Hub : Genes

NTAN1P2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.193 0.067 0.00059 0.144 NA 0.103 NA 0.020 4.9e-05 NA 0.00060 NA 8.2e-02
2 GTEx Cells Transformed fibroblasts 0.066 0.027 0.00170 0.020 NA 0.023 NA 0.031 1.2e-02 NA 0.00690 NA 2.0e-03
3 GTEx Thyroid 0.056 0.027 0.00660 0.051 NA 0.040 NA 0.055 9.2e-05 NA 0.00049 NA 4.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.4 0.8 -0.1 0.6 0.9
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 -0.2 0.1 0.4
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.7 -0.1 0.0
Depression (Nagel 2018) 0.2 0.2 0.7 0.8 0.2 0.1
Intelligence (Savage-Jansen 2018) 3.6 11.1 17.3 3.3 -4.2 -2.3
Neuroticism (Nagel 2018) 0.2 0.5 0.9 -0.1 1.0 0.7
Schizophrenia (2018) 0.0 0.1 0.1 -0.2 -0.3 -0.2
Schizophrenia vs Biploar Disorder 2.3 3.0 3.3 1.7 -1.8 -1.7
Worry (Nagel 2018) 0.1 0.3 0.6 0.5 0.3 -0.8
Alzheimer’s Disease (in mother) 1.9 2.2 3.2 1.2 -1.8 -1.4
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.6 0.4 0.2
Alzheimer’s Disease (including proxy) 0.6 0.9 2.1 -0.0 -0.8 -1.5
Crohns Disease (2017) 0.1 0.2 0.4 0.3 -0.4 -0.6
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 0.7 -0.4 0.1
Ulcerative Colitis (UC) 0.3 0.6 0.8 0.9 -0.6 0.8
Major Depression (MDD) 1.1 1.3 2.3 1.5 -0.8 -1.0
Reaction Time 3.8 7.3 9.7 -3.1 2.3 2.6
Verbal and Numeric Reasoning (VNR) 4.8 11.6 16.7 3.8 -4.1 -1.9
Breast Cancer 0.1 0.1 0.4 0.6 -0.2 0.2
Ovarian Cancer 0.9 1.2 1.4 1.2 -1.0 -1.2
Prostate Cancer 0.2 0.3 0.5 0.7 0.7 0.2
Age at First Birth 1.2 1.7 3.1 0.9 -1.1 1.7
Bipolar Disorder (2011) 0.6 0.6 0.9 -0.9 1.0 -0.1
Body Mass Index (BMI) (2010) 1.9 2.6 3.8 -1.8 2.0 1.0
Coronary Artery Disease (CAD) 1.8 2.2 4.5 1.1 -1.0 -2.1
Crohns Disease (2012) 0.2 0.3 0.7 -0.5 0.9 0.1
Mean Putamen Volume 0.9 1.0 1.3 0.9 -1.1 -1.0
Fasting Glucose 2.5 2.9 4.9 2.2 -1.0 -1.7
HbA1C 2.6 2.9 3.5 -1.7 1.9 1.5
HDL Cholesterol 0.1 0.2 0.3 0.4 -0.3 -0.5
LDL Cholesterol 0.7 1.1 3.0 -0.2 0.4 -1.7
Lupus 0.1 0.1 0.3 0.5 -0.1 0.3
Neuroticism (2016) 0.6 0.8 2.4 1.6 0.2 0.0
Primary Biliary Cirrhosis 2.1 3.0 3.2 -1.7 1.6 1.8
Rheumatoid Arthritis 0.7 0.9 1.6 -1.0 1.2 -0.3
Schizophrenia (2014) 0.0 0.0 0.1 -0.3 0.2 0.1
Triglycerides 1.3 2.1 4.3 -1.2 2.1 0.7
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.1 1.0 -0.7 -0.2
Ulcerative Colitis 0.9 1.3 3.0 1.7 -1.0 -0.1
Blood Eosinophil Count 0.2 1.8 4.6 -0.9 0.3 -2.1
Blood Platelet Count 0.6 7.3 8.8 -2.6 2.5 3.0
Blood Red Count 0.9 8.6 11.6 -3.4 3.0 2.3
Blood White Count 1.2 8.9 14.4 -3.5 3.8 -0.1
Heel T-Score 0.2 1.9 4.8 -2.2 0.7 0.6
BMI 3.9 22.6 33.2 -5.8 5.3 2.5
Height 2.1 39.7 65.0 5.0 -8.1 -5.4
Waist Hip Ratio (WHR) 0.0 0.0 0.1 -0.2 0.1 0.3
Systolic Blood Pressure 0.1 0.6 0.8 -0.4 -0.9 -0.9
Smoking Status 0.1 0.2 0.3 -0.4 0.5 -0.5
