TWAS hub - MAST1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0282	0.0177	0.0079	0.005	0.010	0.003	NA	0.001	0.08900	0.02500	0.14000	NA	0.24000
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.0760	0.0440	0.0015	0.038	0.021	0.037	NA	0.047	0.00140	0.01300	0.00140	NA	0.00041
3	TCGA	Thyroid Carcinoma	0.0270	0.0150	0.0013	0.035	0.028	0.033	NA	0.031	0.00022	0.00082	0.00034	NA	0.00050

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Red Count	36.0	348.0	428.5	20.2	20.7	14.4
Diabetes (self-reported)	9.4	14.4	18.4	3.9	4.3	3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	8.3	9.7	10.8	-3.0	-3.3	-3.0
Type 2 Diabetes (T2D) (2018)	8.0	15.0	20.2	3.8	4.5	3.2
Diabetes (mother)	7.5	9.5	13.0	3.2	3.6	2.4
BMI	6.7	38.6	43.2	5.9	6.6	6.2
Medication: Metformin	6.0	8.4	12.9	2.7	3.6	2.2
Smoking status: Previous	5.9	8.8	14.2	-2.9	-3.8	-2.0
Diabetes diagnosed by doctor	5.3	8.7	12.6	3.1	3.6	2.0
Medication: Omeprazole (e.g. Zanprol)	5.3	6.4	8.7	-2.6	-2.9	-2.0
Medication: Omeprazole	5.1	6.1	9.7	-2.3	-3.1	-1.8
Hand grip strength (left)	4.7	12.3	20.4	-3.0	-4.5	-2.7
Hair/balding pattern: Pattern 3	4.6	6.8	8.9	3.0	2.5	2.2
Family relationship satisfaction	4.5	5.5	7.3	2.7	2.1	2.2
Worrier / anxious feelings	4.1	7.7	8.5	-2.6	-2.9	-2.8
Qualifications: O levels/GCSEs or equivalent	3.9	6.2	8.4	2.3	2.9	2.2
Hip circumference	3.7	16.0	17.2	4.1	3.8	4.2
Age at last live birth	3.7	5.4	12.0	-3.5	-1.3	-1.6
Qualifications: A levels/AS levels or equivalent	3.5	7.8	12.2	1.9	3.5	2.7
Impedance of arm (left)	3.5	16.3	17.8	-4.2	-4.1	-3.8
Basal cell carcinoma (self-reported)	3.5	4.1	6.3	-1.9	-2.5	-1.6
Medication: Lansoprazole	3.4	3.8	5.3	-1.3	-2.3	-2.1
Impedance of arm (right)	3.3	15.2	16.3	-4.0	-4.0	-3.7
Risk taking	3.2	4.7	6.3	1.8	2.5	2.1
Illnesses of father: Heart disease	3.1	4.3	6.2	2.5	1.7	2.0
Wears glasses or contact lenses	3.1	3.6	4.8	1.3	2.1	2.2
Alcohol drinker status: Previous	3.1	3.5	6.2	-2.0	-2.5	-0.4
Ever had hysterectomy (womb removed)	2.9	3.2	5.8	1.2	2.4	1.6
Financial difficulties in last 2 years	2.9	4.0	7.2	2.7	1.6	1.4
Illnesses of mother	2.9	3.6	3.9	-1.8	-2.0	-1.8
Financial situation satisfaction	2.9	3.6	6.8	2.6	1.5	1.3
Alcohol drinker status: Never	2.9	3.5	5.6	-0.6	-2.4	-2.1
Breast Cancer	2.7	6.5	14.8	1.8	3.9	1.1
Average weekly champagne plus white wine intake	2.7	3.7	5.4	1.2	2.3	2.0
Intelligence (Savage-Jansen 2018)	2.6	7.9	11.9	1.8	3.5	2.9
Body mass index (BMI)	2.6	11.1	12.5	3.5	3.2	3.3
Leg pain on walking	2.5	3.2	4.4	-1.6	-1.6	-2.1
Osteoarthritis (self-reported)	2.4	3.1	3.9	1.9	1.4	2.0
High blood pressure (mother)	2.3	3.2	4.8	2.2	1.4	1.7
Loud music exposure frequency	2.3	2.5	3.5	-1.9	-1.6	-1.2
Prostate Cancer	2.2	3.2	5.9	-1.5	-2.4	-1.2
