Hub : Genes

ITCH

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.0910	0.0400	1.4e-05	0.039	NA	0.089	NA	0.067	4.3e-03	NA	2.5e-05	NA	2.5e-04
2	GTEx	Breast Mammary Tissue (Female)	0.0921	0.0495	2.5e-03	0.016	NA	0.058	NA	0.043	1.1e-01	NA	8.2e-03	NA	1.9e-02
3	GTEx	Esophagus Gastroesophageal Junction	0.1110	0.0600	4.6e-03	0.033	NA	0.040	NA	0.045	2.3e-02	NA	1.4e-02	NA	9.9e-03
4	GTEx	Esophagus Muscularis	0.0750	0.0460	1.5e-03	0.019	NA	-0.002	NA	0.011	2.3e-02	NA	4.4e-01	NA	6.3e-02
5	GTEx	Skin Not Sun Exposed Suprapubic	0.0770	0.0360	3.0e-04	0.009	NA	0.006	NA	0.018	1.0e-01	NA	1.4e-01	NA	3.5e-02
6	GTEx	Skin Sun Exposed Lower leg	0.0350	0.0170	6.3e-04	0.042	NA	0.035	NA	-0.003	2.2e-04	NA	6.3e-04	NA	9.3e-01
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.1370	0.0630	1.2e-03	0.040	0.022	0.015	NA	0.030	1.0e-03	1.2e-02	2.9e-02	NA	3.8e-03
8	TCGA	Thyroid Carcinoma	0.0380	0.0210	3.3e-06	0.059	0.064	0.058	NA	0.049	2.1e-06	8.4e-07	2.3e-06	NA	1.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	5.0	7.9	17.0	-3.3	-2.2	-4.1	-3.3	-0.5	-2.7	0.4	3.5
Bipolar Disorder or Schizophrenia	5.8	14.2	25.6	-5.1	-4.1	-3.2	-4.4	-2.7	-3.8	-1.2	4.3
Depressed Affect (Nagel 2018)	0.7	1.5	4.4	-0.1	0.0	1.7	0.7	0.3	1.2	-2.1	-1.6
Depression (Nagel 2018)	0.9	1.4	3.2	-0.1	0.3	1.7	0.4	-0.6	1.4	-1.8	-1.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.8	0.0	1.4	-1.1	-2.0	2.2	-1.2	0.3	1.4
Neuroticism (Nagel 2018)	2.5	5.9	24.2	1.0	1.4	4.9	1.3	1.6	1.0	-3.3	-2.2
Schizophrenia (2018)	3.8	8.0	14.6	-3.8	-3.6	-0.7	-3.0	-3.0	-2.7	-1.8	2.8
Schizophrenia vs Biploar Disorder	0.9	1.1	4.6	0.3	-0.2	2.1	1.1	-1.0	0.6	-0.5	-1.2
Worry (Nagel 2018)	2.1	4.4	18.6	-0.0	0.9	4.3	-0.1	1.2	-0.6	-3.7	-0.6
Alzheimer’s Disease (in mother)	0.3	0.3	1.8	0.4	0.1	0.7	0.0	1.3	0.2	-0.1	-0.5
Alzheimer’s Disease (in father)	0.7	0.7	2.2	0.8	0.6	-0.7	1.0	0.9	0.5	1.5	-0.2
Alzheimer’s Disease (including proxy)	1.0	1.4	2.7	1.3	1.3	-0.2	1.2	1.6	0.9	1.6	-0.7
Crohns Disease (2017)	0.2	0.5	1.3	1.2	1.0	0.1	0.8	0.5	0.5	0.8	-0.4
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	-0.7	-0.4	0.7	-0.7	-0.3	-1.5	-0.2	1.2
Ulcerative Colitis (UC)	1.5	2.8	5.5	-2.2	-1.3	1.4	-1.6	-1.0	-2.4	-1.0	1.8
Major Depression (MDD)	1.4	1.8	6.7	-1.4	-1.0	-0.2	-1.5	-0.8	-0.9	-2.6	0.9
Reaction Time	1.4	2.7	4.3	1.5	1.4	-1.4	1.8	1.2	2.0	2.1	-1.4
Verbal and Numeric Reasoning (VNR)	1.5	3.6	8.7	-1.4	-0.3	-0.7	-2.9	2.2	-2.4	-1.3	2.3
Breast Cancer	1.0	2.4	10.2	-1.6	-1.3	-3.2	-0.7	-1.6	-0.3	0.7	1.0
Ovarian Cancer	0.3	0.3	1.5	-0.1	-0.0	-1.2	-0.1	0.6	-0.2	-0.7	0.4
Prostate Cancer	1.1	1.6	5.4	2.3	1.5	0.7	1.2	0.6	1.2	0.1	-1.1
Age at First Birth	0.8	1.1	2.7	-0.4	-0.4	1.1	-1.5	-0.1	-1.6	-1.0	1.3
Bipolar Disorder (2011)	6.8	6.6	11.2	-2.8	-1.9	-3.4	-3.3	-0.4	-2.7	-0.5	3.3
Body Mass Index (BMI) (2010)	4.0	5.4	12.5	-3.0	-2.8	-2.8	-1.9	-3.5	-0.9	-0.5	1.2
Coronary Artery Disease (CAD)	1.5	1.8	4.9	-1.3	-1.1	-1.5	-2.2	-0.5	-1.2	-0.7	1.4
Crohns Disease (2012)	0.5	0.7	2.3	1.2	0.9	0.8	0.7	1.5	0.2	0.2	-0.4
Mean Putamen Volume	5.1	5.8	14.1	-2.2	-1.8	-3.8	-2.6	-1.4	-2.3	0.6	3.1
Fasting Glucose	4.1	4.9	9.1	-2.6	-2.1	-0.7	-2.8	-0.9	-3.0	-1.6	2.7
HbA1C	0.9	1.0	4.7	0.2	-0.2	-2.2	0.1	0.3	0.3	1.7	0.2
HDL Cholesterol	6.4	10.6	15.7	3.6	3.9	2.2	3.9	1.7	3.8	1.9	-4.0
LDL Cholesterol	0.3	0.5	2.3	-0.0	0.7	-1.5	-0.2	0.7	0.5	0.6	-0.1
Lupus	0.8	1.2	4.3	-0.0	0.2	-1.0	-1.2	-0.8	-1.0	2.1	1.3
Neuroticism (2016)	0.8	1.2	5.5	0.6	0.4	2.3	0.4	0.2	0.5	-1.6	-0.9
Primary Biliary Cirrhosis	1.3	1.9	6.2	0.2	0.6	-2.2	0.2	-1.7	0.8	2.5	0.1
