TWAS hub - NTAN1P2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.193	0.067	0.00059	0.144	NA	0.103	NA	0.020	4.9e-05	NA	0.00060	NA	8.2e-02
2	GTEx	Cells Transformed fibroblasts	0.066	0.027	0.00170	0.020	NA	0.023	NA	0.031	1.2e-02	NA	0.00690	NA	2.0e-03
3	GTEx	Thyroid	0.056	0.027	0.00660	0.051	NA	0.040	NA	0.055	9.2e-05	NA	0.00049	NA	4.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Reason for reducing amount of alcohol drunk: Health precaution	8.4	9.9	12.6	-3.5	3.1	2.7
Heart disease (mother)	7.0	8.6	11.1	-3.3	3.1	2.3
Average weekly fortified wine intake	6.8	8.0	10.1	3.2	-2.9	-2.3
Leg fat percentage (left)	6.8	24.7	34.9	-5.8	5.9	2.3
Heart attack/myocardial infarction (self-reported)	6.3	8.1	10.5	2.1	-3.1	-3.2
Leg fat percentage (right)	5.9	21.5	30.5	-5.5	5.4	2.2
Age when periods started (menarche)	5.5	13.2	19.5	3.0	-3.4	-4.4
Comparative body size at age 10	5.0	13.8	18.0	-3.8	4.2	3.0
Qualifications: nursing, teaching	4.9	7.6	11.4	3.4	-3.3	-0.7
Verbal and Numeric Reasoning (VNR)	4.8	11.6	16.7	3.8	-4.1	-1.9
Heart attack	4.7	6.0	8.4	1.5	-2.7	-2.9
Qualifications: College or University degree	4.7	14.7	17.3	4.1	-4.2	-3.2
Age at first live birth	4.6	8.2	11.3	3.4	-3.3	-1.6
Illness, injury, bereavement, stress in last 2 years	4.4	5.4	8.1	-2.9	2.3	1.7
Time employed in main current job	4.2	4.8	8.6	-2.0	2.9	1.3
Body fat percentage	4.1	16.2	25.3	-5.0	4.6	1.5
Multivitamins +/- minerals	4.0	5.0	7.9	2.4	-2.8	-1.2
Age at last live birth	4.0	5.9	8.3	2.9	-2.5	-1.8
BMI	3.9	22.6	33.2	-5.8	5.3	2.5
Hayfever/allergic rhinitis (self-reported)	3.9	5.1	9.8	2.3	-3.1	-0.7
Reaction Time	3.8	7.3	9.7	-3.1	2.3	2.6
Ever depressed for a whole week	3.8	4.7	10.2	3.2	-1.1	-1.6
Leg fat mass (left)	3.7	14.6	23.9	-4.9	4.2	1.5
Intelligence (Savage-Jansen 2018)	3.6	11.1	17.3	3.3	-4.2	-2.3
Alcohol usually taken with meals	3.6	5.9	9.0	3.0	-2.9	-0.6
Alcohol drinker status: Previous	3.6	4.1	11.0	-1.1	3.3	-0.1
Sensitivity / hurt feelings	3.5	6.0	8.9	-2.5	3.0	1.7
Body mass index (BMI)	3.4	14.4	23.4	-4.8	4.1	1.8
Leg fat mass (right)	3.4	13.2	22.3	-4.7	3.9	1.6
Arm fat percentage (left)	3.4	13.7	21.5	-4.6	4.1	1.6
Waist circumference	3.3	11.9	20.3	-4.5	3.5	1.7
Ever had hysterectomy (womb removed)	3.2	3.7	4.3	-2.1	1.9	1.7
Trunk fat percentage	3.2	12.9	20.6	-4.5	4.0	1.3
Fluid intelligence score	3.2	6.7	10.4	3.2	-2.9	-1.1
Arm fat percentage (right)	3.2	12.7	20.2	-4.5	4.0	1.4
Health satisfaction	3.2	4.2	9.6	-1.7	3.1	0.4
Qualifications: None of the above	3.0	6.5	10.5	-3.0	3.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	4.6	1.9	-1.2	-2.2
Pulse rate	2.9	4.8	5.8	-2.4	2.2	1.9
Qualifications: A levels/AS levels or equivalent	2.9	6.5	12.4	3.5	-2.6	-0.2
Mean time to correctly identify matches	2.9	5.5	7.0	-2.6	2.0	2.3
