Best TWAS P=6.46e-13 · Best GWAS P=1.82e-18 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RCN1 | 0.19 | 0.13 | lasso | 5 | 0.15 | 1.1e-17 | -5.1 | -5.2 | 2.5e-07 | -0.03 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | ARL14EP | 0.16 | 0.02 | lasso | 5 | 0.05 | 7.4e-04 | -7.7 | -6.2 | 4.6e-10 | 0.47 | 0.37 | 0.31 | FALSE |
3 | GTEx | Brain Cerebellum | ARL14EP | 0.33 | 0.25 | lasso | 10 | 0.26 | 3.7e-08 | 6.2 | -6.5 | 1.0e-10 | 0.40 | 0.97 | 0.00 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | RCN1 | 0.31 | 0.23 | lasso | 4 | 0.24 | 5.8e-18 | -5.4 | -5.6 | 1.9e-08 | -0.04 | 0.00 | 1.00 | TRUE |
5 | GTEx | Colon Sigmoid | ARL14EP | 0.16 | 0.05 | lasso | 13 | 0.10 | 2.6e-04 | 5.8 | -6.0 | 1.4e-09 | 0.51 | 0.09 | 0.59 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | ARL14EP | 0.15 | 0.14 | lasso | 3 | 0.11 | 1.2e-04 | 6.2 | -6.3 | 3.3e-10 | 0.39 | 0.57 | 0.04 | TRUE |
7 | GTEx | Esophagus Mucosa | ARL14EP | 0.09 | 0.03 | enet | 11 | 0.05 | 1.8e-04 | 5.8 | -5.6 | 2.2e-08 | 0.49 | 0.31 | 0.32 | TRUE |
8 | GTEx | Esophagus Muscularis | ARL14EP | 0.18 | 0.20 | lasso | 8 | 0.19 | 9.5e-12 | 6.4 | -7.2 | 6.7e-13 | 0.46 | 1.00 | 0.00 | TRUE |
9 | GTEx | Lung | ARL14EP | 0.10 | 0.06 | lasso | 8 | 0.11 | 1.1e-08 | -3.3 | -7.0 | 2.2e-12 | 0.71 | 0.31 | 0.69 | FALSE |
10 | GTEx | Nerve Tibial | ARL14EP | 0.19 | 0.17 | enet | 22 | 0.18 | 4.2e-13 | 6.3 | -6.5 | 7.9e-11 | 0.46 | 1.00 | 0.00 | TRUE |
11 | GTEx | Ovary | ARL14EP | 0.35 | 0.21 | enet | 31 | 0.18 | 2.8e-05 | 6.4 | -5.3 | 8.7e-08 | 0.36 | 0.18 | 0.18 | TRUE |
12 | GTEx | Pancreas | ARL14EP | 0.16 | 0.08 | lasso | 6 | 0.07 | 1.0e-03 | 5.6 | -6.5 | 1.1e-10 | 0.39 | 0.16 | 0.52 | FALSE |
13 | GTEx | Pituitary | ARL14EP | 0.30 | 0.28 | lasso | 4 | 0.22 | 3.0e-06 | 7.0 | -7.2 | 6.5e-13 | 0.55 | 0.44 | 0.10 | FALSE |
14 | GTEx | Spleen | ARL14EP | 0.34 | 0.19 | enet | 24 | 0.30 | 1.7e-08 | 2.3 | -5.5 | 3.6e-08 | 0.68 | 0.11 | 0.80 | TRUE |
15 | GTEx | Thyroid | RCN1 | 0.16 | 0.09 | enet | 23 | 0.11 | 6.9e-09 | 3.8 | -5.3 | 1.2e-07 | -0.07 | 0.41 | 0.54 | FALSE |
16 | GTEx | Thyroid | ARL14EP | 0.20 | 0.05 | lasso | 6 | 0.09 | 1.0e-07 | -2.1 | -6.2 | 5.3e-10 | 0.50 | 0.90 | 0.10 | TRUE |
17 | METSIM | Adipose | RCN1 | 0.09 | 0.09 | lasso | 2 | 0.09 | 2.6e-13 | -5.2 | -5.2 | 1.7e-07 | -0.05 | 0.01 | 0.99 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | MPPED2 | 0.25 | 0.29 | lasso | 7 | 0.29 | 4.4e-37 | 6.5 | -6.6 | 5.1e-11 | 0.54 | 1.00 | 0.00 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | ARL14EP | 0.08 | 0.07 | enet | 13 | 0.08 | 5.3e-10 | 6.4 | -6.0 | 1.5e-09 | 0.35 | 1.00 | 0.00 | FALSE |
20 | The Cancer Genome Atlas | Lung Adenocarcinoma | MPPED2 | 0.07 | 0.01 | blup | 149 | 0.03 | 7.0e-05 | 7.0 | -5.3 | 9.8e-08 | 0.38 | 0.32 | 0.26 | TRUE |