Best TWAS P=1.67e-12 · Best GWAS P=1.25e-13 conditioned to 6.7e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | SLC5A11 | 0.23 | 0.28 | lasso | 10 | 0.28 | 1.6e-42 | -6.4 | -6.5 | 1.0e-10 | -0.03 | 0.45 | 0.55 | FALSE |
| 2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SLC5A11 | 0.17 | 0.21 | lasso | 4 | 0.21 | 1.7e-17 | -6.1 | -6.4 | 1.7e-10 | -0.03 | 0.02 | 0.98 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC5A11 | 0.12 | 0.17 | enet | 9 | 0.18 | 1.1e-35 | -6.5 | -6.2 | 4.8e-10 | -0.05 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SLC5A11 | 0.27 | 0.24 | lasso | 6 | 0.24 | 4.5e-12 | -6.5 | -6.9 | 6.5e-12 | -0.04 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC5A11 | 0.27 | 0.21 | lasso | 2 | 0.20 | 5.2e-12 | -6.5 | -6.5 | 7.1e-11 | -0.03 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | RBBP6 | 0.22 | 0.16 | blup | 55 | 0.17 | 7.8e-06 | 7.4 | 5.7 | 1.3e-08 | 0.91 | 0.00 | 0.99 | TRUE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC5A11 | 0.13 | 0.15 | enet | 8 | 0.15 | 6.6e-17 | -6.5 | -6.3 | 2.5e-10 | -0.04 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC5A11 | 0.07 | 0.07 | enet | 7 | 0.06 | 1.7e-07 | -6.5 | -6.4 | 1.7e-10 | -0.04 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC5A11 | 0.14 | 0.20 | enet | 9 | 0.20 | 2.2e-23 | -6.4 | -6.5 | 6.4e-11 | -0.03 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC5A11 | 0.06 | 0.05 | lasso | 1 | 0.05 | 4.9e-06 | -6.4 | -6.4 | 1.2e-10 | -0.03 | 0.01 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC5A11 | 0.14 | 0.02 | blup | 62 | 0.07 | 1.4e-05 | -6.5 | -6.9 | 6.0e-12 | -0.06 | 0.01 | 0.97 | FALSE |
| 12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SLC5A11 | 0.30 | 0.33 | lasso | 2 | 0.32 | 2.8e-14 | -6.5 | -7.1 | 1.7e-12 | -0.05 | 0.01 | 0.99 | TRUE |
| 13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SLC5A11 | 0.54 | 0.32 | lasso | 6 | 0.30 | 1.8e-12 | -6.1 | -6.0 | 1.6e-09 | -0.05 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC5A11 | 0.26 | 0.28 | lasso | 6 | 0.31 | 1.0e-32 | -6.5 | -6.0 | 1.7e-09 | -0.03 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SLC5A11 | 0.17 | 0.21 | lasso | 3 | 0.18 | 4.9e-11 | -6.5 | -6.6 | 5.5e-11 | -0.04 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SLC5A11 | 0.20 | 0.05 | lasso | 4 | 0.04 | 2.8e-02 | -6.4 | -6.0 | 1.4e-09 | -0.01 | 0.01 | 0.65 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SLC5A11 | 0.12 | 0.08 | enet | 7 | 0.07 | 7.0e-06 | -6.5 | -6.7 | 2.4e-11 | -0.05 | 0.01 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SLC5A11 | 0.21 | 0.10 | lasso | 5 | 0.07 | 2.2e-03 | -6.5 | -6.6 | 4.9e-11 | -0.03 | 0.01 | 0.95 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC5A11 | 0.35 | 0.44 | lasso | 4 | 0.44 | 4.2e-47 | -6.5 | -6.5 | 1.0e-10 | -0.04 | 0.01 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SLC5A11 | 0.24 | 0.15 | lasso | 3 | 0.14 | 1.1e-04 | -6.4 | -6.5 | 1.1e-10 | -0.03 | 0.01 | 0.92 | FALSE |