Allergy or Eczema 1.0 2.8 5.4 1.7 -2.3 0.1
Cardiovascular Disease 0.3 1.2 2.7 -0.8 1.6 -0.4
Hypothyroidism (self reported) 0.5 1.1 2.7 0.5 0.6 -1.6
Respiratory disease 0.2 0.5 1.0 -0.1 -1.0 0.8
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.0 -0.6 -0.3
Lung FEV1/FVC ratio 0.4 1.9 3.0 -0.1 1.6 1.7
Lung FVC 0.2 0.8 1.5 -0.4 1.2 -0.9
Neuroticism 0.1 0.3 0.5 0.5 0.3 0.7
Chronotype (morning person) 0.3 0.8 1.3 -1.0 -0.2 1.2
Hair Pigment 0.1 3.9 5.5 2.1 -2.4 -1.3
Tanning 0.2 2.4 3.2 1.8 -1.1 -1.7
Hand grip strength (left) 0.3 0.7 1.7 0.2 -1.3 -0.6
Number of treatments/medications taken 1.5 2.7 5.2 -1.6 2.3 -0.2
Average weekly spirits intake 2.0 2.5 4.2 -1.8 2.1 0.1
Sensitivity / hurt feelings 3.5 6.0 8.9 -2.5 3.0 1.7
Frequency of depressed mood in last 2 weeks 1.3 1.9 4.4 2.1 -0.8 -0.7
Hearing difficulty/problems: Yes 0.1 0.1 0.2 -0.1 0.5 0.0
Relative age of first facial hair 1.8 3.7 4.4 2.1 -1.6 -2.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.1 -0.1 1.1 0.1
Ever used hormone-replacement therapy (HRT) 1.7 2.1 3.8 -1.5 1.9 -0.6
Ever had hysterectomy (womb removed) 3.2 3.7 4.3 -2.1 1.9 1.7
Systolic blood pressure, automated reading 0.2 0.5 1.2 -1.1 0.5 0.3
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.2 -0.7 1.1 0.7
Angina 1.3 1.7 2.8 -0.1 -1.5 -1.7
Medication for hormone replacement therapy 2.7 3.1 3.7 1.9 -1.5 -1.8
Vitamin and mineral supplements 1.0 1.3 2.0 -1.4 1.4 0.5
Supplements: Zinc 1.3 1.4 3.1 1.0 -1.7 -0.3
Medication: Co-codamol 0.4 0.5 0.8 -0.4 0.7 -0.9
Medication: Metformin 0.7 0.9 2.7 0.3 -1.6 -0.3
Diabetes (father) 2.4 3.0 3.9 2.0 -1.4 -1.8
Diabetes (mother) 0.3 0.3 0.5 -0.7 0.7 -0.3
Severe depression (siblings) 0.2 0.2 0.3 -0.5 0.2 0.5
Pack years adult smoking proportion 1.3 2.0 5.7 -0.6 -0.1 -2.4
Impedance of leg (right) 0.0 0.2 0.5 0.3 0.7 -0.3
Leg fat-free mass (left) 0.1 0.6 0.8 -0.9 -0.9 -0.4
Trunk fat percentage 3.2 12.9 20.6 -4.5 4.0 1.3
Hand grip strength (right) 0.7 2.0 4.1 0.4 -2.0 -1.3
Townsend deprivation index at recruitment 1.6 2.3 5.4 -0.9 2.3 0.9
Current tobacco smoking 0.6 1.0 1.6 -1.3 1.2 0.1
Average weekly fortified wine intake 6.8 8.0 10.1 3.2 -2.9 -2.3
Maternal smoking around birth 0.7 1.0 2.4 -0.4 1.5 0.7
Fed-up feelings 0.6 1.1 2.0 1.4 -1.1 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.3 0.5 0.4 -0.5
Relative age voice broke 2.3 3.5 5.0 2.1 -2.2 -1.1
Taking other prescription medications 1.8 2.8 5.1 -1.1 2.3 -1.4
Age when periods started (menarche) 5.5 13.2 19.5 3.0 -3.4 -4.4
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 3.4 -1.8 1.8 1.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 4.6 -2.2 1.2 -0.7
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 -0.2 0.4 0.2
Qualifications: CSEs or equivalent 0.1 0.2 0.4 0.7 0.1 -0.4
