Hub : Genes

PTK2B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1104	0.0455	3.0e-03	0.015	NA	0.003	NA	0.016	2.4e-02	NA	1.7e-01	NA	2.0e-02
2	GTEx	Esophagus Muscularis	0.1880	0.0660	1.9e-03	0.188	NA	0.175	NA	0.188	1.4e-11	NA	8.3e-11	NA	1.4e-11
3	GTEx	Testis	0.1770	0.0580	1.2e-03	0.110	NA	0.061	NA	0.074	1.4e-05	NA	1.1e-03	NA	3.6e-04
4	METSIM	Adipose	0.0534	0.0187	3.7e-04	0.012	0.012	0.003	0.011	0.003	6.2e-03	4.6e-03	9.1e-02	7.7e-03	1.1e-01
5	NTR	Blood	0.0310	0.0126	1.9e-03	0.023	0.006	0.007	0.012	0.021	3.9e-08	2.6e-03	1.9e-03	7.5e-05	2.1e-07
6	YFS	Blood	0.0861	0.0195	1.3e-15	0.075	0.058	0.083	0.082	0.090	1.6e-23	2.9e-18	7.8e-26	1.3e-25	7.8e-28
7	TCGA	Colon Adenocarcinoma	0.0720	0.0390	1.6e-03	0.073	0.042	0.037	NA	0.060	5.1e-05	1.8e-03	3.4e-03	NA	2.3e-04
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0847	0.0472	1.2e-03	0.065	0.017	0.026	NA	0.054	8.2e-08	4.8e-03	5.5e-04	NA	9.4e-07
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2810	0.0970	1.2e-04	0.042	0.032	0.018	NA	0.018	1.9e-03	5.9e-03	3.1e-02	NA	2.9e-02
10	TCGA	Thyroid Carcinoma	0.0440	0.0280	8.2e-03	0.002	0.016	0.014	NA	0.000	2.0e-01	9.9e-03	1.4e-02	NA	3.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.8	2.1	-1.5	-0.8	0.8	1.1	0.7	0.8	1.0	0.7	0.4	0.4
Bipolar Disorder or Schizophrenia	1.2	3.0	8.0	-2.3	-0.0	1.7	2.8	0.9	1.3	2.6	0.4	1.5	1.4
Depressed Affect (Nagel 2018)	1.5	3.2	6.8	1.6	-0.1	-2.0	-1.5	-1.8	-2.0	-2.6	-1.0	-1.2	-2.6
Depression (Nagel 2018)	0.8	1.3	2.9	1.5	1.3	1.1	-1.0	0.5	0.5	-1.6	-0.2	0.6	-1.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.2	0.5	-0.8	0.7	-0.4	-0.6	0.2	0.5	0.2	0.4
Neuroticism (Nagel 2018)	1.0	2.5	6.2	0.7	0.2	-2.2	-1.7	-1.4	-1.6	-2.1	-0.2	-1.1	-2.5
Schizophrenia (2018)	1.2	2.5	7.5	-1.7	0.6	1.5	2.7	0.5	1.0	2.5	-0.0	1.6	1.5
Schizophrenia vs Biploar Disorder	1.1	1.5	3.4	-1.9	-1.7	-0.2	1.8	0.3	0.2	1.8	0.9	0.3	1.1
Worry (Nagel 2018)	0.3	0.7	1.9	-0.1	0.4	-1.4	-0.5	-0.7	-0.9	-0.9	-0.2	-0.9	-1.3
Alzheimer’s Disease (in mother)	2.7	3.2	11.8	1.1	0.8	1.5	-0.8	3.4	3.0	-1.0	2.3	0.7	-0.1
Alzheimer’s Disease (in father)	2.7	2.9	10.5	0.7	0.6	1.3	-0.2	3.2	2.9	-0.5	2.1	1.5	-0.8
Alzheimer’s Disease (including proxy)	9.9	14.4	60.9	0.4	-0.1	2.1	-1.0	7.8	6.7	-0.6	5.5	1.2	-0.4
Crohns Disease (2017)	1.9	4.2	13.1	1.7	0.8	-0.8	0.0	-3.6	-3.0	-2.0	-3.1	-0.9	-1.2
Irritable Bowel Disease (IBD)	2.1	5.1	13.2	1.9	1.3	-0.7	-1.1	-3.6	-2.9	-2.5	-3.1	-1.6	-2.0
Ulcerative Colitis (UC)	0.8	1.4	2.8	0.6	0.9	-0.4	-1.3	-1.7	-1.2	-1.4	-1.3	-1.3	-1.3
Major Depression (MDD)	0.8	0.9	2.9	0.1	0.5	-0.5	1.3	-1.5	-1.7	0.6	-0.8	0.7	0.6
Reaction Time	0.2	0.4	2.0	0.4	0.8	-0.2	-0.1	-0.3	-0.1	-0.2	-0.9	-1.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.2	-1.3	-0.0	-1.7	2.0	-0.4	-1.0	1.8	0.9	1.6	2.3
Breast Cancer	0.2	0.6	1.4	-0.2	-0.8	-1.2	-1.2	-0.7	-1.2	-0.6	0.2	-0.2	0.2
Ovarian Cancer	0.6	0.8	2.4	0.1	0.5	1.5	1.0	-0.8	-0.1	1.3	-1.1	0.3	1.1
Prostate Cancer	0.9	1.3	5.9	-1.3	-2.4	0.9	-0.1	1.1	1.2	1.3	0.5	-0.2	0.3
Age at First Birth	0.2	0.3	1.6	-0.6	-0.4	0.2	0.2	-0.1	-0.2	0.8	0.1	1.3	0.4
Bipolar Disorder (2011)	0.9	0.9	4.0	2.0	0.1	0.8	-0.8	-1.0	-0.5	-1.2	0.0	-0.0	-1.0
Body Mass Index (BMI) (2010)	1.1	1.6	4.5	2.0	-0.2	-0.3	-1.4	-0.7	-0.6	-1.9	-0.7	-0.4	-2.1
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-0.8	0.3	0.8	1.3	0.6	1.0	1.1	0.2	-0.3	0.6
Crohns Disease (2012)	1.4	2.3	9.3	1.7	0.8	0.1	-0.1	-3.1	-2.4	-1.6	0.0	-0.9	-0.7
Mean Putamen Volume	1.2	1.4	3.6	-1.9	-1.7	-0.7	1.9	-0.2	-0.4	1.4	0.1	-0.9	0.7
Fasting Glucose	1.0	1.3	2.6	-0.6	-1.4	1.6	-0.0	1.1	1.6	1.3	1.4	0.7	-0.1
HbA1C	1.0	1.1	2.5	-0.8	-1.2	1.4	1.1	0.0	0.7	1.5	1.6	0.4	0.8
HDL Cholesterol	0.2	0.3	0.7	-0.6	0.5	-0.7	0.6	-0.6	-0.9	0.1	0.5	-0.3	-0.2
LDL Cholesterol	0.1	0.2	0.7	-0.6	0.3	0.1	0.6	0.0	-0.4	0.6	0.5	-0.0	0.9
Lupus	0.3	0.4	2.1	1.5	0.0	-0.3	-0.8	0.2	-0.2	-1.0	0.4	0.3	-0.3
Neuroticism (2016)	4.1	6.0	15.1	2.6	2.2	-1.7	-3.4	-0.9	-1.3	-3.6	-0.6	-1.8	-3.9
