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chr12:69,045,442-70,476,863

Best TWAS P=1.42e-09 · Best GWAS P=5.78e-08 conditioned to 0.123

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	YEATS4	0.26	0.18	enet	17	0.29	4.9e-33	-4.5	6.1	1.4e-09	-0.72	0.04	0.92	TRUE
3	GTEx	Artery Aorta	YEATS4	0.25	0.12	enet	11	0.21	5.0e-12	3.9	6.0	2.2e-09	-0.58	0.50	0.45	FALSE
13	GTEx	Stomach	YEATS4	0.19	0.16	lasso	8	0.12	2.7e-06	-4.5	6.0	2.5e-09	-0.72	0.10	0.87	FALSE
4	GTEx	Artery Coronary	YEATS4	0.34	0.10	lasso	11	0.12	7.0e-05	-3.5	5.9	2.8e-09	-0.62	0.02	0.91	FALSE
11	GTEx	Nerve Tibial	YEATS4	0.32	0.22	enet	15	0.32	2.6e-23	-4.5	5.8	7.0e-09	-0.67	0.28	0.69	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	YEATS4	0.39	0.27	enet	12	0.47	1.2e-50	-4.5	5.7	9.6e-09	-0.67	0.04	0.92	FALSE
10	GTEx	Colon Transverse	YEATS4	0.17	0.06	enet	11	0.10	1.2e-05	-4.4	5.7	1.2e-08	-0.72	0.07	0.89	FALSE
5	GTEx	Artery Tibial	YEATS4	0.37	0.23	enet	21	0.35	3.2e-28	-4.5	5.7	1.4e-08	-0.65	0.30	0.68	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LYZ	0.06	0.03	blup	42	0.05	6.9e-05	-4.5	5.6	2.2e-08	-0.85	0.03	0.94	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	YEATS4	0.18	0.15	lasso	11	0.21	1.1e-21	-4.5	5.6	2.6e-08	-0.70	0.04	0.92	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	YEATS4	0.12	0.12	lasso	5	0.17	3.4e-10	-4.5	5.5	2.9e-08	-0.71	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	YEATS4	0.19	0.04	enet	15	0.08	4.2e-04	-4.5	5.5	2.9e-08	-0.66	0.04	0.68	FALSE
1	CommonMind	Brain Pre-frontal Cortex	YEATS4	0.37	0.23	lasso	7	0.45	4.6e-61	-4.5	5.5	3.4e-08	-0.63	0.37	0.59	FALSE
7	GTEx	Brain Cortex	YEATS4	0.22	0.11	enet	18	0.09	1.8e-03	-5.2	5.5	3.6e-08	-0.94	0.01	0.96	FALSE
2	GTEx	Adipose Subcutaneous	YEATS4	0.32	0.28	enet	17	0.30	1.0e-24	-4.5	5.5	3.7e-08	-0.86	0.23	0.75	FALSE
8	GTEx	Brain Frontal Cortex BA9	YEATS4	0.28	0.00	lasso	4	0.08	4.1e-03	-4.5	5.5	3.7e-08	-0.64	0.04	0.69	FALSE
22	The Cancer Genome Atlas	Soft Tissue Sarcoma	LYZ	0.06	0.02	blup	43	0.03	7.4e-03	4.5	5.5	4.8e-08	-0.87	0.00	0.69	FALSE
12	GTEx	Prostate	YEATS4	0.40	0.01	lasso	6	0.06	1.6e-02	3.7	5.4	5.9e-08	-0.54	0.04	0.67	FALSE
14	NTR	Blood	LYZ	0.19	0.22	lasso	6	0.26	2.6e-83	-4.5	5.4	6.1e-08	-0.88	0.24	0.74	FALSE
6	GTEx	Brain Cerebellum	YEATS4	0.35	0.16	enet	34	0.20	1.5e-06	4.5	5.4	7.9e-08	-0.54	0.04	0.88	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	YEATS4	0.24	0.14	lasso	7	0.26	1.8e-29	3.6	5.3	1.4e-07	-0.61	0.12	0.78	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	LYZ	0.05	0.05	lasso	2	0.05	2.1e-05	-5.2	5.2	2.1e-07	-0.97	0.00	0.99	FALSE
20	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LYZ	0.29	0.14	lasso	6	0.26	6.8e-11	-5.1	5.1	2.7e-07	-0.80	0.00	0.99	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	YEATS4	0.29	0.25	enet	8	0.17	2.6e-05	-4.5	5.1	2.9e-07	-0.74	0.03	0.92	FALSE