TWAS hub - RALY

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0883	0.0264	1.1e-16	0.155	0.133	0.145	0.138	0.146	2.3e-19	1.1e-16	3.7e-18	2.8e-17	2.7e-18
2	TCGA	Thyroid Carcinoma	0.0550	0.0320	5.2e-06	0.041	0.048	0.047	NA	0.046	7.2e-05	1.6e-05	2.0e-05	NA	2.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Tanning	91.6	1118.8	1239.0	-35.2	31.6
Hair Pigment	46.2	1318.5	1433.1	37.9	-34.7
Basal cell carcinoma (self-reported)	14.3	17.0	18.5	3.9	-4.3
Multivitamins +/- minerals	13.0	16.6	18.7	-4.3	3.8
Arm predicted mass (left)	11.4	58.1	77.6	-8.8	6.2
Vitamin and mineral supplements	11.3	15.3	16.6	4.1	-3.7
Arm fat-free mass (right)	11.3	57.8	77.6	-8.8	6.2
Breastfed as a baby	11.2	13.9	14.3	3.8	-3.7
Lung FVC	10.1	51.2	56.2	7.5	-6.8
Arm predicted mass (right)	10.1	51.7	69.8	-8.4	5.8
Arm fat-free mass (left)	10.1	51.3	69.8	-8.4	5.7
Trunk fat-free mass	9.3	53.2	77.8	-8.8	5.3
Trunk predicted mass	9.2	52.5	76.7	-8.8	5.3
Impedance of arm (left)	9.1	42.3	43.0	6.6	-6.5
Whole body fat-free mass	9.0	51.3	73.4	-8.6	5.4
Basal metabolic rate	9.0	49.8	69.7	-8.3	5.5
Whole body water mass	8.9	50.7	72.6	-8.5	5.4
Sitting height	8.2	58.0	93.5	-9.7	4.7
Health satisfaction	7.9	10.3	10.8	-3.3	3.1
Leg fat-free mass (left)	7.6	40.4	57.2	-7.6	4.9
Impedance of arm (right)	7.6	35.6	36.2	6.0	-5.9
Type 2 Diabetes (T2D) (2018)	7.5	14.1	15.7	-3.5	4.0
Leg predicted mass (left)	7.5	39.5	56.1	-7.5	4.8
Long-standing illness, disability or infirmity	7.5	11.4	11.8	-3.4	3.3
Impedance of whole body	7.5	38.1	42.2	6.5	-5.8
Weight	7.3	35.9	46.6	-6.8	5.0
Leg fat-free mass (right)	7.3	38.9	55.7	-7.5	4.7
Leg predicted mass (right)	7.3	38.9	56.0	-7.5	4.7
Type 2 Diabetes (T2D) (2012)	7.0	8.0	10.0	-3.2	2.5
Angina (self-reported)	6.9	9.1	10.1	-3.2	2.9
Pulse wave Arterial Stiffness index	6.8	8.0	10.1	-3.2	2.4
Severe depression (siblings)	6.7	7.4	9.2	-3.0	2.4
Body Mass Index (BMI) (2010)	6.2	8.5	8.7	-2.9	2.9
Lung FEV1/FVC ratio	6.2	31.6	42.9	-6.6	4.5
Osteoarthritis (self-reported)	5.9	7.7	10.0	-2.3	3.2
Leg fat mass (left)	5.9	22.9	24.0	-4.7	4.9
Angina	5.8	7.6	8.6	-2.9	2.6
Past tobacco smoking	5.8	10.7	13.5	-3.7	2.8
Hair/balding pattern: Pattern 4	5.8	14.0	18.3	-4.3	3.1
Leg fat mass (right)	5.7	22.0	23.3	-4.5	4.8
Medication: Aspirin	5.7	7.5	8.0	-2.8	2.6
Diabetes (self-reported)	5.3	8.3	9.5	-2.6	3.1
Smoking status: Previous	5.3	7.9	9.1	3.0	-2.6
Supplements: Glucosamine	5.2	6.8	7.8	-2.8	2.4
Hair/balding pattern: Pattern 2	5.2	6.6	7.8	2.8	-2.3
Hair/balding pattern: Pattern 3	5.2	7.8	10.4	-3.2	2.3
HDL Cholesterol	5.1	8.5	10.3	3.2	-2.6
Hip circumference	5.1	21.8	25.4	-5.0	4.3
Pulse wave peak to peak time	5.1	6.0	6.9	2.6	-2.2
Bipolar Disorder or Schizophrenia	5.0	12.2	12.5	-3.5	3.4
Heel T-Score	5.0	39.7	46.4	-6.8	5.7
BMI	5.0	29.2	31.3	-5.2	5.6
Arm fat mass (right)	4.9	20.0	20.9	-4.6	4.4
Diabetes diagnosed by doctor	4.9	8.0	9.2	-2.6	3.0
Allergy	4.8	11.1	13.4	3.7	-2.9