Serious illness, injury or assault to yourself 1.8 2.2 3.8 2.0 -1.1 -1.2
High blood pressure 0.4 1.0 1.5 -0.8 1.2 -0.9
Hayfever, allergic rhinitis or eczema 0.9 2.0 3.9 1.4 -2.0 0.6
Multivitamins +/- minerals 4.0 5.0 7.9 2.4 -2.8 -1.2
Stomach or abdominal pain in last month 2.3 2.9 6.1 -1.0 1.2 2.5
Supplements: Glucosamine 1.8 2.4 3.4 1.9 -1.2 -1.5
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 5.1 2.3 -1.8 -0.2
Medication: Atenolol 0.8 1.0 2.7 -0.4 0.0 -1.7
Medication: Levothyroxine sodium 0.7 1.2 3.5 0.2 0.3 -1.9
Sitting height 0.8 6.0 10.3 1.4 -3.2 -2.4
Chronic bronchitis/emphysema (father) 0.4 0.5 0.9 -1.0 0.7 0.3
High blood pressure (mother) 0.3 0.5 0.9 -0.7 0.9 0.3
Body mass index (BMI) 3.4 14.4 23.4 -4.8 4.1 1.8
Impedance of leg (left) 0.1 0.6 1.9 -0.1 1.4 -0.1
Leg predicted mass (left) 0.1 0.5 0.8 -0.8 -0.9 -0.4
Trunk fat mass 2.5 10.7 19.1 -4.4 3.4 1.0
Waist circumference 3.3 11.9 20.3 -4.5 3.5 1.7
Number of incorrect matches in round 0.5 0.9 1.3 -1.0 0.5 1.2
Past tobacco smoking 0.8 1.5 1.8 1.3 -1.4 -1.0
Alcohol usually taken with meals 3.6 5.9 9.0 3.0 -2.9 -0.6
Nervous feelings 0.0 0.1 0.2 -0.0 0.2 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.3 1.1 0.1 -0.1
Hearing difficulty/problems with background noise 0.2 0.4 0.8 -0.4 0.9 -0.4
Hair/balding pattern: Pattern 2 1.1 1.4 1.6 1.2 -1.3 -1.1
Had menopause 0.3 0.4 0.5 -0.6 0.7 -0.6
Had other major operations 0.4 0.5 0.6 0.7 -0.8 -0.6
Forced vital capacity (FVC) 1.1 4.2 6.2 1.6 -2.0 -2.5
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 2.7 -1.6 1.3 -0.8
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 3.3 1.8 -0.4 -0.6
Qualifications: None of the above 3.0 6.5 10.5 -3.0 3.2 0.2
Financial difficulties in last 2 years 0.3 0.4 0.9 1.0 -0.1 -0.6
Mouth/teeth dental problems 0.0 0.1 0.1 0.2 -0.0 -0.4
Heart attack 4.7 6.0 8.4 1.5 -2.7 -2.9
Allergy 0.5 1.1 2.3 -0.1 0.9 -1.5
Pain all over the body in last month 1.6 1.7 3.9 2.0 -0.6 -1.0
Diabetes (self-reported) 0.3 0.4 0.9 0.4 -0.9 -0.5
Hayfever/allergic rhinitis (self-reported) 3.9 5.1 9.8 2.3 -3.1 -0.7
Medication: Ramipril 1.9 2.4 3.5 1.0 -1.9 -1.6
Medication: Simvastatin 0.3 0.4 1.0 -0.4 1.0 -0.4
Fluid intelligence score 3.2 6.7 10.4 3.2 -2.9 -1.1
Illnesses of siblings 0.8 1.2 1.6 -0.6 1.3 1.2
Neuroticism score 0.2 0.3 0.5 0.7 0.3 0.6
Weight 1.0 5.1 11.5 -3.4 1.9 0.4
Impedance of arm (right) 0.5 2.4 4.1 2.0 -1.4 -1.2
Arm fat percentage (right) 3.2 12.7 20.2 -4.5 4.0 1.4
Trunk fat-free mass 0.1 0.8 1.4 -0.5 -1.2 -0.9
Hip circumference 1.1 4.7 9.4 -3.1 2.1 0.6
Time employed in main current job 4.2 4.8 8.6 -2.0 2.9 1.3
Alcohol intake versus 10 years previously 1.1 1.7 2.9 -1.3 0.7 1.7
Father’s age at death 2.3 3.1 3.9 2.0 -1.6 -1.7
