[Hub]/) : Traits : Cardiovascular Disease : ← →

chr16:29,711,343-31,860,399

Best TWAS P=1.32e-12 · Best GWAS P=1.27e-12 conditioned to 0.00213

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KAT8	0.06	0.07	lasso	1	0.07	3.9e-09	-6.94	6.9	3.9e-12	-0.69	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	VKORC1	0.03	0.04	lasso	3	0.03	4.9e-05	-6.98	-7.1	1.6e-12	0.97	0.01	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNF646	0.04	0.06	lasso	7	0.04	4.5e-06	-6.56	6.7	1.9e-11	-0.70	0.09	0.90	FALSE
4	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	4.72	6.5	9.2e-11	-0.54	0.66	0.34	FALSE
5	GTEx	Adipose Subcutaneous	RP11-196G11.2	0.23	0.20	lasso	9	0.21	4.2e-17	5.37	5.3	1.1e-07	-0.45	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	KAT8	0.07	0.02	lasso	5	0.02	4.0e-02	-6.94	6.7	1.6e-11	-0.65	0.02	0.94	FALSE
7	GTEx	Adrenal Gland	KAT8	0.11	0.06	enet	11	0.07	1.8e-03	-6.72	6.1	8.1e-10	-0.67	0.04	0.85	FALSE
8	GTEx	Artery Aorta	KAT8	0.23	0.20	lasso	4	0.20	2.7e-11	-6.94	7.1	1.6e-12	-0.66	0.02	0.98	FALSE
9	GTEx	Artery Aorta	RP11-196G11.2	0.10	0.16	lasso	2	0.14	7.1e-08	5.44	5.3	8.7e-08	-0.45	0.98	0.02	FALSE
10	GTEx	Artery Coronary	KAT8	0.22	0.19	lasso	2	0.19	6.6e-07	-6.94	7.0	3.6e-12	-0.68	0.02	0.96	FALSE
11	GTEx	Artery Coronary	RP11-196G11.2	0.12	0.06	lasso	6	0.06	3.4e-03	5.37	5.1	3.0e-07	-0.45	0.32	0.12	FALSE
12	GTEx	Artery Tibial	KAT8	0.30	0.23	lasso	5	0.27	3.3e-21	4.72	6.5	1.1e-10	-0.56	0.47	0.53	FALSE
13	GTEx	Brain Cerebellar Hemisphere	KAT8	0.12	0.23	lasso	3	0.18	2.9e-05	-6.94	7.0	2.8e-12	-0.72	0.02	0.92	FALSE
14	GTEx	Brain Cerebellum	STX4	0.14	0.25	lasso	1	0.24	8.3e-08	5.38	5.4	7.4e-08	-0.45	0.79	0.03	FALSE
15	GTEx	Brain Cerebellum	KAT8	0.21	0.01	lasso	9	0.05	1.4e-02	-6.95	7.0	1.8e-12	-0.58	0.03	0.88	FALSE
16	GTEx	Brain Cerebellum	RP11-196G11.2	0.31	0.30	lasso	4	0.36	1.3e-11	5.38	5.5	4.2e-08	-0.45	0.99	0.00	FALSE
17	GTEx	Brain Cortex	KAT8	0.14	0.14	lasso	3	0.10	8.9e-04	-5.98	6.6	4.4e-11	-0.78	0.04	0.79	FALSE
18	GTEx	Brain Frontal Cortex BA9	KAT8	0.16	0.20	lasso	1	0.17	2.6e-05	-6.92	6.9	4.6e-12	-0.70	0.02	0.92	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	-6.91	6.8	1.1e-11	-0.59	0.02	0.86	FALSE
20	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	-6.95	6.7	1.8e-11	-0.61	0.02	0.98	FALSE
21	GTEx	Breast Mammary Tissue	RP11-196G11.2	0.13	0.16	lasso	4	0.17	5.0e-09	5.42	5.6	2.5e-08	-0.44	0.99	0.00	FALSE
22	GTEx	Breast Mammary Tissue (Male)	RP11-196G11.2	0.15	0.16	lasso	4	0.09	3.9e-03	5.42	5.4	6.2e-08	-0.45	0.37	0.12	FALSE
23	GTEx	Cells Transformed fibroblasts	KAT8	0.31	0.31	lasso	4	0.32	1.9e-24	4.73	5.5	4.4e-08	-0.39	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	RP11-196G11.2	0.14	0.14	lasso	6	0.13	2.9e-10	5.05	5.2	1.7e-07	-0.47	1.00	0.00	FALSE