Medication: Aspirin	4.8	6.4	6.4	-2.5	2.5
Schizophrenia (2018)	4.7	9.8	10.0	-3.2	3.1
Body mass index (BMI)	4.7	20.2	22.5	-4.2	4.7
Arm fat mass (left)	4.5	18.5	19.8	-4.5	4.2
Impedance of leg (left)	4.4	21.2	27.4	5.2	-3.9
Eye problems/disorders: Cataract	4.4	5.1	5.2	-2.2	2.3
Ever had prostate specific antigen (PSA) test	4.4	5.1	5.9	2.4	-2.1
Relative age of first facial hair	4.3	8.9	11.6	3.4	-2.5
Respiratory disease	4.2	9.4	9.7	-3.1	3.0
Mean Putamen Volume	4.1	4.7	5.6	-2.4	1.9
Hayfever/allergic rhinitis (self-reported)	4.1	5.4	6.8	-2.6	2.0
Whole body fat mass	4.1	17.1	18.5	-4.3	4.0
Neck or shoulder pain in last month	4.0	5.7	5.7	-2.4	2.4
Bipolar Disorder (2011)	3.9	3.7	4.3	-2.1	1.8
High blood pressure (mother)	3.9	5.4	6.5	-2.5	2.1
Wheeze or whistling in the chest in last year	3.8	6.8	8.3	-2.3	2.9
Allergy or Eczema	3.7	9.8	12.6	-3.6	2.7
Hand grip strength (left)	3.7	9.6	15.5	-3.9	1.9
Impedance of leg (right)	3.7	18.1	23.2	4.8	-3.6
Blood White Count	3.6	27.0	29.0	-5.0	5.4
Alcohol intake versus 10 years previously	3.6	5.5	6.7	-2.6	2.0
Relative age voice broke	3.5	5.3	6.8	2.6	-2.0
Number of incorrect matches in round	3.5	5.8	6.2	2.5	-2.3
Mineral and other dietary supplements	3.5	4.7	5.2	2.3	-2.0
Hayfever, allergic rhinitis or eczema	3.4	7.3	9.2	-3.0	2.3
Waist circumference	3.3	12.2	13.0	-3.6	3.4
Mouth/teeth dental problems: Bleeding gums	3.3	4.3	5.2	2.3	-1.8
Blood clot in the leg (DVT)	3.3	4.2	6.8	-2.6	1.3
Myopia	3.3	4.7	5.5	-2.0	2.3
Deep venous thrombosis (DVT) (self-reported)	3.3	4.2	6.6	-2.6	1.3
Fasting Glucose	3.2	3.8	5.8	-2.4	1.4
Hand grip strength (right)	3.2	8.7	15.3	-3.9	1.5
Supplements: Zinc	3.1	3.3	4.3	-2.1	1.5
Medication: Gliclazide	3.1	3.5	4.3	-2.1	1.7
Number of self-reported non-cancer illnesses	3.1	5.3	5.3	-2.3	2.3
Supplements: Fish oil (including cod liver oil)	3.1	4.0	5.6	-2.4	1.6
Ever smoked	3.1	5.5	7.4	2.7	-1.9
Chronic bronchitis/emphysema (mother)	3.0	3.5	3.8	-1.8	1.9
Pain type(s) experienced in last month: Hip pain	3.0	3.7	4.8	-1.6	2.2
Risk taking	3.0	4.4	5.0	-2.2	2.0
Blood Platelet Count	2.9	33.2	35.5	-5.6	6.0
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.6	7.3	-2.7	2.4
Hearing difficulty/problems with background noise	2.9	4.6	6.3	-2.5	1.7
Illnesses of siblings	2.9	4.0	4.2	2.0	-2.0
Peak expiratory flow (PEF)	2.9	6.8	11.1	-3.3	1.6
Chest pain or discomfort	2.9	4.2	5.2	-2.3	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	4.2	2.0	-1.6
Leg fat percentage (left)	2.9	10.4	15.3	-2.4	3.9
Pulse wave reflection index	2.8	3.5	3.9	-2.0	1.8
Leg fat percentage (right)	2.8	10.2	14.9	-2.4	3.9
Irritability	2.8	4.7	6.9	2.6	-1.6
Diabetes (father)	2.7	3.4	4.1	-1.6	2.0
Trunk fat mass	2.6	11.4	13.5	-3.7	3.0
Standing height	2.6	25.8	48.9	-7.0	1.6
Illnesses of siblings: Diabetes	2.6	3.2	3.7	-1.7	1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.4	8.6	-2.9	1.5
