Hub : Genes

RALY

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0883 0.0264 1.1e-16 0.155 0.133 0.145 0.138 0.146 2.3e-19 1.1e-16 3.7e-18 2.8e-17 2.7e-18
2 TCGA Thyroid Carcinoma 0.0550 0.0320 5.2e-06 0.041 0.048 0.047 NA 0.046 7.2e-05 1.6e-05 2.0e-05 NA 2.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.8 2.8 3.0 -1.7 1.6
Bipolar Disorder or Schizophrenia 5.0 12.2 12.5 -3.5 3.4
Depressed Affect (Nagel 2018) 0.2 0.5 0.5 0.7 0.7
Depression (Nagel 2018) 0.5 0.8 1.4 0.3 1.2
Intelligence (Savage-Jansen 2018) 1.5 4.6 4.8 2.2 -2.1
Neuroticism (Nagel 2018) 0.8 2.0 3.7 1.9 -0.5
Schizophrenia (2018) 4.7 9.8 10.0 -3.2 3.1
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.2 0.4
Worry (Nagel 2018) 0.4 0.9 1.6 1.3 -0.4
Alzheimer’s Disease (in mother) 1.5 1.8 2.4 1.1 -1.5
Alzheimer’s Disease (in father) 0.1 0.1 0.1 0.3 0.0
Alzheimer’s Disease (including proxy) 1.1 1.6 1.6 1.3 -1.3
Crohns Disease (2017) 0.4 0.9 0.9 0.9 -1.0
Irritable Bowel Disease (IBD) 0.0 0.1 0.1 -0.3 -0.2
Ulcerative Colitis (UC) 0.6 1.0 1.7 -1.3 0.6
Major Depression (MDD) 1.2 1.5 2.3 -0.8 1.5
Reaction Time 1.6 3.1 3.3 1.7 -1.8
Verbal and Numeric Reasoning (VNR) 0.7 1.7 1.9 1.3 -1.4
Breast Cancer 1.7 4.1 4.2 -2.0 2.0
Ovarian Cancer 0.0 0.0 0.1 -0.0 -0.2
Prostate Cancer 1.2 1.7 3.4 1.8 0.0
Age at First Birth 0.4 0.5 1.0 0.1 -1.0
Bipolar Disorder (2011) 3.9 3.7 4.3 -2.1 1.8
Body Mass Index (BMI) (2010) 6.2 8.5 8.7 -2.9 2.9
Coronary Artery Disease (CAD) 0.2 0.3 0.3 -0.5 0.6
Crohns Disease (2012) 1.5 2.4 2.9 1.4 -1.7
Mean Putamen Volume 4.1 4.7 5.6 -2.4 1.9
Fasting Glucose 3.2 3.8 5.8 -2.4 1.4
HbA1C 0.0 0.0 0.0 -0.1 -0.0
HDL Cholesterol 5.1 8.5 10.3 3.2 -2.6
LDL Cholesterol 0.6 1.0 1.1 1.0 -1.0
Lupus 0.2 0.3 0.6 -0.8 -0.1
Neuroticism (2016) 0.3 0.5 1.0 1.0 -0.1
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.3 0.7
Rheumatoid Arthritis 2.4 3.3 3.6 1.9 -1.8
Schizophrenia (2014) 2.4 5.3 5.6 -2.2 2.4
Triglycerides 1.4 2.2 3.1 -1.8 1.1
Type 2 Diabetes (T2D) (2012) 7.0 8.0 10.0 -3.2 2.5
Ulcerative Colitis 0.8 1.1 2.2 -1.5 0.3
Blood Eosinophil Count 0.4 2.8 3.1 -1.6 1.7
Blood Platelet Count 2.9 33.2 35.5 -5.6 6.0
Blood Red Count 0.2 2.1 3.0 -1.7 1.1
Blood White Count 3.6 27.0 29.0 -5.0 5.4
Heel T-Score 5.0 39.7 46.4 -6.8 5.7
BMI 5.0 29.2 31.3 -5.2 5.6
Height 2.0 38.2 75.3 -8.7 1.0
Waist Hip Ratio (WHR) 0.7 3.0 3.8 2.0 -1.5
Systolic Blood Pressure 0.1 0.3 0.5 -0.7 -0.2
Smoking Status 2.0 4.8 7.6 2.8 -1.4
Allergy or Eczema 3.7 9.8 12.6 -3.6 2.7
Cardiovascular Disease 0.3 0.9 1.1 -0.8 1.1
Hypothyroidism (self reported) 0.4 0.9 1.2 -1.1 0.8
Respiratory disease 4.2 9.4 9.7 -3.1 3.0
Type 2 Diabetes (T2D) (2018) 7.5 14.1 15.7 -3.5 4.0
Lung FEV1/FVC ratio 6.2 31.6 42.9 -6.6 4.5
Lung FVC 10.1 51.2 56.2 7.5 -6.8
Neuroticism 0.6 1.4 2.8 1.7 -0.2
Chronotype (morning person) 1.6 3.6 5.7 -2.4 1.2
Hair Pigment 46.2 1318.5 1433.1 37.9 -34.7
Tanning 91.6 1118.8 1239.0 -35.2 31.6
Hand grip strength (left) 3.7 9.6 15.5 -3.9 1.9
