Best TWAS P=1.14e-10 · Best GWAS P=1.17e-10 conditioned to 5.97e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | GLYR1 | 0.14 | 0.03 | bslmm | 416 | 0.07 | 3.8e-09 | -2.3 | 5.7 | 1.2e-08 | -0.50 | 0.64 | 0.28 | TRUE |
2 | GTEx | Adipose Visceral Omentum | AC006111.1 | 0.18 | 0.12 | enet | 12 | 0.10 | 1.1e-05 | 4.5 | 6.5 | 1.1e-10 | 0.02 | 0.64 | 0.06 | TRUE |
3 | GTEx | Brain Cortex | AC006111.1 | 0.32 | 0.02 | enet | 16 | 0.00 | 3.2e-01 | -4.3 | 6.2 | 6.1e-10 | -0.04 | 0.03 | 0.31 | TRUE |
4 | GTEx | Pancreas | TRAP1 | 0.36 | 0.09 | lasso | 6 | 0.13 | 2.9e-06 | -3.6 | 5.3 | 1.4e-07 | 0.01 | 0.18 | 0.09 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | AC006111.1 | 0.19 | 0.12 | enet | 13 | 0.18 | 2.1e-10 | -3.6 | 5.8 | 5.1e-09 | 0.02 | 0.52 | 0.45 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | AC006111.1 | 0.23 | 0.10 | enet | 25 | 0.12 | 9.2e-10 | -3.6 | 5.1 | 3.0e-07 | 0.03 | 0.97 | 0.02 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NAT15 | 0.05 | 0.04 | blup | 56 | 0.03 | 1.7e-07 | 4.6 | -5.1 | 2.9e-07 | -0.02 | 0.91 | 0.09 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | UBN1 | 0.05 | 0.04 | enet | 7 | 0.05 | 4.2e-04 | 5.2 | -5.5 | 3.7e-08 | 0.67 | 0.04 | 0.51 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TRAP1 | 0.11 | 0.01 | blup | 43 | 0.05 | 9.4e-04 | -1.5 | 5.5 | 5.1e-08 | 0.02 | 0.00 | 0.18 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | NAT15 | 0.06 | 0.04 | blup | 56 | 0.04 | 4.1e-05 | 5.1 | -5.7 | 1.4e-08 | -0.01 | 0.09 | 0.78 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NAT15 | 0.04 | 0.01 | blup | 56 | 0.04 | 4.2e-05 | 4.9 | -5.9 | 3.3e-09 | -0.05 | 0.16 | 0.46 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | NAT15 | 0.10 | 0.05 | lasso | 6 | 0.07 | 6.1e-07 | 5.0 | -5.3 | 1.4e-07 | -0.04 | 0.76 | 0.22 | FALSE |