Primary Biliary Cirrhosis	0.8	1.1	2.3	1.5	1.5	0.5	-0.5	0.8	0.9	-1.3	0.5	-0.6	-1.4
Rheumatoid Arthritis	0.5	0.7	2.2	-0.9	-0.4	-1.5	0.2	-0.0	-0.6	-0.1	1.1	1.4	-0.3
Schizophrenia (2014)	1.6	3.5	10.0	-2.1	0.1	2.4	3.2	0.9	1.7	2.7	-0.1	0.9	1.7
Triglycerides	0.4	0.7	2.1	-0.8	0.1	0.8	-0.9	1.4	1.4	-0.1	0.5	-0.8	-0.3
Type 2 Diabetes (T2D) (2012)	1.3	1.6	3.6	1.9	1.0	1.0	-1.9	0.0	0.6	-1.9	-0.7	-0.6	-1.3
Ulcerative Colitis	2.0	2.9	6.8	1.7	0.7	-0.1	-2.1	-1.9	-1.5	-2.6	0.0	-2.0	-2.2
Blood Eosinophil Count	1.7	12.8	42.2	-4.0	0.2	-0.9	4.3	-0.6	-1.1	5.9	2.0	2.9	6.5
Blood Platelet Count	0.8	9.7	21.8	2.7	1.0	-0.8	-1.6	-4.7	-3.6	-3.5	-4.2	-3.4	-3.2
Blood Red Count	0.2	1.5	4.0	1.4	-0.8	0.0	-1.7	-0.7	-0.3	-1.3	-1.5	-1.0	-2.0
Blood White Count	1.6	12.1	46.8	-0.8	-0.7	-4.7	0.8	-6.3	-6.8	0.7	-2.4	0.2	2.0
Heel T-Score	0.3	2.7	9.7	0.7	1.8	-3.1	1.5	-1.5	-2.3	-0.3	-0.4	1.8	0.5
BMI	2.9	16.9	33.8	3.9	-0.1	-1.9	-3.9	-4.3	-3.7	-5.3	-3.9	-5.1	-5.8
Height	0.1	2.2	5.5	-1.0	-0.7	-0.2	-1.1	2.3	2.0	-0.7	1.8	-2.0	-1.4
Waist Hip Ratio (WHR)	0.9	4.2	11.8	1.3	0.5	1.5	-1.6	-1.8	-0.4	-1.5	-3.1	-3.4	-2.8
Systolic Blood Pressure	0.7	3.3	14.5	-0.2	3.8	-0.7	1.2	-0.5	-0.8	1.2	0.5	2.7	2.6
Smoking Status	1.0	2.4	9.9	-3.2	-2.2	0.1	-0.1	0.1	0.3	2.6	0.3	-1.5	0.4
Allergy or Eczema	0.9	2.4	5.7	-1.4	0.3	0.2	2.4	1.4	1.1	1.7	1.5	1.8	2.1
Cardiovascular Disease	0.6	2.1	7.0	0.1	-0.7	-2.5	-0.4	-2.4	-2.6	-0.8	-0.6	-0.2	-0.7
Hypothyroidism (self reported)	0.7	1.5	3.9	-1.6	-0.1	-1.5	2.0	-0.0	-0.5	1.7	1.1	0.3	1.3
Respiratory disease	0.1	0.3	0.9	-0.3	0.3	0.2	0.7	-0.9	-0.7	0.3	-0.7	0.0	0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.0	2.1	1.2	1.2	-0.4	-0.1	-1.3	-1.1	-1.5	-1.1	-0.9	-0.7
Lung FEV1/FVC ratio	1.0	5.1	13.9	-1.1	-3.3	-0.5	-1.0	3.7	3.0	-0.4	2.8	-1.0	-2.3
Lung FVC	0.0	0.2	0.5	0.7	-0.7	-0.3	-0.3	0.2	0.0	-0.6	0.3	0.5	-0.5
Neuroticism	0.7	1.7	4.2	0.4	-0.2	-1.8	-1.2	-1.1	-1.3	-1.6	-0.4	-1.5	-2.1
Chronotype (morning person)	1.4	3.3	14.2	-0.2	-1.4	-3.8	-0.7	-2.1	-3.1	-1.0	0.5	-0.1	-1.1
Hair Pigment	0.1	2.3	4.3	2.1	1.1	-0.2	-1.5	-1.5	-1.1	-2.0	-2.0	-1.1	-1.7
Tanning	0.0	0.6	1.9	-0.9	0.3	-0.5	0.8	1.4	1.0	0.3	1.1	-0.1	-0.4
Hand grip strength (left)	0.5	1.4	4.7	0.7	-1.0	0.2	-1.4	1.1	1.2	-1.5	0.0	-1.0	-2.2
Number of treatments/medications taken	1.2	2.1	6.2	0.6	-2.1	-1.0	-0.2	-2.5	-2.3	-0.3	-1.5	-1.1	-0.6
Average weekly spirits intake	0.3	0.4	1.0	0.1	-0.4	0.2	-0.8	1.0	0.8	-0.2	1.0	-0.0	-0.4
Sensitivity / hurt feelings	2.8	4.8	17.2	1.1	-0.3	-0.3	-3.1	-1.5	-0.7	-1.9	-1.8	-4.2	-3.2
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.5	1.6	0.7	1.2	-1.3	1.6	1.5	-1.0	0.4	1.0	-1.4
Hearing difficulty/problems: Yes	3.8	5.8	9.8	2.8	1.3	2.2	-3.1	-1.2	0.1	-2.6	-3.0	-2.7	-3.1
Relative age of first facial hair	0.7	1.5	5.0	0.4	1.3	2.2	-0.7	-0.2	1.0	-0.7	-2.1	-1.2	-0.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.5	-0.5	-0.8	-1.0	-1.2	-1.5	-1.3	-0.8	-0.8	-1.9	-2.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.8	-0.7	0.7	0.6	-0.3	-0.2	0.6	-0.0	0.6	-0.2
Ever had hysterectomy (womb removed)	1.3	1.5	5.2	-1.1	-0.7	-0.8	1.1	0.3	-0.1	2.3	1.0	1.9	1.1
Systolic blood pressure, automated reading	0.8	2.4	8.1	1.2	2.9	-1.9	0.6	-1.6	-2.0	-0.5	-0.1	1.3	1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.6	0.3	-0.4	1.6	-0.1	-0.1	0.6	-0.1	-1.3	-0.9	-0.3
Angina	0.8	1.0	2.6	-1.0	-1.4	-1.6	1.0	-1.2	-1.3	0.6	-0.1	-0.2	-0.3
Medication for hormone replacement therapy	0.3	0.4	1.5	-0.3	0.0	0.3	0.8	-0.7	-0.5	0.4	-0.5	1.2	0.3
Vitamin and mineral supplements	0.4	0.5	1.4	-0.4	-0.4	-1.2	0.4	-0.9	-1.0	0.6	-0.1	0.8	0.9
Supplements: Zinc	1.5	1.6	4.9	-1.1	-0.5	1.8	-0.0	2.0	2.2	0.9	0.9	1.0	-0.1
Medication: Co-codamol	1.7	1.9	5.9	0.7	1.5	0.6	-1.7	-1.7	-0.5	-0.4	-2.4	-1.8	-0.7
Medication: Metformin	0.7	0.9	2.8	0.8	-0.1	-0.7	1.0	-1.7	-1.4	-0.6	-1.1	-0.8	-0.1
Diabetes (father)	1.8	2.2	7.3	1.3	1.0	-0.5	-1.2	-2.7	-2.3	-0.7	-2.1	0.0	-0.2