Medication for hormone replacement therapy	2.7	3.1	3.7	1.9	-1.5	-1.8
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	6.5	2.5	-2.5	0.3
Whole body fat mass	2.7	11.2	19.7	-4.4	3.6	1.1
Arm fat mass (left)	2.7	11.1	20.0	-4.5	3.4	1.3
HbA1C	2.6	2.9	3.5	-1.7	1.9	1.5
Alcohol intake frequency.	2.6	6.0	10.5	-2.4	3.2	1.3
Irritability	2.6	4.4	6.1	-1.4	2.5	2.3
Fasting Glucose	2.5	2.9	4.9	2.2	-1.0	-1.7
Trunk fat mass	2.5	10.7	19.1	-4.4	3.4	1.0
Length of working week for main job	2.5	2.8	3.9	1.7	-2.0	-1.2
Diabetes (father)	2.4	3.0	3.9	2.0	-1.4	-1.8
Schizophrenia vs Biploar Disorder	2.3	3.0	3.3	1.7	-1.8	-1.7
Relative age voice broke	2.3	3.5	5.0	2.1	-2.2	-1.1
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	3.4	-1.8	1.8	1.3
Stomach or abdominal pain in last month	2.3	2.9	6.1	-1.0	1.2	2.5
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.1	2.3	-1.8	-0.2
Father’s age at death	2.3	3.1	3.9	2.0	-1.6	-1.7
Arm fat mass (right)	2.3	9.5	16.9	-4.1	3.2	1.1
Pulse wave reflection index	2.2	2.7	4.1	1.9	-2.0	-0.7
Primary Biliary Cirrhosis	2.1	3.0	3.2	-1.7	1.6	1.8
Height	2.1	39.7	65.0	5.0	-8.1	-5.4
Average weekly spirits intake	2.0	2.5	4.2	-1.8	2.1	0.1
Mouth/teeth dental problems: Dentures	2.0	3.3	7.5	-1.5	2.7	0.3
Wheeze or whistling in the chest in last year	2.0	3.6	6.0	-2.2	2.5	0.2
Family relationship satisfaction	2.0	2.5	4.4	2.1	-1.6	-0.6
Mineral and other dietary supplements	2.0	2.8	4.4	-1.4	1.3	2.1
Alzheimer’s Disease (in mother)	1.9	2.2	3.2	1.2	-1.8	-1.4
Body Mass Index (BMI) (2010)	1.9	2.6	3.8	-1.8	2.0	1.0
Medication: Ramipril	1.9	2.4	3.5	1.0	-1.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	8.8	-0.6	0.1	3.0
Myopia	1.9	2.8	6.1	1.4	-2.5	-0.6
Coronary Artery Disease (CAD)	1.8	2.2	4.5	1.1	-1.0	-2.1
Relative age of first facial hair	1.8	3.7	4.4	2.1	-1.6	-2.0
Taking other prescription medications	1.8	2.8	5.1	-1.1	2.3	-1.4
Serious illness, injury or assault to yourself	1.8	2.2	3.8	2.0	-1.1	-1.2
Supplements: Glucosamine	1.8	2.4	3.4	1.9	-1.2	-1.5
Medication: Cholesterol lowering	1.8	2.8	7.8	0.7	-0.0	-2.8
Pulse rate, automated reading	1.8	6.0	8.3	-1.6	2.7	2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	5.2	-0.9	2.3	0.3
Ever used hormone-replacement therapy (HRT)	1.7	2.1	3.8	-1.5	1.9	-0.6
Medication: Lansoprazole	1.7	1.9	3.2	-0.7	1.5	-1.8
Angina (self-reported)	1.7	2.3	3.9	-0.1	-1.7	-2.0
Townsend deprivation index at recruitment	1.6	2.3	5.4	-0.9	2.3	0.9
Pain all over the body in last month	1.6	1.7	3.9	2.0	-0.6	-1.0
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.3	-0.9	2.1	-0.7
Loud music exposure frequency	1.6	1.8	3.9	-1.0	2.0	0.7
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.3	-1.4	1.1	-1.5
Illnesses of father: None of the above (group 1)	1.6	2.0	2.8	-0.7	1.7	1.6
