TWAS hub - ST5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0320	5.8e-05	0.084	0.037	0.082	0.084	0.087	1.9e-10	2.2e-05	3.0e-10	2.2e-10	8.6e-11
2	GTEx	Brain Cortex	0.3080	0.1080	2.5e-03	-0.004	NA	0.014	NA	-0.010	4.2e-01	NA	1.3e-01	NA	7.5e-01
3	GTEx	Whole Blood	0.0720	0.0260	1.0e-04	0.076	NA	0.047	NA	0.047	1.6e-07	NA	3.3e-05	NA	3.9e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.0786	0.0242	1.3e-05	0.064	0.051	0.053	0.056	0.059	1.1e-08	3.2e-07	2.0e-07	8.7e-08	4.4e-08
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0262	0.0129	7.6e-04	0.051	0.036	0.031	NA	0.045	2.1e-06	6.1e-05	1.7e-04	NA	8.0e-06
6	TCGA	Testicular Germ Cell Tumors	0.4130	0.1280	5.1e-05	0.018	0.131	0.115	NA	0.102	7.7e-02	2.3e-05	7.6e-05	NA	1.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Red Count	8.8	84.8	123.2	-10.7	2.9	-11.1	-10.9	-10.8	-5.2
Blood Platelet Count	8.6	99.6	213.2	-9.2	0.7	-13.8	-9.6	-14.6	-4.0
Guilty feelings	5.2	7.8	15.5	2.6	-1.9	3.9	2.8	3.6	0.6
Heel T-Score	4.7	37.3	76.2	6.7	-0.6	5.1	8.7	7.5	4.5
Other serious medical condition/disability diagnosed by doctor	4.5	5.8	11.6	2.1	-2.9	3.4	2.1	2.5	0.3
Worry too long after embarrassment	4.5	7.5	15.4	2.1	-1.7	3.9	2.5	3.9	-1.0
Breast cancer (self-reported)	4.4	5.3	9.7	-2.8	0.3	-2.7	-2.6	-3.1	-0.6
Ulcerative Colitis	4.0	5.8	9.8	3.1	1.8	1.7	2.8	2.4	2.2
Irritability	3.9	6.5	11.6	2.9	0.1	3.1	3.0	3.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.8	4.9	8.9	2.6	-1.5	3.0	2.1	2.5	0.7
Blood White Count	3.6	27.0	46.2	-6.8	0.4	-5.5	-6.4	-5.4	-4.0
Medication: Lisinopril	3.6	4.6	8.5	2.6	0.5	2.1	2.9	2.1	1.9
Age when periods started (menarche)	3.5	8.4	28.2	2.0	0.2	-3.7	-0.1	-2.1	5.3
Supplements: Zinc	3.2	3.5	5.9	-2.4	-1.2	-2.0	-2.4	-0.8	-1.8
Worry (Nagel 2018)	3.1	6.4	14.5	2.2	-0.1	3.5	2.5	3.8	0.9
Heel bone mineral density (BMD) T-score, automated (left)	3.1	6.9	14.3	2.2	0.8	2.6	3.3	3.8	2.0
Nervous feelings	3.0	5.6	10.7	2.1	-0.1	3.3	2.7	3.2	1.0
Neuroticism score	3.0	6.3	13.4	2.0	-0.9	3.7	2.5	3.6	-0.6
Depression (self-reported)	2.9	3.5	5.8	1.9	-2.3	2.4	1.8	1.7	-0.5
Hair/balding pattern: Pattern 2	2.8	3.6	8.9	-0.6	-3.0	2.2	-0.7	1.5	-2.1
Tense / ‘highly strung’	2.8	4.6	9.4	2.0	-1.6	2.4	2.1	3.1	1.1
Medication: Amlodipine	2.8	4.0	6.6	1.4	2.1	1.4	2.0	2.2	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.2	8.4	1.8	-2.8	2.9	1.5	1.3	-1.2
Illnesses of father: Heart disease	2.7	3.8	12.9	-1.8	-3.6	-0.1	-2.1	0.1	-1.4
Allergy or Eczema	2.5	6.7	13.2	0.4	-3.1	3.3	0.6	3.6	-2.4
Lung FEV1/FVC ratio	2.5	12.5	25.6	5.1	-1.2	2.0	4.9	0.7	4.4
High blood pressure	2.5	7.1	23.7	2.3	1.4	0.6	3.0	1.5	4.9
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	11.1	2.1	0.2	2.3	3.1	3.3	2.0
Neuroticism (Nagel 2018)	2.4	5.6	14.5	1.5	0.5	3.5	2.1	3.8	-0.2
Waist circumference	2.4	8.6	28.0	-2.9	-3.0	1.3	-2.2	0.1	-5.3
Arm fat mass (right)	2.4	9.8	29.5	-2.6	-3.9	2.0	-1.7	0.3	-5.4
Leg fat mass (right)	2.4	9.2	26.2	-2.8	-3.6	1.9	-1.9	0.7	-5.1
Illnesses of father: None of the above (group 1)	2.4	2.9	4.9	2.0	1.3	1.1	2.2	1.2	2.1