Diabetes (mother)	0.4	0.5	1.6	0.3	-0.2	0.2	-1.0	-0.9	-0.8	0.2	-0.8	-1.2	0.0
Severe depression (siblings)	1.6	1.8	3.7	1.9	0.9	1.9	-1.3	-0.0	0.8	-1.2	-1.6	-0.2	-1.8
Pack years adult smoking proportion	2.8	4.3	10.2	1.7	0.7	0.2	-1.3	-2.1	-1.3	-2.3	-3.1	-2.6	-3.2
Impedance of leg (right)	0.0	0.2	0.9	0.5	0.1	0.3	0.3	-0.2	-0.4	-0.2	0.2	1.0	-0.3
Leg fat-free mass (left)	0.2	0.9	2.0	-0.1	-0.2	-1.4	-1.2	-0.3	-0.6	-1.1	-0.0	-1.4	-1.3
Trunk fat percentage	1.8	7.3	13.0	1.8	-0.1	-1.3	-2.9	-3.6	-3.0	-2.7	-3.1	-3.4	-2.9
Hand grip strength (right)	0.5	1.5	4.3	-0.1	-1.4	1.2	-0.5	2.1	2.0	-0.5	0.7	-0.2	-1.4
Townsend deprivation index at recruitment	1.5	2.1	7.3	0.9	-0.5	1.0	-0.3	-1.5	-0.6	-0.8	-2.7	-2.1	-2.0
Current tobacco smoking	1.2	1.9	4.9	-1.0	-1.3	2.2	-0.8	1.1	1.8	0.2	-0.4	-1.7	-1.8
Average weekly fortified wine intake	0.2	0.2	1.1	0.3	-1.0	-0.2	-0.6	0.1	-0.0	0.1	0.6	-0.5	-0.1
Maternal smoking around birth	1.4	2.1	8.2	-2.9	-2.5	0.1	0.3	0.1	-0.1	2.0	0.9	-0.4	1.1
Fed-up feelings	0.6	1.1	2.7	1.0	-0.3	-1.3	-1.6	-0.8	-1.0	-1.4	-0.3	0.5	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.2	1.5	0.2	1.0	-1.4	0.8	0.7	-1.5	-0.0	0.4	-1.8
Relative age voice broke	2.5	3.8	14.4	1.1	1.0	3.8	-0.3	2.5	3.7	-0.0	-0.9	-0.8	-0.7
Taking other prescription medications	2.3	3.6	10.6	0.9	-0.6	-0.5	-0.4	-3.3	-2.5	-1.1	-2.7	-2.4	-1.7
Age when periods started (menarche)	1.2	2.8	15.2	0.2	0.8	3.9	0.2	1.7	2.8	0.4	-0.9	-0.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.6	0.2	-1.3	-0.1	-0.8	0.5	0.5	0.9	0.2	0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.5	-0.8	-1.9	-1.6	0.6	-0.3	-0.7	0.7	0.4	0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.8	1.0	0.0	1.7	-0.7	0.6	0.9	0.3	0.2	-0.2	0.6
Qualifications: CSEs or equivalent	1.3	1.7	6.1	1.3	0.9	0.2	-1.8	0.9	0.7	-1.8	0.4	-0.3	-2.5
Serious illness, injury or assault to yourself	2.0	2.5	7.4	1.1	1.2	1.1	-2.2	-0.0	0.7	-1.8	-1.3	-1.7	-2.7
High blood pressure	1.2	3.3	12.5	0.8	0.2	-2.9	-0.2	-3.1	-3.5	-0.6	-1.0	0.3	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.6	-0.7	1.0	-0.5	1.2	0.6	0.4	1.2	0.8	1.2	1.6
Multivitamins +/- minerals	1.5	2.0	4.3	2.0	1.3	2.1	-1.0	0.7	1.3	-1.3	-0.6	-1.0	-2.0
Stomach or abdominal pain in last month	0.7	0.8	2.6	-0.3	-0.0	1.0	-1.1	1.4	1.6	-0.0	0.3	-0.9	-0.5
Supplements: Glucosamine	0.6	0.8	1.7	0.4	-1.3	0.3	-0.3	1.1	1.3	-1.0	0.1	-0.9	-1.3
Diverticular disease/diverticulitis (self-reported)	2.6	3.0	8.4	2.4	0.4	0.9	-0.9	-0.9	-0.7	-2.9	-1.3	-1.9	-2.8
Medication: Atenolol	1.1	1.3	4.4	-0.9	-0.2	-0.6	1.4	1.4	1.0	1.3	2.1	0.9	0.6
Medication: Levothyroxine sodium	0.5	0.8	2.4	-1.0	-0.1	0.0	1.2	0.5	0.4	1.5	0.9	0.5	1.2
Sitting height	0.1	0.8	1.9	-1.1	-0.1	1.1	-0.6	1.2	1.4	0.5	0.5	-1.2	-0.1
Chronic bronchitis/emphysema (father)	0.8	0.9	4.8	-2.2	-1.1	-0.8	0.5	-0.5	-0.5	1.2	0.5	-0.6	0.2
High blood pressure (mother)	0.5	0.7	2.5	0.7	1.6	-0.4	0.1	-0.6	-0.7	0.5	-0.2	1.5	0.9
Body mass index (BMI)	1.6	6.7	11.2	1.7	-0.8	-1.8	-2.9	-3.3	-3.0	-2.6	-2.7	-3.2	-2.7
Impedance of leg (left)	0.1	0.3	1.2	0.8	0.1	1.1	-0.1	-0.0	0.3	-0.3	-0.6	0.7	-0.5
Leg predicted mass (left)	0.2	1.0	2.4	-0.0	-0.1	-1.5	-1.2	-0.5	-0.7	-1.1	-0.1	-1.4	-1.3
Trunk fat mass	1.6	6.8	12.5	1.6	-0.3	-1.6	-3.0	-3.2	-2.8	-2.8	-2.6	-3.5	-3.0
Waist circumference	2.5	9.3	16.9	2.2	-0.3	-1.2	-3.3	-3.8	-3.0	-3.1	-3.6	-4.1	-3.5
Number of incorrect matches in round	0.6	0.9	1.8	1.0	1.3	-1.0	-0.2	-1.0	-1.3	-1.3	0.3	0.9	-0.2
Past tobacco smoking	0.9	1.7	7.0	2.6	1.1	0.8	0.7	-0.2	0.0	-2.1	-1.2	1.2	-0.8
Alcohol usually taken with meals	1.1	1.8	8.2	2.3	0.7	-0.3	-1.2	0.1	-0.1	-2.9	0.1	0.3	-1.5
Nervous feelings	0.5	1.0	3.2	-1.8	-0.2	-1.2	0.7	0.9	0.4	1.5	1.1	0.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.9	9.7	2.6	1.0	-0.1	-1.8	0.6	0.5	-2.7	-0.2	0.3	-3.1
Hearing difficulty/problems with background noise	1.9	3.1	6.1	1.9	1.8	0.8	-2.3	0.2	0.9	-2.2	-1.1	-2.2	-2.5
Hair/balding pattern: Pattern 2	1.0	1.3	3.4	-1.1	0.9	-1.0	0.7	1.4	1.0	1.3	1.8	0.9	0.3
