Best TWAS P=2.21e-09 · Best GWAS P=6.56e-11 conditioned to 3.17e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | MPI | 0.14 | 0.09 | enet | 13 | 0.09 | 9.7e-04 | 5.2 | 5.4 | 6.2e-08 | 0.47 | 0.31 | 0.27 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | MPI | 0.16 | 0.00 | lasso | 8 | 0.01 | 1.4e-01 | -5.8 | 6.0 | 2.2e-09 | 0.37 | 0.06 | 0.26 | TRUE |
| 3 | METSIM | Adipose | RPP25 | 0.04 | 0.06 | lasso | 7 | 0.05 | 1.4e-08 | -5.6 | -5.7 | 1.5e-08 | -0.47 | 0.32 | 0.68 | FALSE |
| 4 | YFS | Blood | COX5A | 0.01 | 0.01 | lasso | 3 | 0.01 | 1.9e-05 | 4.1 | 5.1 | 2.7e-07 | 0.42 | 0.65 | 0.31 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ULK3 | 0.06 | 0.03 | enet | 6 | 0.05 | 6.2e-05 | -5.1 | -5.9 | 4.2e-09 | -0.33 | 0.01 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | MPI | 0.02 | 0.02 | lasso | 1 | 0.02 | 4.7e-03 | -5.3 | 5.3 | 1.3e-07 | 0.40 | 0.00 | 0.97 | FALSE |