Best TWAS P=7.07e-13 · Best GWAS P=1.3e-18 conditioned to 0.000308
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STK33 | 0.18 | 0.18 | lasso | 9 | 0.20 | 3.8e-24 | -6.3 | 7.2 | 7.1e-13 | -0.70 | 0.98 | 0.02 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-152H18.3 | 0.23 | 0.01 | enet | 1 | 0.06 | 1.1e-02 | -6.0 | -6.0 | 2.7e-09 | 0.78 | 0.02 | 0.83 | FALSE |
| 3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RPL27A | 0.04 | 0.01 | blup | 39 | 0.02 | 2.1e-03 | -2.9 | 5.2 | 2.1e-07 | -0.54 | 0.07 | 0.13 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STK33 | 0.05 | 0.03 | lasso | 2 | 0.03 | 2.5e-04 | -7.1 | 6.8 | 8.9e-12 | -0.45 | 0.50 | 0.07 | TRUE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ST5 | 0.41 | 0.02 | blup | 128 | 0.13 | 2.3e-05 | 3.8 | -5.8 | 7.5e-09 | 0.55 | 0.03 | 0.55 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | STK33 | 0.14 | 0.08 | lasso | 6 | 0.10 | 1.0e-09 | -6.6 | 7.0 | 3.4e-12 | -0.69 | 1.00 | 0.00 | FALSE |