Had menopause	0.6	0.7	1.8	1.2	0.2	0.9	-0.5	-1.0	-0.5	-0.8	-1.3	-0.3	-1.1
Had other major operations	0.5	0.6	1.4	1.2	-0.2	-0.6	-0.1	-1.0	-0.7	-0.6	-0.9	-0.1	-1.1
Forced vital capacity (FVC)	0.8	3.0	12.0	-0.3	-0.6	1.0	-0.3	3.5	3.3	0.4	2.1	1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	4.2	0.1	-0.2	-2.1	0.5	-0.8	-1.2	-0.4	0.2	-0.0	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.4	0.9	0.5	1.6	-1.3	-0.3	0.2	-0.2	-1.3	-0.3	-0.9
Qualifications: None of the above	1.6	3.4	12.4	0.3	0.1	-2.8	0.3	-3.4	-3.5	-0.0	-1.3	-0.8	0.1
Financial difficulties in last 2 years	2.5	3.3	8.7	1.5	1.7	1.8	-2.0	-0.3	0.5	-2.2	-1.9	-3.0	-1.8
Mouth/teeth dental problems	1.2	1.8	6.5	-1.0	-1.1	-0.2	0.7	0.5	-0.1	1.5	1.2	2.5	2.2
Heart attack	1.7	2.2	6.1	0.7	-0.4	-1.2	-1.1	-2.5	-2.1	-1.3	-1.7	-0.8	-1.9
Allergy	0.5	1.1	2.6	1.2	-0.2	1.1	-1.6	0.3	0.5	-1.6	-0.4	-0.7	-1.4
Pain all over the body in last month	1.2	1.3	2.5	-1.2	-0.1	-0.5	1.1	1.1	0.7	1.5	1.2	1.4	1.6
Diabetes (self-reported)	1.8	2.7	8.4	1.1	-0.5	-1.9	0.3	-2.8	-2.9	-1.4	-1.5	-1.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.2	-1.0	-1.8	0.3	1.6	0.9	0.9	1.1	0.7	-0.6	0.8
Medication: Ramipril	0.5	0.6	2.3	0.5	0.3	-0.9	0.0	-1.1	-0.9	-0.8	-0.7	-1.5	-0.1
Medication: Simvastatin	1.1	1.5	5.2	0.3	-0.8	-1.9	0.2	-2.2	-2.3	-0.5	-0.5	0.5	-0.6
Fluid intelligence score	0.6	1.2	4.0	-0.4	-0.5	-0.5	1.4	0.0	-0.4	1.3	0.8	2.0	1.6
Illnesses of siblings	0.2	0.3	0.9	-0.1	-0.7	0.5	0.3	0.9	0.9	-0.1	0.4	0.8	-0.3
Neuroticism score	0.5	1.0	2.9	0.6	-0.4	-1.7	-1.5	-0.1	-0.4	-1.0	0.3	-1.1	-1.4
Weight	0.9	4.5	10.1	0.9	-0.8	-1.6	-2.7	-2.1	-2.0	-2.2	-1.8	-3.2	-2.6
Impedance of arm (right)	0.4	1.8	5.8	-1.1	2.0	0.8	0.8	0.8	0.6	1.3	0.7	2.4	1.5
Arm fat percentage (right)	1.4	5.5	10.5	1.2	-0.4	-1.7	-2.6	-3.2	-2.9	-2.3	-2.4	-2.9	-2.4
Trunk fat-free mass	0.1	0.8	2.2	-0.8	-1.1	-1.5	-0.4	0.1	-0.4	-0.6	0.6	-1.5	-0.8
Hip circumference	0.8	3.4	5.9	1.0	-0.6	-2.0	-2.1	-2.3	-2.4	-2.2	-1.5	-1.5	-1.9
Time employed in main current job	1.4	1.6	6.1	-0.3	-0.2	1.1	-0.4	2.5	2.4	1.2	1.0	0.4	0.7
Alcohol intake versus 10 years previously	1.5	2.3	6.2	-0.9	-2.5	-0.8	1.2	-1.8	-1.5	0.7	-1.3	-2.4	-0.1
Father’s age at death	2.4	3.2	12.9	3.6	3.1	-0.2	-1.3	-0.1	-0.0	-2.5	-0.3	0.9	-0.8
Worrier / anxious feelings	0.3	0.5	1.5	0.1	-0.8	-1.2	-1.1	0.5	0.2	0.2	0.7	-0.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	9.3	2.8	1.4	0.2	-2.9	-0.8	-0.5	-2.9	-1.7	-1.2	-3.1
Falls in the last year	1.1	1.5	5.9	0.2	-0.8	0.3	-0.3	2.4	2.1	0.1	1.7	0.6	-0.3
Hair/balding pattern: Pattern 3	0.8	1.1	3.2	-1.1	-1.0	-0.7	0.2	-1.3	-1.6	0.8	-0.3	-0.7	1.8
Number of live births	0.2	0.3	1.1	0.5	0.6	-0.6	0.1	-0.5	-0.4	0.6	-0.6	1.0	0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	13.0	0.1	-1.4	0.9	-1.2	3.6	3.3	-0.1	2.2	0.9	-0.9
Pulse rate	0.9	1.5	4.2	2.0	1.2	1.7	-0.5	-0.8	-0.1	-1.0	-2.1	-0.2	-0.9
Happiness	0.5	0.6	2.3	-0.0	1.5	0.3	0.5	0.4	0.6	-0.1	0.2	-1.4	-0.7
Noisy workplace	0.9	1.1	2.9	-1.4	0.9	-0.3	-0.0	-1.3	-0.8	1.3	-0.9	-1.7	0.7
Qualifications: A levels/AS levels or equivalent	1.2	2.6	5.6	-1.0	-1.2	0.8	0.8	2.4	2.0	1.4	2.3	1.4	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.7	0.7	1.9	-0.8	-1.5	0.5	0.2	-0.6	0.7	0.5	0.0
Mouth/teeth dental problems: Dentures	0.5	0.9	2.8	-0.3	0.9	0.1	-0.0	-1.7	-1.1	0.0	-1.6	-0.8	-0.8
Asthma	0.2	0.4	1.1	-0.4	0.2	0.8	0.9	-0.5	-0.1	1.1	-0.7	0.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	6.2	0.4	-1.1	2.1	-1.3	2.3	2.5	0.2	0.9	-0.4	-1.0
Medication: Cholesterol lowering	2.5	3.8	9.4	1.1	1.1	-2.3	-1.1	-3.1	-3.1	-1.9	-1.4	-1.7	-1.5
Depression (self-reported)	1.9	2.3	5.1	1.7	0.6	0.6	-2.2	-0.2	0.3	-1.5	-1.6	-2.2	-2.2
Medication: Lansoprazole	0.5	0.6	2.1	-0.8	-1.0	-1.4	-0.4	-0.3	-0.5	0.0	0.7	0.9	0.0
Prospective memory result	0.4	0.5	1.9	0.0	0.2	-1.4	0.7	-0.8	-1.1	-0.1	-0.3	0.2	-0.2
Lung cancer (father)	0.6	0.7	2.0	0.1	-0.3	1.1	-0.2	-1.3	-0.8	0.7	-1.4	-1.1	0.1