Number of treatments/medications taken 1.1 2.0 2.7 -1.6 1.1
Average weekly spirits intake 0.0 0.0 0.1 0.3 -0.0
Sensitivity / hurt feelings 0.8 1.3 2.2 1.5 -0.6
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.3 1.2 0.3
Hearing difficulty/problems: Yes 0.1 0.1 0.1 -0.2 -0.4
Relative age of first facial hair 4.3 8.9 11.6 3.4 -2.5
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 2.9 1.7 -0.9
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.1 -1.0 0.6
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 -0.6 0.0
Systolic blood pressure, automated reading 1.9 5.4 7.0 -2.6 1.9
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 2.8 -1.7 0.9
Angina 5.8 7.6 8.6 -2.9 2.6
Medication for hormone replacement therapy 0.6 0.7 0.9 -0.9 0.7
Vitamin and mineral supplements 11.3 15.3 16.6 4.1 -3.7
Supplements: Zinc 3.1 3.3 4.3 -2.1 1.5
Medication: Co-codamol 0.3 0.3 0.4 -0.6 0.6
Medication: Metformin 1.5 2.2 2.4 -1.4 1.5
Diabetes (father) 2.7 3.4 4.1 -1.6 2.0
Diabetes (mother) 0.5 0.6 0.7 -0.7 0.8
Severe depression (siblings) 6.7 7.4 9.2 -3.0 2.4
Pack years adult smoking proportion 1.3 2.0 2.3 -1.5 1.3
Impedance of leg (right) 3.7 18.1 23.2 4.8 -3.6
Leg fat-free mass (left) 7.6 40.4 57.2 -7.6 4.9
Trunk fat percentage 0.6 2.3 2.7 -1.4 1.6
Hand grip strength (right) 3.2 8.7 15.3 -3.9 1.5
Townsend deprivation index at recruitment 0.4 0.6 0.8 0.9 -0.7
Current tobacco smoking 0.6 1.0 2.1 1.4 -0.1
Average weekly fortified wine intake 0.1 0.1 0.2 -0.4 0.2
Maternal smoking around birth 0.0 0.0 0.0 0.2 0.2
Fed-up feelings 0.1 0.1 0.2 0.3 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.9 0.9 -0.3
Relative age voice broke 3.5 5.3 6.8 2.6 -2.0
Taking other prescription medications 0.3 0.4 0.6 -0.8 0.4
Age when periods started (menarche) 0.7 1.6 2.2 1.5 -1.0
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.5 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 2.9 6.6 7.3 -2.7 2.4
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 2.1 0.5 -1.4
Qualifications: CSEs or equivalent 0.6 0.8 1.2 1.1 -0.7
Serious illness, injury or assault to yourself 0.6 0.7 1.0 -0.7 1.0
High blood pressure 0.1 0.3 0.5 0.7 -0.4
Hayfever, allergic rhinitis or eczema 3.4 7.3 9.2 -3.0 2.3
Multivitamins +/- minerals 13.0 16.6 18.7 -4.3 3.8
Stomach or abdominal pain in last month 0.0 0.0 0.1 -0.0 0.3
Supplements: Glucosamine 5.2 6.8 7.8 -2.8 2.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 0.9 -0.6 0.9
Medication: Atenolol 0.2 0.2 0.4 -0.6 0.3
Medication: Levothyroxine sodium 0.1 0.2 0.2 -0.5 0.4
Sitting height 8.2 58.0 93.5 -9.7 4.7
Chronic bronchitis/emphysema (father) 0.7 0.8 1.2 1.1 -0.7
High blood pressure (mother) 3.9 5.4 6.5 -2.5 2.1
Body mass index (BMI) 4.7 20.2 22.5 -4.2 4.7
Impedance of leg (left) 4.4 21.2 27.4 5.2 -3.9
Leg predicted mass (left) 7.5 39.5 56.1 -7.5 4.8
Trunk fat mass 2.6 11.4 13.5 -3.7 3.0
Waist circumference 3.3 12.2 13.0 -3.6 3.4