Rheumatoid Arthritis	2.5	3.4	6.9	2.6	1.9	0.8	2.5	1.4	1.7	1.1	-1.9
Schizophrenia (2014)	2.6	5.7	10.5	-3.2	-2.7	-1.7	-2.9	-1.9	-2.4	-0.4	2.7
Triglycerides	4.7	7.7	22.6	-2.4	-2.1	-4.8	-3.0	-0.8	-2.6	0.4	3.5
Type 2 Diabetes (T2D) (2012)	4.6	5.3	8.4	-2.6	-2.9	-0.9	-2.6	-2.2	-2.5	-1.2	2.6
Ulcerative Colitis	1.9	2.7	6.6	-1.8	-1.4	0.2	-1.7	-0.8	-2.6	-0.9	2.3
Blood Eosinophil Count	0.6	4.6	9.3	-2.3	-2.8	-0.9	-1.8	-0.6	-2.2	-3.0	2.1
Blood Platelet Count	1.1	12.5	31.6	-4.1	-4.3	3.1	-1.5	-3.5	-2.6	-5.6	1.3
Blood Red Count	1.3	12.5	32.1	-3.3	-3.9	3.1	-2.4	1.3	-4.1	-5.7	2.8
Blood White Count	2.6	19.1	30.8	-5.5	-5.2	-2.1	-4.8	-3.9	-4.0	-4.1	4.2
Heel T-Score	8.3	66.2	100.0	-10.0	-9.3	-0.7	-9.8	-2.8	-9.2	-9.3	8.1
BMI	3.1	18.0	34.3	-5.9	-5.6	-4.8	-3.8	-4.6	-2.3	-1.9	3.3
Height	11.0	211.6	420.2	-12.9	-10.4	-11.6	-20.1	-10.1	-18.9	-0.3	20.5
Waist Hip Ratio (WHR)	1.4	6.4	10.1	3.1	2.2	3.1	3.2	3.1	1.7	-0.4	-2.1
Systolic Blood Pressure	0.6	2.9	6.1	-1.7	-0.4	-1.9	-2.0	0.9	-2.3	0.6	2.5
Smoking Status	4.7	11.2	20.8	3.6	3.3	2.1	4.2	1.0	4.3	1.9	-4.6
Allergy or Eczema	4.0	10.4	18.4	-3.4	-3.4	-1.0	-4.0	-1.9	-4.3	-2.3	4.0
Cardiovascular Disease	0.6	1.9	5.3	-1.6	-1.3	-2.3	-1.7	-0.5	-0.7	-0.9	1.1
Hypothyroidism (self reported)	0.9	2.1	4.5	-1.1	-0.8	-2.0	-1.5	-0.9	-1.8	-0.1	2.1
Respiratory disease	1.4	3.2	8.5	-2.5	-1.7	0.5	-1.0	-2.9	-1.7	-1.5	1.1
Type 2 Diabetes (T2D) (2018)	1.6	3.0	5.9	-2.4	-1.7	-1.9	-1.6	-2.4	-0.9	-0.3	1.4
Lung FEV1/FVC ratio	6.8	34.7	55.3	-6.6	-7.2	-2.1	-6.3	-4.7	-7.4	-3.5	7.0
Lung FVC	6.4	32.5	62.9	7.9	6.0	4.6	6.3	3.8	6.1	1.6	-6.7
Neuroticism	2.1	5.0	20.3	0.5	0.9	4.5	0.8	1.5	0.8	-3.5	-1.7
Chronotype (morning person)	1.4	3.3	7.2	-1.8	-2.7	0.3	-1.4	-1.8	-2.3	-0.9	2.1
Hair Pigment	33.6	958.9	3153.3	27.3	12.3	56.2	27.0	32.6	16.9	-25.9	-29.5
Tanning	66.8	815.3	2580.6	-25.8	-11.9	-50.8	-25.4	-30.3	-17.3	21.7	28.3
Hand grip strength (left)	8.6	22.6	37.8	-5.2	-4.9	-2.3	-6.2	-3.3	-6.1	-1.9	5.9
Number of treatments/medications taken	1.5	2.7	6.0	-1.7	-1.8	-0.8	-1.7	-2.4	-1.1	-1.9	1.0
Average weekly spirits intake	0.1	0.1	0.2	0.2	-0.2	0.2	-0.3	-0.3	0.1	-0.4	-0.2
Sensitivity / hurt feelings	1.7	2.9	6.6	1.3	1.0	2.6	1.8	-0.2	2.0	-1.1	-2.4
Frequency of depressed mood in last 2 weeks	1.4	2.0	4.7	1.3	1.0	1.4	1.2	0.0	2.2	-0.7	-2.1
Hearing difficulty/problems: Yes	0.9	1.4	5.0	-0.5	-1.0	2.2	0.1	0.2	-0.6	-2.1	-0.3
Relative age of first facial hair	4.8	9.9	17.7	3.8	3.0	4.2	3.7	2.8	2.6	-0.0	-3.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.6	1.5	0.6	1.9	0.1	0.3	0.6	-1.6	-0.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.9	-0.3	-0.8	0.5	-1.2	-0.6	-1.6	-1.7	1.4
Ever had hysterectomy (womb removed)	0.6	0.7	2.6	-0.2	-0.2	-1.6	-0.8	-0.4	-0.8	-0.4	1.0
Systolic blood pressure, automated reading	2.3	6.8	12.5	-3.5	-2.5	-1.8	-3.3	-0.8	-3.1	-1.6	2.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.3	-1.0	-1.5	-0.2	-0.4	-1.3	-1.2	-1.1	1.3
Angina	6.3	8.2	11.3	-3.4	-3.1	-2.7	-3.3	-2.8	-2.3	-2.0	3.0
Medication for hormone replacement therapy	0.2	0.3	0.6	-0.3	-0.6	0.4	-0.4	-0.3	-0.7	-0.7	0.6
Vitamin and mineral supplements	8.7	11.8	19.7	4.2	3.7	1.0	3.6	4.4	3.3	3.0	-3.2
Supplements: Zinc	4.6	5.0	9.8	-3.1	-2.5	-2.6	-2.3	-1.1	-2.0	0.3	2.5
Medication: Co-codamol	0.6	0.7	2.9	0.2	-1.1	0.8	0.3	-1.7	0.2	-0.8	-0.4
Medication: Metformin	0.6	0.9	1.4	-1.1	-1.2	-1.1	-0.8	0.1	-0.8	-0.7	1.1
Diabetes (father)	0.9	1.2	3.8	-0.5	0.2	-1.8	0.1	-1.4	0.3	1.9	0.1
Diabetes (mother)	0.9	1.1	1.8	-1.2	-0.9	-1.2	-1.3	0.4	-1.1	0.8	1.2
Severe depression (siblings)	7.5	8.3	15.1	-3.5	-2.9	-1.4	-3.9	-2.2	-3.2	-1.4	3.4