Relative age of first facial hair	2.3	4.8	11.0	3.1	1.6	0.9	2.2	0.0	3.3
Leg fat percentage (right)	2.3	8.3	23.1	-3.2	-2.9	1.6	-2.0	1.1	-4.8
Leg fat mass (left)	2.3	8.9	26.3	-2.7	-3.6	1.8	-1.8	0.7	-5.1
Hayfever, allergic rhinitis or eczema	2.2	4.7	9.4	0.2	-2.2	2.7	0.4	3.1	-2.5
Diabetes (self-reported)	2.2	3.4	10.0	-2.4	-1.1	1.0	-1.5	0.6	-3.2
Whole body fat mass	2.2	9.3	26.5	-2.5	-3.9	2.2	-1.6	0.9	-5.2
Hypertension (Self-reported)	2.2	6.1	19.5	2.1	1.6	0.7	2.8	1.4	4.4
Illnesses of siblings: Diabetes	2.2	2.7	8.6	-0.9	-0.7	2.9	0.1	1.6	-1.9
Diabetes diagnosed by doctor	2.2	3.7	8.5	-2.6	-0.8	1.2	-1.8	1.3	-2.9
Leg fat percentage (left)	2.2	7.9	22.8	-3.1	-2.8	1.3	-2.1	0.9	-4.8
Neuroticism	2.1	5.1	11.9	1.8	-0.5	3.1	2.2	3.5	-0.7
Stomach or abdominal pain in last month	2.1	2.7	10.3	0.2	-0.2	2.2	0.5	3.2	-0.9
Medication: Allopurinol	2.1	2.8	6.6	-0.3	2.6	-1.7	-0.1	-1.4	2.3
Qualifications: nursing, teaching	2.1	3.2	4.8	2.0	-2.2	1.6	1.8	1.6	1.5
Arm fat mass (left)	2.1	8.8	26.6	-2.2	-3.9	1.9	-1.4	0.4	-5.2
Medication: Bendroflumethiazide	2.1	3.1	4.8	1.4	1.5	1.1	2.1	2.1	2.2
Risk taking	2.1	3.1	4.5	2.0	0.0	1.9	1.6	2.1	1.9
Irritable Bowel Disease (IBD)	2.0	4.9	7.6	2.7	0.7	2.1	2.6	2.8	1.7
Ulcerative Colitis (UC)	2.0	3.7	6.2	2.5	1.2	1.4	2.1	2.0	2.1
Type 2 Diabetes (T2D) (2018)	2.0	3.8	10.2	-2.1	-0.5	2.1	-1.4	1.2	-3.2
Arm fat percentage (right)	2.0	8.0	23.1	-2.6	-3.4	2.0	-1.5	0.8	-4.8
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.5	6.4	-1.8	-1.3	0.6	-1.7	0.4	-2.5
Sensitivity / hurt feelings	1.9	3.2	6.8	1.3	0.2	2.6	2.1	2.4	-0.9
Ever had hysterectomy (womb removed)	1.9	2.2	3.8	-1.7	0.6	-1.7	-1.7	-1.9	-0.5
Medication: Atenolol	1.9	2.4	6.1	0.3	0.3	-2.5	0.2	-1.8	2.1
Had other major operations	1.9	2.3	4.5	-1.8	-1.3	-1.5	-2.1	-1.4	-0.3
Alcohol intake versus 10 years previously	1.9	2.8	5.4	-2.3	1.4	-1.5	-1.8	-2.0	-0.1
Medication: Lansoprazole	1.9	2.2	4.3	1.6	-0.2	2.1	1.4	1.6	1.2
Eye problems/disorders: None of the above	1.9	2.2	5.4	0.9	0.4	-1.4	0.3	-2.3	2.2
Medication: Seretide 50 evohaler	1.9	2.1	9.7	-0.7	-3.1	1.0	-0.3	-0.2	-1.3
Fasting Glucose	1.8	2.2	4.7	-1.8	-0.2	-1.4	-1.4	-2.2	-0.8
BMI	1.8	10.4	33.4	-2.9	-3.9	1.5	-1.7	0.0	-5.8
Body mass index (BMI)	1.8	7.8	24.4	-2.9	-3.2	0.7	-1.8	-0.6	-4.9
Trunk fat mass	1.8	7.9	22.4	-1.9	-3.7	2.3	-1.1	1.1	-4.7
Weight	1.8	8.8	26.4	-1.6	-4.3	2.2	-1.0	0.1	-5.1
Illnesses of mother	1.8	2.3	7.3	-0.3	1.1	-2.1	-0.7	-2.7	-0.5
Glaucoma (self-reported)	1.8	2.1	5.1	0.4	-1.0	1.9	1.0	2.3	-1.3
Heart disease (mother)	1.8	2.2	5.7	-0.1	-1.6	2.4	0.1	2.1	-0.7
Vascular/heart problems diagnosed by doctor	1.8	4.9	17.5	-1.7	-1.0	-0.3	-2.5	-1.3	-4.2
Diabetes (mother)	1.7	2.2	7.7	0.2	-0.1	2.0	1.0	2.8	0.2
Allergy	1.7	4.0	8.1	0.7	1.5	-2.5	0.7	-2.5	2.8
Hip circumference	1.7	7.5	20.3	-2.5	-2.9	-0.0	-2.4	-2.0	-4.5
Time employed in main current job	1.7	1.9	4.6	1.3	-0.7	1.5	1.5	2.1	-0.3
Worrier / anxious feelings	1.7	3.1	7.6	1.6	0.0	2.3	1.8	2.8	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.6	11.9	3.5	-0.6	1.4	3.0	0.7	3.1
Body fat percentage	1.7	6.7	19.2	-2.5	-2.8	1.8	-1.6	1.2	-4.4