Number of incorrect matches in round 3.5 5.8 6.2 2.5 -2.3
Past tobacco smoking 5.8 10.7 13.5 -3.7 2.8
Alcohol usually taken with meals 0.6 1.0 1.1 -0.9 1.1
Nervous feelings 1.8 3.3 4.9 2.2 -1.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.3 0.2 1.1
Hearing difficulty/problems with background noise 2.9 4.6 6.3 -2.5 1.7
Hair/balding pattern: Pattern 2 5.2 6.6 7.8 2.8 -2.3
Had menopause 0.3 0.4 0.6 0.5 -0.8
Had other major operations 0.8 0.9 1.3 0.7 -1.2
Forced vital capacity (FVC) 1.2 4.7 7.7 1.3 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 2.3 5.2 6.6 -2.6 1.9
Ever unenthusiastic/disinterested for a whole week 0.0 0.1 0.1 -0.2 0.3
Qualifications: None of the above 0.1 0.3 0.5 0.2 0.7
Financial difficulties in last 2 years 2.1 2.8 3.7 -1.4 1.9
Mouth/teeth dental problems 0.9 1.4 1.8 -1.3 1.0
Heart attack 0.0 0.1 0.1 -0.3 0.0
Allergy 4.8 11.1 13.4 3.7 -2.9
Pain all over the body in last month 1.8 1.9 2.0 -1.4 1.4
Diabetes (self-reported) 5.3 8.3 9.5 -2.6 3.1
Hayfever/allergic rhinitis (self-reported) 4.1 5.4 6.8 -2.6 2.0
Medication: Ramipril 0.8 1.1 1.5 -0.8 1.2
Medication: Simvastatin 1.8 2.7 3.2 -1.8 1.5
Fluid intelligence score 0.4 0.9 1.2 1.1 -0.8
Illnesses of siblings 2.9 4.0 4.2 2.0 -2.0
Neuroticism score 1.7 3.6 6.3 2.5 -1.0
Weight 7.3 35.9 46.6 -6.8 5.0
Impedance of arm (right) 7.6 35.6 36.2 6.0 -5.9
Arm fat percentage (right) 1.5 6.1 7.8 -2.1 2.8
Trunk fat-free mass 9.3 53.2 77.8 -8.8 5.3
Hip circumference 5.1 21.8 25.4 -5.0 4.3
Time employed in main current job 0.6 0.7 0.8 -0.9 0.7
Alcohol intake versus 10 years previously 3.6 5.5 6.7 -2.6 2.0
Father’s age at death 0.0 0.0 0.1 -0.0 -0.2
Worrier / anxious feelings 0.2 0.4 0.6 -0.4 0.8
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.9 4.9 -1.7 2.2
Falls in the last year 0.3 0.4 0.6 -0.4 0.8
Hair/balding pattern: Pattern 3 5.2 7.8 10.4 -3.2 2.3
Number of live births 0.0 0.0 0.0 0.0 -0.2
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.8 -0.2 -1.4
Pulse rate 0.1 0.1 0.2 -0.4 -0.1
Happiness 0.2 0.2 0.4 -0.1 0.6
Noisy workplace 2.1 2.6 2.6 1.6 -1.6
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.1 0.2 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.5 0.7 -0.2
Mouth/teeth dental problems: Dentures 1.1 1.9 2.9 -1.7 1.0
Asthma 0.8 1.6 1.8 -1.3 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 0.0 -0.0
Medication: Cholesterol lowering 1.3 2.1 2.4 -1.6 1.3
Depression (self-reported) 0.7 0.8 1.5 0.4 1.2
Medication: Lansoprazole 0.0 0.1 0.1 0.3 -0.1
Prospective memory result 1.2 1.5 1.8 -1.4 1.1
Lung cancer (father) 0.5 0.6 1.2 -1.1 0.3
Illnesses of mother 0.6 0.8 1.1 1.1 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.8 -0.2 -1.3
Pulse wave Arterial Stiffness index 6.8 8.0 10.1 -3.2 2.4
Impedance of arm (left) 9.1 42.3 43.0 6.6 -6.5
Arm fat mass (right) 4.9 20.0 20.9 -4.6 4.4
Trunk predicted mass 9.2 52.5 76.7 -8.8 5.3
Standing height 2.6 25.8 48.9 -7.0 1.6