Pack years adult smoking proportion	2.1	3.2	6.2	-1.8	-1.5	-0.9	-2.5	-1.3	-2.0	-1.7	2.1
Impedance of leg (right)	3.3	16.2	26.8	4.8	4.6	5.2	3.9	4.1	3.1	-0.8	-4.0
Leg fat-free mass (left)	12.8	67.7	104.0	-9.1	-7.8	-8.3	-10.2	-7.2	-8.6	-0.6	9.9
Trunk fat percentage	1.2	4.9	8.6	-2.3	-2.9	-1.6	-2.3	-2.0	-1.3	-2.9	1.7
Hand grip strength (right)	10.4	28.3	50.0	-5.7	-4.9	-3.1	-7.1	-3.2	-6.9	-1.7	7.0
Townsend deprivation index at recruitment	1.1	1.6	3.8	1.0	0.6	1.1	1.6	-0.3	1.9	-0.5	-2.0
Current tobacco smoking	2.3	3.8	8.4	2.2	1.9	1.3	2.2	-0.0	2.6	0.2	-2.9
Average weekly fortified wine intake	0.5	0.6	4.0	0.3	0.2	2.0	0.4	0.0	-0.4	-0.4	-0.2
Maternal smoking around birth	1.3	1.9	4.7	1.6	0.3	1.1	2.2	-1.1	1.5	-0.1	-1.8
Fed-up feelings	0.5	0.9	2.0	-0.5	-0.5	0.1	0.4	-0.6	1.4	-1.4	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.4	0.5	0.7	1.3	0.6	-0.4	1.6	-0.8	-1.6
Relative age voice broke	3.9	5.9	16.2	2.5	2.1	4.0	2.5	2.8	1.2	-1.2	-1.9
Taking other prescription medications	0.4	0.7	1.0	-0.7	-1.0	-0.9	-0.9	-0.5	-0.8	-0.8	0.8
Age when periods started (menarche)	2.5	6.1	16.1	2.2	2.7	4.0	2.6	2.2	1.5	0.9	-2.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	4.7	0.6	0.3	-2.2	0.1	-0.2	0.3	0.9	0.3
Heel bone mineral density (BMD) T-score, automated (left)	4.2	9.6	17.1	-3.9	-3.5	-2.4	-4.1	-1.0	-3.2	-2.1	3.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.3	0.6	0.0	0.5	0.2	0.2	0.9	-0.4
Qualifications: CSEs or equivalent	2.0	2.7	4.7	1.9	1.2	0.7	2.1	0.1	2.2	1.6	-2.0
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.1	-0.5	-0.2	0.5	-0.4	0.7	0.2	-0.5
High blood pressure	0.4	1.0	5.7	0.5	0.6	-2.4	0.1	-0.2	1.1	0.7	-0.5
Hayfever, allergic rhinitis or eczema	2.8	6.0	10.1	-2.6	-2.2	-1.0	-3.2	-2.0	-3.1	-1.5	3.0
Multivitamins +/- minerals	11.0	14.0	22.5	-4.7	-4.3	-2.2	-4.3	-3.5	-3.8	-2.7	3.8
Stomach or abdominal pain in last month	0.4	0.6	1.8	0.5	0.1	1.3	0.6	0.2	0.7	-0.3	-1.2
Supplements: Glucosamine	5.7	7.5	10.9	-3.2	-3.1	-0.7	-3.3	-2.9	-2.8	-1.9	2.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	2.5	0.3	0.2	1.2	0.2	-1.6	0.2	-0.0	-0.5
Medication: Atenolol	0.6	0.8	1.6	-1.0	-1.3	-0.7	-0.7	-0.8	-0.4	-1.2	0.5
Medication: Levothyroxine sodium	0.8	1.4	2.2	-1.4	-1.2	-1.3	-1.5	-0.8	-1.0	-0.9	1.3
Sitting height	21.7	154.3	272.2	-13.2	-10.1	-12.0	-16.5	-8.7	-14.4	-0.3	16.1
Chronic bronchitis/emphysema (father)	0.7	0.8	2.3	1.5	1.1	0.0	1.1	0.4	0.9	0.5	-0.8
High blood pressure (mother)	2.4	3.3	4.7	-2.2	-1.5	-2.1	-2.1	-2.0	-1.7	-0.2	2.0
Body mass index (BMI)	2.7	11.7	22.6	-4.5	-4.8	-3.6	-3.1	-3.6	-1.7	-2.3	2.5
Impedance of leg (left)	3.9	19.0	27.8	5.3	5.1	5.1	4.4	4.4	3.8	-0.2	-4.5
Leg predicted mass (left)	12.6	66.7	102.0	-9.1	-7.7	-8.3	-10.1	-7.1	-8.6	-0.5	9.9
Trunk fat mass	4.4	18.9	27.6	-4.9	-4.9	-3.8	-5.3	-4.0	-3.9	-2.7	4.7
Waist circumference	3.1	11.4	16.2	-4.0	-4.0	-3.3	-3.8	-3.4	-2.6	-1.8	3.4
Number of incorrect matches in round	2.5	4.1	7.1	2.7	2.0	0.2	2.0	1.9	2.3	2.2	-2.0
Past tobacco smoking	8.3	15.2	24.5	-4.5	-3.8	-3.0	-5.0	-2.0	-4.5	-2.3	4.9
Alcohol usually taken with meals	0.5	0.8	3.4	-0.4	-0.5	-1.8	-0.8	-0.5	-0.4	0.7	0.8
Nervous feelings	3.1	5.7	25.0	1.2	1.2	5.0	1.7	1.4	0.7	-2.9	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	6.5	0.5	-0.0	2.6	0.9	-1.2	1.4	-2.1	-1.7
Hearing difficulty/problems with background noise	3.0	4.7	7.2	-2.4	-2.4	2.1	-1.9	-1.7	-2.3	-2.7	1.6
Hair/balding pattern: Pattern 2	2.7	3.4	7.0	2.1	1.1	2.7	1.1	1.4	1.9	-1.4	-2.4
Had menopause	0.4	0.5	2.2	0.2	0.3	0.1	-1.5	-0.2	-0.8	-0.9	0.7