Number of treatments/medications taken	1.5	2.7	5.2	-1.6	2.3	-0.2
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.1	1.3	-1.8	-0.9
Illnesses of father: Heart disease	1.5	2.1	3.6	1.5	-1.9	-0.6
Age started oral contraceptive pill	1.5	1.9	3.4	1.3	-1.8	-0.8
Lung cancer (father)	1.4	1.6	3.6	-1.0	1.9	0.6
Forced vital capacity (FVC), Best measure	1.4	5.2	8.5	1.5	-2.2	-2.9
Shortness of breath walking on level ground	1.4	1.7	2.6	-1.6	1.5	0.3
Medication: Omeprazole	1.4	1.7	2.1	-1.3	1.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.1	-1.3	1.4	1.1
Osteoarthritis (self-reported)	1.4	1.8	2.1	1.3	-1.4	-1.2
Triglycerides	1.3	2.1	4.3	-1.2	2.1	0.7
Frequency of depressed mood in last 2 weeks	1.3	1.9	4.4	2.1	-0.8	-0.7
Angina	1.3	1.7	2.8	-0.1	-1.5	-1.7
Supplements: Zinc	1.3	1.4	3.1	1.0	-1.7	-0.3
Pack years adult smoking proportion	1.3	2.0	5.7	-0.6	-0.1	-2.4
Hair/balding pattern: Pattern 3	1.3	1.9	3.4	-1.9	0.7	1.3
Number of live births	1.3	1.8	2.6	-1.3	1.6	1.0
Noisy workplace	1.3	1.7	3.7	-1.1	1.9	-0.1
Chest pain or discomfort	1.3	1.9	3.4	-0.9	1.2	1.8
Average weekly red wine intake	1.3	1.9	2.8	1.7	-1.1	-1.3
Age at First Birth	1.2	1.7	3.1	0.9	-1.1	1.7
Blood White Count	1.2	8.9	14.4	-3.5	3.8	-0.1
Illnesses of mother	1.2	1.5	2.6	0.9	-1.6	-0.9
Blood clot in the leg (DVT)	1.2	1.5	2.1	-1.1	1.1	1.4
Unable to work because of sickness or disability	1.2	1.6	4.1	0.3	2.0	-0.7
Pack years of smoking	1.2	1.7	4.2	-0.9	0.0	-2.1
Major Depression (MDD)	1.1	1.3	2.3	1.5	-0.8	-1.0
Hair/balding pattern: Pattern 2	1.1	1.4	1.6	1.2	-1.3	-1.1
Forced vital capacity (FVC)	1.1	4.2	6.2	1.6	-2.0	-2.5
Hip circumference	1.1	4.7	9.4	-3.1	2.1	0.6
Alcohol intake versus 10 years previously	1.1	1.7	2.9	-1.3	0.7	1.7
Standing height	1.1	10.8	18.3	2.5	-4.3	-2.8
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.7	1.6	-0.7	0.7
Medication for pain relief, constipation, heartburn	1.1	2.0	3.1	1.8	-1.5	-0.7
Commuting to job workplace: Walk	1.1	1.2	3.1	0.6	-0.1	1.8
Number of self-reported non-cancer illnesses	1.1	1.9	4.8	-0.9	2.2	-0.4
Allergy or Eczema	1.0	2.8	5.4	1.7	-2.3	0.1
Vitamin and mineral supplements	1.0	1.3	2.0	-1.4	1.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.6	-2.2	1.2	-0.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.3	1.8	-0.4	-0.6
Weight	1.0	5.1	11.5	-3.4	1.9	0.4
Happiness	1.0	1.2	1.8	1.4	-1.3	-0.2
Prospective memory result	1.0	1.2	2.0	0.9	-1.4	-0.9
Headache pain in last month	1.0	1.8	3.0	-1.5	1.7	0.2
Number of full sisters	1.0	1.2	1.9	-0.9	1.4	0.9
Number of operations (self-reported)	1.0	1.5	2.9	1.7	-1.0	-0.7
Ovarian Cancer	0.9	1.2	1.4	1.2	-1.0	-1.2
Mean Putamen Volume	0.9	1.0	1.3	0.9	-1.1	-1.0
Ulcerative Colitis	0.9	1.3	3.0	1.7	-1.0	-0.1
Blood Red Count	0.9	8.6	11.6	-3.4	3.0	2.3