Length of working week for main job 0.0 0.0 0.0 0.1 -0.2
Exposure to tobacco smoke at home 0.2 0.2 0.3 0.6 0.1
Breastfed as a baby 11.2 13.9 14.3 3.8 -3.7
Tense / ‘highly strung’ 1.1 1.9 2.7 1.7 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.5 0.4 0.7
Hair/balding pattern: Pattern 4 5.8 14.0 18.3 -4.3 3.1
Birth weight of first child 0.1 0.1 0.2 0.5 -0.1
Peak expiratory flow (PEF) 2.9 6.8 11.1 -3.3 1.6
Pulse wave reflection index 2.8 3.5 3.9 -2.0 1.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.4 0.4 -0.6
Loud music exposure frequency 0.0 0.0 0.1 0.2 -0.2
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 2.3 1.2 -1.5
Mouth/teeth dental problems: Bleeding gums 3.3 4.3 5.2 2.3 -1.8
Blood clot in the leg (DVT) 3.3 4.2 6.8 -2.6 1.3
Medication: Paracetamol 0.1 0.1 0.1 -0.4 0.4
Headache pain in last month 0.6 1.0 1.7 0.6 -1.3
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.2 1.1 -1.1
Glaucoma (self-reported) 0.1 0.1 0.1 0.3 -0.3
Gout (self-reported) 0.4 0.5 0.8 -0.9 0.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.1 -0.4 0.3
Medication: Amlodipine 0.6 0.8 0.8 0.9 -0.9
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.6 0.8 -0.6
Birth weight 0.1 0.2 0.3 -0.5 -0.3
Chronic bronchitis/emphysema (mother) 3.0 3.5 3.8 -1.8 1.9
High blood pressure (siblings) 0.5 0.8 1.0 -1.0 0.7
Forced vital capacity (FVC), Best measure 1.2 4.4 7.7 1.1 -2.8
Body fat percentage 1.1 4.2 5.8 -1.6 2.4
Leg fat percentage (right) 2.8 10.2 14.9 -2.4 3.9
Arm fat-free mass (right) 11.3 57.8 77.6 -8.8 6.2
Exposure to tobacco smoke outside home 0.8 1.1 1.6 1.3 -0.8
Comparative body size at age 10 0.4 1.1 1.6 -1.3 0.8
Number of full brothers 1.2 1.6 2.4 -1.5 0.9
Worry too long after embarrassment 1.4 2.4 3.6 1.9 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 1.8 -0.4 1.4
Wheeze or whistling in the chest in last year 3.8 6.8 8.3 -2.3 2.9
Number of children fathered 0.4 0.4 0.6 -0.5 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.9 -1.0 0.6
Age at first live birth 0.2 0.4 0.5 -0.4 -0.7
Pulse wave peak to peak time 5.1 6.0 6.9 2.6 -2.2
Health satisfaction 7.9 10.3 10.8 -3.3 3.1
Shortness of breath walking on level ground 0.1 0.1 0.1 -0.0 0.4
Qualifications: College or University degree 0.2 0.6 1.1 -1.0 0.1
Eye problems/disorders: None of the above 0.5 0.6 0.8 0.9 -0.6
Mouth/teeth dental problems: Loose teeth 0.4 0.4 0.8 -0.2 0.9
Emphysema/chronic bronchitis 0.0 0.0 0.0 0.2 0.1
Medication for pain relief, constipation, heartburn 0.4 0.6 0.6 0.8 -0.8
Neck or shoulder pain in last month 4.0 5.7 5.7 -2.4 2.4
Medication: Blood pressure 0.2 0.3 0.3 -0.5 0.5
Angina (self-reported) 6.9 9.1 10.1 -3.2 2.9
Migraine (self-reported) 2.2 2.7 2.9 1.7 -1.6
Medication: Ibuprofen 0.0 0.0 0.0 -0.1 -0.1
Medication: Allopurinol 0.4 0.5 0.8 -0.9 0.4
Medication: Omeprazole 2.0 2.3 3.4 -1.8 1.1
Medication: Seretide 50 evohaler 0.2 0.2 0.4 0.6 -0.1
Mean time to correctly identify matches 1.1 2.0 2.2 1.4 -1.5