Health satisfaction	1.7	2.3	5.4	-0.2	-0.7	2.1	0.3	2.3	-1.7
Long-standing illness, disability or infirmity	1.7	2.7	4.7	-1.3	-2.2	1.5	-0.8	1.8	-1.9
Medication: Blood pressure	1.7	3.3	9.5	1.2	2.5	-0.2	1.5	0.4	3.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	5.2	-2.3	0.7	0.1	-1.9	0.1	-1.2
Multivitamins +/- minerals	1.6	2.0	8.7	-0.3	-3.0	0.6	-0.9	1.0	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	5.1	0.7	-1.8	2.2	1.1	2.3	-0.5
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	5.2	-0.6	-2.3	0.9	-0.5	1.6	-1.9
Gout (self-reported)	1.6	2.2	4.5	-0.5	1.7	-1.9	-0.3	-1.4	2.1
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.2	1.8	-0.4	1.8	1.6	1.2	0.6
Arm fat percentage (left)	1.6	6.2	19.1	-2.1	-3.0	1.8	-1.1	0.7	-4.4
Medication: Gliclazide	1.6	1.8	5.2	-1.2	-1.1	1.0	-0.9	1.1	-2.3
Body Mass Index (BMI) (2010)	1.5	2.1	7.7	-1.4	-1.3	0.0	-0.6	-0.9	-2.8
HbA1C	1.5	1.6	3.9	-1.0	-0.4	-1.2	-1.5	-2.0	-1.1
Father’s age at death	1.5	2.0	6.6	-1.2	-1.0	1.1	-0.8	1.1	-2.6
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	7.4	0.0	-2.7	1.5	-0.1	0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	4.2	-1.0	-0.4	-2.1	-1.3	-1.9	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	4.1	-1.7	-1.1	0.1	-1.4	-0.6	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	10.3	1.4	1.3	-1.9	0.9	-0.8	3.2
Medication: Atorvastatin	1.5	1.8	6.9	-1.3	-2.6	-0.6	-0.9	-1.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	6.7	-0.1	-2.6	1.7	-0.2	1.0	0.1
Bipolar Disorder (2011)	1.4	1.4	2.5	0.0	-1.0	1.6	0.4	1.5	-1.6
Waist Hip Ratio (WHR)	1.4	6.2	18.9	-0.3	-0.7	3.5	0.8	4.3	-2.2
Systolic Blood Pressure	1.4	7.2	28.2	1.4	0.8	0.3	3.0	1.8	5.3
Trunk fat percentage	1.4	5.5	15.9	-1.8	-2.7	1.8	-1.1	1.2	-4.0
Number of incorrect matches in round	1.4	2.3	7.4	0.8	1.0	2.0	0.7	2.7	-0.5
Hair/balding pattern: Pattern 3	1.4	2.1	5.6	-0.9	0.6	-2.3	-0.4	-2.4	0.5
Shortness of breath walking on level ground	1.4	1.7	4.8	0.5	-0.2	2.0	0.6	2.2	-1.0
Had major operations	1.4	1.7	2.3	-1.2	-1.5	0.8	-1.2	1.5	-1.5
Arm fat-free mass (left)	1.4	7.1	21.1	-1.3	-3.9	1.7	-1.1	-0.6	-4.6
Arm predicted mass (left)	1.4	7.0	21.4	-1.2	-3.8	1.8	-0.8	-0.7	-4.6
LDL Cholesterol	1.3	2.1	3.4	-1.4	1.9	-1.1	-1.5	-1.8	-0.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	3.6	1.2	-0.4	1.4	1.3	1.9	0.4
Medication: Ramipril	1.3	1.6	3.7	0.2	0.1	-1.8	0.5	-1.9	1.5
Falls in the last year	1.3	1.8	5.0	1.1	-1.2	2.2	1.0	1.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	3.6	0.8	1.4	-0.8	0.5	-1.1	1.9
Hearing aid user	1.3	1.4	3.8	-0.8	0.4	-2.0	-1.1	-1.5	-0.5
Basal metabolic rate	1.3	7.0	20.1	-0.8	-4.0	2.1	-0.4	-0.5	-4.5
Reaction Time	1.2	2.2	4.9	-1.7	0.8	0.6	-1.5	1.6	-2.2
Prostate Cancer	1.2	1.6	3.5	-0.8	1.8	-0.8	-0.9	-1.9	-1.0
Mean Putamen Volume	1.2	1.4	2.0	1.2	0.6	-1.4	0.9	-1.4	1.3
Neuroticism (2016)	1.2	1.7	3.7	1.1	0.6	1.4	1.7	1.9	0.4
Blood Eosinophil Count	1.2	9.3	15.8	-4.0	-0.9	-2.4	-3.9	-3.1	-3.0
Medication: Levothyroxine sodium	1.2	2.1	6.1	-0.6	0.7	-1.5	-1.1	-2.5	1.5
Mouth/teeth dental problems: Dentures	1.2	2.0	3.8	-1.9	0.3	-1.5	-1.9	-1.4	-0.3
