Best TWAS P=4.3e-16 · Best GWAS P=3.47e-18 conditioned to 0.00121
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RANBP17 | 0.10 | 0.14 | lasso | 3 | 0.13 | 1.4e-15 | -7.0 | 7.2 | 4.2e-13 | -0.92 | 0.32 | 0.68 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RANBP17 | 0.26 | 0.19 | lasso | 5 | 0.14 | 9.7e-05 | -7.0 | 7.0 | 2.6e-12 | -0.87 | 0.33 | 0.52 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | RANBP17 | 0.20 | 0.04 | lasso | 5 | 0.05 | 1.6e-02 | -7.0 | 7.2 | 4.2e-13 | -0.89 | 0.06 | 0.78 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RANBP17 | 0.12 | 0.02 | lasso | 2 | 0.02 | 3.5e-02 | -7.1 | 6.9 | 5.8e-12 | -0.89 | 0.14 | 0.75 | FALSE |
| 5 | GTEx | Uterus | NPM1 | 0.31 | 0.17 | lasso | 9 | 0.09 | 7.4e-03 | -7.0 | 7.0 | 3.5e-12 | -0.89 | 0.13 | 0.29 | FALSE |
| 6 | METSIM | Adipose | RANBP17 | 0.08 | 0.06 | blup | 710 | 0.06 | 1.5e-09 | -7.0 | 6.5 | 9.3e-11 | -0.79 | 0.76 | 0.24 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RANBP17 | 0.02 | 0.00 | blup | 135 | 0.01 | 3.7e-04 | -8.7 | 8.1 | 4.3e-16 | -0.88 | 0.02 | 0.92 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RANBP17 | 0.03 | 0.06 | lasso | 4 | 0.05 | 8.1e-06 | -7.1 | 7.0 | 2.0e-12 | -0.89 | 0.26 | 0.74 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RANBP17 | 0.09 | 0.09 | blup | 135 | 0.06 | 5.0e-03 | -7.0 | 5.1 | 2.8e-07 | -0.78 | 0.13 | 0.52 | FALSE |