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.9	1.4	-2.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.9	1.4	-0.7	-0.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.1	1.1	-1.0	1.5
Hypertension (Self-reported)	0.9	2.5	4.0	-1.6	2.0	-0.9
Illnesses of siblings: Diabetes	0.9	1.1	3.2	0.1	0.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.6	0.9	-2.1	-0.3
Long-standing illness, disability or infirmity	0.9	1.4	3.4	-0.0	0.9	-1.8
Medication: Atenolol	0.8	1.0	2.7	-0.4	0.0	-1.7
Sitting height	0.8	6.0	10.3	1.4	-3.2	-2.4
Past tobacco smoking	0.8	1.5	1.8	1.3	-1.4	-1.0
Illnesses of siblings	0.8	1.2	1.6	-0.6	1.3	1.2
Birth weight of first child	0.8	1.5	3.6	0.8	-1.9	0.4
Glaucoma (self-reported)	0.8	0.9	2.4	0.6	-1.5	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.7	-1.0	0.4	1.3
Eye problems/disorders: Cataract	0.8	1.0	1.6	1.3	-1.1	-0.3
Medication: Atorvastatin	0.8	1.0	1.6	-1.3	0.0	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-0.6	0.9	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.9	-0.7	0.8	1.4
LDL Cholesterol	0.7	1.1	3.0	-0.2	0.4	-1.7
Rheumatoid Arthritis	0.7	0.9	1.6	-1.0	1.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.2	-0.7	1.1	0.7
Medication: Metformin	0.7	0.9	2.7	0.3	-1.6	-0.3
Hand grip strength (right)	0.7	2.0	4.1	0.4	-2.0	-1.3
Maternal smoking around birth	0.7	1.0	2.4	-0.4	1.5	0.7
Medication: Levothyroxine sodium	0.7	1.2	3.5	0.2	0.3	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.7	-1.6	1.3	-0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.1	1.3	-1.4	-1.8
Peak expiratory flow (PEF)	0.7	1.7	3.4	0.4	-1.3	-1.9
Medication: Paracetamol	0.7	1.2	1.7	-1.1	1.3	0.8
Medication: Amlodipine	0.7	0.9	2.0	-1.4	0.9	0.3
High blood pressure (siblings)	0.7	1.0	1.4	0.9	-0.9	-1.2
Worry too long after embarrassment	0.7	1.1	2.4	1.5	-1.0	-0.2
Medication: Blood pressure	0.7	1.2	2.8	-1.7	1.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	-1.3	0.6	0.6
Friendships satisfaction	0.7	0.9	1.4	1.2	-1.0	-0.5
Medication: Aspirin	0.7	0.9	2.0	-1.4	0.9	-0.1
Financial situation satisfaction	0.7	0.8	2.3	0.3	-0.0	-1.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.5	1.1	-0.2	-1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	-0.0	-0.8	-1.5
Bipolar Disorder (2011)	0.6	0.6	0.9	-0.9	1.0	-0.1
Neuroticism (2016)	0.6	0.8	2.4	1.6	0.2	0.0
Blood Platelet Count	0.6	7.3	8.8	-2.6	2.5	3.0
Current tobacco smoking	0.6	1.0	1.6	-1.3	1.2	0.1
Fed-up feelings	0.6	1.1	2.0	1.4	-1.1	-0.1
Falls in the last year	0.6	0.9	1.4	0.9	-0.5	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.1	1.0	-1.1	-0.4
Depression (self-reported)	0.6	0.7	1.3	-0.8	1.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	2.7	0.9	-1.4	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.2	1.5	-0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.0	0.1	0.8	-1.7