Asthma	1.2	2.4	5.4	-2.1	0.6	-0.2	-2.3	-0.5	-2.0
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.3	0.9	-1.3	1.4	0.9	1.8	0.7
Leg pain on walking	1.2	1.5	4.0	0.5	-1.6	2.0	0.9	1.0	-0.7
Ever had bowel cancer screening	1.2	1.4	2.9	1.5	-0.6	1.7	0.8	1.5	0.4
Average weekly beer plus cider intake	1.2	1.7	3.4	-1.8	1.2	-1.3	-1.7	-1.0	0.1
Cholesterol lowering medication	1.2	1.7	3.5	-1.9	-0.3	-1.4	-1.7	-1.3	-0.5
Ovarian Cancer	1.1	1.4	3.4	-0.3	-1.0	-1.3	-0.9	-1.8	1.2
Crohns Disease (2012)	1.1	1.7	3.5	1.3	-0.1	1.5	1.6	1.9	0.6
Medication: Co-codamol	1.1	1.2	3.7	-1.1	0.3	-1.9	-1.0	-0.9	0.8
Trunk predicted mass	1.1	6.0	17.1	-0.6	-3.8	1.9	-0.3	-0.8	-4.1
Pulse wave reflection index	1.1	1.4	3.1	-0.5	1.2	-1.5	-1.0	-1.8	0.6
High blood pressure (siblings)	1.1	1.5	3.0	1.5	0.3	0.7	1.7	1.2	1.3
Number of children fathered	1.1	1.3	2.6	-1.6	-0.9	-0.4	-1.5	-0.4	-1.3
Medication: Omeprazole	1.1	1.4	6.3	-0.5	-2.5	1.1	-0.6	0.3	-0.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	6.7	-0.3	2.6	-0.7	-0.3	-0.6	0.0
Asthma (self-reported)	1.1	2.2	5.1	-2.0	0.4	-0.1	-2.3	-0.4	-1.9
Number of operations (self-reported)	1.1	1.6	5.2	-0.3	-2.3	1.3	0.1	1.5	-0.8
Fractured/broken bones in last 5 years	1.1	1.4	2.9	1.7	1.5	0.1	1.2	-0.4	1.4
Height	1.0	19.2	47.7	4.4	-4.7	6.9	3.3	3.7	-1.1
Respiratory disease	1.0	2.1	5.7	-1.8	-0.5	0.3	-2.4	0.4	-1.8
Heart attack	1.0	1.3	3.2	-1.0	0.4	-1.4	-1.0	-1.8	-0.8
Trunk fat-free mass	1.0	5.9	16.6	-0.5	-3.8	1.9	-0.3	-0.8	-4.1
Number of live births	1.0	1.4	3.2	-1.8	-0.6	0.6	-1.5	-0.6	-1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.0	-0.9	-1.3	1.2	-0.9	1.0	-1.4
Forced vital capacity (FVC), Best measure	1.0	3.8	8.4	2.9	-0.8	1.5	2.4	0.8	2.3
Arm fat-free mass (right)	1.0	5.0	15.5	-0.7	-3.4	1.4	-0.4	-0.6	-3.9
Qualifications: College or University degree	1.0	3.1	6.3	1.8	-2.5	1.5	1.2	2.2	0.8
Migraine (self-reported)	1.0	1.2	3.3	1.8	-0.7	0.0	1.1	0.5	1.4
Arm predicted mass (right)	1.0	5.0	15.1	-0.6	-3.4	1.7	-0.5	-0.3	-3.9
Suffer from ‘nerves’	1.0	1.5	4.0	0.7	-0.2	2.0	1.1	1.9	-0.0
Overall health rating	1.0	2.1	4.2	-0.8	-1.9	2.0	-0.1	1.4	-1.4
Whole body fat-free mass	1.0	5.6	15.8	-0.3	-3.7	1.9	-0.1	-0.7	-4.0
Medication for cholesterol	1.0	1.5	4.1	-0.0	-1.9	1.2	-0.1	0.5	-2.0
Back pain experienced in last month	1.0	1.5	4.3	0.4	-2.1	1.1	0.4	1.8	-0.2
Smoking status: Current	1.0	1.5	4.7	2.2	0.3	0.4	2.0	-0.3	0.5
Whole body water mass	1.0	5.7	16.1	-0.3	-3.7	2.0	-0.1	-0.6	-4.0
High cholesterol (Self-reported)	1.0	1.7	3.2	-1.8	-0.0	-1.6	-1.4	-1.6	-0.2
Illnesses of father: High blood pressure	1.0	1.2	2.1	-1.4	-1.3	-0.4	-1.3	0.2	-1.2
Depression (Nagel 2018)	0.9	1.4	4.2	-0.5	-1.2	1.4	0.2	0.6	-2.0
Major Depression (MDD)	0.9	1.1	3.1	0.2	-1.2	1.8	0.5	0.8	-1.0
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.9	-0.0	-1.6	1.7	0.4	0.8	-1.3
Hearing difficulty/problems: Yes	0.9	1.3	2.7	0.7	1.3	-1.6	0.4	-1.6	0.7
Angina	0.9	1.2	2.8	-1.7	-1.6	-0.3	-0.8	-0.1	-1.0
Medication: Metformin	0.9	1.3	5.1	-0.9	-0.3	1.0	-0.1	0.7	-2.3
