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chr15:74,042,497-75,930,199

Best TWAS P=3.75e-11 · Best GWAS P=5.49e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ULK3	0.22	0.10	enet	19	0.12	2.9e-10	5.8	5.7	1.2e-08	0.62	0.08	0.92	FALSE
2	GTEx	Adipose Subcutaneous	FAM219B	0.07	0.01	lasso	6	0.02	1.4e-02	3.8	-5.3	1.5e-07	-0.77	0.30	0.32	FALSE
3	GTEx	Adipose Subcutaneous	CTD-2235H24.2	0.09	0.01	lasso	13	0.01	1.2e-01	5.6	-6.2	6.4e-10	-0.77	0.28	0.26	FALSE
4	GTEx	Adipose Visceral Omentum	ULK3	0.13	0.12	enet	8	0.11	3.3e-06	5.8	5.7	9.8e-09	0.82	0.08	0.92	FALSE
5	GTEx	Brain Caudate basal ganglia	MPI	0.23	0.25	lasso	4	0.23	3.1e-07	5.4	-5.3	1.1e-07	-0.77	0.20	0.76	FALSE
6	GTEx	Brain Frontal Cortex BA9	MPI	0.29	0.12	lasso	10	0.19	9.7e-06	4.7	-5.6	2.7e-08	-0.81	0.14	0.82	FALSE
7	GTEx	Brain Hippocampus	MPI	0.13	0.07	lasso	3	0.06	1.7e-02	5.8	-5.5	4.0e-08	-0.75	0.05	0.30	FALSE
8	GTEx	Breast Mammary Tissue	ULK3	0.15	0.11	lasso	3	0.09	1.6e-05	5.4	5.4	5.9e-08	0.77	0.22	0.77	FALSE
9	GTEx	Breast Mammary Tissue (Female)	ULK3	0.08	0.01	lasso	2	0.01	1.8e-01	5.8	5.8	8.9e-09	0.75	0.04	0.19	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	ULK3	0.19	0.04	lasso	2	0.08	1.2e-03	5.7	5.7	1.4e-08	0.75	0.11	0.67	FALSE
11	GTEx	Lung	CSK	0.09	0.06	lasso	3	0.05	1.4e-04	6.5	6.5	7.4e-11	0.84	0.02	0.98	FALSE
12	GTEx	Muscle Skeletal	UBL7	0.06	0.02	lasso	6	0.01	3.7e-02	6.3	-6.3	2.5e-10	-0.84	0.02	0.87	FALSE
13	GTEx	Ovary	ULK3	0.19	0.23	lasso	1	0.23	3.0e-06	5.8	5.8	8.9e-09	0.75	0.10	0.45	FALSE
14	GTEx	Pancreas	ULK3	0.12	0.10	lasso	4	0.07	6.9e-04	5.7	5.8	8.6e-09	0.78	0.10	0.85	FALSE
15	GTEx	Stomach	ULK3	0.16	0.13	lasso	2	0.11	9.7e-06	5.7	5.8	7.3e-09	0.72	0.23	0.75	FALSE
16	GTEx	Testis	ULK3	0.15	0.03	enet	24	0.06	1.6e-03	5.8	5.6	1.9e-08	0.59	0.10	0.81	FALSE
17	GTEx	Thyroid	ULK3	0.11	0.09	lasso	4	0.13	5.9e-10	5.8	5.6	2.4e-08	0.65	0.35	0.65	FALSE
18	GTEx	Uterus	ULK3	0.40	0.16	lasso	16	0.12	2.2e-03	5.6	5.5	4.8e-08	0.81	0.05	0.65	FALSE
19	GTEx	Vagina	COX5A	0.38	0.02	lasso	7	0.02	9.3e-02	6.4	-6.2	4.6e-10	-0.78	0.04	0.62	FALSE
20	GTEx	Whole Blood	ULK3	0.14	0.06	lasso	5	0.04	8.3e-05	5.8	5.5	3.7e-08	0.69	0.16	0.81	FALSE
21	METSIM	Adipose	ULK3	0.14	0.14	lasso	10	0.15	3.2e-22	5.8	6.0	2.5e-09	0.84	0.08	0.92	FALSE
22	YFS	Blood	CSK	0.13	0.15	lasso	11	0.16	6.7e-51	6.6	6.6	3.7e-11	0.97	0.00	1.00	TRUE
23	YFS	Blood	ULK3	0.09	0.11	lasso	6	0.11	1.1e-33	5.8	6.0	1.9e-09	0.80	0.40	0.60	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	ULK3	0.02	0.02	blup	49	0.02	1.1e-05	5.8	6.0	2.1e-09	0.79	0.07	0.92	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ULK3	0.03	0.03	lasso	3	0.03	5.3e-04	5.6	5.8	5.7e-09	0.79	0.04	0.93	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCAMP2	0.18	0.04	enet	5	0.06	6.1e-07	5.9	-5.1	3.0e-07	-0.79	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ULK3	0.10	0.02	blup	49	0.07	2.5e-04	5.8	5.3	1.2e-07	0.67	0.04	0.94	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ULK3	0.04	0.06	lasso	4	0.04	7.6e-06	5.6	5.8	7.2e-09	0.77	0.06	0.93	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	ULK3	0.08	0.11	lasso	5	0.10	4.6e-10	5.6	5.9	3.2e-09	0.80	0.05	0.95	FALSE