Had other major operations	1.6	1.9	4.5	-0.7	-1.2	-0.8	-2.1	0.3	-1.7	-1.5	1.8
Forced vital capacity (FVC)	0.5	1.8	3.4	0.5	0.7	-1.2	-1.8	-1.5	-1.3	1.6	1.6
Heel bone mineral density (BMD) T-score, automated (right)	3.8	8.7	15.7	-3.8	-3.3	-1.7	-4.0	-0.4	-3.3	-1.6	3.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.8	0.2	-0.3	0.9	0.1	-1.3	0.1	-1.1	-0.4
Qualifications: None of the above	1.0	2.2	5.9	0.9	0.5	-0.1	2.2	-0.5	2.4	-0.4	-2.4
Financial difficulties in last 2 years	1.3	1.7	7.5	-0.6	-0.8	0.7	1.0	-2.7	1.2	-0.6	-1.2
Mouth/teeth dental problems	0.9	1.4	5.1	-1.2	-1.2	2.3	0.1	0.0	-0.9	-1.4	-0.0
Heart attack	1.4	1.8	4.5	-0.9	-1.1	-1.2	-2.1	-0.7	-1.1	-1.5	1.4
Allergy	2.9	6.6	10.2	3.1	2.4	0.8	2.9	2.7	3.2	1.4	-2.9
Pain all over the body in last month	2.6	2.8	4.5	-1.8	-1.7	-1.4	-2.1	-2.1	-1.1	-1.6	1.3
Diabetes (self-reported)	1.1	1.8	5.7	-1.5	-1.2	-1.1	-1.3	-2.4	-0.7	-0.4	1.0
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	7.8	-2.6	-2.5	-1.1	-2.4	-1.1	-2.8	-1.5	2.8
Medication: Ramipril	0.5	0.6	2.4	-0.6	-0.7	0.3	-0.5	-1.1	-0.3	-1.5	0.2
Medication: Simvastatin	1.6	2.3	3.8	-1.9	-2.0	-1.8	-1.6	-1.1	-1.2	-0.7	1.6
Fluid intelligence score	1.1	2.2	6.2	-1.0	-0.2	-0.1	-2.5	1.6	-1.6	-1.7	1.5
Illnesses of siblings	5.5	7.8	13.0	3.5	2.4	1.6	3.6	1.5	3.1	2.8	-3.0
Neuroticism score	3.1	6.4	22.2	1.7	1.5	4.7	2.0	1.6	1.9	-2.6	-2.7
Weight	10.9	53.8	80.6	-8.3	-7.5	-7.2	-9.0	-6.6	-7.3	-1.8	8.5
Impedance of arm (right)	4.5	21.2	38.4	6.1	4.9	6.2	4.9	4.2	3.1	-0.4	-4.2
Arm fat percentage (right)	1.2	4.7	11.4	-2.5	-3.4	-1.2	-1.6	-2.3	-0.8	-3.0	1.1
Trunk fat-free mass	16.2	93.1	148.8	-10.6	-8.5	-9.3	-12.2	-8.2	-10.6	-0.2	12.0
Hip circumference	6.6	28.6	40.7	-6.3	-5.6	-5.8	-6.4	-5.5	-4.4	-1.6	5.5
Time employed in main current job	0.6	0.7	1.5	-0.6	-0.3	-0.4	-1.2	-0.9	-0.9	0.4	1.2
Alcohol intake versus 10 years previously	1.9	2.8	7.0	-2.3	-2.6	0.2	-0.6	-1.7	-1.7	-1.5	1.3
Father’s age at death	1.4	1.8	3.8	1.3	1.1	1.8	2.0	0.9	0.7	1.4	-1.1
Worrier / anxious feelings	1.4	2.6	10.8	-1.2	-0.6	3.3	0.0	-0.3	-0.7	-2.7	-0.2
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.6	7.9	-2.5	-2.2	-0.9	-2.8	-2.1	-1.6	-2.7	1.7
Falls in the last year	0.1	0.2	0.5	0.1	0.4	0.6	-0.3	-0.0	-0.4	-0.7	0.3
Hair/balding pattern: Pattern 3	9.3	13.9	22.7	-4.5	-4.2	-2.6	-4.2	-0.9	-4.7	-2.1	4.8
Number of live births	0.1	0.2	0.7	0.8	0.4	0.3	0.3	-0.0	0.4	0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	7.4	-0.7	-0.7	-1.2	-2.6	-2.1	-2.6	0.5	2.7
Pulse rate	0.6	1.0	4.6	0.7	-0.0	-1.3	0.8	-0.5	0.2	2.2	0.1
Happiness	0.7	0.9	2.3	0.2	0.1	1.3	0.7	0.0	0.9	-1.5	-1.3
Noisy workplace	2.0	2.5	4.3	1.9	1.0	1.4	2.1	1.2	1.8	0.0	-2.0
Qualifications: A levels/AS levels or equivalent	2.0	4.5	10.8	-1.1	-0.5	-1.7	-3.3	0.4	-3.0	-0.4	3.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.0	1.3	1.3	0.7	1.4	1.2	1.3	1.3	-1.3
Mouth/teeth dental problems: Dentures	3.1	5.2	17.6	-1.7	-1.7	-4.2	-2.1	-1.9	-1.6	1.0	2.6
Asthma	0.3	0.7	1.5	-1.2	-0.6	0.4	-0.5	-1.2	-0.9	-0.7	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.1	0.0	-0.4	-0.2	-0.6	-0.3	-0.5	-1.1	0.5
Medication: Cholesterol lowering	1.1	1.7	3.9	-1.8	-1.1	-1.2	-1.6	-2.0	-0.5	-0.9	0.7
Depression (self-reported)	3.1	3.8	8.9	2.2	1.5	0.4	2.4	-1.1	3.0	0.6	-2.6
Medication: Lansoprazole	0.8	0.9	3.5	0.4	-0.4	1.9	0.9	-0.3	0.8	-1.0	-1.0
Prospective memory result	0.9	1.1	4.0	-0.7	-0.2	-1.2	0.5	-2.0	0.8	1.1	-0.7
Lung cancer (father)	0.4	0.5	1.5	-0.2	-0.0	1.2	-0.3	-1.2	-0.8	-0.1	0.3