Alcohol drinker status: Previous	2.6	2.9	3.7	-1.9	1.5
Overall health rating	2.5	5.4	5.9	-2.2	2.4
Rheumatoid Arthritis	2.4	3.3	3.6	1.9	-1.8
Schizophrenia (2014)	2.4	5.3	5.6	-2.2	2.4
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	4.9	-1.7	2.2
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	6.6	-2.6	1.9
Migraine (self-reported)	2.2	2.7	2.9	1.7	-1.6
Financial difficulties in last 2 years	2.1	2.8	3.7	-1.4	1.9
Noisy workplace	2.1	2.6	2.6	1.6	-1.6
Height	2.0	38.2	75.3	-8.7	1.0
Smoking Status	2.0	4.8	7.6	2.8	-1.4
Medication: Omeprazole	2.0	2.3	3.4	-1.8	1.1
Systolic blood pressure, automated reading	1.9	5.4	7.0	-2.6	1.9
Pack years of smoking	1.9	2.8	3.3	-1.8	1.5
Bipolar Disorder (2018)	1.8	2.8	3.0	-1.7	1.6
Nervous feelings	1.8	3.3	4.9	2.2	-1.3
Pain all over the body in last month	1.8	1.9	2.0	-1.4	1.4
Medication: Simvastatin	1.8	2.7	3.2	-1.8	1.5
Breast Cancer	1.7	4.1	4.2	-2.0	2.0
Neuroticism score	1.7	3.6	6.3	2.5	-1.0
Commuting to job workplace: Car/motor vehicle	1.7	1.9	2.7	-1.1	1.6
Supplements: Vitamin C	1.7	2.0	2.5	-1.6	1.2
Cholesterol lowering medication	1.7	2.5	2.6	-1.6	1.6
Reaction Time	1.6	3.1	3.3	1.7	-1.8
Chronotype (morning person)	1.6	3.6	5.7	-2.4	1.2
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	2.8	-1.7	0.9
Commuting to job workplace: Public transport	1.6	1.9	2.5	1.2	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	3.1	-1.8	0.9
Intelligence (Savage-Jansen 2018)	1.5	4.6	4.8	2.2	-2.1
Alzheimer’s Disease (in mother)	1.5	1.8	2.4	1.1	-1.5
Crohns Disease (2012)	1.5	2.4	2.9	1.4	-1.7
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.9	1.7	-0.9
Medication: Metformin	1.5	2.2	2.4	-1.4	1.5
Arm fat percentage (right)	1.5	6.1	7.8	-2.1	2.8
Heart disease (siblings)	1.5	1.8	2.6	-1.6	1.0
Triglycerides	1.4	2.2	3.1	-1.8	1.1
Worry too long after embarrassment	1.4	2.4	3.6	1.9	-1.1
Average weekly red wine intake	1.4	2.0	2.7	-1.7	1.2
Pack years adult smoking proportion	1.3	2.0	2.3	-1.5	1.3
Medication: Cholesterol lowering	1.3	2.1	2.4	-1.6	1.3
Pain experienced in last month	1.3	2.1	2.1	1.5	-1.4
Major Depression (MDD)	1.2	1.5	2.3	-0.8	1.5
Prostate Cancer	1.2	1.7	3.4	1.8	0.0
Forced vital capacity (FVC)	1.2	4.7	7.7	1.3	-2.8
Prospective memory result	1.2	1.5	1.8	-1.4	1.1
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.3	1.2	-1.5
Forced vital capacity (FVC), Best measure	1.2	4.4	7.7	1.1	-2.8
Number of full brothers	1.2	1.6	2.4	-1.5	0.9
Arm fat percentage (left)	1.2	4.7	6.3	-1.8	2.5
Breast cancer (self-reported)	1.2	1.4	1.7	1.1	-1.3
Alzheimer’s Disease (including proxy)	1.1	1.6	1.6	1.3	-1.3
Number of treatments/medications taken	1.1	2.0	2.7	-1.6	1.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.1	0.5	-1.4
Mouth/teeth dental problems: Dentures	1.1	1.9	2.9	-1.7	1.0
Tense / ‘highly strung’	1.1	1.9	2.7	1.7	-1.0
Body fat percentage	1.1	4.2	5.8	-1.6	2.4
Mean time to correctly identify matches	1.1	2.0	2.2	1.4	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.8	0.9	-1.3