25	GTEx	Colon Sigmoid	KAT8	0.20	0.10	lasso	3	0.14	1.0e-05	-6.94	6.8	9.5e-12	-0.59	0.02	0.92	FALSE
26	GTEx	Colon Transverse	STX4	0.10	0.09	lasso	3	0.06	6.6e-04	5.42	5.4	5.9e-08	-0.45	0.37	0.06	FALSE
27	GTEx	Colon Transverse	KAT8	0.14	0.12	lasso	6	0.05	1.4e-03	4.72	5.8	6.8e-09	-0.40	0.14	0.61	FALSE
28	GTEx	Colon Transverse	RP11-196G11.2	0.24	0.11	lasso	5	0.15	1.9e-07	5.44	5.8	6.6e-09	-0.48	0.98	0.02	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	4.72	6.8	1.3e-11	-0.60	0.09	0.90	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	RP11-196G11.2	0.13	0.11	enet	8	0.14	1.2e-05	5.44	5.5	3.0e-08	-0.39	0.68	0.10	FALSE
31	GTEx	Esophagus Mucosa	STX1B	0.12	0.03	lasso	5	0.05	1.7e-04	5.36	5.7	1.6e-08	-0.41	0.77	0.11	FALSE
32	GTEx	Esophagus Mucosa	HSD3B7	0.38	0.32	lasso	5	0.36	1.2e-24	5.38	5.2	2.4e-07	-0.49	1.00	0.00	FALSE
33	GTEx	Esophagus Mucosa	BCKDK	0.05	0.05	enet	6	0.06	8.7e-05	-6.63	-6.6	3.4e-11	0.78	0.04	0.92	FALSE
34	GTEx	Esophagus Mucosa	KAT8	0.21	0.15	lasso	4	0.23	3.5e-15	4.72	6.6	3.1e-11	-0.57	0.10	0.90	FALSE
35	GTEx	Esophagus Mucosa	RP11-196G11.2	0.09	0.03	enet	13	0.05	1.5e-04	5.37	6.1	1.1e-09	-0.59	0.11	0.83	FALSE
36	GTEx	Esophagus Muscularis	STX4	0.05	0.05	lasso	3	0.03	6.7e-03	5.44	5.3	9.6e-08	-0.44	0.41	0.18	FALSE
37	GTEx	Esophagus Muscularis	KAT8	0.29	0.19	lasso	4	0.21	1.2e-12	4.72	6.4	1.6e-10	-0.52	0.25	0.75	FALSE
38	GTEx	Esophagus Muscularis	RP11-196G11.2	0.14	0.14	lasso	6	0.13	3.7e-08	5.37	5.3	1.3e-07	-0.44	0.97	0.03	FALSE
39	GTEx	Heart Atrial Appendage	KAT8	0.12	0.02	lasso	4	0.01	1.6e-01	-6.94	6.2	7.2e-10	-0.51	0.04	0.72	FALSE
40	GTEx	Liver	PRSS53	0.22	0.08	lasso	5	0.11	5.5e-04	-6.22	6.5	9.8e-11	-0.71	0.04	0.82	FALSE
41	GTEx	Liver	VKORC1	0.22	0.20	lasso	5	0.22	1.1e-06	-6.63	6.7	1.8e-11	-0.72	0.03	0.96	FALSE
42	GTEx	Liver	PRSS36	0.13	0.03	enet	34	0.04	2.2e-02	4.45	5.7	1.4e-08	-0.52	0.07	0.38	FALSE
43	GTEx	Lung	KAT8	0.14	0.08	lasso	3	0.12	1.7e-09	-6.95	6.9	4.9e-12	-0.60	0.02	0.98	FALSE
44	GTEx	Muscle Skeletal	HSD3B7	0.15	0.13	enet	19	0.14	5.5e-14	5.38	5.6	2.5e-08	-0.52	1.00	0.00	FALSE
45	GTEx	Muscle Skeletal	KAT8	0.08	0.04	enet	16	0.06	1.4e-06	4.82	5.7	1.6e-08	-0.54	0.38	0.61	FALSE
46	GTEx	Nerve Tibial	KAT8	0.17	0.06	enet	24	0.08	3.0e-06	4.72	6.5	1.0e-10	-0.61	0.02	0.98	FALSE
47	GTEx	Nerve Tibial	RP11-196G11.2	0.17	0.22	lasso	6	0.22	2.3e-15	5.44	5.2	1.9e-07	-0.48	1.00	0.00	FALSE
48	GTEx	Ovary	KAT8	0.16	0.09	lasso	4	0.06	1.2e-02	-6.94	7.0	1.9e-12	-0.65	0.03	0.83	FALSE
49	GTEx	Pancreas	STX1B	0.23	0.18	lasso	3	0.16	2.8e-07	5.42	5.4	5.9e-08	-0.45	0.94	0.05	FALSE
