Best TWAS P=1.83e-10 · Best GWAS P=2.53e-10 conditioned to 8.6e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TRIM35 | 0.22 | 0.19 | lasso | 7 | 0.21 | 8.4e-25 | 6.1 | -6.4 | 1.8e-10 | 0.02 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Brain Cortex | ELP3 | 0.41 | 0.12 | enet | 20 | 0.11 | 6.2e-04 | 4.1 | 5.2 | 1.7e-07 | 0.71 | 0.02 | 0.91 | TRUE |
| 3 | NTR | Blood | TRIM35 | 0.06 | 0.06 | enet | 8 | 0.07 | 9.2e-21 | 4.5 | 5.2 | 1.7e-07 | -0.05 | 0.84 | 0.15 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | PTK2B | 0.07 | 0.07 | lasso | 3 | 0.06 | 2.3e-04 | 4.6 | -5.3 | 9.1e-08 | -0.01 | 0.02 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TRIM35 | 0.12 | 0.05 | blup | 58 | 0.06 | 4.0e-07 | 6.1 | -5.2 | 1.9e-07 | 0.03 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PTK2B | 0.04 | 0.00 | blup | 143 | 0.02 | 9.9e-03 | 5.2 | -5.8 | 6.2e-09 | -0.04 | 0.02 | 0.58 | FALSE |