Worrier / anxious feelings 0.2 0.3 0.6 0.8 0.3 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.6 0.2 1.3 0.7
Falls in the last year 0.6 0.9 1.4 0.9 -0.5 -1.2
Hair/balding pattern: Pattern 3 1.3 1.9 3.4 -1.9 0.7 1.3
Number of live births 1.3 1.8 2.6 -1.3 1.6 1.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 3.1 1.3 -1.4 -1.8
Pulse rate 2.9 4.8 5.8 -2.4 2.2 1.9
Happiness 1.0 1.2 1.8 1.4 -1.3 -0.2
Noisy workplace 1.3 1.7 3.7 -1.1 1.9 -0.1
Qualifications: A levels/AS levels or equivalent 2.9 6.5 12.4 3.5 -2.6 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 1.9 1.4 -0.7 -0.9
Mouth/teeth dental problems: Dentures 2.0 3.3 7.5 -1.5 2.7 0.3
Asthma 0.2 0.3 0.4 -0.4 -0.6 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.1 1.0 -1.1 -0.4
Medication: Cholesterol lowering 1.8 2.8 7.8 0.7 -0.0 -2.8
Depression (self-reported) 0.6 0.7 1.3 -0.8 1.1 -0.4
Medication: Lansoprazole 1.7 1.9 3.2 -0.7 1.5 -1.8
Prospective memory result 1.0 1.2 2.0 0.9 -1.4 -0.9
Lung cancer (father) 1.4 1.6 3.6 -1.0 1.9 0.6
Illnesses of mother 1.2 1.5 2.6 0.9 -1.6 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 2.7 0.9 -1.4 -1.6
Pulse wave Arterial Stiffness index 0.2 0.2 0.5 -0.7 0.1 0.2
Impedance of arm (left) 0.3 1.3 2.7 1.6 -1.0 -0.6
Arm fat mass (right) 2.3 9.5 16.9 -4.1 3.2 1.1
Trunk predicted mass 0.1 0.8 1.4 -0.5 -1.2 -0.9
Standing height 1.1 10.8 18.3 2.5 -4.3 -2.8
Length of working week for main job 2.5 2.8 3.9 1.7 -2.0 -1.2
Exposure to tobacco smoke at home 0.2 0.2 0.4 -0.6 0.4 0.3
Breastfed as a baby 0.3 0.3 1.0 0.1 -0.0 1.0
Tense / ‘highly strung’ 0.2 0.3 0.5 0.0 0.7 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.2 1.5 -0.2 -0.6
Hair/balding pattern: Pattern 4 0.5 1.1 2.2 1.5 -0.8 0.6
Birth weight of first child 0.8 1.5 3.6 0.8 -1.9 0.4
Peak expiratory flow (PEF) 0.7 1.7 3.4 0.4 -1.3 -1.9
Pulse wave reflection index 2.2 2.7 4.1 1.9 -2.0 -0.7
Ever highly irritable/argumentative for 2 days 1.6 1.9 4.3 -0.9 2.1 -0.7
Loud music exposure frequency 1.6 1.8 3.9 -1.0 2.0 0.7
Qualifications: O levels/GCSEs or equivalent 2.7 4.3 6.5 2.5 -2.5 0.3
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 3.1 1.3 -1.8 -0.9
Blood clot in the leg (DVT) 1.2 1.5 2.1 -1.1 1.1 1.4
Medication: Paracetamol 0.7 1.2 1.7 -1.1 1.3 0.8
Headache pain in last month 1.0 1.8 3.0 -1.5 1.7 0.2
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 2.1 1.1 -1.0 1.5
Glaucoma (self-reported) 0.8 0.9 2.4 0.6 -1.5 -0.2
Gout (self-reported) 0.1 0.1 0.4 0.6 0.0 -0.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.0 0.1 0.8 -1.7
Medication: Amlodipine 0.7 0.9 2.0 -1.4 0.9 0.3
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.9 0.1 0.9 0.2
Birth weight 0.3 0.7 1.4 -0.3 -0.8 1.2
Chronic bronchitis/emphysema (mother) 1.1 1.2 2.7 1.6 -0.7 0.7
