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chr2:15,703-1,384,725

Best TWAS P=4.02e-19 · Best GWAS P=2.37e-111 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM110C	0.09	0.00	bslmm	232	0.01	8.2e-03	1.4	5.5	4.0e-08	-0.05	0.41	0.02	FALSE
2	GTEx	Adipose Subcutaneous	SH3YL1	0.08	0.10	lasso	1	0.08	4.1e-07	-5.9	-5.9	4.3e-09	-0.04	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	TMEM18	0.32	0.21	lasso	9	0.25	4.7e-20	5.6	6.7	1.8e-11	-0.23	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	AC092159.2	0.29	0.14	lasso	14	0.19	4.2e-15	4.4	6.1	1.0e-09	-0.17	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	SH3YL1	0.15	0.03	lasso	4	0.01	6.5e-02	-5.1	-6.4	1.7e-10	-0.01	0.17	0.04	FALSE
6	GTEx	Adipose Visceral Omentum	TMEM18	0.23	0.14	lasso	4	0.17	5.7e-09	5.8	5.4	5.9e-08	-0.15	0.99	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	AC092159.2	0.29	0.11	enet	41	0.14	1.5e-07	5.8	6.0	1.4e-09	-0.12	0.92	0.00	FALSE
8	GTEx	Artery Aorta	TMEM18	0.32	0.16	lasso	5	0.15	1.4e-08	5.6	6.4	2.0e-10	-0.19	1.00	0.00	FALSE
9	GTEx	Artery Aorta	AC092159.2	0.29	0.19	enet	9	0.23	9.7e-13	5.8	6.8	9.8e-12	-0.19	1.00	0.00	FALSE
10	GTEx	Artery Tibial	SH3YL1	0.10	0.02	lasso	3	0.01	2.9e-02	-5.8	-8.8	2.0e-18	0.09	0.65	0.03	FALSE
11	GTEx	Artery Tibial	TMEM18	0.35	0.08	enet	28	0.19	9.2e-15	5.8	6.2	5.0e-10	-0.19	1.00	0.00	FALSE
12	GTEx	Artery Tibial	AC092159.2	0.38	0.24	lasso	5	0.30	5.6e-24	6.6	7.7	9.7e-15	-0.19	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	SH3YL1	0.16	0.09	lasso	7	0.10	3.3e-08	6.6	-5.7	1.1e-08	0.03	0.99	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	AC092159.2	0.26	0.17	enet	5	0.21	1.8e-15	5.8	5.9	4.3e-09	-0.16	1.00	0.00	FALSE
15	GTEx	Colon Transverse	SH3YL1	0.36	0.25	lasso	7	0.26	1.2e-12	-5.8	6.4	2.0e-10	0.03	1.00	0.00	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	SH3YL1	0.21	0.09	lasso	7	0.14	1.3e-05	-3.8	-6.5	5.8e-11	0.03	0.52	0.02	TRUE
17	GTEx	Esophagus Mucosa	SH3YL1	0.60	0.67	lasso	4	0.66	9.2e-58	-5.8	5.7	1.4e-08	0.05	1.00	0.00	FALSE
18	GTEx	Esophagus Mucosa	TMEM18	0.37	0.20	lasso	7	0.20	2.3e-13	5.6	6.0	2.1e-09	-0.20	1.00	0.00	FALSE
19	GTEx	Esophagus Mucosa	AC092159.2	0.27	0.18	enet	5	0.20	2.5e-13	5.8	6.4	1.9e-10	-0.20	1.00	0.00	FALSE
20	GTEx	Esophagus Muscularis	SH3YL1	0.30	0.23	enet	50	0.28	4.6e-17	-5.8	-6.1	1.4e-09	-0.03	1.00	0.00	TRUE
21	GTEx	Esophagus Muscularis	TMEM18	0.37	0.20	lasso	8	0.18	2.0e-11	6.6	7.9	3.5e-15	-0.28	1.00	0.00	TRUE
22	GTEx	Esophagus Muscularis	AC092159.2	0.26	0.16	enet	7	0.20	5.3e-12	6.6	7.3	3.2e-13	-0.30	1.00	0.00	FALSE
23	GTEx	Heart Atrial Appendage	TMEM18	0.26	0.16	lasso	7	0.09	5.0e-05	5.6	6.2	6.1e-10	-0.24	0.83	0.06	FALSE
24	GTEx	Heart Left Ventricle	SH3YL1	0.14	0.11	enet	16	0.10	8.2e-06	-5.5	-6.8	9.7e-12	-0.04	0.80	0.01	TRUE
25	GTEx	Heart Left Ventricle	TMEM18	0.22	0.19	lasso	7	0.16	8.3e-09	5.8	7.5	5.1e-14	-0.19	0.99	0.00	FALSE
26	GTEx	Heart Left Ventricle	AC092159.2	0.35	0.24	lasso	6	0.23	2.3e-12	5.8	7.0	1.8e-12	-0.20	1.00	0.00	FALSE
27	GTEx	Lung	TMEM18	0.13	0.11	lasso	2	0.10	4.5e-08	5.8	5.8	7.0e-09	-0.17	0.99	0.00	FALSE