Illnesses of mother	0.2	0.3	1.4	-0.4	-1.2	-0.1	0.9	0.4	0.4	-0.0	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	7.3	-0.0	-1.3	-0.9	-0.3	2.7	1.9	-0.2	2.6	1.4	-0.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	-0.9	-0.9	0.8	0.3	0.1	0.4	1.1	-0.3	-0.6	0.9
Impedance of arm (left)	0.2	1.0	2.9	-0.5	1.7	1.5	0.3	0.8	1.1	0.6	0.3	1.4	0.5
Arm fat mass (right)	1.4	5.6	9.5	1.2	-0.6	-1.9	-2.6	-3.1	-2.9	-2.4	-2.3	-3.0	-2.6
Trunk predicted mass	0.1	0.8	2.2	-0.8	-1.2	-1.5	-0.4	0.1	-0.4	-0.5	0.6	-1.5	-0.8
Standing height	0.1	1.3	4.8	-1.4	0.2	0.2	-0.1	2.2	1.9	0.3	1.5	-0.5	0.0
Length of working week for main job	0.5	0.6	1.4	-1.0	0.4	-1.2	0.5	-0.6	-0.7	1.0	0.3	0.0	0.9
Exposure to tobacco smoke at home	0.2	0.2	1.0	0.3	-0.3	-0.7	0.1	-0.8	-1.0	0.1	-0.0	0.2	-0.0
Breastfed as a baby	0.3	0.4	1.2	0.1	0.2	0.7	0.0	1.1	1.1	-0.3	0.7	0.6	0.4
Tense / ‘highly strung’	0.3	0.5	1.3	-0.8	0.8	-0.7	0.0	0.2	-0.0	1.2	0.7	0.9	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	6.0	-0.0	0.4	1.2	-2.4	1.0	1.2	-1.1	-0.4	-1.8	-1.6
Hair/balding pattern: Pattern 4	0.6	1.4	6.0	1.0	0.4	-0.2	-2.5	-0.2	0.0	-1.4	-0.6	-1.6	-1.5
Birth weight of first child	0.7	1.3	4.4	0.4	-0.9	0.6	-1.1	-1.6	-1.1	-0.7	-2.1	-0.2	-1.3
Peak expiratory flow (PEF)	1.9	4.4	16.7	-0.6	-1.0	1.7	-0.5	4.1	3.9	0.9	2.5	0.8	0.7
Pulse wave reflection index	0.4	0.5	1.7	-0.9	-1.3	-0.6	-0.3	0.6	0.2	0.4	0.8	-0.6	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.5	1.1	-0.8	-0.5	-1.9	0.2	0.2	-1.1	0.1	-0.3	-1.0
Loud music exposure frequency	1.2	1.4	4.1	0.6	-0.1	1.4	-1.6	1.4	2.0	-0.5	0.3	-1.1	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.1	-0.0	-0.1	1.7	-0.3	1.9	2.0	0.8	0.7	0.6	0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.9	1.3	1.0	-0.9	0.2	0.2	-0.2	-1.4	0.4	-1.1	-0.8
Blood clot in the leg (DVT)	0.6	0.8	2.6	-0.3	0.5	-1.0	0.3	-1.6	-1.5	0.6	-0.8	-0.1	0.7
Medication: Paracetamol	1.0	1.6	5.2	-1.8	-1.3	0.1	-0.5	1.0	1.1	2.3	0.6	0.7	1.6
Headache pain in last month	1.7	2.9	9.5	0.2	-3.1	0.7	-2.6	1.9	1.8	-0.2	1.5	-0.4	-1.4
Medication for cholesterol, blood pressure or diabetes	2.0	3.2	11.0	-1.1	-0.9	2.4	0.1	3.1	3.3	1.3	1.2	0.3	0.7
Glaucoma (self-reported)	1.2	1.4	3.9	-1.1	-1.4	1.3	-0.4	0.9	1.0	1.4	0.4	2.0	1.0
Gout (self-reported)	0.8	1.0	3.3	-0.7	-1.1	-0.4	1.8	1.4	1.3	0.8	0.6	-0.8	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.9	-1.0	0.5	-0.6	1.6	-0.1	-0.1	1.7	0.7	0.7	1.5
Medication: Amlodipine	0.8	1.1	3.1	-0.7	-0.9	-1.8	1.3	-1.2	-1.5	0.6	-0.4	0.7	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.6	0.8	1.3	0.6	0.5	-0.4	-0.2	-0.3	-0.8	0.0	0.1
Birth weight	0.9	2.0	7.1	1.6	0.9	-0.4	-2.3	0.3	0.3	-1.8	-0.1	-0.7	-2.7
Chronic bronchitis/emphysema (mother)	3.9	4.5	17.1	-4.1	-1.0	-2.4	2.0	0.4	-0.3	2.7	2.0	1.9	1.6
High blood pressure (siblings)	1.1	1.6	4.6	1.1	2.1	0.0	-0.7	-1.9	-1.6	-0.5	-1.6	-0.4	0.3
Forced vital capacity (FVC), Best measure	0.6	2.1	6.2	-0.3	-0.3	-0.7	0.6	2.5	1.7	0.6	2.4	2.1	0.5
Body fat percentage	2.2	8.6	15.5	1.9	-0.5	-1.6	-3.2	-3.9	-3.4	-2.9	-3.3	-3.7	-3.2
Leg fat percentage (right)	2.4	8.6	14.0	1.9	-1.4	-2.1	-3.3	-3.7	-3.5	-2.9	-2.5	-3.7	-3.1
Arm fat-free mass (right)	0.4	1.9	6.1	0.7	-1.1	-1.3	-1.2	-0.7	-0.9	-1.6	-0.6	-2.5	-1.9
Exposure to tobacco smoke outside home	0.2	0.3	1.6	1.2	-0.1	0.4	-0.3	0.2	0.0	-0.4	0.0	0.9	0.2
Comparative body size at age 10	0.9	2.4	6.3	1.7	0.5	-0.3	-2.1	-0.9	-0.5	-1.9	-1.6	-1.8	-2.5
Number of full brothers	0.7	0.9	2.2	-0.4	1.3	-0.2	-0.6	-1.5	-1.2	0.2	-0.8	-1.2	0.8
Worry too long after embarrassment	0.4	0.6	1.4	0.0	-0.2	-1.0	-0.7	1.1	0.6	-0.8	1.2	-0.4	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.5	0.5	-1.0	-0.7	-0.6	-0.4	-0.5	-1.0	-0.6	-0.5	-1.6
Wheeze or whistling in the chest in last year	1.3	2.4	10.2	-3.2	-2.0	-1.1	0.1	-0.7	-0.6	2.5	-0.3	-0.4	0.9
Number of children fathered	0.7	0.8	2.5	-0.8	0.2	0.5	-0.3	1.6	1.3	0.2	1.4	-0.0	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.7	0.7	0.7	-0.4	-0.9	-1.1	-0.9	-1.3	-0.8	-0.9	-1.2