Age when periods started (menarche)	2.2	5.2	7.8	-2.8	-2.6	-1.0
Nervous feelings	2.2	4.2	7.5	-1.4	-2.7	-1.8
Leg fat percentage (left)	2.2	8.1	11.5	3.4	2.3	2.7
Impedance of whole body	2.2	11.1	12.2	-3.2	-3.5	-3.3
Waist Hip Ratio (WHR)	2.1	9.2	15.8	-2.5	-4.0	-2.4
Leg fat mass (right)	2.1	8.1	9.7	3.1	2.3	3.0
Leg fat mass (left)	2.1	8.2	10.3	3.2	2.4	3.0
Past tobacco smoking	2.0	3.6	7.0	1.8	2.6	0.9
Falls in the last year	2.0	2.7	5.1	1.5	0.9	2.3
Leg fat percentage (right)	2.0	7.3	10.1	3.2	2.1	2.7
Qualifications: College or University degree	2.0	6.4	13.1	1.9	3.6	1.6
Chest pain or discomfort	2.0	2.8	3.2	1.7	1.5	1.8
Breast cancer (self-reported)	2.0	2.4	3.3	-0.7	-1.8	-1.8
Ulcerative Colitis (UC)	1.9	3.6	5.5	-1.0	-2.3	-2.1
Verbal and Numeric Reasoning (VNR)	1.9	4.6	8.8	0.6	3.0	2.2
Allergy or Eczema	1.9	5.1	6.6	2.1	2.6	2.1
Arm fat mass (left)	1.9	7.9	8.8	3.0	2.6	2.9
Hearing aid user	1.9	2.1	3.1	1.8	1.3	1.2
Blood Eosinophil Count	1.8	13.8	16.4	3.1	4.0	3.9
Cardiovascular Disease	1.8	5.9	6.3	2.5	2.3	2.4
Hand grip strength (right)	1.8	4.9	9.1	-2.0	-3.0	-1.3
Arm fat mass (right)	1.7	7.0	8.1	2.8	2.3	2.8
Exposure to tobacco smoke outside home	1.7	2.2	5.6	0.7	2.4	0.8
Medication: Allopurinol	1.7	2.3	3.7	1.9	1.4	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	3.3	-1.3	-1.8	-1.0
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.5	-0.7	-1.0	-2.1
Heart disease (siblings)	1.7	2.0	3.4	0.8	1.8	1.5
Blood Platelet Count	1.6	18.3	32.3	-5.7	-3.9	-2.6
High blood pressure (siblings)	1.6	2.3	2.8	1.6	1.3	1.7
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	3.1	-1.8	-1.5	-0.8
Arm predicted mass (left)	1.6	7.9	10.1	2.7	2.5	3.2
Alzheimer’s Disease (in mother)	1.5	1.7	3.8	0.5	1.1	1.9
Primary Biliary Cirrhosis	1.5	2.1	3.5	0.5	1.9	1.6
Medication: Ramipril	1.5	2.0	3.4	1.1	1.8	1.2
Noisy workplace	1.5	1.9	2.9	-0.0	-1.7	-1.7
Number of full brothers	1.5	1.9	2.2	1.2	1.4	1.5
Shortness of breath walking on level ground	1.5	1.8	2.3	1.1	1.5	1.4
Loneliness, isolation	1.5	2.1	3.4	1.2	1.2	1.8
Qualifications: nursing, teaching	1.5	2.4	4.7	1.0	2.2	1.2
Irritable Bowel Disease (IBD)	1.4	3.4	5.4	-1.5	-2.3	-1.6
Chronotype (morning person)	1.4	3.2	4.6	-2.1	-1.6	-1.6
Impedance of leg (right)	1.4	6.9	9.7	-2.3	-3.1	-2.4
Impedance of leg (left)	1.4	6.9	8.5	-2.2	-2.9	-2.7
Qualifications: None of the above	1.4	3.1	5.8	-1.3	-2.4	-1.2
Arm fat-free mass (right)	1.4	7.1	9.5	2.5	2.4	3.1
Mean time to correctly identify matches	1.4	2.6	4.5	-0.9	-2.1	-1.6
Friendships satisfaction	1.4	1.8	2.6	1.3	1.6	1.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.9	-0.8	-1.1	-2.2
Arm fat-free mass (left)	1.4	6.9	8.9	2.5	2.3	3.0
Ovarian Cancer	1.3	1.7	2.3	0.8	1.5	1.5
Triglycerides	1.3	2.2	3.2	-1.2	-1.4	-1.8