Leg fat-free mass (left)	0.9	5.0	12.4	0.1	-3.5	2.2	0.3	-0.3	-3.5
Chronic bronchitis/emphysema (father)	0.9	1.0	2.1	1.1	1.4	1.0	1.1	0.7	0.4
Leg predicted mass (left)	0.9	5.0	12.5	0.1	-3.5	2.3	0.4	-0.2	-3.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	7.8	2.5	-0.1	0.4	1.9	-0.0	2.8
Impedance of arm (left)	0.9	4.1	7.2	2.4	1.2	1.5	1.8	2.1	2.7
Angina (self-reported)	0.9	1.2	3.0	-1.7	-1.4	-0.5	-0.9	-0.2	-0.9
Pulse rate, automated reading	0.9	2.9	6.7	-0.2	-1.1	2.6	0.3	2.0	-2.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.5	1.0	1.2	0.3	1.1	0.3	1.6
Friendships satisfaction	0.9	1.1	3.0	-1.7	-0.8	0.4	-1.4	0.1	-1.0
Commuting to job workplace: Walk	0.9	0.9	2.5	-1.6	1.1	-0.2	-1.2	0.4	-0.1
Medication: Aspirin	0.9	1.1	2.8	-0.8	-1.7	1.0	-0.5	0.8	-1.3
Pack years of smoking	0.9	1.3	2.4	0.7	-1.0	1.6	1.3	1.1	-1.1
Alzheimer’s Disease (in father)	0.8	0.9	2.8	-0.7	0.7	1.0	-0.1	0.5	-1.7
Crohns Disease (2017)	0.8	1.8	3.7	1.3	-0.5	1.7	1.5	1.9	0.3
Lupus	0.8	1.2	6.1	0.0	-0.1	0.6	0.1	2.5	-0.7
Systolic blood pressure, automated reading	0.8	2.2	9.9	0.1	-0.4	-0.6	1.7	0.4	3.1
Pack years adult smoking proportion	0.8	1.2	2.1	1.0	-1.1	1.3	1.5	0.9	-0.7
Townsend deprivation index at recruitment	0.8	1.1	2.8	0.4	1.7	-0.3	0.8	-1.5	0.9
Average weekly fortified wine intake	0.8	0.9	1.4	-0.8	-1.1	-1.2	-0.9	-1.0	-0.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.2	-0.1	0.5	1.5	0.5	1.5	-0.5
Illnesses of siblings	0.8	1.1	2.4	-0.8	0.5	-1.4	-1.0	-1.6	-0.6
Birth weight of first child	0.8	1.4	4.2	0.5	-2.0	1.3	0.8	1.1	-0.2
Comparative height size at age 10	0.8	4.2	11.8	-1.6	-2.8	1.1	-1.4	-0.5	-3.4
Medication: Aspirin	0.8	1.1	3.1	-0.5	-1.8	1.1	-0.1	0.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.6	1.7	-0.7	1.8	1.9	0.4	-0.4
Leg fat-free mass (right)	0.8	4.3	11.1	0.3	-3.3	1.8	0.4	-0.6	-3.3
Average weekly red wine intake	0.8	1.1	2.3	-0.2	-1.2	1.2	-0.5	1.5	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.8	0.6	-2.2	0.9	0.3	1.0	-0.2
Leg predicted mass (right)	0.8	4.4	11.4	0.3	-3.4	1.9	0.4	-0.6	-3.4
Average weekly champagne plus white wine intake	0.8	1.1	2.8	-0.5	-1.1	-1.2	-1.0	-1.7	0.0
Commuting to job workplace: Cycle	0.8	1.0	2.1	0.0	1.4	-1.5	0.2	-0.3	1.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.6	-0.9	0.4	-1.1	-0.8	-1.6	-0.8
Heart disease (siblings)	0.8	1.0	2.5	-1.0	-1.1	-0.8	-1.6	-0.7	-0.4
Schizophrenia vs Biploar Disorder	0.7	0.9	4.6	-0.8	2.1	0.1	-0.3	0.3	0.3
Cardiovascular Disease	0.7	2.2	9.8	0.8	0.8	0.1	1.4	0.3	3.1
Lung FVC	0.7	3.4	9.9	0.6	0.3	-2.5	0.0	-2.0	3.1
Average weekly spirits intake	0.7	0.9	1.9	1.3	-1.4	0.1	1.3	0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.6	-0.0	-1.9	0.3	-0.4	-0.1	-1.2
Current tobacco smoking	0.7	1.1	3.2	1.8	-0.2	0.1	1.6	-0.7	0.4
Alcohol usually taken with meals	0.7	1.1	2.6	-0.9	-0.8	0.7	-1.4	0.4	-1.6
Mouth/teeth dental problems	0.7	1.1	3.1	1.3	1.1	0.7	1.8	0.3	-0.0
Impedance of arm (right)	0.7	3.0	5.9	1.7	0.7	1.8	1.2	2.4	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.1	-0.1	-1.0	1.8	0.0	1.4	-0.8