Age at first live birth	0.6	1.1	3.0	-1.0	0.4	0.3	1.5	-0.1	0.1	1.5	-0.7	1.3	1.7
Pulse wave peak to peak time	0.5	0.6	1.7	0.8	0.7	-0.9	-0.5	0.0	-0.3	-1.3	0.5	0.4	-1.1
Health satisfaction	2.9	3.8	8.0	1.4	1.3	-0.2	-2.4	-1.9	-1.4	-1.8	-2.1	-2.8	-2.7
Shortness of breath walking on level ground	0.4	0.4	1.4	0.4	0.1	0.2	-0.6	-0.8	-0.3	-0.2	-1.2	-0.4	-1.1
Qualifications: College or University degree	1.4	4.5	10.4	-1.3	-1.0	0.9	1.4	3.2	2.5	2.0	2.9	2.3	2.4
Eye problems/disorders: None of the above	1.3	1.5	3.2	1.3	0.9	-0.5	-1.7	-1.1	-1.0	-1.8	-0.7	-1.3	-1.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.0	-0.1	-0.2	0.9	0.4	-0.2	0.1	-0.8	-0.7	-0.7	-1.4
Emphysema/chronic bronchitis	0.9	1.0	3.1	-1.2	0.4	0.2	1.0	-1.2	-0.5	0.9	-1.8	-1.1	0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	0.0	1.2	0.4	1.1	0.4	0.2	-0.6	0.1	0.8	0.2
Neck or shoulder pain in last month	0.4	0.6	2.4	0.3	-0.0	1.1	-0.4	1.1	1.5	-0.1	-0.3	0.3	-0.9
Medication: Blood pressure	1.6	2.8	10.3	1.0	0.7	-2.5	0.4	-2.8	-3.2	-0.9	-0.9	0.3	-0.1
Angina (self-reported)	0.8	1.1	2.5	-1.2	-1.6	-1.5	1.2	-1.2	-1.1	0.8	-0.2	-0.4	-0.3
Migraine (self-reported)	3.4	4.3	9.8	-1.8	-1.7	0.3	1.9	2.9	2.2	2.1	3.1	1.9	1.3
Medication: Ibuprofen	1.8	2.1	6.1	1.1	-0.5	2.5	-1.4	1.9	2.4	-0.3	0.2	-0.5	-1.4
Medication: Allopurinol	0.5	0.6	1.4	0.4	0.7	-0.5	1.2	0.8	0.6	-0.9	0.5	-1.1	-0.7
Medication: Omeprazole	0.5	0.6	3.4	-0.3	-0.5	-1.9	-0.0	-0.6	-1.1	0.3	0.5	0.0	0.0
Medication: Seretide 50 evohaler	0.4	0.5	1.6	-1.3	-0.3	0.5	0.2	-0.3	0.2	1.1	-0.6	-0.7	0.8
Mean time to correctly identify matches	0.3	0.5	1.3	0.7	1.0	-1.1	0.5	-0.7	-0.8	0.1	-0.4	-0.9	0.4
Heart disease (mother)	2.5	3.0	6.5	1.4	-0.2	0.6	-2.4	-2.5	-1.8	-0.8	-2.4	-2.4	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.4	1.8	0.1	-0.2	0.1	0.3	-0.1	-1.2	0.3	1.4	-0.9
Whole body fat mass	1.7	7.2	11.6	1.8	-0.4	-1.8	-3.1	-3.4	-3.0	-2.8	-2.8	-3.3	-3.0
Leg fat mass (right)	2.1	8.0	12.5	2.0	-0.7	-2.0	-3.5	-3.3	-3.1	-3.1	-2.4	-3.5	-3.3
Arm predicted mass (right)	0.4	1.9	6.1	0.6	-1.2	-1.1	-1.3	-0.8	-0.8	-1.6	-0.8	-2.5	-2.1
Pulse rate, automated reading	0.6	1.9	4.9	1.3	-0.2	-0.0	-1.1	-1.3	-1.1	-2.2	-1.9	-1.2	-1.7
Alcohol intake frequency.	0.6	1.5	3.7	-1.2	0.4	1.9	-0.1	0.9	1.6	1.6	-0.7	-1.0	1.5
Comparative height size at age 10	0.3	1.5	3.1	-1.8	-0.4	-1.7	0.3	0.4	-0.3	1.6	1.7	0.7	1.5
Number of full sisters	0.1	0.2	1.0	-1.0	0.2	0.2	-0.4	-0.3	-0.0	0.3	-0.2	0.0	0.3
Suffer from ‘nerves’	1.8	2.7	6.6	1.7	0.2	-1.5	-1.3	-1.5	-1.4	-2.3	-1.6	-1.3	-2.6
Overall health rating	2.8	6.1	17.1	2.5	0.8	-0.7	-2.6	-2.3	-1.7	-3.0	-2.6	-2.4	-4.1
Chest pain or discomfort	0.9	1.3	3.8	0.3	-1.3	0.0	-0.6	-1.3	-0.7	-0.6	-1.4	-2.0	-1.6
Had major operations	5.4	6.4	17.2	1.9	3.0	-1.3	-1.7	-4.2	-3.5	-2.0	-3.0	-1.8	-1.3
Age at last live birth	1.0	1.5	4.2	-0.6	1.8	0.5	1.1	-0.2	-0.1	1.5	-0.7	1.8	2.0
Family relationship satisfaction	0.3	0.4	0.9	-0.5	0.6	-0.3	-0.2	-0.8	-0.9	0.5	-0.3	-1.0	0.6
Leg pain on walking	2.3	2.9	7.5	0.5	0.2	-0.7	-1.1	-2.7	-2.0	-1.3	-2.6	-2.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.7	-0.1	-0.6	0.7	-1.2	-0.3	0.4	-0.3	-1.0	-1.7	-1.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.0	-1.7	-1.7	-1.0	0.1	-0.2	-0.7	0.5	0.9	0.6	0.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	6.7	-1.4	-1.7	0.1	2.6	-0.1	-0.1	1.8	0.4	1.0	1.7
Medication: Aspirin	1.4	1.8	5.2	1.4	0.3	-1.5	0.1	-2.3	-2.1	-1.0	-1.0	-1.1	-0.8
Supplements: Vitamin C	0.1	0.1	0.4	0.1	0.5	-0.3	-0.1	-0.3	-0.4	-0.6	-0.3	0.0	-0.3
Knee pain experienced in last month	1.2	1.8	7.2	1.1	0.5	-0.0	-2.7	-0.6	-0.2	-1.7	-1.0	-1.6	-1.7
Hypertension (Self-reported)	1.2	3.2	11.2	1.2	0.5	-2.5	-0.9	-3.1	-3.3	-0.9	-1.3	-0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.8	-0.5	-1.1	-1.3	-0.5	-1.7	-1.5	-0.3	-0.6	-0.7	-0.8
Illnesses of father: Heart disease	0.8	1.1	3.4	1.0	0.9	0.0	-1.8	-0.8	-0.5	-1.5	-1.1	-0.3	-1.3
