-0.8	0.4	0.4	-1.2	-2.2	-1.0	-0.1	-1.0
Medication: Omeprazole	1.0	1.2	4.2	2.0	0.7	0.4	1.5	-0.7	-0.1	0.4	1.6	0.0
Medication: Seretide 50 evohaler	1.0	1.2	3.5	0.7	1.0	0.7	1.1	0.8	1.9	1.5	0.8	-0.2
Mean time to correctly identify matches	0.4	0.8	2.6	0.7	-1.2	-0.0	-0.2	-0.5	-1.6	-0.4	0.1	-1.4
Heart disease (mother)	7.5	9.2	40.4	-2.5	-3.3	-6.4	-2.3	-0.5	-3.0	-1.5	-2.0	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	1.4	-1.0	0.4	-0.2	0.6	-1.3	-0.5	0.6	-0.6
Whole body fat mass	0.4	1.5	5.2	-1.8	2.3	-0.0	-0.1	-0.3	2.2	0.5	-0.5	0.3
Leg fat mass (right)	0.2	0.9	2.5	-1.5	1.6	-0.2	-0.0	-0.7	1.6	-0.0	-0.4	0.7
Arm predicted mass (right)	0.9	4.8	16.2	-4.0	0.7	-1.7	-1.6	2.2	2.5	2.4	-2.0	0.4
Pulse rate, automated reading	1.2	3.9	9.5	0.9	2.1	2.4	-0.1	-3.1	2.2	-2.7	0.6	1.2
Alcohol intake frequency.	1.1	2.5	7.0	-0.4	-2.5	0.1	-1.8	0.5	-0.9	-0.7	-2.0	-2.6
Comparative height size at age 10	0.4	2.3	10.6	-3.3	0.5	-0.1	-1.4	1.2	1.3	1.4	-1.4	0.5
Number of full sisters	0.6	0.7	3.4	1.8	-0.7	-0.3	0.1	-0.7	-1.2	-0.4	0.5	0.1
Suffer from ‘nerves’	0.6	1.0	3.7	-0.9	-0.3	-1.9	-0.4	0.2	-1.1	0.9	-0.8	-1.2
Overall health rating	1.1	2.3	3.9	-1.3	-1.8	-1.7	-1.8	-1.4	-1.0	-1.6	-2.0	0.4
Chest pain or discomfort	0.8	1.1	4.9	-0.7	-1.2	-2.2	0.2	1.0	-1.0	0.2	-0.3	1.0
Had major operations	1.2	1.5	5.9	1.2	-1.1	-0.2	1.4	-0.1	0.3	0.2	1.6	2.4
Age at last live birth	0.9	1.3	3.0	1.7	-1.5	-0.2	1.0	-0.8	-0.3	-0.3	1.7	1.2
Family relationship satisfaction	1.4	1.8	4.2	-2.0	-1.9	-1.8	-1.0	-0.2	-0.3	-0.7	-1.4	1.3
Leg pain on walking	0.5	0.6	1.2	-0.8	-1.1	-0.4	-0.9	-0.8	-0.9	-0.6	-0.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.4	1.5	-1.2	1.2	0.2	0.0	0.7	-0.7	0.5	0.3
Commuting to job workplace: Car/motor vehicle	2.2	2.5	5.2	2.3	0.1	0.8	1.9	-0.7	1.9	0.8	1.9	2.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.2	0.9	1.8	-0.2	1.1	-0.5	0.1	-0.1	1.2	0.9
Medication: Aspirin	4.0	5.3	21.6	-1.2	-4.6	-4.1	-1.4	0.5	-0.3	0.0	-1.8	1.5
Supplements: Vitamin C	0.3	0.3	1.1	0.3	-0.0	-1.0	-0.4	0.1	-0.5	0.0	-1.0	-0.3
Knee pain experienced in last month	0.5	0.8	2.3	0.5	-0.7	-1.3	-0.5	-0.4	-1.0	-0.6	-0.6	-1.5
Hypertension (Self-reported)	1.8	4.9	19.1	-2.1	-4.4	-2.1	-2.2	-0.5	-1.0	-1.5	-1.8	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.2	0.9	-0.2	1.5	0.2	-0.8	0.4	-0.2	0.9	-0.4
Illnesses of father: Heart disease	10.9	15.1	33.2	-2.7	-4.3	-5.8	-5.2	-2.0	-4.6	-2.3	-4.4	0.5
Illnesses of siblings: Diabetes	1.5	1.9	7.6	-0.4	-1.6	0.4	-0.5	1.5	-0.7	1.3	-1.4	-2.8