Back pain experienced in last month	1.1	1.6	1.9	-1.2	1.4
Comparative height size at age 10	1.0	5.5	10.6	-3.3	-0.5
Mouth/teeth dental problems	0.9	1.4	1.8	-1.3	1.0
Neuroticism (Nagel 2018)	0.8	2.0	3.7	1.9	-0.5
Ulcerative Colitis	0.8	1.1	2.2	-1.5	0.3
Sensitivity / hurt feelings	0.8	1.3	2.2	1.5	-0.6
Had other major operations	0.8	0.9	1.3	0.7	-1.2
Medication: Ramipril	0.8	1.1	1.5	-0.8	1.2
Asthma	0.8	1.6	1.8	-1.3	1.2
Exposure to tobacco smoke outside home	0.8	1.1	1.6	1.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.8	-0.4	1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	1.9	1.4	-0.9
Asthma (self-reported)	0.8	1.6	1.7	-1.3	1.2
Average weekly beer plus cider intake	0.8	1.1	1.7	-0.7	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	1.9	1.3	-1.4
Waist Hip Ratio (WHR)	0.7	3.0	3.8	2.0	-1.5
Age when periods started (menarche)	0.7	1.6	2.2	1.5	-1.0
Chronic bronchitis/emphysema (father)	0.7	0.8	1.2	1.1	-0.7
Depression (self-reported)	0.7	0.8	1.5	0.4	1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.2	1.1	-1.1
Heart disease (mother)	0.7	0.8	1.5	-1.2	0.3
Alcohol intake frequency.	0.7	1.6	1.6	1.2	-1.3
Commuting to job workplace: Walk	0.7	0.7	1.4	0.2	-1.2
Smoking status: Current	0.7	1.1	2.0	1.4	-0.2
Guilty feelings	0.7	1.1	2.1	1.4	-0.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	-1.1	0.6
Ulcerative Colitis (UC)	0.6	1.0	1.7	-1.3	0.6
LDL Cholesterol	0.6	1.0	1.1	1.0	-1.0
Neuroticism	0.6	1.4	2.8	1.7	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.1	-1.0	0.6
Medication for hormone replacement therapy	0.6	0.7	0.9	-0.9	0.7
Trunk fat percentage	0.6	2.3	2.7	-1.4	1.6
Current tobacco smoking	0.6	1.0	2.1	1.4	-0.1
Qualifications: CSEs or equivalent	0.6	0.8	1.2	1.1	-0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.0	-0.7	1.0
Alcohol usually taken with meals	0.6	1.0	1.1	-0.9	1.1
Time employed in main current job	0.6	0.7	0.8	-0.9	0.7
Illnesses of mother	0.6	0.8	1.1	1.1	-0.6
Headache pain in last month	0.6	1.0	1.7	0.6	-1.3
Medication: Amlodipine	0.6	0.8	0.8	0.9	-0.9
Ever had bowel cancer screening	0.6	0.7	1.0	-0.7	1.0
Friendships satisfaction	0.6	0.7	1.3	-0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.2	1.1	-1.1
Number of operations (self-reported)	0.6	1.0	1.1	1.1	-0.9
Depression (Nagel 2018)	0.5	0.8	1.4	0.3	1.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	1.2	0.3
Diabetes (mother)	0.5	0.6	0.7	-0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	-0.6	0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	0.2	-1.4
Lung cancer (father)	0.5	0.6	1.2	-1.1	0.3
High blood pressure (siblings)	0.5	0.8	1.0	-1.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.9	-1.0	0.6
Eye problems/disorders: None of the above	0.5	0.6	0.8	0.9	-0.6
Suffer from ‘nerves’	0.5	0.7	1.3	1.1	-0.3
Loneliness, isolation	0.5	0.6	1.1	0.4	1.0