Heart disease (mother) 0.7 0.8 1.5 -1.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 -0.6 0.2
Whole body fat mass 4.1 17.1 18.5 -4.3 4.0
Leg fat mass (right) 5.7 22.0 23.3 -4.5 4.8
Arm predicted mass (right) 10.1 51.7 69.8 -8.4 5.8
Pulse rate, automated reading 0.0 0.1 0.1 -0.4 0.1
Alcohol intake frequency. 0.7 1.6 1.6 1.2 -1.3
Comparative height size at age 10 1.0 5.5 10.6 -3.3 -0.5
Number of full sisters 0.4 0.5 0.9 -0.2 1.0
Suffer from ‘nerves’ 0.5 0.7 1.3 1.1 -0.3
Overall health rating 2.5 5.4 5.9 -2.2 2.4
Chest pain or discomfort 2.9 4.2 5.2 -2.3 1.8
Had major operations 0.3 0.4 0.4 0.6 -0.6
Age at last live birth 0.3 0.5 1.0 -1.0 0.1
Family relationship satisfaction 0.1 0.1 0.1 -0.2 0.3
Leg pain on walking 0.1 0.1 0.2 0.4 0.0
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.8 0.9 -1.3
Commuting to job workplace: Car/motor vehicle 1.7 1.9 2.7 -1.1 1.6
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.1 -0.4
Medication: Aspirin 4.8 6.4 6.4 -2.5 2.5
Supplements: Vitamin C 1.7 2.0 2.5 -1.6 1.2
Knee pain experienced in last month 0.2 0.3 0.3 0.6 0.5
Hypertension (Self-reported) 0.3 0.7 1.0 1.0 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.5 -0.7 0.7
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.5 0.3
Illnesses of siblings: Diabetes 2.6 3.2 3.7 -1.7 1.9
Smoking status: Previous 5.3 7.9 9.1 3.0 -2.6
Forced expiratory volume in 1-second (FEV1), predicted 2.6 5.4 8.6 -2.9 1.5
Whole body fat-free mass 9.0 51.3 73.4 -8.6 5.4
Leg fat-free mass (right) 7.3 38.9 55.7 -7.5 4.7
Arm fat percentage (left) 1.2 4.7 6.3 -1.8 2.5
Average weekly red wine intake 1.4 2.0 2.7 -1.7 1.2
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.3 -0.5 0.3
Mood swings 0.2 0.4 0.8 0.9 0.1
Loneliness, isolation 0.5 0.6 1.1 0.4 1.0
Long-standing illness, disability or infirmity 7.5 11.4 11.8 -3.4 3.3
Ever had bowel cancer screening 0.6 0.7 1.0 -0.7 1.0
Diabetes diagnosed by doctor 4.9 8.0 9.2 -2.6 3.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 0.8 -0.3
Friendships satisfaction 0.6 0.7 1.3 -0.4 1.1
Qualifications: nursing, teaching 0.0 0.1 0.1 -0.2 0.3
Commuting to job workplace: Walk 0.7 0.7 1.4 0.2 -1.2
Eye problems/disorders: Cataract 4.4 5.1 5.2 -2.2 2.3
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 1.9 1.4 -0.9
Medication for cholesterol 0.0 0.1 0.1 -0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.9 3.4 4.2 2.0 -1.6
Back pain experienced in last month 1.1 1.6 1.9 -1.2 1.4
Mineral and other dietary supplements 3.5 4.7 5.2 2.3 -2.0
Breast cancer (self-reported) 1.2 1.4 1.7 1.1 -1.3
Asthma (self-reported) 0.8 1.6 1.7 -1.3 1.2
Osteoporosis (self-reported) 0.4 0.5 0.5 0.7 -0.7
Osteoarthritis (self-reported) 5.9 7.7 10.0 -2.3 3.2
Medication: Aspirin 5.7 7.5 8.0 -2.8 2.6
Medication: Gliclazide 3.1 3.5 4.3 -2.1 1.7
Illnesses of father: None of the above (group 1) 0.1 0.2 0.3 0.1 -0.6
Smoking status: Current 0.7 1.1 2.0 1.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 1.2 1.1 -1.1