Smoking status: Previous	0.7	1.0	4.9	-0.2	-1.3	-2.2	-0.2	1.2	0.3	0.5	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.9	-0.7	-0.1	0.7	0.5	1.6	1.6	1.1	0.5	2.0
Whole body fat-free mass	0.8	4.8	15.4	-3.9	0.7	-1.5	-1.5	2.9	2.1	2.6	-1.9	-0.1
Leg fat-free mass (right)	0.9	4.7	14.6	-3.8	1.7	-1.2	-1.2	2.3	2.7	2.6	-1.6	-0.0
Arm fat percentage (left)	0.3	1.2	5.4	-0.1	2.3	0.6	0.5	-1.1	1.7	-0.6	0.5	0.3
Average weekly red wine intake	2.0	3.0	6.1	-2.2	-2.0	-2.5	-1.7	1.6	-1.1	0.1	-2.1	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.5	0.2	-0.8	0.0	0.3	1.2	-0.2	0.9	0.3	-0.7
Mood swings	1.9	3.5	7.6	-2.7	0.4	-1.8	-1.7	0.7	-1.4	0.9	-2.8	-2.6
Loneliness, isolation	1.7	2.3	5.5	-1.6	0.6	-1.8	-2.1	0.9	-1.2	0.4	-2.3	-1.5
Long-standing illness, disability or infirmity	0.6	1.0	6.1	-0.2	-2.5	0.2	0.3	-0.3	-0.9	-0.9	0.3	0.7
Ever had bowel cancer screening	0.5	0.6	2.2	-1.1	-0.5	-0.1	-0.1	-0.8	1.1	-0.5	0.1	1.5
Diabetes diagnosed by doctor	2.1	3.4	23.2	-0.8	-4.8	0.5	0.9	0.9	-0.4	0.5	0.8	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	3.2	-0.8	-1.3	-0.9	-0.0	-0.0	-1.8	0.7	-0.5	-0.8
Friendships satisfaction	2.0	2.5	4.9	-2.2	-1.3	-1.3	-1.8	-1.2	0.5	-1.2	-2.0	2.0
Qualifications: nursing, teaching	1.1	1.8	7.1	0.7	-1.3	1.2	0.0	-1.2	1.5	-1.1	0.7	2.7
Commuting to job workplace: Walk	1.0	1.1	2.8	-1.1	0.4	-1.1	-1.7	-0.7	-1.3	-0.6	-1.0	-1.0
Eye problems/disorders: Cataract	0.6	0.6	1.3	0.2	-1.0	-0.7	-0.5	-0.8	1.1	-0.6	-0.6	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.8	1.0	0.4	0.3	-0.3	-1.6	-0.0	-1.7	0.6	0.6
Medication for cholesterol	1.8	2.8	10.7	0.7	3.3	2.5	0.3	0.5	-0.4	0.2	0.1	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	-0.2	-0.1	0.2	1.3	0.5	0.9	1.2	0.8	0.2
Back pain experienced in last month	0.5	0.7	2.3	-0.6	-1.2	-1.5	-0.9	0.6	-0.4	-0.5	-0.8	-0.5
Mineral and other dietary supplements	1.8	2.4	11.2	-0.2	3.4	0.6	0.0	-1.1	1.4	-1.3	1.2	1.9
Breast cancer (self-reported)	0.2	0.3	0.8	-0.0	0.0	0.8	0.1	-0.4	0.9	-0.7	0.3	0.5
Asthma (self-reported)	0.3	0.5	1.2	0.6	1.1	0.9	0.5	-1.0	-0.2	-0.4	0.4	0.8
Osteoporosis (self-reported)	1.7	2.1	4.5	-1.1	-1.3	-2.0	-2.0	-0.2	-1.2	-1.6	-2.1	-0.4
Osteoarthritis (self-reported)	0.6	0.8	2.8	0.3	-0.6	0.7	0.6	-1.3	0.7	-0.4	0.7	1.7
Medication: Aspirin	4.8	6.2	23.1	-1.5	-4.6	-4.8	-1.9	0.5	-0.4	-0.3	-2.0	1.3
Medication: Gliclazide	0.6	0.7	4.6	-0.6	-2.1	-0.1	0.9	-0.2	-0.6	0.4	0.3	0.5
Illnesses of father: None of the above (group 1)	3.6	4.5	13.2	1.9	3.6	2.9	2.3	1.0	1.9	0.4	2.1	-0.9