Illnesses of father: High blood pressure	0.5	0.7	0.9	0.7	-0.9
Fractured/broken bones in last 5 years	0.5	0.7	0.9	-0.7	0.9
Worry (Nagel 2018)	0.4	0.9	1.6	1.3	-0.4
Crohns Disease (2017)	0.4	0.9	0.9	0.9	-1.0
Age at First Birth	0.4	0.5	1.0	0.1	-1.0
Blood Eosinophil Count	0.4	2.8	3.1	-1.6	1.7
Hypothyroidism (self reported)	0.4	0.9	1.2	-1.1	0.8
Townsend deprivation index at recruitment	0.4	0.6	0.8	0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	0.9	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	0.2	1.1
Fluid intelligence score	0.4	0.9	1.2	1.1	-0.8
Gout (self-reported)	0.4	0.5	0.8	-0.9	0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.6	0.8	-0.6
Comparative body size at age 10	0.4	1.1	1.6	-1.3	0.8
Number of children fathered	0.4	0.4	0.6	-0.5	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	-0.2	0.9
Medication for pain relief, constipation, heartburn	0.4	0.6	0.6	0.8	-0.8
Medication: Allopurinol	0.4	0.5	0.8	-0.9	0.4
Number of full sisters	0.4	0.5	0.9	-0.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.5	-0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.8	-0.3
Osteoporosis (self-reported)	0.4	0.5	0.5	0.7	-0.7
Medication: Bendroflumethiazide	0.4	0.6	0.7	0.7	-0.8
Medication: Atorvastatin	0.4	0.5	0.7	-0.9	0.5
Neuroticism (2016)	0.3	0.5	1.0	1.0	-0.1
Cardiovascular Disease	0.3	0.9	1.1	-0.8	1.1
Medication: Co-codamol	0.3	0.3	0.4	-0.6	0.6
Taking other prescription medications	0.3	0.4	0.6	-0.8	0.4
Had menopause	0.3	0.4	0.6	0.5	-0.8
Falls in the last year	0.3	0.4	0.6	-0.4	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.8	-0.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.8	-0.2	-1.3
Had major operations	0.3	0.4	0.4	0.6	-0.6
Age at last live birth	0.3	0.5	1.0	-1.0	0.1
Hypertension (Self-reported)	0.3	0.7	1.0	1.0	-0.7
Miserableness	0.3	0.5	0.7	0.8	0.6
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	0.4	-0.7
High cholesterol (Self-reported)	0.3	0.5	0.6	-0.8	0.7
Alcohol drinker status: Never	0.3	0.4	0.6	0.8	-0.4
Depressed Affect (Nagel 2018)	0.2	0.5	0.5	0.7	0.7
Coronary Artery Disease (CAD)	0.2	0.3	0.3	-0.5	0.6
Lupus	0.2	0.3	0.6	-0.8	-0.1
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.3	0.7
Blood Red Count	0.2	2.1	3.0	-1.7	1.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.6	0.0
Medication: Atenolol	0.2	0.2	0.4	-0.6	0.3
Worrier / anxious feelings	0.2	0.4	0.6	-0.4	0.8
Happiness	0.2	0.2	0.4	-0.1	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	0.7	-0.2
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.4	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	0.4	-0.6
Age at first live birth	0.2	0.4	0.5	-0.4	-0.7
Qualifications: College or University degree	0.2	0.6	1.1	-1.0	0.1
Medication: Blood pressure	0.2	0.3	0.3	-0.5	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.6	0.2
Knee pain experienced in last month	0.2	0.3	0.3	0.6	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.5	0.3