Illnesses of siblings: Diabetes	0.9	1.1	3.2	1.8	0.9	0.9	-1.7	-0.3	-0.0	-0.8	-0.9	-1.0	-0.4
Smoking status: Previous	1.0	1.5	4.9	-2.2	-0.4	-1.5	-0.4	-0.0	-0.5	1.9	1.5	-0.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	11.5	-2.5	-0.4	-0.0	-1.4	3.4	2.8	1.0	2.8	0.2	-0.3
Whole body fat-free mass	0.1	0.8	2.4	-0.5	-0.9	-1.6	-0.7	-0.2	-0.6	-0.8	0.2	-1.4	-1.0
Leg fat-free mass (right)	0.1	0.5	1.6	-0.4	-0.1	-1.1	-1.0	0.1	-0.1	-0.7	-0.0	-1.3	-1.0
Arm fat percentage (left)	1.8	7.1	12.4	1.6	-0.2	-1.5	-2.9	-3.5	-3.0	-2.8	-2.9	-3.4	-2.9
Average weekly red wine intake	1.1	1.7	5.8	1.7	1.7	0.8	-0.9	0.3	0.4	-2.4	-0.3	0.4	-1.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.3	0.4	0.6	-0.6	-1.2	-0.1	-0.1	-0.5	0.1	-0.5	-0.6
Mood swings	1.7	3.0	9.2	2.2	0.2	-1.3	-2.1	-0.5	-0.6	-2.7	-0.6	-1.3	-3.0
Loneliness, isolation	0.4	0.5	2.3	0.5	1.0	-0.3	-1.5	0.3	0.1	-0.8	0.2	-0.6	-0.8
Long-standing illness, disability or infirmity	1.0	1.6	5.9	-0.7	-0.7	-0.5	0.4	-2.4	-1.8	0.4	-1.8	-1.3	0.0
Ever had bowel cancer screening	0.9	1.1	3.0	0.1	1.2	-1.6	1.7	0.4	-0.0	0.6	1.4	0.3	0.9
Diabetes diagnosed by doctor	2.4	4.0	10.6	1.9	0.9	-1.0	-0.2	-3.2	-2.9	-2.1	-2.6	-1.7	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.2	0.0	0.8	0.9	-0.6	1.1	1.5	0.9	-0.0	0.8	0.5
Friendships satisfaction	0.7	0.9	2.6	-1.4	-1.6	-0.2	-1.3	0.7	0.5	0.5	0.8	-1.0	-0.3
Qualifications: nursing, teaching	0.8	1.3	3.5	-1.3	-0.4	0.1	0.4	1.6	1.0	0.6	1.9	1.3	1.4
Commuting to job workplace: Walk	1.0	1.1	3.3	1.7	1.0	1.8	0.0	0.2	1.0	-0.7	-1.3	0.5	0.5
Eye problems/disorders: Cataract	0.3	0.3	1.0	0.4	0.9	1.0	0.1	0.7	0.9	-0.2	-0.3	-0.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	0.8	0.2	0.2	-1.4	0.0	0.5	-1.0	-0.9	-0.6	-0.7
Medication for cholesterol	0.6	0.8	3.6	0.5	0.1	0.9	-0.2	1.9	1.8	-0.2	0.6	-0.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.6	0.8	0.5	0.5	-0.8	-0.4	-0.0	-1.5	-0.9	-2.1	-1.6
Back pain experienced in last month	0.3	0.5	2.0	-0.8	-1.4	-0.6	-0.3	0.0	-0.2	0.7	0.6	-0.6	-0.2
Mineral and other dietary supplements	0.8	1.1	2.2	1.5	1.1	-0.6	-0.7	-1.3	-1.1	-1.2	-1.3	0.2	-1.0
Breast cancer (self-reported)	0.1	0.2	0.6	0.4	0.5	0.6	0.8	0.2	0.3	-0.1	-0.3	0.2	-0.3
Asthma (self-reported)	0.2	0.5	1.3	-0.6	-0.0	1.0	0.8	-0.3	0.2	1.1	-0.7	0.3	0.9
Osteoporosis (self-reported)	0.8	1.0	2.8	-1.4	-1.2	-0.5	0.2	1.2	0.7	0.6	1.7	0.9	0.8
Osteoarthritis (self-reported)	0.6	0.8	4.9	0.3	-0.0	-2.2	0.0	0.0	-0.6	-0.8	1.0	0.8	-0.4
Medication: Aspirin	1.7	2.2	6.4	1.5	0.5	-1.8	0.3	-2.5	-2.4	-1.0	-1.2	-1.1	-0.6
Medication: Gliclazide	3.3	3.8	8.6	1.9	0.8	-0.9	-1.4	-2.9	-2.4	-2.1	-2.4	-1.7	-1.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.3	-0.3	-0.2	0.8	0.7	0.4	-0.0	0.6	-0.2	0.3
Smoking status: Current	0.9	1.5	3.1	-1.4	-1.4	1.8	-0.5	1.1	1.6	0.5	-0.1	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	7.6	0.6	-1.7	0.2	-0.2	2.8	1.9	-0.6	2.4	1.5	-0.3
Whole body water mass	0.1	0.8	2.3	-0.5	-0.9	-1.4	-0.6	-0.2	-0.6	-0.8	0.1	-1.5	-1.0
Leg predicted mass (right)	0.1	0.6	2.0	-0.3	-0.1	-1.1	-1.1	-0.0	-0.2	-0.9	-0.1	-1.4	-1.1
Arm fat mass (left)	1.5	6.3	11.4	1.3	-0.6	-1.6	-2.8	-3.1	-2.7	-2.7	-2.5	-3.4	-2.9
Number of self-reported non-cancer illnesses	1.0	1.8	5.7	0.0	-1.3	-1.5	0.5	-2.4	-2.2	-0.1	-0.9	-1.3	-0.8
Average weekly champagne plus white wine intake	0.4	0.5	1.2	0.9	-0.2	1.1	0.4	1.1	1.0	-1.0	0.2	0.4	0.0
Miserableness	1.1	1.9	4.5	2.1	0.4	-1.5	-2.0	-0.8	-1.2	-2.0	-0.2	0.1	-1.5
Guilty feelings	0.7	1.1	2.8	0.4	-0.0	1.1	-1.4	1.4	1.7	-0.7	0.1	-0.1	-1.4
Wears glasses or contact lenses	3.1	3.6	10.7	1.4	0.9	-2.2	-0.4	-3.2	-3.3	-1.5	-1.6	-1.5	-0.8
Ever taken oral contraceptive pill	1.1	1.2	3.3	-1.8	0.5	-1.0	0.5	-0.2	-0.6	1.2	1.0	1.4	1.5
Hearing aid user	0.6	0.7	2.2	-0.3	0.3	-1.0	1.5	-1.1	-1.0	0.3	-0.0	0.9	0.1
Mother’s age at death	0.8	1.0	5.5	2.3	1.1	-0.6	-0.0	0.2	-0.0	-1.4	0.2	0.9	-0.6