Smoking Status	1.3	3.2	5.8	-1.8	-2.4	-0.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.2	0.8	1.8	0.8
Waist circumference	1.3	4.9	7.2	2.3	1.5	2.7
Arm fat percentage (right)	1.3	5.1	5.9	2.4	2.1	2.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.3	1.5	1.1	0.9
Arm predicted mass (right)	1.3	6.7	9.0	2.3	2.4	3.0
Number of full sisters	1.3	1.6	1.9	1.1	1.3	1.4
Arm fat percentage (left)	1.3	5.2	5.6	2.4	2.1	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	2.6	-0.8	-1.6	-0.9
Eye problems/disorders: Cataract	1.3	1.5	1.9	1.4	1.1	1.1
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.1	1.4	1.5	0.5
Illnesses of siblings	1.2	1.6	2.3	-0.7	-1.5	-1.5
Weight	1.2	6.0	7.8	2.5	2.0	2.8
Prospective memory result	1.2	1.5	1.6	-1.2	-1.2	-1.3
Supplements: Zinc	1.1	1.2	2.3	-1.1	-1.5	-0.5
Medication: Gliclazide	1.1	1.3	2.2	1.5	1.3	-0.2
Height	1.0	19.6	30.7	-4.2	-5.5	-3.2
Diabetes (father)	1.0	1.2	2.4	1.5	0.6	0.9
Medication: Atenolol	1.0	1.2	2.4	0.4	1.6	1.0
Fluid intelligence score	1.0	2.1	4.2	0.9	2.0	1.1
Pulse rate	1.0	1.6	2.5	-0.7	-1.6	-1.3
Whole body fat mass	1.0	4.0	5.1	2.1	1.6	2.2
Medication for cholesterol	1.0	1.5	3.3	-0.6	-1.8	-1.0
Fasting Glucose	0.9	1.0	1.4	-1.2	-1.0	-0.8
HbA1C	0.9	1.0	2.1	1.5	0.8	0.3
High blood pressure	0.9	2.4	2.8	1.7	1.4	1.6
Hair/balding pattern: Pattern 2	0.9	1.1	1.8	-0.6	-1.1	-1.4
Forced vital capacity (FVC)	0.9	3.7	5.4	-1.5	-2.3	-1.8
Medication: Simvastatin	0.9	1.3	2.3	1.5	0.5	1.2
Body fat percentage	0.9	3.7	4.8	2.2	1.5	2.0
Worry too long after embarrassment	0.9	1.5	1.6	-1.3	-1.2	-1.3
Had major operations	0.9	1.0	2.2	-1.5	0.9	0.3
Average weekly red wine intake	0.9	1.4	1.7	1.0	1.3	1.2
Long-standing illness, disability or infirmity	0.9	1.3	2.5	0.3	1.6	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	1.5	-1.0	-1.2	-0.7
Ever smoked	0.9	1.6	4.3	-0.7	-2.1	-0.2
Myopia	0.9	1.3	1.7	1.3	1.0	1.0
Hearing difficulty/problems: Yes	0.8	1.2	1.8	1.3	0.7	1.1
Medication: Co-codamol	0.8	0.9	1.6	0.7	1.3	0.8
Taking other prescription medications	0.8	1.3	2.2	-1.5	-0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.2	1.2	0.9	1.8
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.6	1.1	1.6	1.1
Trunk fat mass	0.8	3.6	4.8	2.0	1.5	2.2
Glaucoma (self-reported)	0.8	1.0	1.3	-0.9	-1.2	-0.9
Gout (self-reported)	0.8	1.1	1.5	1.2	1.0	0.9
Medication: Amlodipine	0.8	1.1	2.1	0.9	0.6	1.4
Hypertension (Self-reported)	0.8	2.3	2.8	1.7	1.4	1.5
Commuting to job workplace: Walk	0.8	0.9	1.3	-0.9	-0.7	-1.2
Whole body water mass	0.8	4.3	6.8	1.6	1.8	2.6
Guilty feelings	0.8	1.2	2.7	-0.9	-1.7	-0.2
Medication: Blood pressure	0.8	1.5	2.5	0.8	1.6	1.1
Basal metabolic rate	0.8	4.7	7.1	1.9	1.9	2.7
Vascular/heart problems diagnosed by doctor	0.8	2.2	2.3	-1.4	-1.5	-1.5