Illnesses of mother	1.0	1.3	2.4	1.4	1.5	1.4	1.3	0.6	0.9	0.7	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	8.7	-0.5	-0.7	-1.7	-2.9	-1.9	-2.7	0.8	3.0
Pulse wave Arterial Stiffness index	6.2	7.3	12.7	-3.0	-3.6	-1.6	-2.9	-2.1	-2.9	-1.8	3.0
Impedance of arm (left)	4.8	22.0	40.6	6.4	5.2	5.7	4.9	5.0	3.2	0.2	-4.2
Arm fat mass (right)	4.8	19.8	29.5	-5.3	-5.4	-4.2	-4.9	-4.5	-3.6	-2.6	4.4
Trunk predicted mass	16.0	91.6	146.4	-10.5	-8.4	-9.3	-12.1	-8.3	-10.4	-0.1	11.9
Standing height	11.4	112.9	217.9	-9.9	-7.6	-9.0	-14.5	-7.5	-13.5	0.2	14.8
Length of working week for main job	0.8	0.9	3.4	0.3	1.0	-1.4	-0.3	0.5	0.1	1.8	0.5
Exposure to tobacco smoke at home	1.2	1.3	4.3	0.6	-0.2	2.1	1.6	0.1	0.7	-1.1	-1.2
Breastfed as a baby	6.2	7.7	15.3	3.9	3.1	1.9	2.8	2.7	2.7	1.7	-2.8
Tense / ‘highly strung’	2.9	4.9	19.9	1.7	1.6	4.5	1.1	0.8	0.7	-3.0	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.0	0.4	-0.8	-0.7	-0.8	0.5	-0.2	-0.1
Hair/balding pattern: Pattern 4	5.8	14.2	26.7	-5.2	-4.4	-0.4	-4.0	-1.8	-4.3	-4.0	3.6
Birth weight of first child	0.2	0.3	1.5	0.0	-0.2	1.2	0.4	-0.4	0.3	-0.2	-0.6
Peak expiratory flow (PEF)	7.1	16.4	30.7	-3.8	-3.6	-1.5	-5.3	-3.4	-5.5	-1.9	5.3
Pulse wave reflection index	1.1	1.4	2.1	-1.3	-1.3	-0.2	-1.4	-1.2	-1.3	-1.0	1.1
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.7	1.0	-0.3	1.9	1.8	-0.7	1.5	-0.5	-1.9
Loud music exposure frequency	0.4	0.5	0.9	-0.1	-0.5	0.9	0.2	-0.9	0.7	-0.9	-0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.5	0.5	1.1	-1.2	-1.6	0.8	-0.7	0.8	1.2
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.8	2.0	1.5	0.5	0.9	1.1	1.5	0.6	-1.2
Blood clot in the leg (DVT)	4.3	5.5	8.9	-2.5	-2.0	-3.0	-2.2	-2.2	-2.5	1.1	2.8
Medication: Paracetamol	0.2	0.3	0.8	-0.9	-0.7	-0.8	-0.5	0.0	-0.0	-0.5	0.2
Headache pain in last month	0.3	0.5	1.7	1.3	1.1	0.5	0.3	0.6	-0.1	0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.8	0.7	0.4	1.1	0.1	1.7	-0.6	-0.3	0.4
Glaucoma (self-reported)	1.2	1.4	3.7	0.8	1.9	-1.6	0.4	0.1	0.4	1.9	-0.1
Gout (self-reported)	0.6	0.8	1.6	-1.1	-1.3	-0.5	-1.0	-0.3	-0.8	-0.8	0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.4	-0.8	-0.7	-1.2	-1.3	-0.4	-1.3	-0.7	1.5
Medication: Amlodipine	1.3	1.8	3.2	1.5	1.4	0.1	1.8	0.0	1.7	1.2	-1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.8	0.7	0.6	-0.1	0.5	1.3	0.5	0.2	-0.5
Birth weight	0.4	0.9	2.8	-0.5	-0.9	-0.0	-0.6	-1.7	-1.1	0.8	0.9
Chronic bronchitis/emphysema (mother)	1.6	1.8	8.7	-0.5	-0.8	-0.1	1.3	-3.0	1.2	0.7	-1.3
High blood pressure (siblings)	2.4	3.5	7.0	-1.8	-0.8	-2.4	-2.6	0.1	-2.2	-0.7	2.5
Forced vital capacity (FVC), Best measure	0.7	2.7	5.5	0.5	0.4	-1.6	-2.4	-1.4	-1.8	1.6	2.2
Body fat percentage	1.0	4.1	9.7	-2.3	-2.9	-1.4	-1.7	-1.9	-0.7	-3.1	1.1
Leg fat percentage (right)	1.1	3.8	10.6	-2.5	-2.8	-0.9	-1.0	-2.1	0.2	-3.2	0.1
Arm fat-free mass (right)	16.7	85.6	136.9	-10.4	-8.4	-9.5	-11.7	-7.8	-9.6	-0.5	11.2
Exposure to tobacco smoke outside home	1.9	2.5	6.3	1.6	0.8	2.5	1.8	0.4	1.6	-0.7	-2.0
Comparative body size at age 10	2.4	6.7	23.2	-1.9	-2.1	-4.8	-2.6	-1.9	-1.6	1.1	2.9
Number of full brothers	0.9	1.1	3.9	-1.1	-1.2	-0.8	-0.6	-2.0	-0.7	0.4	0.7
Worry too long after embarrassment	2.3	3.8	17.3	0.5	0.7	4.2	0.8	1.2	0.5	-2.9	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.2	-0.2	-0.6	-1.4	-0.3	-1.5	0.6	-0.4	-0.1
Wheeze or whistling in the chest in last year	0.4	0.7	2.5	-1.4	-0.8	0.3	-0.0	-1.6	-0.0	-0.8	-0.2
Number of children fathered	0.4	0.4	1.3	-0.5	-0.2	-0.5	-0.5	-0.2	-1.0	0.2	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.4	-1.5	-0.8	0.7	-1.1	-0.3	-1.1	-1.2	0.7
