Best TWAS P=2.12e-11 · Best GWAS P=8.39e-11 conditioned to 0.148
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CPNE3 | 0.17 | 0.07 | blup | 453 | 0.10 | 7.9e-12 | 5.0 | -5.4 | 8.6e-08 | 0.59 | 0.20 | 0.80 | FALSE |
2 | GTEx | Artery Tibial | RMDN1 | 0.18 | 0.08 | lasso | 9 | 0.10 | 1.8e-08 | -6.2 | 6.0 | 2.4e-09 | -0.95 | 0.01 | 0.99 | FALSE |
3 | GTEx | Brain Cerebellum | NTAN1P2 | 0.19 | 0.14 | enet | 11 | 0.10 | 6.0e-04 | -5.8 | -5.8 | 8.4e-09 | 0.90 | 0.02 | 0.95 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | WWP1 | 0.06 | 0.00 | lasso | 6 | 0.00 | 1.5e-01 | 5.2 | -5.4 | 6.1e-08 | 0.71 | 0.14 | 0.09 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | RMDN1 | 0.27 | 0.15 | enet | 30 | 0.23 | 1.5e-17 | 2.3 | 5.4 | 6.1e-08 | -0.81 | 0.17 | 0.83 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | NTAN1P2 | 0.07 | 0.02 | lasso | 6 | 0.03 | 2.0e-03 | -6.2 | 5.3 | 9.6e-08 | -0.84 | 0.01 | 0.98 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | RMDN1 | 0.22 | 0.07 | lasso | 7 | 0.11 | 1.9e-06 | 4.9 | 5.8 | 7.7e-09 | -0.82 | 0.04 | 0.93 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | RMDN1 | 0.05 | 0.04 | lasso | 2 | 0.01 | 1.1e-01 | 5.2 | 5.2 | 2.3e-07 | -0.80 | 0.08 | 0.87 | FALSE |
9 | GTEx | Spleen | RMDN1 | 0.46 | 0.20 | enet | 29 | 0.18 | 2.2e-05 | -6.5 | 5.8 | 5.5e-09 | -0.83 | 0.02 | 0.97 | FALSE |
10 | GTEx | Stomach | RMDN1 | 0.15 | 0.05 | lasso | 6 | 0.06 | 1.2e-03 | -6.5 | 6.4 | 1.2e-10 | -0.88 | 0.01 | 0.97 | FALSE |
11 | METSIM | Adipose | RMDN1 | 0.13 | 0.07 | enet | 39 | 0.06 | 8.9e-09 | 5.2 | 5.2 | 2.5e-07 | -0.61 | 0.20 | 0.80 | FALSE |
12 | YFS | Blood | WWP1 | 0.09 | 0.06 | blup | 457 | 0.09 | 1.3e-26 | 5.0 | -5.4 | 6.6e-08 | 0.77 | 0.08 | 0.92 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CPNE3 | 0.07 | 0.03 | lasso | 4 | 0.05 | 2.3e-06 | -6.2 | -5.4 | 5.1e-08 | 0.82 | 0.00 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WWP1 | 0.03 | 0.01 | blup | 63 | 0.02 | 1.8e-03 | -5.7 | -6.2 | 7.0e-10 | 0.92 | 0.03 | 0.90 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | WWP1 | 0.05 | 0.01 | enet | 8 | 0.02 | 2.0e-02 | 5.2 | -5.7 | 1.4e-08 | 0.80 | 0.02 | 0.61 | FALSE |
16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FAM82B | 0.07 | 0.00 | blup | 45 | 0.01 | 1.1e-01 | -6.5 | 6.7 | 2.1e-11 | -0.86 | 0.00 | 0.66 | TRUE |