Smoking status: Current	1.5	2.4	8.3	-1.4	-0.2	-1.5	-1.7	0.8	-1.0	0.5	-2.2	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.5	1.2	-1.3	1.1	0.5	-1.9	-0.8	-1.2	0.7	1.7
Whole body water mass	0.8	4.4	14.7	-3.8	0.8	-1.4	-1.4	2.5	2.1	2.5	-1.8	0.1
Leg predicted mass (right)	0.8	4.5	14.5	-3.8	1.6	-1.3	-1.2	2.2	2.7	2.5	-1.5	0.1
Arm fat mass (left)	0.3	1.4	5.5	-1.4	2.2	0.1	0.0	-0.3	2.4	0.3	-0.2	0.4
Number of self-reported non-cancer illnesses	3.3	5.7	19.3	-0.4	-4.4	-2.8	-1.6	-1.8	-0.3	-2.3	-0.8	3.5
Average weekly champagne plus white wine intake	1.4	1.9	7.1	-0.5	2.7	-0.9	0.6	1.5	0.0	2.3	0.1	-1.2
Miserableness	0.6	1.1	5.1	-0.1	-0.3	-2.2	-1.5	-0.5	-0.5	-0.3	-1.2	0.7
Guilty feelings	2.8	4.2	7.8	-1.6	-1.4	-2.2	-2.7	2.4	-1.1	1.4	-2.8	-2.1
Wears glasses or contact lenses	1.2	1.4	3.1	-1.3	-1.3	-1.8	-1.0	1.1	-1.1	-0.2	-1.1	-1.1
Ever taken oral contraceptive pill	1.0	1.1	6.3	-0.0	0.1	2.5	0.9	-0.1	0.5	0.6	1.1	1.2
Hearing aid user	0.8	0.9	4.9	-2.2	0.9	-0.5	-0.4	0.7	0.6	0.3	-0.1	0.8
Mother’s age at death	2.6	3.3	13.4	1.3	1.2	3.7	2.5	-1.2	0.5	-0.1	2.2	0.0
Financial situation satisfaction	1.1	1.3	3.6	-0.4	0.0	0.8	-1.8	-1.9	0.4	-1.2	-1.6	0.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.3	1.8	-0.7	0.8	1.0	-0.4	-1.4	-1.1	1.0	-0.6
Commuting to job workplace: Public transport	0.6	0.7	2.8	-0.3	-1.7	-0.3	-0.3	0.3	-1.5	-0.4	-0.4	-0.7
Eye problems/disorders: Glaucoma	0.9	1.1	3.8	-0.3	-0.0	-0.5	0.8	1.8	0.3	1.9	-0.2	-1.3
Medication: Blood pressure	0.9	1.7	6.9	-1.2	-2.6	-0.8	-0.7	0.5	0.9	0.1	-0.1	2.2
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.1	-1.9	-0.3	-2.3	-2.2	0.9	0.2	-0.4	-2.1	-1.4
Supplements: Fish oil (including cod liver oil)	1.9	2.5	11.3	-0.1	-3.4	-1.1	-0.4	1.4	-1.2	1.4	-1.7	-1.3
High cholesterol (Self-reported)	10.2	18.1	50.1	-0.3	-6.6	-7.1	-2.2	-4.2	-2.8	-4.8	-2.2	3.1
Medication: Bendroflumethiazide	0.6	0.9	3.2	0.7	-0.2	0.9	0.8	-0.4	1.8	-0.1	1.0	1.3
Medication: Paracetamol	0.3	0.5	2.0	-0.1	0.7	-0.4	-0.6	0.3	0.1	1.4	-0.4	-0.9
Medication: Lisinopril	0.5	0.6	1.9	-1.0	-1.4	-0.7	0.2	0.7	-0.3	1.0	-0.1	0.7
Medication: Atorvastatin	6.1	7.6	28.8	-0.6	-4.6	-5.4	-0.9	-1.8	-1.3	-1.8	-1.1	2.8
Illnesses of father: High blood pressure	0.8	1.0	2.7	0.7	-1.4	-0.9	0.3	-1.2	-0.4	-0.4	1.0	1.6
Alcohol drinker status: Never	0.7	0.8	3.8	-0.2	0.2	-0.2	0.4	0.4	-1.7	0.6	-0.2	-2.0
Ever smoked	0.6	1.1	7.6	-0.0	-0.4	-2.8	-0.3	0.8	-0.4	0.2	-1.0	-0.8