Age at first live birth	0.7	1.2	2.6	-1.1	-0.6	-0.4	-1.5	0.3	-1.6	-0.2	1.6
Pulse wave peak to peak time	2.8	3.3	7.7	2.1	2.8	1.0	1.6	1.5	1.7	1.5	-1.7
Health satisfaction	3.0	4.0	8.7	-2.5	-2.4	0.5	-1.1	-2.9	-1.2	-2.7	0.6
Shortness of breath walking on level ground	0.4	0.5	1.0	0.6	0.3	0.0	0.7	-1.0	1.0	-0.3	-0.9
Qualifications: College or University degree	1.8	5.6	13.6	-2.1	-0.7	-0.9	-3.5	0.5	-3.7	0.1	3.6
Eye problems/disorders: None of the above	1.7	1.9	4.2	0.9	0.6	1.0	1.9	-0.1	2.0	1.3	-2.1
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.4	-1.1	-0.6	-0.8	-1.2	0.9	-0.8	0.1	1.0
Emphysema/chronic bronchitis	0.4	0.4	0.9	-0.0	0.0	0.9	0.9	-0.5	0.7	-0.2	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	0.7	0.6	1.1	1.1	0.5	0.7	1.3	-0.9
Neck or shoulder pain in last month	4.3	6.1	10.7	-2.7	-2.2	0.4	-3.3	-1.3	-2.9	-3.0	2.4
Medication: Blood pressure	0.5	0.9	1.9	0.1	0.6	-1.2	0.7	-1.0	1.4	1.1	-1.1
Angina (self-reported)	7.6	9.9	14.8	-3.9	-3.3	-2.8	-3.7	-2.9	-2.7	-2.4	3.3
Migraine (self-reported)	1.7	2.1	4.2	2.0	1.8	-0.2	0.8	2.0	0.9	1.8	-0.8
Medication: Ibuprofen	0.2	0.2	0.4	-0.1	-0.2	-0.2	-0.6	-0.5	-0.6	-0.6	0.6
Medication: Allopurinol	0.5	0.7	1.0	-1.0	-0.8	-0.6	-0.9	-0.9	-0.7	-0.8	0.8
Medication: Omeprazole	1.8	2.1	4.1	-1.4	-1.3	-0.9	-1.7	-2.0	-1.5	-1.0	1.6
Medication: Seretide 50 evohaler	0.5	0.6	1.9	0.2	0.6	-0.5	0.5	1.4	0.9	0.6	-1.0
Mean time to correctly identify matches	0.9	1.7	2.4	1.4	1.4	-1.0	1.5	1.0	1.5	1.2	-1.2
Heart disease (mother)	4.0	4.9	7.0	-2.0	-2.5	-2.0	-2.6	-1.4	-2.4	-1.9	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.2	-0.9	-0.4	-1.5	-0.9	-0.3	-0.8	0.5	1.1
Whole body fat mass	4.7	19.8	27.7	-5.2	-5.3	-4.1	-5.1	-4.2	-3.7	-2.8	4.6
Leg fat mass (right)	4.1	16.1	25.8	-5.1	-5.0	-3.7	-4.4	-4.1	-2.8	-2.7	3.6
Arm predicted mass (right)	15.7	80.3	128.4	-10.0	-8.0	-9.6	-11.3	-7.5	-9.2	-0.3	10.8
Pulse rate, automated reading	0.2	0.8	1.9	1.3	0.4	-0.6	1.3	-0.3	0.4	1.4	-0.0
Alcohol intake frequency.	0.4	0.9	2.1	0.4	-0.2	1.4	0.7	1.5	0.4	-1.3	-0.7
Comparative height size at age 10	8.1	44.8	82.6	-5.9	-5.2	-6.8	-9.1	-5.6	-7.9	0.1	8.6
Number of full sisters	0.4	0.5	1.2	0.0	-0.3	0.9	0.9	-0.3	0.9	0.0	-1.1
Suffer from ‘nerves’	0.7	1.1	3.6	0.6	0.9	1.9	0.1	0.5	0.3	-1.7	-0.7
Overall health rating	1.3	2.8	8.9	-1.8	-2.1	0.2	-1.1	-1.7	-1.0	-3.0	0.7
Chest pain or discomfort	3.3	4.8	7.7	-2.4	-2.2	-1.2	-2.8	-2.3	-2.0	-2.4	2.0
Had major operations	0.4	0.5	2.4	0.7	0.4	-1.6	0.2	0.4	0.1	0.8	0.2
Age at last live birth	0.7	1.0	2.0	-1.2	-1.0	-0.1	-1.3	-0.3	-1.4	-0.2	1.4
Family relationship satisfaction	0.4	0.4	1.0	0.2	0.6	0.4	1.0	-0.4	0.8	0.3	-1.0
Leg pain on walking	0.8	0.9	1.9	1.4	1.0	1.4	0.8	-0.1	0.7	-0.6	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.5	1.5	0.3	0.1	1.6	-0.7	1.6	1.0	-1.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	-0.5	-0.7	-0.9	-0.5	-0.9	0.3	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.7	-1.3	-0.6	-1.0	-1.9	0.5	-1.7	-1.1	1.6
Medication: Aspirin	2.3	3.0	5.6	-2.2	-1.9	-0.9	-1.4	-1.8	-1.4	-2.4	1.3
Supplements: Vitamin C	1.5	1.8	4.5	-1.7	-1.1	-1.2	-1.1	-2.1	-1.0	0.3	1.3
Knee pain experienced in last month	2.5	3.9	10.5	1.8	1.1	3.2	2.1	-0.3	1.6	-1.9	-2.3
Hypertension (Self-reported)	0.4	1.0	3.4	0.8	0.7	-1.8	0.4	0.1	1.4	0.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	6.4	0.3	-0.6	2.5	1.0	-0.3	0.1	-1.3	-0.6
Illnesses of father: Heart disease	3.2	4.4	10.1	-2.0	-1.9	-1.5	-3.2	-1.1	-1.9	-2.3	2.2
Illnesses of siblings: Diabetes	4.1	5.0	11.6	-3.0	-2.4	0.5	-2.3	-0.7	-2.3	-3.4	1.9