Cholesterol lowering medication	0.8	1.1	1.9	1.4	0.9	0.8
Heel T-Score	0.7	5.5	10.0	-1.1	-3.2	-2.3
Leg fat-free mass (left)	0.7	3.7	5.6	1.7	1.6	2.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.7	-0.1	-0.7	-1.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.0	-1.0	-0.8	-0.8
Hearing difficulty/problems with background noise	0.7	1.1	1.6	1.2	0.4	1.2
Hair/balding pattern: Pattern 4	0.7	1.8	3.8	0.2	1.2	1.9
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.4	-1.1	-1.2	-0.5
Headache pain in last month	0.7	1.3	2.2	-0.4	-1.5	-1.2
Emphysema/chronic bronchitis	0.7	0.8	1.9	-1.4	-0.6	0.2
Whole body fat-free mass	0.7	3.8	6.2	1.6	1.7	2.5
Medication: Aspirin	0.7	0.9	2.2	-0.5	0.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.3	-0.8	-1.2	-1.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.1	-1.0	-1.0	-0.9
Age at First Birth	0.6	0.9	1.3	-0.7	-1.1	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	-1.3	-0.5	-0.8
Medication for hormone replacement therapy	0.6	0.6	1.5	-1.2	0.4	-0.5
Average weekly fortified wine intake	0.6	0.7	1.7	-0.5	-0.5	-1.3
Maternal smoking around birth	0.6	0.9	1.0	-0.9	-1.0	-1.0
Relative age voice broke	0.6	0.9	2.2	-0.7	-1.5	-0.2
Multivitamins +/- minerals	0.6	0.7	1.7	-1.3	0.0	0.6
Leg predicted mass (left)	0.6	3.4	5.1	1.6	1.6	2.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.8	1.3	0.7	0.1
Mouth/teeth dental problems	0.6	0.9	1.4	0.9	0.6	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.1	2.4	-0.7	-1.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.2	-0.9	-2.1	-1.2
Age at first live birth	0.6	1.1	2.6	-1.6	0.7	0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	2.2	0.3	1.5	0.9
Knee pain experienced in last month	0.6	1.0	1.6	-0.7	-1.3	-0.9
Leg fat-free mass (right)	0.6	3.2	4.4	1.6	1.6	2.1
Mineral and other dietary supplements	0.6	0.8	1.0	0.8	1.0	0.8
Leg predicted mass (right)	0.6	3.0	4.2	1.6	1.5	2.0
Medication: Lisinopril	0.6	0.7	1.6	-0.2	-0.8	-1.2
Reaction Time	0.5	0.9	2.3	0.0	-1.5	-0.7
Body Mass Index (BMI) (2010)	0.5	0.6	0.8	0.9	0.8	0.7
Mean Putamen Volume	0.5	0.6	0.7	-0.7	-0.7	-0.9
Rheumatoid Arthritis	0.5	0.7	1.6	0.3	1.3	0.6
Average weekly spirits intake	0.5	0.7	1.5	-1.2	-0.4	-0.6
Trunk fat percentage	0.5	2.0	2.6	1.6	1.0	1.5
Sitting height	0.5	3.5	5.2	1.6	2.3	1.7
Trunk fat-free mass	0.5	3.0	5.7	1.1	1.4	2.4
Alcohol intake versus 10 years previously	0.5	0.8	2.0	-0.2	-1.4	-0.6
Number of live births	0.5	0.8	1.4	-1.2	-0.9	-0.3
Happiness	0.5	0.6	1.0	1.0	0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.1	0.6	0.7	1.1
Trunk predicted mass	0.5	3.1	5.9	1.1	1.4	2.4
Tense / ‘highly strung’	0.5	0.8	1.3	0.9	0.4	1.2
Peak expiratory flow (PEF)	0.5	1.1	2.8	-0.4	-1.7	-0.6