Medication: Aspirin	0.6	0.7	1.9	-1.4	0.6	-0.0
Breast cancer (self-reported)	0.6	0.7	1.7	-0.4	-1.3	-0.6
Guilty feelings	0.6	1.0	1.5	0.3	1.2	1.1
Mother’s age at death	0.6	0.8	1.8	0.5	-0.5	1.3
Medication: Blood pressure	0.6	1.2	2.7	-1.6	1.0	-0.3
Medication: Bendroflumethiazide	0.6	0.9	1.4	-0.8	0.8	-1.2
Medication: Paracetamol	0.6	1.0	1.7	-0.7	1.3	0.8
Cholesterol lowering medication	0.6	0.8	2.4	-1.5	0.2	0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	1.0	-0.7	-0.2
Hypothyroidism (self reported)	0.5	1.1	2.7	0.5	0.6	-1.6
Number of incorrect matches in round	0.5	0.9	1.3	-1.0	0.5	1.2
Allergy	0.5	1.1	2.3	-0.1	0.9	-1.5
Impedance of arm (right)	0.5	2.4	4.1	2.0	-1.4	-1.2
Hair/balding pattern: Pattern 4	0.5	1.1	2.2	1.5	-0.8	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.0	-1.0	0.8	0.4
Overall health rating	0.5	1.0	2.2	-0.9	1.5	-0.3
Had major operations	0.5	0.6	1.3	1.1	-0.8	0.2
Smoking status: Current	0.5	0.8	1.3	-1.0	1.1	-0.2
Wears glasses or contact lenses	0.5	0.6	1.5	0.3	-0.3	1.2
Lung FEV1/FVC ratio	0.4	1.9	3.0	-0.1	1.6	1.7
Medication: Co-codamol	0.4	0.5	0.8	-0.4	0.7	-0.9
High blood pressure	0.4	1.0	1.5	-0.8	1.2	-0.9
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-1.0	0.7	0.3
Had other major operations	0.4	0.5	0.6	0.7	-0.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.6	0.2	1.3	0.7
Supplements: Vitamin C	0.4	0.5	0.9	0.6	0.9	0.3
Smoking status: Previous	0.4	0.6	0.8	-0.8	0.6	0.9
Medication: Gliclazide	0.4	0.4	0.9	-1.0	0.1	0.5
Average weekly champagne plus white wine intake	0.4	0.6	1.5	0.5	-1.2	-0.2
Ever taken oral contraceptive pill	0.4	0.4	1.1	-0.4	-0.1	1.0
High cholesterol (Self-reported)	0.4	0.8	1.7	-0.5	0.6	-1.3
Illnesses of father: High blood pressure	0.4	0.5	0.6	0.8	-0.5	-0.8
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	1.1	-0.2	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	1.5	1.1	-1.0	1.2
Ulcerative Colitis (UC)	0.3	0.6	0.8	0.9	-0.6	0.8
Cardiovascular Disease	0.3	1.2	2.7	-0.8	1.6	-0.4
Chronotype (morning person)	0.3	0.8	1.3	-1.0	-0.2	1.2
Hand grip strength (left)	0.3	0.7	1.7	0.2	-1.3	-0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-0.1	1.1	0.1
Diabetes (mother)	0.3	0.3	0.5	-0.7	0.7	-0.3
High blood pressure (mother)	0.3	0.5	0.9	-0.7	0.9	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.3	1.1	0.1	-0.1
Had menopause	0.3	0.4	0.5	-0.6	0.7	-0.6
Financial difficulties in last 2 years	0.3	0.4	0.9	1.0	-0.1	-0.6
Diabetes (self-reported)	0.3	0.4	0.9	0.4	-0.9	-0.5
Medication: Simvastatin	0.3	0.4	1.0	-0.4	1.0	-0.4
Impedance of arm (left)	0.3	1.3	2.7	1.6	-1.0	-0.6
Breastfed as a baby	0.3	0.3	1.0	0.1	-0.0	1.0
Birth weight	0.3	0.7	1.4	-0.3	-0.8	1.2
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.5	0.2	-0.8