28	GTEx	Lung	AC092159.2	0.22	0.17	lasso	3	0.18	1.1e-13	5.8	5.9	2.8e-09	-0.13	1.00	0.00	FALSE
29	GTEx	Muscle Skeletal	SH3YL1	0.12	0.10	lasso	3	0.09	4.1e-09	-5.8	-5.5	3.9e-08	-0.07	1.00	0.00	FALSE
30	GTEx	Muscle Skeletal	TMEM18	0.40	0.30	lasso	7	0.33	2.0e-33	6.6	6.2	5.5e-10	-0.17	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	AC092159.2	0.46	0.34	enet	18	0.39	1.1e-40	6.6	6.4	1.4e-10	-0.17	1.00	0.00	FALSE
32	GTEx	Nerve Tibial	SH3YL1	0.33	0.23	enet	35	0.25	5.6e-18	-5.8	-7.7	2.1e-14	0.07	1.00	0.00	FALSE
33	GTEx	Nerve Tibial	AC092159.2	0.18	0.09	lasso	5	0.10	1.5e-07	6.6	6.7	2.7e-11	-0.16	0.99	0.00	FALSE
34	GTEx	Ovary	SH3YL1	0.48	0.29	enet	18	0.34	3.2e-09	-5.5	-7.7	1.2e-14	0.15	0.67	0.03	TRUE
35	GTEx	Pancreas	SH3YL1	0.48	0.43	lasso	11	0.41	6.9e-19	-5.8	6.0	1.9e-09	0.04	1.00	0.00	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	SH3YL1	0.47	0.53	lasso	2	0.53	2.1e-33	-5.9	5.8	4.8e-09	0.04	1.00	0.00	FALSE
37	GTEx	Skin Sun Exposed Lower leg	SH3YL1	0.42	0.44	lasso	5	0.45	3.3e-41	-5.9	6.1	1.2e-09	0.04	1.00	0.00	FALSE
38	GTEx	Stomach	SH3YL1	0.33	0.21	lasso	6	0.20	3.8e-10	-5.5	5.9	4.5e-09	0.05	1.00	0.00	FALSE
39	GTEx	Thyroid	SH3YL1	0.29	0.32	lasso	4	0.31	2.9e-24	-5.8	5.8	8.6e-09	0.05	1.00	0.00	FALSE
40	GTEx	Whole Blood	SH3YL1	0.21	0.17	lasso	6	0.18	2.6e-16	-5.8	6.0	1.7e-09	0.05	1.00	0.00	FALSE
41	METSIM	Adipose	TMEM18	0.20	0.12	lasso	6	0.12	9.2e-17	5.8	6.7	2.1e-11	-0.19	1.00	0.00	FALSE
42	NTR	Blood	SH3YL1	0.12	0.17	lasso	5	0.16	6.2e-51	-5.9	5.5	3.4e-08	0.05	1.00	0.00	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	ACP1	0.03	0.04	lasso	2	0.02	4.7e-04	-5.5	5.5	2.8e-08	0.00	0.61	0.01	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	FAM150B	0.06	0.01	bslmm	381	0.03	9.9e-05	6.7	8.9	4.0e-19	-0.07	0.40	0.02	TRUE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	SH3YL1	0.19	0.31	lasso	5	0.32	2.5e-66	-5.8	5.4	6.2e-08	0.05	0.49	0.51	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	SH3YL1	0.32	0.34	lasso	6	0.35	2.8e-21	-5.8	5.9	3.4e-09	0.05	0.48	0.52	FALSE
47	The Cancer Genome Atlas	Esophageal Carcinoma	SH3YL1	0.16	0.02	blup	67	0.08	1.9e-03	-5.5	6.2	5.8e-10	0.00	0.10	0.32	TRUE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SH3YL1	0.24	0.25	lasso	4	0.25	8.1e-28	-5.5	5.6	1.7e-08	0.05	0.54	0.46	TRUE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SH3YL1	0.16	0.04	blup	67	0.06	5.6e-07	-6.0	6.0	1.4e-09	0.02	0.04	0.96	TRUE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SH3YL1	0.20	0.05	blup	67	0.09	9.5e-06	-6.0	6.2	4.9e-10	0.05	0.24	0.60	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM150B	0.07	0.07	lasso	2	0.06	5.8e-07	-6.0	6.0	1.8e-09	0.05	0.42	0.58	FALSE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SH3YL1	0.21	0.18	lasso	1	0.15	9.6e-07	-5.5	5.5	3.1e-08	0.05	0.54	0.46	FALSE
53	The Cancer Genome Atlas	Soft Tissue Sarcoma	SH3YL1	0.07	0.04	enet	9	0.05	1.0e-03	6.4	-5.6	1.7e-08	0.03	0.02	0.81	TRUE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM18	0.11	0.01	blup	74	0.04	1.3e-03	5.6	6.8	1.1e-11	-0.23	0.11	0.04	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	SH3YL1	0.54	0.56	lasso	4	0.57	1.1e-67	-5.8	5.6	2.2e-08	0.06	0.54	0.46	FALSE