High blood pressure (siblings) 0.7 1.0 1.4 0.9 -0.9 -1.2
Forced vital capacity (FVC), Best measure 1.4 5.2 8.5 1.5 -2.2 -2.9
Body fat percentage 4.1 16.2 25.3 -5.0 4.6 1.5
Leg fat percentage (right) 5.9 21.5 30.5 -5.5 5.4 2.2
Arm fat-free mass (right) 0.1 0.7 2.0 -1.4 -0.3 -0.2
Exposure to tobacco smoke outside home 0.2 0.3 0.3 -0.6 0.6 -0.4
Comparative body size at age 10 5.0 13.8 18.0 -3.8 4.2 3.0
Number of full brothers 0.2 0.3 0.9 0.1 -0.9 0.1
Worry too long after embarrassment 0.7 1.1 2.4 1.5 -1.0 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.2 0.4 -0.2
Wheeze or whistling in the chest in last year 2.0 3.6 6.0 -2.2 2.5 0.2
Number of children fathered 0.1 0.1 0.2 -0.5 -0.4 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 8.4 9.9 12.6 -3.5 3.1 2.7
Age at first live birth 4.6 8.2 11.3 3.4 -3.3 -1.6
Pulse wave peak to peak time 0.2 0.2 0.4 0.6 -0.2 -0.4
Health satisfaction 3.2 4.2 9.6 -1.7 3.1 0.4
Shortness of breath walking on level ground 1.4 1.7 2.6 -1.6 1.5 0.3
Qualifications: College or University degree 4.7 14.7 17.3 4.1 -4.2 -3.2
Eye problems/disorders: None of the above 0.3 0.3 0.6 -0.5 0.2 -0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.6 0.1 -0.4 0.8
Emphysema/chronic bronchitis 0.5 0.6 1.0 -1.0 0.8 0.4
Medication for pain relief, constipation, heartburn 1.1 2.0 3.1 1.8 -1.5 -0.7
Neck or shoulder pain in last month 0.2 0.3 0.6 0.3 0.8 0.5
Medication: Blood pressure 0.7 1.2 2.8 -1.7 1.0 -0.1
Angina (self-reported) 1.7 2.3 3.9 -0.1 -1.7 -2.0
Migraine (self-reported) 0.3 0.3 0.5 0.7 -0.5 0.5
Medication: Ibuprofen 0.2 0.2 0.3 0.5 -0.3 -0.5
Medication: Allopurinol 0.1 0.1 0.1 0.4 0.2 -0.3
Medication: Omeprazole 1.4 1.7 2.1 -1.3 1.4 -1.1
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.0 0.3 0.6
Mean time to correctly identify matches 2.9 5.5 7.0 -2.6 2.0 2.3
Heart disease (mother) 7.0 8.6 11.1 -3.3 3.1 2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.7 -1.0 0.4 1.3
Whole body fat mass 2.7 11.2 19.7 -4.4 3.6 1.1
Leg fat mass (right) 3.4 13.2 22.3 -4.7 3.9 1.6
Arm predicted mass (right) 0.2 0.8 2.4 -1.6 -0.0 -0.2
Pulse rate, automated reading 1.8 6.0 8.3 -1.6 2.7 2.9
Alcohol intake frequency. 2.6 6.0 10.5 -2.4 3.2 1.3
Comparative height size at age 10 0.0 0.2 0.4 0.2 -0.6 0.2
Number of full sisters 1.0 1.2 1.9 -0.9 1.4 0.9
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.1 0.5 0.2
Overall health rating 0.5 1.0 2.2 -0.9 1.5 -0.3
Chest pain or discomfort 1.3 1.9 3.4 -0.9 1.2 1.8
Had major operations 0.5 0.6 1.3 1.1 -0.8 0.2
Age at last live birth 4.0 5.9 8.3 2.9 -2.5 -1.8
Family relationship satisfaction 2.0 2.5 4.4 2.1 -1.6 -0.6
Leg pain on walking 0.2 0.2 0.4 -0.7 0.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.6 -1.3 0.6 0.6
