Best TWAS P=1.99e-11 · Best GWAS P=7.47e-11 conditioned to 0.268
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | WDR83 | 0.08 | 0.00 | lasso | 3 | 0.02 | 1.1e-02 | 5.4 | -5.5 | 3.5e-08 | -0.80 | 0.04 | 0.49 | FALSE |
| 2 | GTEx | Muscle Skeletal | DNASE2 | 0.19 | 0.16 | enet | 15 | 0.16 | 3.5e-15 | 6.3 | -5.8 | 5.5e-09 | -0.93 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Whole Blood | DNASE2 | 0.09 | 0.03 | enet | 9 | 0.03 | 1.3e-03 | 6.5 | -6.7 | 2.0e-11 | -0.90 | 0.01 | 0.98 | TRUE |
| 4 | GTEx | Whole Blood | CTD-2265O21.7 | 0.08 | 0.02 | enet | 9 | 0.04 | 1.5e-04 | 6.5 | -6.6 | 5.6e-11 | -0.93 | 0.01 | 0.98 | FALSE |
| 5 | YFS | Blood | DNASE2 | 0.22 | 0.27 | enet | 27 | 0.29 | 4.5e-97 | 6.5 | -6.3 | 2.9e-10 | -0.93 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST1 | 0.03 | 0.00 | blup | 47 | 0.01 | 2.5e-02 | 6.1 | 5.9 | 3.7e-09 | 0.78 | 0.01 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RTBDN | 0.03 | 0.03 | lasso | 2 | 0.02 | 2.3e-03 | 6.5 | -6.5 | 8.6e-11 | -0.99 | 0.00 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MAST1 | 0.08 | 0.04 | lasso | 5 | 0.05 | 4.1e-04 | 6.5 | 6.6 | 4.9e-11 | 0.87 | 0.00 | 0.89 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST1 | 0.03 | 0.04 | enet | 9 | 0.03 | 3.4e-04 | 5.6 | 6.2 | 7.4e-10 | 0.92 | 0.01 | 0.96 | FALSE |