Best TWAS P=2.08e-09 · Best GWAS P=1.21e-17 conditioned to 0.0111
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MYO9A | 0.06 | 0.03 | lasso | 2 | 0.01 | 4.7e-02 | -5.4 | 5.2 | 1.6e-07 | -0.36 | 0.02 | 0.93 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | MYO9A | 0.19 | 0.02 | lasso | 8 | 0.03 | 9.4e-03 | -5.4 | 5.8 | 7.1e-09 | -0.31 | 0.01 | 0.95 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | RP11-1006G14.4 | 0.12 | 0.06 | lasso | 11 | 0.05 | 2.3e-03 | -5.9 | -5.2 | 1.5e-07 | 0.37 | 0.13 | 0.08 | FALSE |
| 4 | GTEx | Nerve Tibial | MYO9A | 0.13 | 0.13 | lasso | 3 | 0.11 | 2.1e-08 | -5.3 | 5.8 | 5.2e-09 | -0.37 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Nerve Tibial | NEO1 | 0.07 | 0.09 | lasso | 2 | 0.09 | 3.9e-07 | -6.0 | -6.0 | 2.1e-09 | 0.45 | 0.93 | 0.02 | TRUE |
| 6 | GTEx | Pituitary | BBS4 | 0.27 | 0.02 | enet | 21 | 0.05 | 2.1e-02 | -5.1 | -5.7 | 1.6e-08 | 0.69 | 0.05 | 0.52 | FALSE |
| 7 | GTEx | Testis | ADPGK-AS1 | 0.17 | 0.05 | lasso | 4 | 0.03 | 1.3e-02 | -3.6 | 5.5 | 4.6e-08 | -0.72 | 0.02 | 0.90 | TRUE |
| 8 | NTR | Blood | NEO1 | 0.04 | 0.01 | lasso | 4 | 0.02 | 4.1e-06 | 3.7 | -5.5 | 3.1e-08 | 0.25 | 0.94 | 0.01 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | HCN4 | 0.03 | 0.00 | blup | 52 | 0.02 | 2.0e-03 | 2.0 | 5.4 | 5.9e-08 | -0.16 | 0.02 | 0.08 | TRUE |