Ever taken oral contraceptive pill	0.5	0.5	1.4	-0.1	-0.4	-1.2
Medication: Bendroflumethiazide	0.5	0.7	1.3	0.3	0.9	1.1
Medication: Paracetamol	0.5	0.7	1.2	-0.5	-1.1	-0.9
Pack years of smoking	0.5	0.8	0.8	-0.8	-0.9	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	0.3	1.0	0.7
Crohns Disease (2017)	0.4	0.9	1.2	-1.1	-1.1	-0.6
LDL Cholesterol	0.4	0.6	1.2	0.4	-0.6	1.1
Neuroticism (2016)	0.4	0.6	0.7	-0.9	-0.8	-0.7
Respiratory disease	0.4	0.9	1.7	0.3	1.3	0.9
Pack years adult smoking proportion	0.4	0.6	0.8	-0.6	-0.8	-0.9
Serious illness, injury or assault to yourself	0.4	0.5	1.0	0.6	1.0	0.5
Had menopause	0.4	0.6	0.7	0.8	0.6	0.8
Had other major operations	0.4	0.5	1.2	0.4	-0.5	-1.1
Length of working week for main job	0.4	0.4	0.8	0.2	-0.9	-0.7
Exposure to tobacco smoke at home	0.4	0.4	0.5	0.7	0.6	0.6
Comparative body size at age 10	0.4	1.2	2.1	0.2	1.4	1.1
Health satisfaction	0.4	0.5	1.5	1.2	-0.0	0.1
Medication: Seretide 50 evohaler	0.4	0.5	0.9	0.5	0.5	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.0	-0.2	-0.5	1.0
Medication: Aspirin	0.4	0.5	1.2	-0.6	0.0	1.1
Mood swings	0.4	0.7	1.5	-0.7	-1.2	-0.5
Ever had bowel cancer screening	0.4	0.5	0.9	0.3	0.9	0.7
Osteoporosis (self-reported)	0.4	0.5	1.2	-0.1	0.4	1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	-1.0	-0.1	-0.6
Miserableness	0.4	0.6	1.8	-1.4	-0.2	-0.2
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.0	1.1	0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	0.8	0.6	0.7
Average weekly beer plus cider intake	0.4	0.6	1.7	0.2	-1.3	0.3
Ever depressed for a whole week	0.4	0.5	1.6	0.1	-0.1	-1.3
Supplements: Calcium	0.4	0.5	0.6	-0.7	-0.8	-0.6
Worry (Nagel 2018)	0.3	0.6	0.9	-0.3	-1.0	-0.9
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.1	-1.0	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	0.2	0.4	1.0
Blood White Count	0.3	2.6	5.8	-2.4	-1.4	-0.2
Lung FEV1/FVC ratio	0.3	1.4	3.4	1.9	0.1	0.8
Sensitivity / hurt feelings	0.3	0.6	1.1	-0.1	-0.7	-1.1
Vitamin and mineral supplements	0.3	0.5	1.0	1.0	-0.5	-0.3
Severe depression (siblings)	0.3	0.3	0.6	0.2	0.8	0.6
Number of incorrect matches in round	0.3	0.4	0.9	-0.3	-0.6	-1.0
Alcohol usually taken with meals	0.3	0.5	1.5	-0.3	1.2	0.2
Allergy	0.3	0.8	1.4	-0.5	-1.2	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	-0.1	-0.1	-1.1
Standing height	0.3	3.5	5.7	-2.0	-2.4	-0.8
Neck or shoulder pain in last month	0.3	0.5	1.0	-0.0	-0.7	-1.0
Medication: Blood pressure	0.3	0.5	0.7	0.8	0.5	0.8
Alcohol intake frequency.	0.3	0.6	1.4	-0.1	-1.2	-0.5
Comparative height size at age 10	0.3	1.5	3.1	-1.8	-0.8	-0.9
Suffer from ‘nerves’	0.3	0.5	1.4	0.2	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	-0.7	-1.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.2	-0.5	-0.9