Headache pain in last month	0.7	1.2	2.8	1.6	1.7	-0.1	1.0	-0.2	0.6
Exposure to tobacco smoke outside home	0.7	0.9	1.7	0.6	-1.3	1.3	0.3	1.2	0.1
Supplements: Vitamin C	0.7	0.9	1.5	-1.2	0.6	-1.1	-0.9	-0.5	-1.0
Loneliness, isolation	0.7	1.0	4.0	-1.1	0.5	0.4	-0.7	-0.0	-2.0
Ever taken oral contraceptive pill	0.7	0.8	1.6	-0.8	0.5	-0.8	-0.9	-1.0	-1.2
Eye problems/disorders: Glaucoma	0.7	0.8	2.0	-0.1	-0.3	1.1	0.6	1.4	-1.2
Ever smoked	0.7	1.2	2.8	1.7	-1.2	1.0	0.7	0.2	1.2
Diastolic blood pressure, automated reading	0.7	2.3	8.5	0.3	0.3	-1.3	1.3	-1.3	2.9
Myopia	0.7	1.0	2.5	0.9	-0.4	1.6	0.3	1.2	1.0
Alcohol drinker status: Previous	0.7	0.8	2.0	0.5	-0.7	1.4	0.4	1.2	-0.2
Bipolar Disorder (2018)	0.6	0.9	2.6	-0.1	-1.5	0.2	-0.5	-0.3	-1.6
Smoking Status	0.6	1.5	3.9	2.0	-1.4	1.0	1.3	-0.6	0.4
Hand grip strength (left)	0.6	1.5	6.8	1.2	-2.6	-0.2	0.6	-0.6	0.2
Diabetes (father)	0.6	0.7	3.0	-0.1	-1.7	0.2	-0.3	0.6	-1.0
Relative age voice broke	0.6	0.9	2.2	0.5	1.2	-0.9	-0.3	-0.7	1.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	-0.8	-1.3	0.5	-0.7	-0.4	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	2.2	-0.4	1.4	-0.8	0.1	-1.5	-0.1
Supplements: Glucosamine	0.6	0.8	2.3	-0.5	-1.5	0.3	-0.5	-0.0	-1.3
Sitting height	0.6	4.3	11.4	1.4	-3.4	2.6	1.2	0.7	-1.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.7	0.2	-1.3	0.9	0.6	0.3	-1.2
Happiness	0.6	0.7	1.6	-1.3	-0.6	-0.2	-0.7	0.9	-1.0
Pulse wave Arterial Stiffness index	0.6	0.6	2.4	0.5	1.6	-0.4	0.2	-0.4	0.9
Standing height	0.6	6.4	13.4	2.8	-3.2	3.7	1.9	1.5	-1.2
Breastfed as a baby	0.6	0.7	2.1	0.7	1.3	-0.3	0.3	0.1	1.5
Comparative body size at age 10	0.6	1.7	6.8	-1.6	-0.3	0.1	-0.6	0.5	-2.6
Wheeze or whistling in the chest in last year	0.6	1.1	1.9	-1.3	0.6	1.0	-1.0	1.4	-1.0
Pulse wave peak to peak time	0.6	0.6	2.1	-0.5	-1.4	0.6	-0.1	0.5	-1.0
Medication: Blood pressure	0.6	1.1	3.2	0.6	0.1	0.2	1.7	0.5	1.8
Medication: Ibuprofen	0.6	0.7	1.6	0.8	-0.9	1.3	0.9	0.3	-0.5
Mean time to correctly identify matches	0.6	1.1	1.9	-1.1	0.7	0.5	-1.0	1.4	-1.3
Smoking status: Previous	0.6	0.9	3.9	0.3	-2.0	0.4	-0.7	-0.8	0.6
Osteoporosis (self-reported)	0.6	0.7	2.3	-0.5	-0.1	-0.4	-1.3	-1.5	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-0.8	0.1	-1.1	-0.8	-1.2	-0.3
Medication: Paracetamol	0.6	0.9	3.6	0.5	-1.9	0.7	0.1	0.8	-0.7
Supplements: Calcium	0.6	0.6	2.5	0.3	-0.1	1.0	0.2	1.6	0.4
Impedance of whole body	0.6	3.3	6.4	1.7	1.4	1.1	1.1	2.5	2.4
Verbal and Numeric Reasoning (VNR)	0.5	1.1	4.2	1.0	0.2	0.8	1.0	2.0	0.2
Taking other prescription medications	0.5	0.7	1.8	-0.5	-1.3	0.5	-1.2	0.0	-0.6
Past tobacco smoking	0.5	0.8	2.0	-1.4	0.9	-0.7	-0.4	0.5	-1.1
Had menopause	0.5	0.6	1.2	0.9	-1.1	0.5	0.7	0.8	0.5
Pain all over the body in last month	0.5	0.5	1.5	0.3	-1.2	0.8	0.5	0.2	-0.8
Noisy workplace	0.5	0.7	3.8	-0.0	2.0	-0.2	0.1	-0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	1.2	-0.5	0.6	1.2	-0.2	0.2
Loud music exposure frequency	0.5	0.6	1.6	0.8	1.0	0.5	1.3	-0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.4	-0.6	-0.6	-0.3	-1.0	-1.6	1.3