Basal metabolic rate	0.8	4.2	12.9	-3.6	1.2	-1.1	-1.1	2.4	2.5	2.5	-1.5	0.2
Leg fat percentage (left)	0.3	0.9	3.1	-0.2	1.0	1.0	0.2	-1.8	1.1	-1.3	0.2	0.5
Arm fat-free mass (left)	0.7	3.5	13.2	-3.6	0.6	-1.0	-1.1	2.0	2.2	2.1	-1.6	0.2
Number of operations (self-reported)	1.0	1.5	5.6	0.5	-1.5	-0.4	1.3	-1.0	0.5	-0.6	1.2	2.4
Average weekly beer plus cider intake	1.5	2.2	11.3	0.4	-0.2	0.7	-0.0	-3.4	0.8	-1.5	0.5	2.3
Irritability	0.3	0.5	1.4	0.3	1.2	-1.1	-0.4	-0.9	-0.4	-0.5	0.3	-0.3
Risk taking	0.5	0.7	2.3	-0.2	1.5	-0.9	0.5	-1.2	0.5	0.2	0.7	0.7
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.1	0.3	-0.6	-1.4	-1.0	0.6	-2.0	-1.2	-0.9	-1.2
Fractured/broken bones in last 5 years	0.1	0.2	0.9	-0.1	0.6	-0.1	-0.0	-0.4	-0.3	-0.2	-0.4	-1.0
Age started oral contraceptive pill	1.8	2.2	7.9	-1.2	0.5	-1.2	-2.8	-0.7	-1.8	-1.1	-1.9	-0.8
Diastolic blood pressure, automated reading	0.7	2.1	4.1	-0.8	1.3	1.5	-1.6	-1.4	2.0	-1.3	-0.4	2.0
Ever depressed for a whole week	1.6	2.0	8.1	-2.8	-0.5	-1.4	-1.4	1.0	-1.0	0.4	-1.9	-0.1
Unable to work because of sickness or disability	1.0	1.3	4.3	-1.0	-2.1	0.6	-0.9	-1.0	-0.6	-1.5	-1.2	-0.1
Commuting to job workplace: Cycle	0.3	0.4	1.9	-0.1	0.6	0.5	0.3	-0.5	-1.4	-0.7	-0.2	-0.1
Myopia	0.1	0.1	0.5	0.4	-0.5	0.3	0.2	0.1	-0.2	-0.4	0.7	-0.2
Vascular/heart problems diagnosed by doctor	2.2	6.1	18.7	2.6	4.3	3.1	2.5	0.5	1.3	1.3	2.1	-2.3
Cholesterol lowering medication	3.2	4.7	14.7	1.3	-3.8	-3.7	-0.9	-1.9	-0.4	-1.8	-0.5	2.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	1.4	0.9	-0.6	0.7	-0.5	-0.4	0.3	0.7	-0.4
Pain experienced in last month	0.8	1.4	3.6	1.1	-0.2	1.7	1.0	0.3	0.9	0.4	1.5	1.9
Supplements: Calcium	0.4	0.4	1.3	-0.0	0.6	-0.2	1.0	0.4	-0.3	0.8	0.1	-1.2
Basal cell carcinoma (self-reported)	0.8	0.9	4.8	0.5	0.2	2.2	1.3	-0.1	0.7	0.7	0.8	0.3
Heart attack/myocardial infarction (self-reported)	6.9	9.0	26.2	-1.6	-3.9	-5.1	-2.7	-1.6	-3.3	-2.3	-2.8	1.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.7	-0.7	0.1	-0.1	0.1	0.2	1.3	-0.4	0.4	0.0
Heart disease (siblings)	7.0	8.6	22.1	-1.9	-3.6	-4.7	-3.0	-2.0	-3.5	-3.0	-1.9	0.9
Alcohol drinker status: Previous	2.3	2.6	6.4	-1.4	-2.5	-1.6	-1.7	1.3	-2.1	-0.6	-1.5	-1.0
Pack years of smoking	1.0	1.4	3.9	-1.2	-0.2	-0.8	-1.6	-0.3	-0.4	-1.0	-2.0	-1.7
Impedance of whole body	0.4	1.9	7.7	2.8	1.4	1.4	1.3	-1.0	0.7	-0.1	1.5	-0.2
Leg fat mass (left)	0.3	1.0	3.3	-1.8	1.4	-0.2	-0.2	-0.5	1.8	0.1	-0.6	0.6
Arm predicted mass (left)	0.7	3.6	13.4	-3.7	0.7	-1.1	-1.2	1.9	2.5	1.9	-1.5	0.6