Financial situation satisfaction	1.9	2.4	6.8	1.1	2.6	0.6	-1.7	-0.8	-0.4	-1.6	-1.3	-2.4	-1.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	5.0	0.4	-0.8	-1.5	0.9	-2.2	-2.0	-0.7	-1.4	-0.6	-0.6
Commuting to job workplace: Public transport	2.1	2.5	7.5	1.7	1.5	-0.5	0.7	-2.7	-2.3	0.2	-2.3	0.7	0.7
Eye problems/disorders: Glaucoma	0.4	0.5	2.1	-0.9	-0.7	0.2	0.0	-0.0	-0.1	0.9	0.2	1.4	0.9
Medication: Blood pressure	1.0	1.8	6.8	-0.3	-0.1	-1.7	0.2	-2.6	-2.6	0.4	-1.0	-0.2	0.8
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.4	-1.1	1.2	-0.3	-0.5	1.1	1.0	0.8	1.1	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	-0.8	-0.2	0.3	0.1	0.8	0.7	0.5	1.1	-0.6	0.6
High cholesterol (Self-reported)	0.6	1.1	3.8	0.4	-0.7	-0.0	-0.2	-1.0	-0.5	-1.4	-1.0	-2.0	-1.5
Medication: Bendroflumethiazide	0.4	0.6	2.0	-0.2	-0.6	-1.1	-0.7	-1.1	-1.4	-0.0	-0.4	0.5	0.1
Medication: Paracetamol	0.7	1.1	4.1	-1.2	-1.1	-0.3	0.4	0.4	0.4	2.0	0.3	1.3	1.3
Medication: Lisinopril	0.6	0.7	1.8	-0.1	-0.9	-0.7	-0.3	-1.3	-1.4	-0.6	-0.6	-0.7	-1.0
Medication: Atorvastatin	0.5	0.6	3.0	-0.3	1.0	-0.9	0.1	-0.2	-0.2	-0.7	0.2	-1.7	-0.7
Illnesses of father: High blood pressure	0.3	0.3	1.2	1.1	0.7	1.0	-0.4	0.3	0.6	-0.3	-0.3	0.3	0.1
Alcohol drinker status: Never	0.6	0.7	1.8	0.9	-1.0	-0.2	0.1	-1.4	-1.4	-0.2	-1.0	-0.5	0.3
Ever smoked	0.6	1.1	4.4	-0.2	0.1	1.0	-2.1	0.8	1.1	0.0	0.3	-1.8	-0.8
Basal metabolic rate	0.2	1.3	3.5	-0.2	-0.9	-1.5	-1.2	-0.6	-0.9	-1.1	-0.2	-1.9	-1.4
Leg fat percentage (left)	2.4	8.5	14.1	2.1	-1.4	-1.6	-3.4	-3.7	-3.2	-2.9	-3.0	-3.8	-3.1
Arm fat-free mass (left)	0.2	1.2	3.7	0.1	-1.2	-1.3	-0.9	-0.7	-0.9	-1.1	-0.4	-1.9	-1.4
Number of operations (self-reported)	2.5	3.7	8.8	2.1	2.2	-1.3	-1.2	-3.0	-2.7	-1.8	-1.8	-0.0	-1.2
Average weekly beer plus cider intake	0.2	0.3	0.7	0.8	0.1	-0.6	0.2	-0.9	-0.7	0.0	-0.6	-0.3	0.1
Irritability	0.2	0.4	1.3	0.5	-0.8	-0.8	-0.8	0.3	0.2	-0.7	-0.0	-0.4	-1.1
Risk taking	0.7	1.0	5.1	0.3	-0.8	-0.2	-2.3	0.9	0.5	-0.8	1.3	0.3	-0.6
Ever had prostate specific antigen (PSA) test	2.3	2.7	8.1	-1.0	-0.4	-1.8	1.6	-0.7	-1.6	2.0	1.6	1.3	2.9
Fractured/broken bones in last 5 years	0.5	0.7	1.7	-0.2	-0.1	0.8	-1.1	1.3	1.3	0.1	0.5	0.9	-0.3
Age started oral contraceptive pill	1.0	1.2	3.1	-1.2	-0.2	1.7	1.1	0.0	0.4	1.7	-0.5	0.7	1.8
Diastolic blood pressure, automated reading	0.3	0.9	4.2	0.5	0.0	-2.0	0.0	-0.3	-0.9	0.2	0.5	1.7	0.6
Ever depressed for a whole week	0.8	1.0	3.2	1.3	0.8	0.0	-0.2	-1.8	-1.6	-0.1	-1.4	0.4	0.2
Unable to work because of sickness or disability	0.5	0.6	1.5	-0.5	0.4	1.2	0.3	1.1	1.2	0.3	0.7	0.7	-0.3
Commuting to job workplace: Cycle	0.1	0.2	1.2	0.5	0.0	0.3	-0.4	-0.2	-0.0	0.1	-0.1	-1.1	0.2
Myopia	0.7	1.1	4.8	2.2	1.6	-0.4	-0.9	-0.5	-0.6	-1.2	-0.1	-0.1	-0.5
Vascular/heart problems diagnosed by doctor	1.7	4.6	17.3	-1.1	0.1	3.3	0.4	3.8	4.2	0.8	1.4	-0.1	0.3
Cholesterol lowering medication	0.4	0.6	3.3	-0.5	-1.8	-0.3	0.9	-0.7	-0.5	0.4	-0.2	-0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.6	-0.9	-1.6	-2.4	0.6	-0.6	-1.4	1.0	1.2	0.9	1.1
Pain experienced in last month	0.5	0.8	4.6	0.1	0.7	-0.3	2.1	-0.3	-0.6	-0.2	0.2	1.4	0.5
Supplements: Calcium	0.3	0.3	0.9	-0.6	0.1	-0.4	-0.0	-0.3	-0.5	0.8	0.3	1.0	0.6
Basal cell carcinoma (self-reported)	1.4	1.7	3.8	0.6	0.7	0.6	-0.4	-1.8	-1.2	-1.4	-2.0	-1.3	-1.7
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.9	0.5	-0.4	-1.4	-1.1	-2.4	-2.1	-1.2	-1.5	-0.8	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.3	-0.3	0.4	-1.2	0.3	-1.5	-1.5	0.7	-0.7	-0.1	0.8
Heart disease (siblings)	0.3	0.4	1.3	-1.0	0.1	-1.2	-0.0	0.1	-0.3	0.3	0.8	-0.5	-0.3
Alcohol drinker status: Previous	0.8	0.9	3.1	-1.7	1.8	0.1	0.6	0.5	0.4	0.7	0.5	-0.1	1.1
Pack years of smoking	2.8	4.2	8.6	1.8	0.8	-0.3	-1.1	-2.4	-1.7	-2.3	-2.9	-2.6	-2.7
Impedance of whole body	0.2	0.9	3.2	0.3	1.4	1.8	0.1	0.8	1.1	0.3	0.0	1.4	0.2
Leg fat mass (left)	2.1	8.1	12.5	2.2	-0.7	-1.8	-3.5	-3.3	-3.0	-3.1	-2.8	-3.5	-3.3
Arm predicted mass (left)	0.2	1.1	3.3	-0.1	-1.2	-1.3	-0.9	-0.8	-1.0	-1.0	-0.3	-1.8	-1.1