Number of full sisters	0.5	0.6	1.8	-0.3	0.1	-1.3	-0.6	-0.4	1.1
Chest pain or discomfort	0.5	0.8	2.1	0.1	-0.9	1.2	0.4	1.4	-0.5
Osteoarthritis (self-reported)	0.5	0.6	1.3	0.7	0.1	0.1	1.1	-0.9	1.0
Wears glasses or contact lenses	0.5	0.6	3.0	-0.2	-1.7	0.6	0.2	0.4	-0.1
Financial situation satisfaction	0.5	0.7	2.0	-0.1	0.2	0.7	0.4	1.1	-1.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	-0.5	-1.1	0.5	-0.5	0.5	-0.6
Age at First Birth	0.4	0.6	2.2	0.7	0.6	-0.3	0.7	0.3	1.5
HDL Cholesterol	0.4	0.6	1.6	-0.7	-1.3	-0.3	-1.1	-0.2	-0.5
Hypothyroidism (self reported)	0.4	0.9	1.8	-0.9	-1.1	0.0	-1.1	-1.4	0.5
Tanning	0.4	4.8	13.4	-0.9	-1.0	-3.7	-1.5	-3.4	-0.0
Vitamin and mineral supplements	0.4	0.6	1.9	0.6	0.5	0.3	1.4	-0.3	0.8
Impedance of leg (right)	0.4	1.8	6.5	0.2	1.2	1.0	-0.2	2.6	1.4
Hand grip strength (right)	0.4	1.0	3.3	0.5	-1.8	-0.3	-0.2	-1.4	-0.1
High blood pressure (mother)	0.4	0.6	1.9	0.0	-0.6	0.4	0.6	1.4	0.9
Hearing difficulty/problems with background noise	0.4	0.7	1.4	0.6	0.6	-0.8	0.6	-0.9	1.2
Qualifications: None of the above	0.4	0.9	3.0	-1.0	1.7	-0.4	-0.6	-0.9	-0.3
Pulse rate	0.4	0.6	1.1	0.7	0.5	1.0	0.9	1.0	0.0
Hair/balding pattern: Pattern 4	0.4	0.9	3.6	0.1	0.8	0.9	0.3	1.9	0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.7	-1.0	-0.4	-0.6	-0.9	-0.6
Birth weight	0.4	0.9	2.1	1.2	-1.4	0.8	0.8	0.9	-0.1
Number of full brothers	0.4	0.5	1.4	-1.2	0.7	-0.2	-0.3	-0.6	-0.7
Miserableness	0.4	0.8	2.8	-0.4	-0.4	1.1	-0.1	0.5	-1.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	-0.2	1.2	-0.6	-0.5	-0.4	-0.7
Ever depressed for a whole week	0.4	0.5	1.9	-0.3	0.7	-0.2	-0.1	-0.4	-1.4
Depressed Affect (Nagel 2018)	0.3	0.7	2.1	-0.7	0.6	0.9	-0.2	0.5	-1.4
Schizophrenia (2018)	0.3	0.7	2.2	0.8	0.2	0.7	0.7	1.5	0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.7	-0.3	-0.1	0.9	0.1	0.4	-1.3
Breast Cancer	0.3	0.8	2.0	0.8	0.3	1.0	0.9	1.4	-0.5
Coronary Artery Disease (CAD)	0.3	0.4	1.6	0.5	-0.5	-0.3	0.4	-0.3	1.3
Primary Biliary Cirrhosis	0.3	0.4	1.2	0.8	0.4	-1.1	0.6	-0.2	-0.1
Schizophrenia (2014)	0.3	0.7	1.5	0.7	1.1	0.8	0.5	1.2	-0.3
Maternal smoking around birth	0.3	0.5	1.4	1.2	0.0	0.1	0.6	-0.8	0.6
Fed-up feelings	0.3	0.6	1.0	0.9	0.8	-0.2	0.9	-1.0	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.8	0.2	-1.3	0.4	0.5	-0.4	-0.5
Serious illness, injury or assault to yourself	0.3	0.3	1.9	0.1	-1.4	0.1	0.0	-0.3	-0.1
Impedance of leg (left)	0.3	1.3	4.4	0.1	1.1	0.4	-0.5	2.1	1.4
Length of working week for main job	0.3	0.3	1.2	0.2	1.1	-0.0	-0.2	0.1	-0.7
Peak expiratory flow (PEF)	0.3	0.7	1.1	1.1	-0.9	-0.6	0.6	-0.6	1.0
Medication: Paracetamol	0.3	0.5	1.6	1.0	-1.3	-0.0	0.6	0.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	0.7	-0.7	0.9	0.4	0.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.9	0.3	0.5	-1.0	0.3	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	-1.1	0.9	-0.7	-0.8	-0.2	0.0
Mood swings	0.3	0.5	0.9	0.4	0.2	1.0	0.6	0.9	-0.9
Mineral and other dietary supplements	0.3	0.4	0.7	0.6	-0.6	0.9	0.8	0.5	0.5
Number of self-reported non-cancer illnesses	0.3	0.6	1.7	0.3	-1.3	0.8	0.2	0.7	0.7
