Best TWAS P=1.35e-12 · Best GWAS P=3.71e-13 conditioned to 0.314
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GGT7 | 0.06 | 0.00 | enet | 7 | 0.02 | 1.9e-02 | -5.9 | 7.1 | 1.3e-12 | -0.38 | 0.02 | 0.91 | TRUE |
| 2 | GTEx | Breast Mammary Tissue | ITCH | 0.09 | 0.04 | enet | 28 | 0.09 | 2.5e-05 | 2.7 | -5.9 | 4.7e-09 | 0.72 | 0.25 | 0.71 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | ITCH | 0.09 | 0.02 | enet | 16 | 0.06 | 8.2e-03 | -7.0 | -5.6 | 2.4e-08 | 0.77 | 0.08 | 0.65 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | NCOA6 | 0.11 | 0.06 | enet | 15 | 0.06 | 3.9e-03 | 4.0 | -5.3 | 9.5e-08 | 0.43 | 0.21 | 0.19 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | GGT7 | 0.09 | 0.03 | enet | 33 | 0.05 | 7.5e-05 | -5.7 | 5.2 | 1.8e-07 | -0.06 | 0.02 | 0.94 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RALY | 0.09 | 0.16 | lasso | 7 | 0.15 | 2.7e-18 | -5.4 | -5.2 | 1.9e-07 | 0.82 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | EIF2S2 | 0.07 | 0.07 | enet | 25 | 0.06 | 4.3e-20 | -6.9 | 7.1 | 1.8e-12 | -0.90 | 0.02 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCOA6 | 0.04 | 0.02 | blup | 65 | 0.04 | 6.1e-05 | -4.4 | -5.7 | 1.0e-08 | 0.21 | 0.02 | 0.93 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | RALY | 0.05 | 0.04 | blup | 53 | 0.05 | 1.6e-05 | -5.3 | 5.6 | 2.2e-08 | -0.91 | 0.07 | 0.93 | FALSE |