Commuting to job workplace: Car/motor vehicle 1.6 1.8 2.3 -1.4 1.1 -1.5
Illness, injury, bereavement, stress in last 2 years 4.4 5.4 8.1 -2.9 2.3 1.7
Medication: Aspirin 0.6 0.7 1.9 -1.4 0.6 -0.0
Supplements: Vitamin C 0.4 0.5 0.9 0.6 0.9 0.3
Knee pain experienced in last month 0.1 0.1 0.2 -0.3 -0.1 0.4
Hypertension (Self-reported) 0.9 2.5 4.0 -1.6 2.0 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 5.2 -0.9 2.3 0.3
Illnesses of father: Heart disease 1.5 2.1 3.6 1.5 -1.9 -0.6
Illnesses of siblings: Diabetes 0.9 1.1 3.2 0.1 0.0 -1.8
Smoking status: Previous 0.4 0.6 0.8 -0.8 0.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 4.6 0.9 -2.1 -0.3
Whole body fat-free mass 0.1 0.7 1.0 -0.8 -1.0 -0.7
Leg fat-free mass (right) 0.1 0.6 0.8 -0.8 -0.9 -0.6
Arm fat percentage (left) 3.4 13.7 21.5 -4.6 4.1 1.6
Average weekly red wine intake 1.3 1.9 2.8 1.7 -1.1 -1.3
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.7 0.8 -0.2 0.3
Mood swings 0.0 0.0 0.1 -0.0 0.2 0.3
Loneliness, isolation 0.2 0.3 0.8 0.9 -0.2 -0.5
Long-standing illness, disability or infirmity 0.9 1.4 3.4 -0.0 0.9 -1.8
Ever had bowel cancer screening 0.1 0.1 0.2 -0.4 0.4 -0.2
Diabetes diagnosed by doctor 0.1 0.1 0.2 -0.3 -0.4 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 3.0 3.2 4.6 1.9 -1.2 -2.2
Friendships satisfaction 0.7 0.9 1.4 1.2 -1.0 -0.5
Qualifications: nursing, teaching 4.9 7.6 11.4 3.4 -3.3 -0.7
Commuting to job workplace: Walk 1.1 1.2 3.1 0.6 -0.1 1.8
Eye problems/disorders: Cataract 0.8 1.0 1.6 1.3 -1.1 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.9 3.1 8.8 -0.6 0.1 3.0
Medication for cholesterol 0.2 0.4 0.7 0.6 -0.3 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 2.1 -1.3 1.4 1.1
Back pain experienced in last month 0.3 0.5 1.4 -0.1 -0.2 1.2
Mineral and other dietary supplements 2.0 2.8 4.4 -1.4 1.3 2.1
Breast cancer (self-reported) 0.6 0.7 1.7 -0.4 -1.3 -0.6
Asthma (self-reported) 0.2 0.3 0.5 -0.5 -0.4 0.7
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.2 0.5 -0.6
Osteoarthritis (self-reported) 1.4 1.8 2.1 1.3 -1.4 -1.2
Medication: Aspirin 0.7 0.9 2.0 -1.4 0.9 -0.1
Medication: Gliclazide 0.4 0.4 0.9 -1.0 0.1 0.5
Illnesses of father: None of the above (group 1) 1.6 2.0 2.8 -0.7 1.7 1.6
Smoking status: Current 0.5 0.8 1.3 -1.0 1.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.4 0.6 -0.4 -0.5
Whole body water mass 0.1 0.7 0.9 -0.7 -1.0 -0.8
Leg predicted mass (right) 0.1 0.6 0.9 -0.8 -0.9 -0.6
Arm fat mass (left) 2.7 11.1 20.0 -4.5 3.4 1.3
Number of self-reported non-cancer illnesses 1.1 1.9 4.8 -0.9 2.2 -0.4
Average weekly champagne plus white wine intake 0.4 0.6 1.5 0.5 -1.2 -0.2
Miserableness 0.3 0.6 1.6 0.3 1.3 0.3
Guilty feelings 0.6 1.0 1.5 0.3 1.2 1.1