Mother’s age at death	0.3	0.4	0.7	0.8	0.4	0.2	0.7	0.4	0.8
Commuting to job workplace: Public transport	0.3	0.4	1.5	-0.1	-0.6	-1.2	-0.4	-0.6	-0.2
Age started oral contraceptive pill	0.3	0.4	0.9	-0.8	-0.3	-0.2	-0.9	0.3	-0.9
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.2	0.6	0.7	0.6	-0.8	-0.8
Pain experienced in last month	0.3	0.5	1.3	-1.1	-0.4	-0.3	-1.0	-0.2	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.6	-1.0	0.7	0.2	0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.3	0.7	-0.2	0.8	0.4	1.5	0.2
Rheumatoid Arthritis	0.2	0.3	0.6	0.7	0.7	-0.2	0.4	0.8	0.3
Number of treatments/medications taken	0.2	0.4	1.5	-0.1	-1.2	0.2	-0.6	0.0	0.5
Forced vital capacity (FVC)	0.2	0.7	2.0	1.2	0.3	-0.2	0.6	-0.6	1.4
Medication: Simvastatin	0.2	0.3	0.9	-1.0	0.8	-0.4	-0.5	-0.1	-0.3
Fluid intelligence score	0.2	0.4	2.0	-0.2	-0.1	-0.1	-0.4	1.4	0.1
Medication: Cholesterol lowering	0.2	0.3	0.5	0.0	0.5	0.6	0.7	0.7	0.2
Exposure to tobacco smoke at home	0.2	0.3	1.0	-0.4	0.3	0.3	-1.0	0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.1	0.0	1.1	-0.4	-0.0	-0.0	0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.2	-0.2	-0.1	-0.2	-1.0	-0.4	-1.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.1	-0.5	0.3	-0.1	0.3	-0.9
Age at first live birth	0.2	0.3	1.0	-0.2	-0.8	0.1	-0.4	1.0	-0.0
Alcohol intake frequency.	0.2	0.4	1.5	-1.2	0.6	-0.0	-0.6	0.1	-0.3
Knee pain experienced in last month	0.2	0.3	0.6	0.4	-0.3	0.8	0.6	-0.1	0.5
Eye problems/disorders: Cataract	0.2	0.3	0.6	0.3	0.3	0.4	0.1	0.7	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.3	0.3	0.3	-0.1	0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	-0.3	0.6	-0.1	-0.1	0.9	-0.1
Triglycerides	0.1	0.2	1.0	-0.3	1.0	-0.0	-0.3	-0.1	0.4
Severe depression (siblings)	0.1	0.1	0.4	-0.2	-0.6	-0.4	-0.1	-0.2	-0.5
Financial difficulties in last 2 years	0.1	0.2	0.4	0.6	0.6	-0.3	0.3	-0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	0.3	-0.7	0.3	0.4	0.2	1.0
Prospective memory result	0.1	0.1	0.3	0.3	0.1	0.2	0.1	-0.1	0.6
Lung cancer (father)	0.1	0.1	0.4	0.6	-0.0	-0.2	0.4	0.1	0.1
Blood clot in the leg (DVT)	0.1	0.2	0.7	-0.4	0.3	0.0	-0.1	0.8	-0.4
Emphysema/chronic bronchitis	0.1	0.2	0.5	0.2	0.7	-0.1	-0.0	0.6	0.3
Neck or shoulder pain in last month	0.1	0.2	0.7	-0.1	0.8	-0.4	-0.3	-0.3	0.3
Age at last live birth	0.1	0.2	0.6	-0.3	0.3	0.3	-0.3	0.8	-0.0
Family relationship satisfaction	0.1	0.2	0.7	-0.1	0.8	-0.6	0.1	0.2	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.4	-0.5	0.6	-0.3	-0.3	0.5	-0.1
Alcohol drinker status: Never	0.1	0.1	0.4	0.3	0.1	-0.1	0.1	0.5	0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.3	-0.3	-0.3	0.1	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.1	-0.1	0.3	0.1	0.4	0.1	0.1
Chronotype (morning person)	0.0	0.1	0.3	0.1	0.2	-0.2	0.2	0.5	0.1
Hair Pigment	0.0	0.6	1.8	0.8	1.3	0.5	0.5	0.4	0.5
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.2	0.0	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.0	-0.2	-0.0	-0.1	0.4	0.1

Hub : Genes

ST5

Models

Trait associations