Back pain experienced in last month	0.3	0.4	0.7	0.8	-0.7	0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.6	-1.0	0.0
Neuroticism (Nagel 2018)	0.2	0.5	0.8	-0.6	-0.9	-0.5
Schizophrenia (2018)	0.2	0.3	0.6	0.8	-0.6	0.0
Crohns Disease (2012)	0.2	0.3	0.6	-0.4	-0.3	-0.8
Schizophrenia (2014)	0.2	0.4	0.8	0.6	-0.9	0.3
Ulcerative Colitis	0.2	0.3	0.5	-0.0	-0.7	-0.7
Number of treatments/medications taken	0.2	0.4	1.1	-1.0	-0.2	-0.5
Angina	0.2	0.3	0.7	-0.0	0.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.6	-0.6	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.7	-0.2	0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.5	-0.6	0.0
Heart attack	0.2	0.2	0.4	0.4	0.7	0.0
Father’s age at death	0.2	0.2	0.4	-0.1	0.5	0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	-0.9	-0.2	-0.6
Asthma	0.2	0.3	0.8	-0.0	0.9	0.3
Medication: Cholesterol lowering	0.2	0.2	0.4	-0.5	-0.6	-0.2
Breastfed as a baby	0.2	0.2	0.4	-0.6	-0.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.5	0.7	-0.7	0.2
Medication: Paracetamol	0.2	0.3	0.5	-0.2	-0.7	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.7	0.8	-0.7	-0.9	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.4	0.6	0.2
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	-0.6	-0.5	-0.8
Number of children fathered	0.2	0.3	0.7	-0.3	-0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.5	-0.3	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.7	0.0	0.4
Migraine (self-reported)	0.2	0.2	0.6	-0.3	-0.8	0.0
Medication: Ibuprofen	0.2	0.2	0.4	-0.5	-0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.6	-0.3	0.3
Supplements: Vitamin C	0.2	0.3	0.3	-0.6	0.4	0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.5	0.3	0.6	0.7
Mother’s age at death	0.2	0.3	0.6	-0.4	-0.8	-0.2
Medication: Atorvastatin	0.2	0.2	0.4	0.0	-0.5	-0.6
Number of operations (self-reported)	0.2	0.3	0.6	0.3	0.8	0.5
Irritability	0.2	0.3	0.8	0.1	0.1	0.9
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.0	0.2	-0.8
Age started oral contraceptive pill	0.2	0.2	0.3	-0.3	0.4	-0.6
Pain experienced in last month	0.2	0.4	1.1	-1.1	0.1	0.1
Bipolar Disorder (2018)	0.1	0.2	0.6	0.1	-0.8	0.0
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.5	-0.4	-0.0
Major Depression (MDD)	0.1	0.2	0.5	0.2	-0.7	-0.1
HDL Cholesterol	0.1	0.2	0.3	-0.4	-0.4	-0.6
Lupus	0.1	0.2	0.3	-0.4	0.6	0.1
Systolic Blood Pressure	0.1	0.5	1.0	0.7	1.0	0.3
Hypothyroidism (self reported)	0.1	0.1	0.3	0.3	-0.1	0.6
Lung FVC	0.1	0.5	0.9	0.0	-0.9	-0.8
Hair Pigment	0.1	4.2	9.0	-0.7	-3.0	-1.7
Tanning	0.1	1.5	2.0	-1.0	-1.2	-1.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.0	-0.6	0.4
Relative age of first facial hair	0.1	0.2	0.3	-0.6	-0.5	-0.3