Wears glasses or contact lenses 0.5 0.6 1.5 0.3 -0.3 1.2
Ever taken oral contraceptive pill 0.4 0.4 1.1 -0.4 -0.1 1.0
Hearing aid user 0.1 0.1 0.3 0.1 0.0 -0.5
Mother’s age at death 0.6 0.8 1.8 0.5 -0.5 1.3
Financial situation satisfaction 0.7 0.8 2.3 0.3 -0.0 -1.5
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.8 -0.1 0.9 -0.1
Commuting to job workplace: Public transport 0.3 0.3 0.6 0.5 -0.8 -0.3
Eye problems/disorders: Glaucoma 0.3 0.3 0.9 -0.1 0.3 0.9
Medication: Blood pressure 0.6 1.2 2.7 -1.6 1.0 -0.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.5 0.6 -0.7 -0.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.5 1.1 -0.2 -1.2
High cholesterol (Self-reported) 0.4 0.8 1.7 -0.5 0.6 -1.3
Medication: Bendroflumethiazide 0.6 0.9 1.4 -0.8 0.8 -1.2
Medication: Paracetamol 0.6 1.0 1.7 -0.7 1.3 0.8
Medication: Lisinopril 0.3 0.4 1.0 0.4 0.0 -1.0
Medication: Atorvastatin 0.8 1.0 1.6 -1.3 0.0 -1.2
Illnesses of father: High blood pressure 0.4 0.5 0.6 0.8 -0.5 -0.8
Alcohol drinker status: Never 0.2 0.3 0.8 -0.2 0.9 -0.1
Ever smoked 0.3 0.6 0.7 -0.9 0.8 0.6
Basal metabolic rate 0.1 0.8 2.1 -1.4 -0.3 -0.5
Leg fat percentage (left) 6.8 24.7 34.9 -5.8 5.9 2.3
Arm fat-free mass (left) 0.2 0.9 2.7 -1.7 0.0 -0.3
Number of operations (self-reported) 1.0 1.5 2.9 1.7 -1.0 -0.7
Average weekly beer plus cider intake 0.2 0.3 0.5 -0.6 0.7 -0.0
Irritability 2.6 4.4 6.1 -1.4 2.5 2.3
Risk taking 0.3 0.4 0.6 -0.7 0.8 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.3 1.1 -0.2 0.0
Fractured/broken bones in last 5 years 0.2 0.2 0.4 0.2 0.5 0.6
Age started oral contraceptive pill 1.5 1.9 3.4 1.3 -1.8 -0.8
Diastolic blood pressure, automated reading 0.0 0.1 0.2 -0.3 0.4 -0.4
Ever depressed for a whole week 3.8 4.7 10.2 3.2 -1.1 -1.6
Unable to work because of sickness or disability 1.2 1.6 4.1 0.3 2.0 -0.7
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.1 -0.2 0.5
Myopia 1.9 2.8 6.1 1.4 -2.5 -0.6
Vascular/heart problems diagnosed by doctor 0.4 1.2 1.5 1.1 -1.0 1.2
Cholesterol lowering medication 0.6 0.8 2.4 -1.5 0.2 0.3
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.9 -0.6 0.9 -1.4
Pain experienced in last month 0.2 0.4 0.7 0.5 -0.4 -0.8
Supplements: Calcium 0.2 0.2 0.5 -0.5 0.7 0.0
Basal cell carcinoma (self-reported) 0.1 0.2 0.3 0.6 -0.4 -0.3
Heart attack/myocardial infarction (self-reported) 6.3 8.1 10.5 2.1 -3.1 -3.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.9 -0.7 0.8 1.4
Heart disease (siblings) 0.2 0.3 0.7 -0.3 -0.9 -0.2
Alcohol drinker status: Previous 3.6 4.1 11.0 -1.1 3.3 -0.1
Pack years of smoking 1.2 1.7 4.2 -0.9 0.0 -2.1
Impedance of whole body 0.1 0.4 1.0 1.0 -0.1 -0.4
Leg fat mass (left) 3.7 14.6 23.9 -4.9 4.2 1.5
Arm predicted mass (left) 0.2 0.8 2.5 -1.6 -0.1 -0.2