Whole body water mass 8.9 50.7 72.6 -8.5 5.4
Leg predicted mass (right) 7.3 38.9 56.0 -7.5 4.7
Arm fat mass (left) 4.5 18.5 19.8 -4.5 4.2
Number of self-reported non-cancer illnesses 3.1 5.3 5.3 -2.3 2.3
Average weekly champagne plus white wine intake 0.1 0.1 0.3 -0.5 0.1
Miserableness 0.3 0.5 0.7 0.8 0.6
Guilty feelings 0.7 1.1 2.1 1.4 -0.3
Wears glasses or contact lenses 0.1 0.2 0.3 0.3 -0.5
Ever taken oral contraceptive pill 0.2 0.2 0.3 0.5 -0.4
Hearing aid user 0.1 0.1 0.2 -0.2 -0.5
Mother’s age at death 0.1 0.1 0.1 0.1 -0.4
Financial situation satisfaction 0.0 0.0 0.0 0.2 0.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.3 -1.1 0.6
Commuting to job workplace: Public transport 1.6 1.9 2.5 1.2 -1.6
Eye problems/disorders: Glaucoma 0.3 0.4 0.5 0.4 -0.7
Medication: Blood pressure 0.1 0.3 0.4 0.6 -0.4
Pain type(s) experienced in last month: Hip pain 3.0 3.7 4.8 -1.6 2.2
Supplements: Fish oil (including cod liver oil) 3.1 4.0 5.6 -2.4 1.6
High cholesterol (Self-reported) 0.3 0.5 0.6 -0.8 0.7
Medication: Bendroflumethiazide 0.4 0.6 0.7 0.7 -0.8
Medication: Paracetamol 0.2 0.3 0.5 -0.7 0.3
Medication: Lisinopril 0.1 0.1 0.1 -0.3 0.3
Medication: Atorvastatin 0.4 0.5 0.7 -0.9 0.5
Illnesses of father: High blood pressure 0.5 0.7 0.9 0.7 -0.9
Alcohol drinker status: Never 0.3 0.4 0.6 0.8 -0.4
Ever smoked 3.1 5.5 7.4 2.7 -1.9
Basal metabolic rate 9.0 49.8 69.7 -8.3 5.5
Leg fat percentage (left) 2.9 10.4 15.3 -2.4 3.9
Arm fat-free mass (left) 10.1 51.3 69.8 -8.4 5.7
Number of operations (self-reported) 0.6 1.0 1.1 1.1 -0.9
Average weekly beer plus cider intake 0.8 1.1 1.7 -0.7 1.3
Irritability 2.8 4.7 6.9 2.6 -1.6
Risk taking 3.0 4.4 5.0 -2.2 2.0
Ever had prostate specific antigen (PSA) test 4.4 5.1 5.9 2.4 -2.1
Fractured/broken bones in last 5 years 0.5 0.7 0.9 -0.7 0.9
Age started oral contraceptive pill 0.0 0.1 0.1 -0.3 0.1
Diastolic blood pressure, automated reading 0.1 0.3 0.5 -0.7 0.3
Ever depressed for a whole week 0.0 0.0 0.1 -0.3 0.1
Unable to work because of sickness or disability 0.0 0.0 0.0 0.1 0.2
Commuting to job workplace: Cycle 0.1 0.1 0.1 -0.4 -0.3
Myopia 3.3 4.7 5.5 -2.0 2.3
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.2 0.2 -0.4
Cholesterol lowering medication 1.7 2.5 2.6 -1.6 1.6
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 3.1 -1.8 0.9
Pain experienced in last month 1.3 2.1 2.1 1.5 -1.4
Supplements: Calcium 0.2 0.2 0.4 0.7 -0.2
Basal cell carcinoma (self-reported) 14.3 17.0 18.5 3.9 -4.3
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 -0.3 -0.1
Deep venous thrombosis (DVT) (self-reported) 3.3 4.2 6.6 -2.6 1.3
Heart disease (siblings) 1.5 1.8 2.6 -1.6 1.0
Alcohol drinker status: Previous 2.6 2.9 3.7 -1.9 1.5
Pack years of smoking 1.9 2.8 3.3 -1.8 1.5
Impedance of whole body 7.5 38.1 42.2 6.5 -5.8
Leg fat mass (left) 5.9 22.9 24.0 -4.7 4.9
Arm predicted mass (left) 11.4 58.1 77.6 -8.8 6.2