Migraine (self-reported)	0.3	0.3	0.5	0.7	-0.5	0.5
Back pain experienced in last month	0.3	0.5	1.4	-0.1	-0.2	1.2
Miserableness	0.3	0.6	1.6	0.3	1.3	0.3
Commuting to job workplace: Public transport	0.3	0.3	0.6	0.5	-0.8	-0.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	-0.1	0.3	0.9
Medication: Lisinopril	0.3	0.4	1.0	0.4	0.0	-1.0
Ever smoked	0.3	0.6	0.7	-0.9	0.8	0.6
Risk taking	0.3	0.4	0.6	-0.7	0.8	0.2
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.1	0.6	0.9
Depression (Nagel 2018)	0.2	0.2	0.7	0.8	0.2	0.1
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-0.1	1.0	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	0.4	0.2
Prostate Cancer	0.2	0.3	0.5	0.7	0.7	0.2
Crohns Disease (2012)	0.2	0.3	0.7	-0.5	0.9	0.1
Blood Eosinophil Count	0.2	1.8	4.6	-0.9	0.3	-2.1
Heel T-Score	0.2	1.9	4.8	-2.2	0.7	0.6
Respiratory disease	0.2	0.5	1.0	-0.1	-1.0	0.8
Lung FVC	0.2	0.8	1.5	-0.4	1.2	-0.9
Tanning	0.2	2.4	3.2	1.8	-1.1	-1.7
Systolic blood pressure, automated reading	0.2	0.5	1.2	-1.1	0.5	0.3
Severe depression (siblings)	0.2	0.2	0.3	-0.5	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.3	0.5	0.4	-0.5
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.4	0.9	-0.4
Neuroticism score	0.2	0.3	0.5	0.7	0.3	0.6
Worrier / anxious feelings	0.2	0.3	0.6	0.8	0.3	-0.5
Asthma	0.2	0.3	0.4	-0.4	-0.6	0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.7	0.1	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.6	0.4	0.3
Tense / ‘highly strung’	0.2	0.3	0.5	0.0	0.7	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	0.1	0.9	0.2
Exposure to tobacco smoke outside home	0.2	0.3	0.3	-0.6	0.6	-0.4
Number of full brothers	0.2	0.3	0.9	0.1	-0.9	0.1
Pulse wave peak to peak time	0.2	0.2	0.4	0.6	-0.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.1	-0.4	0.8
Neck or shoulder pain in last month	0.2	0.3	0.6	0.3	0.8	0.5
Medication: Ibuprofen	0.2	0.2	0.3	0.5	-0.3	-0.5
Arm predicted mass (right)	0.2	0.8	2.4	-1.6	-0.0	-0.2
Leg pain on walking	0.2	0.2	0.4	-0.7	0.4	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.8	-0.2	0.3
Loneliness, isolation	0.2	0.3	0.8	0.9	-0.2	-0.5
Medication for cholesterol	0.2	0.4	0.7	0.6	-0.3	0.8
Asthma (self-reported)	0.2	0.3	0.5	-0.5	-0.4	0.7
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.2	0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	-0.1	0.9	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.6	-0.7	-0.3
Alcohol drinker status: Never	0.2	0.3	0.8	-0.2	0.9	-0.1
Arm fat-free mass (left)	0.2	0.9	2.7	-1.7	0.0	-0.3
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.6	0.7	-0.0
Fractured/broken bones in last 5 years	0.2	0.2	0.4	0.2	0.5	0.6
Pain experienced in last month	0.2	0.4	0.7	0.5	-0.4	-0.8
Supplements: Calcium	0.2	0.2	0.5	-0.5	0.7	0.0