Mood swings	0.2	0.4	0.8	0.9	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.5	-0.4
Medication: Paracetamol	0.2	0.3	0.5	-0.7	0.3
Supplements: Calcium	0.2	0.2	0.4	0.7	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.2	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	0.0
Systolic Blood Pressure	0.1	0.3	0.5	-0.7	-0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.1	-0.2	-0.4
Average weekly fortified wine intake	0.1	0.1	0.2	-0.4	0.2
Fed-up feelings	0.1	0.1	0.2	0.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.5	-0.3
High blood pressure	0.1	0.3	0.5	0.7	-0.4
Medication: Levothyroxine sodium	0.1	0.2	0.2	-0.5	0.4
Qualifications: None of the above	0.1	0.3	0.5	0.2	0.7
Pulse rate	0.1	0.1	0.2	-0.4	-0.1
Birth weight of first child	0.1	0.1	0.2	0.5	-0.1
Medication: Paracetamol	0.1	0.1	0.1	-0.4	0.4
Glaucoma (self-reported)	0.1	0.1	0.1	0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	-0.4	0.3
Birth weight	0.1	0.2	0.3	-0.5	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.0	0.4
Family relationship satisfaction	0.1	0.1	0.1	-0.2	0.3
Leg pain on walking	0.1	0.1	0.2	0.4	0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.1	-0.4
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	0.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.1	-0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.5	0.1
Wears glasses or contact lenses	0.1	0.2	0.3	0.3	-0.5
Hearing aid user	0.1	0.1	0.2	-0.2	-0.5
Mother’s age at death	0.1	0.1	0.1	0.1	-0.4
Medication: Blood pressure	0.1	0.3	0.4	0.6	-0.4
Medication: Lisinopril	0.1	0.1	0.1	-0.3	0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.4	-0.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.3	-0.2
Ovarian Cancer	0.0	0.0	0.1	-0.0	-0.2
HbA1C	0.0	0.0	0.0	-0.1	-0.0
Average weekly spirits intake	0.0	0.0	0.1	0.3	-0.0
Maternal smoking around birth	0.0	0.0	0.0	0.2	0.2
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.2	0.3
Heart attack	0.0	0.1	0.1	-0.3	0.0
Father’s age at death	0.0	0.0	0.1	-0.0	-0.2
Number of live births	0.0	0.0	0.0	0.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.0	-0.0
Medication: Lansoprazole	0.0	0.1	0.1	0.3	-0.1
Length of working week for main job	0.0	0.0	0.0	0.1	-0.2
Loud music exposure frequency	0.0	0.0	0.1	0.2	-0.2
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.2	0.1
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	-0.1
Pulse rate, automated reading	0.0	0.1	0.1	-0.4	0.1
Qualifications: nursing, teaching	0.0	0.1	0.1	-0.2	0.3
Medication for cholesterol	0.0	0.1	0.1	-0.2	0.3
Financial situation satisfaction	0.0	0.0	0.0	0.2	0.1
Age started oral contraceptive pill	0.0	0.1	0.1	-0.3	0.1
Ever depressed for a whole week	0.0	0.0	0.1	-0.3	0.1
Unable to work because of sickness or disability	0.0	0.0	0.0	0.1	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

RALY

Models

Trait associations