Best TWAS P=5.11e-12 · Best GWAS P=4.32e-17 conditioned to 0.00102
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM114A2 | 0.28 | 0.39 | lasso | 9 | 0.41 | 1.8e-53 | -6.5 | 6.8 | 9.9e-12 | 0.22 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | GALNT10 | 0.08 | 0.01 | blup | 568 | 0.04 | 1.6e-05 | 6.6 | -6.1 | 1.2e-09 | -0.33 | 0.71 | 0.05 | FALSE |
3 | GTEx | Adipose Visceral Omentum | GALNT10 | 0.14 | 0.10 | lasso | 6 | 0.11 | 1.7e-06 | 5.0 | -5.3 | 1.3e-07 | -0.42 | 0.96 | 0.01 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | GALNT10 | 0.31 | 0.07 | enet | 18 | 0.11 | 5.2e-04 | -6.1 | -6.6 | 5.3e-11 | -0.61 | 0.04 | 0.68 | TRUE |
5 | GTEx | Muscle Skeletal | FAM114A2 | 0.06 | 0.03 | lasso | 2 | 0.04 | 1.2e-04 | -6.6 | 6.4 | 1.4e-10 | 0.18 | 0.80 | 0.01 | FALSE |
6 | GTEx | Pancreas | SAP30L | 0.13 | 0.02 | enet | 20 | 0.03 | 3.0e-02 | -6.4 | 6.1 | 1.3e-09 | 0.17 | 0.13 | 0.05 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | GALNT10 | 0.09 | 0.06 | lasso | 2 | 0.05 | 3.5e-05 | 5.1 | -5.2 | 2.5e-07 | -0.42 | 0.94 | 0.02 | FALSE |
8 | NTR | Blood | FAM114A2 | 0.04 | 0.03 | lasso | 10 | 0.02 | 8.9e-08 | -6.5 | 6.7 | 2.6e-11 | 0.18 | 1.00 | 0.00 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | FAM114A2 | 0.05 | 0.06 | lasso | 6 | 0.05 | 6.3e-07 | -6.9 | 6.9 | 5.1e-12 | 0.29 | 0.98 | 0.00 | TRUE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | FAM114A2 | 0.07 | 0.09 | blup | 54 | 0.06 | 9.1e-03 | -6.6 | -6.5 | 1.0e-10 | -0.16 | 0.02 | 0.65 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM114A2 | 0.03 | 0.02 | blup | 55 | 0.02 | 1.6e-03 | -3.9 | -6.0 | 1.9e-09 | -0.13 | 0.04 | 0.72 | FALSE |
12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FAM114A2 | 0.07 | 0.06 | blup | 56 | 0.06 | 1.5e-03 | -6.3 | -6.6 | 3.4e-11 | -0.15 | 0.03 | 0.62 | FALSE |