Heart disease (siblings)	0.2	0.3	0.7	-0.3	-0.9	-0.2
Arm predicted mass (left)	0.2	0.8	2.5	-1.6	-0.1	-0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.7	-0.1	0.0
Worry (Nagel 2018)	0.1	0.3	0.6	0.5	0.3	-0.8
Crohns Disease (2017)	0.1	0.2	0.4	0.3	-0.4	-0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.7	-0.4	0.1
Breast Cancer	0.1	0.1	0.4	0.6	-0.2	0.2
HDL Cholesterol	0.1	0.2	0.3	0.4	-0.3	-0.5
Lupus	0.1	0.1	0.3	0.5	-0.1	0.3
Systolic Blood Pressure	0.1	0.6	0.8	-0.4	-0.9	-0.9
Smoking Status	0.1	0.2	0.3	-0.4	0.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.0	-0.6	-0.3
Neuroticism	0.1	0.3	0.5	0.5	0.3	0.7
Hair Pigment	0.1	3.9	5.5	2.1	-2.4	-1.3
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.1	0.5	0.0
Leg fat-free mass (left)	0.1	0.6	0.8	-0.9	-0.9	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.2	0.4	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.7	0.1	-0.4
Impedance of leg (left)	0.1	0.6	1.9	-0.1	1.4	-0.1
Leg predicted mass (left)	0.1	0.5	0.8	-0.8	-0.9	-0.4
Trunk fat-free mass	0.1	0.8	1.4	-0.5	-1.2	-0.9
Trunk predicted mass	0.1	0.8	1.4	-0.5	-1.2	-0.9
Gout (self-reported)	0.1	0.1	0.4	0.6	0.0	-0.1
Arm fat-free mass (right)	0.1	0.7	2.0	-1.4	-0.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.2	0.4	-0.2
Number of children fathered	0.1	0.1	0.2	-0.5	-0.4	-0.3
Medication: Allopurinol	0.1	0.1	0.1	0.4	0.2	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.0	0.3	0.6
Suffer from ‘nerves’	0.1	0.1	0.2	-0.1	0.5	0.2
Knee pain experienced in last month	0.1	0.1	0.2	-0.3	-0.1	0.4
Whole body fat-free mass	0.1	0.7	1.0	-0.8	-1.0	-0.7
Leg fat-free mass (right)	0.1	0.6	0.8	-0.8	-0.9	-0.6
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	0.4	-0.2
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.3	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	0.6	-0.4	-0.5
Whole body water mass	0.1	0.7	0.9	-0.7	-1.0	-0.8
Leg predicted mass (right)	0.1	0.6	0.9	-0.8	-0.9	-0.6
Hearing aid user	0.1	0.1	0.3	0.1	0.0	-0.5
Basal metabolic rate	0.1	0.8	2.1	-1.4	-0.3	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.1	-0.2	0.5
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.6	-0.4	-0.3
Impedance of whole body	0.1	0.4	1.0	1.0	-0.1	-0.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.2	0.1	0.4
Schizophrenia (2018)	0.0	0.1	0.1	-0.2	-0.3	-0.2
Schizophrenia (2014)	0.0	0.0	0.1	-0.3	0.2	0.1
Waist Hip Ratio (WHR)	0.0	0.0	0.1	-0.2	0.1	0.3
Impedance of leg (right)	0.0	0.2	0.5	0.3	0.7	-0.3
Nervous feelings	0.0	0.1	0.2	-0.0	0.2	-0.4
Mouth/teeth dental problems	0.0	0.1	0.1	0.2	-0.0	-0.4
Comparative height size at age 10	0.0	0.2	0.4	0.2	-0.6	0.2
Mood swings	0.0	0.0	0.1	-0.0	0.2	0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.3	0.4	-0.4

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