Smoking status: Previous	5.9	8.9	14.0	3.4	2.9	1.9	3.7	1.8	3.5	2.5	-3.5
Forced expiratory volume in 1-second (FEV1), predicted	9.6	20.0	38.8	-4.1	-2.9	-4.8	-6.0	-3.0	-5.3	0.2	6.2
Whole body fat-free mass	15.2	86.7	136.9	-10.3	-8.4	-9.2	-11.7	-8.1	-9.9	-0.3	11.4
Leg fat-free mass (right)	12.3	65.9	99.0	-8.9	-7.5	-8.5	-9.9	-7.2	-8.4	-0.0	9.8
Arm fat percentage (left)	0.9	3.7	9.7	-2.3	-3.1	-1.3	-1.3	-1.8	-0.5	-2.7	0.8
Average weekly red wine intake	1.6	2.4	4.7	-1.3	-1.0	-0.1	-2.2	-2.1	-1.9	-0.8	1.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	-0.7	-0.9	-0.1	-0.9	-0.7	-1.1	-0.3	1.0
Mood swings	1.4	2.4	6.2	0.5	0.1	2.5	1.6	0.1	1.7	-1.7	-2.2
Loneliness, isolation	0.8	1.1	2.9	0.6	0.2	0.6	1.4	-0.5	1.6	-0.6	-1.7
Long-standing illness, disability or infirmity	3.7	5.6	8.1	-2.6	-2.8	-1.0	-2.7	-2.8	-2.1	-2.3	2.1
Ever had bowel cancer screening	0.5	0.6	0.8	-0.9	-0.8	-0.1	-0.9	-0.9	-0.9	-0.8	0.6
Diabetes diagnosed by doctor	1.1	1.8	3.3	-1.6	-1.1	-1.5	-1.6	-1.8	-0.9	-0.3	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	0.8	1.1	0.9	0.8	1.0	1.0	0.0	-1.3
Friendships satisfaction	1.0	1.3	3.5	0.5	0.6	-0.3	1.1	-0.8	1.9	1.1	-1.8
Qualifications: nursing, teaching	0.4	0.6	2.1	-0.2	0.4	-0.5	-0.9	0.2	-1.2	0.1	1.4
Commuting to job workplace: Walk	0.8	0.9	2.1	0.1	0.8	-0.6	-1.1	0.8	-1.4	0.6	1.4
Eye problems/disorders: Cataract	2.4	2.8	4.9	-2.2	-1.5	-1.4	-2.2	-1.0	-1.8	-0.5	2.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.3	1.7	2.1	-0.3	1.1	-0.0	1.3	1.5	-1.2
Medication for cholesterol	0.6	1.0	4.9	0.2	0.6	-0.1	0.9	-1.0	0.6	2.2	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	5.2	2.2	2.3	-0.1	1.1	1.3	1.5	2.1	-1.3
Back pain experienced in last month	1.2	1.8	9.6	-0.1	-0.7	1.7	0.2	-3.1	0.2	-0.9	-0.7
Mineral and other dietary supplements	2.6	3.5	7.5	2.2	2.0	-0.1	1.8	2.7	1.7	1.8	-1.5
Breast cancer (self-reported)	0.3	0.4	1.2	0.5	0.4	0.5	0.3	1.1	0.4	-0.7	-0.7
Asthma (self-reported)	0.3	0.7	1.8	-1.3	-0.7	0.4	-0.3	-1.3	-0.8	-0.7	0.4
Osteoporosis (self-reported)	0.8	1.0	2.9	1.7	1.3	-0.3	0.6	0.1	0.7	1.6	-0.4
Osteoarthritis (self-reported)	1.7	2.1	9.2	-0.9	-1.3	0.7	-0.5	-3.0	-0.4	-2.1	0.1
Medication: Aspirin	3.2	4.1	5.8	-2.4	-2.2	-1.3	-2.0	-2.2	-1.8	-2.2	1.9
Medication: Gliclazide	1.6	1.9	2.7	-1.5	-1.5	-0.3	-1.4	-0.8	-1.6	-1.7	1.5
Illnesses of father: None of the above (group 1)	0.3	0.3	1.7	0.4	0.3	1.3	0.5	0.6	-0.2	-0.0	-0.3
Smoking status: Current	2.8	4.5	9.9	2.4	1.9	1.7	2.4	-0.1	2.7	0.2	-3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.5	1.2	0.1	1.6	0.2	0.5	-0.1	-1.1	-0.4
Whole body water mass	15.2	86.4	136.9	-10.2	-8.3	-9.4	-11.7	-8.0	-9.9	-0.2	11.4
Leg predicted mass (right)	12.4	66.1	98.6	-8.9	-7.6	-8.6	-9.9	-7.3	-8.4	-0.0	9.8
Arm fat mass (left)	4.8	19.7	28.8	-5.4	-5.4	-4.2	-5.0	-4.3	-3.6	-2.5	4.4
Number of self-reported non-cancer illnesses	1.3	2.3	10.0	-1.3	-1.4	-0.5	-1.2	-3.2	-1.1	-0.9	1.0
Average weekly champagne plus white wine intake	0.2	0.3	1.7	0.3	0.5	0.2	0.3	0.1	-0.2	1.3	0.3
Miserableness	0.7	1.2	2.8	0.5	0.3	1.2	1.0	-0.1	1.6	-1.2	-1.7
Guilty feelings	2.4	3.7	7.3	2.2	1.9	2.7	1.8	0.1	2.1	0.1	-2.4
Wears glasses or contact lenses	0.7	0.8	2.9	0.1	-0.4	1.2	-0.6	1.0	-0.9	-1.7	0.3
Ever taken oral contraceptive pill	1.3	1.4	3.3	0.8	1.3	1.8	1.4	0.2	1.3	0.7	-1.4
Hearing aid user	0.4	0.5	0.8	-0.4	-0.8	-0.5	-0.7	0.5	-0.9	-0.8	0.7
Mother’s age at death	0.2	0.2	0.7	0.5	0.4	0.8	0.1	0.4	0.3	0.5	-0.3
Financial situation satisfaction	1.7	2.2	3.8	1.3	0.5	1.7	1.9	-1.4	1.7	-0.1	-1.9