Systolic blood pressure, automated reading	0.1	0.2	0.4	0.3	0.6	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.3	0.1	-0.2
Current tobacco smoking	0.1	0.1	0.3	0.5	-0.0	0.2
Fed-up feelings	0.1	0.2	0.3	0.4	-0.5	0.0
Supplements: Glucosamine	0.1	0.2	0.4	-0.6	-0.2	-0.2
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.1	-0.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.1	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.6	-0.2	0.4
Neuroticism score	0.1	0.2	0.6	-0.2	-0.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.0	0.1	0.6
Depression (self-reported)	0.1	0.2	0.3	0.5	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	-0.2	-0.8	-0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	0.3	-0.2	0.4
Birth weight of first child	0.1	0.2	0.4	0.5	0.1	0.7
Pulse wave reflection index	0.1	0.1	0.2	0.4	0.2	0.5
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.0	-0.6	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.1	-0.2	0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	0.4	-0.1	0.8
Birth weight	0.1	0.2	0.4	0.6	0.4	-0.2
Pulse wave peak to peak time	0.1	0.1	0.3	-0.6	0.1	-0.3
Angina (self-reported)	0.1	0.2	0.5	-0.0	0.3	0.7
Heart disease (mother)	0.1	0.1	0.2	-0.0	-0.1	-0.4
Pulse rate, automated reading	0.1	0.4	0.8	0.5	0.9	-0.5
Overall health rating	0.1	0.3	0.6	0.1	-0.8	-0.6
Asthma (self-reported)	0.1	0.3	0.8	0.1	0.9	0.3
Smoking status: Current	0.1	0.2	0.2	0.5	0.1	0.5
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.4	-0.4	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.3	0.3	0.3
High cholesterol (Self-reported)	0.1	0.3	0.4	0.6	-0.5	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.3	0.2	-0.2
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.1	0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	0.1	0.3	-0.3
Depression (Nagel 2018)	0.0	0.1	0.1	-0.2	-0.4	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism	0.0	0.1	0.2	-0.3	-0.4	-0.1
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.2	-0.2	-0.1
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.4	-0.1	0.1
Pain all over the body in last month	0.0	0.0	0.0	0.2	0.1	-0.2
Time employed in main current job	0.0	0.0	0.1	-0.2	-0.3	0.0
Lung cancer (father)	0.0	0.0	0.0	0.1	0.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.2	0.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	-0.3	-0.1	0.2
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.3	0.2	-0.1
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	0.2	0.0	-0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.3	-0.1	-0.5
Unable to work because of sickness or disability	0.0	0.0	0.1	0.0	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.4	0.1	0.0

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