Tinnitus: Yes, now most or all of the time	3.4	4.0	7.3	-2.0	-1.9	1.2	-2.0	-0.2	-2.6	-2.7	2.1
Commuting to job workplace: Public transport	0.2	0.3	1.0	0.3	0.7	-0.1	-0.3	1.0	-0.3	0.8	0.2
Eye problems/disorders: Glaucoma	1.0	1.2	2.7	1.2	1.6	-1.6	0.7	-0.0	0.5	1.4	-0.3
Medication: Blood pressure	0.2	0.4	1.0	-0.0	-0.3	-1.0	-0.5	0.7	0.2	-1.0	0.0
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.8	-1.4	-1.4	0.7	-1.8	-1.6	-1.1	-2.2	0.8
Supplements: Fish oil (including cod liver oil)	2.3	3.0	4.4	-2.1	-1.8	-0.1	-1.9	-1.9	-2.0	-1.3	1.9
High cholesterol (Self-reported)	1.2	2.2	5.0	-1.7	-1.0	-1.8	-2.2	-0.4	-1.2	-1.1	1.6
Medication: Bendroflumethiazide	0.2	0.3	1.8	-0.1	0.3	-1.3	0.3	0.1	0.6	0.1	-0.4
Medication: Paracetamol	0.6	0.9	2.3	-1.3	-1.0	-1.5	-1.1	-0.4	-0.4	0.0	0.8
Medication: Lisinopril	0.4	0.5	2.6	-0.4	0.1	-1.6	-0.4	-0.5	0.6	0.7	-0.0
Medication: Atorvastatin	1.1	1.3	4.4	-0.8	-0.3	-2.1	-1.4	-1.3	-0.7	-0.3	1.0
Illnesses of father: High blood pressure	1.0	1.3	3.9	1.1	1.3	-0.9	0.9	0.8	1.0	2.0	-0.6
Alcohol drinker status: Never	0.5	0.6	1.3	1.1	1.0	-0.3	0.8	0.1	0.7	0.9	-0.5
Ever smoked	5.3	9.4	17.1	3.0	3.0	2.5	3.9	1.5	3.7	1.7	-4.1
Basal metabolic rate	14.9	82.6	130.0	-10.1	-8.4	-9.1	-11.4	-7.9	-9.6	-0.7	11.0
Leg fat percentage (left)	1.0	3.5	8.8	-2.4	-2.8	-1.0	-0.9	-2.0	0.3	-3.0	0.1
Arm fat-free mass (left)	15.5	78.6	124.7	-10.0	-8.2	-8.9	-11.2	-7.8	-9.2	-0.6	10.6
Number of operations (self-reported)	0.2	0.3	0.8	0.9	0.3	-0.4	-0.5	0.1	-0.4	-0.7	0.7
Average weekly beer plus cider intake	1.3	1.9	4.3	0.3	0.6	0.9	1.4	-2.0	2.0	0.5	-2.1
Irritability	6.5	11.0	43.2	2.4	2.1	6.6	2.6	2.6	1.4	-3.4	-2.8
Risk taking	1.7	2.5	4.5	-2.1	-1.6	-1.5	-1.8	-2.1	-1.3	0.0	1.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.2	1.0	1.7	1.3	0.5	1.8	0.5	-0.5	-0.9
Fractured/broken bones in last 5 years	0.7	0.9	2.2	0.6	0.1	0.6	1.5	-0.9	1.1	0.7	-1.4
Age started oral contraceptive pill	0.4	0.5	1.3	-0.6	-0.4	1.0	-0.7	-0.2	-0.6	-1.1	0.1
Diastolic blood pressure, automated reading	0.5	1.4	2.7	-1.0	-1.1	-1.6	-1.4	-1.1	-1.0	-0.4	1.3
Ever depressed for a whole week	0.5	0.6	2.3	-0.4	-0.4	0.8	-0.2	-1.5	-0.2	-1.2	-0.0
Unable to work because of sickness or disability	0.5	0.7	1.4	0.2	-0.7	-0.1	0.6	-1.1	1.0	-1.2	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.6	-0.0	0.5	0.6	-0.3	0.3	0.5	-0.4
Myopia	0.5	0.7	2.6	-0.6	0.1	1.1	0.6	-1.6	0.4	0.5	-0.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	7.7	0.4	0.6	2.8	0.9	1.0	-0.4	0.0	-0.3
Cholesterol lowering medication	2.6	3.9	6.2	-2.0	-1.8	-2.0	-2.5	-0.6	-2.1	-1.7	2.4
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	4.0	-1.7	-2.0	-0.9	-1.9	-1.7	-1.9	-1.5	2.0
Pain experienced in last month	0.7	1.2	5.4	0.2	0.7	-1.3	0.2	2.3	0.2	1.3	0.3
Supplements: Calcium	0.4	0.4	1.6	0.0	0.4	-1.3	-0.4	-0.5	0.5	0.9	-0.1
Basal cell carcinoma (self-reported)	4.6	5.4	20.0	0.9	0.5	4.5	-0.2	3.8	-0.7	-2.7	-0.2
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.0	-0.8	-1.0	-1.2	-2.0	-0.9	-1.1	-1.2	1.4
Deep venous thrombosis (DVT) (self-reported)	4.2	5.4	8.5	-2.6	-1.9	-2.9	-2.2	-2.1	-2.5	1.3	2.7
Heart disease (siblings)	3.9	4.8	7.5	-2.2	-2.2	-1.3	-2.7	-2.5	-1.9	-2.3	2.1
Alcohol drinker status: Previous	2.8	3.2	6.3	-1.8	-2.0	-0.7	-2.3	-0.3	-2.3	-1.1	2.5
Pack years of smoking	3.0	4.4	7.6	-2.1	-2.0	-0.7	-2.8	-1.4	-2.4	-2.3	2.4
Impedance of whole body	4.8	24.2	40.5	6.4	5.5	6.0	5.0	5.1	3.7	-0.2	-4.7
Leg fat mass (left)	4.3	16.9	26.7	-5.2	-5.1	-3.8	-4.5	-4.2	-3.0	-2.7	3.8
Arm predicted mass (left)	16.4	83.2	130.0	-10.4	-8.4	-9.2	-11.4	-8.2	-9.3	-0.7	10.8