50	GTEx	Pancreas	RP11-196G11.2	0.13	0.11	lasso	1	0.11	2.5e-05	5.44	5.4	5.2e-08	-0.44	0.71	0.06	FALSE
51	GTEx	Pituitary	RP11-196G11.2	0.21	0.28	lasso	6	0.23	1.4e-06	5.37	5.3	1.1e-07	-0.48	0.64	0.06	FALSE
52	GTEx	Prostate	KAT8	0.19	0.09	lasso	3	0.13	3.8e-04	-6.94	7.0	2.5e-12	-0.73	0.02	0.74	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	HSD3B7	0.11	0.12	enet	6	0.10	5.9e-06	5.38	5.2	1.6e-07	-0.49	0.91	0.06	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	KAT8	0.30	0.20	enet	15	0.26	1.9e-14	4.73	6.8	1.3e-11	-0.60	0.04	0.96	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	RP11-196G11.2	0.22	0.21	lasso	9	0.26	3.2e-14	5.37	5.2	1.5e-07	-0.48	1.00	0.00	FALSE
56	GTEx	Skin Sun Exposed Lower leg	STX1B	0.05	0.04	enet	4	0.05	7.2e-05	5.42	5.5	4.9e-08	-0.45	0.80	0.04	FALSE
57	GTEx	Skin Sun Exposed Lower leg	KAT8	0.31	0.23	lasso	6	0.35	2.2e-30	-6.95	6.8	1.0e-11	-0.59	0.02	0.98	FALSE
58	GTEx	Skin Sun Exposed Lower leg	RP11-196G11.2	0.16	0.15	lasso	7	0.15	4.0e-12	5.42	5.3	1.4e-07	-0.46	1.00	0.00	FALSE
59	GTEx	Small Intestine Terminal Ileum	VKORC1	0.30	0.05	enet	18	0.12	1.4e-03	-6.61	5.2	1.9e-07	-0.53	0.03	0.55	FALSE
60	GTEx	Stomach	KAT8	0.12	0.03	lasso	5	0.07	2.9e-04	4.72	6.5	9.9e-11	-0.58	0.06	0.90	FALSE
61	GTEx	Testis	STX4	0.15	0.02	lasso	6	0.01	8.2e-02	5.10	5.3	1.1e-07	-0.38	0.17	0.06	FALSE
62	GTEx	Testis	RP11-196G11.2	0.14	0.11	lasso	4	0.13	3.1e-06	5.44	5.5	4.8e-08	-0.45	0.88	0.09	FALSE
63	GTEx	Thyroid	STX1B	0.11	0.16	enet	19	0.16	3.9e-12	5.10	6.8	1.3e-11	-0.59	0.99	0.01	FALSE
64	GTEx	Thyroid	HSD3B7	0.27	0.12	lasso	4	0.17	7.0e-13	5.38	5.5	5.2e-08	-0.55	1.00	0.00	FALSE
65	GTEx	Thyroid	KAT8	0.21	0.12	lasso	6	0.15	2.2e-11	-6.92	6.9	6.1e-12	-0.64	0.02	0.98	FALSE
66	GTEx	Thyroid	RP11-196G11.2	0.11	0.14	lasso	2	0.14	3.5e-11	5.36	5.4	6.8e-08	-0.45	1.00	0.00	FALSE
67	GTEx	Uterus	FBRS	0.21	0.07	lasso	10	0.07	1.7e-02	-6.56	-6.6	4.9e-11	0.73	0.03	0.58	FALSE
68	GTEx	Uterus	RP11-196G11.2	0.18	0.16	lasso	20	0.15	5.4e-04	5.37	5.2	2.0e-07	-0.51	0.50	0.12	FALSE
69	GTEx	Whole Blood	HSD3B7	0.06	0.06	lasso	4	0.06	2.6e-06	-6.61	-6.8	8.5e-12	0.72	0.03	0.97	FALSE
70	GTEx	Whole Blood	ZNF668	0.05	0.06	lasso	3	0.06	5.9e-06	-6.92	-7.0	2.1e-12	0.66	0.02	0.98	FALSE
71	METSIM	Adipose	KAT8	0.17	0.13	lasso	6	0.20	1.7e-28	-6.92	6.7	2.1e-11	-0.58	0.02	0.98	FALSE
72	NTR	Blood	BCKDK	0.01	0.00	bslmm	242	0.01	2.5e-03	-6.94	-6.2	7.3e-10	0.61	0.02	0.94	FALSE
73	NTR	Blood	ZNF48	0.01	0.00	blup	196	0.00	2.2e-02	0.43	-5.4	8.4e-08	0.54	0.04	0.06	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	HSD3B7	0.03	0.05	lasso	6	0.02	3.0e-04	5.38	5.5	5.1e-08	-0.45	0.85	0.12	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	SETD1A	0.02	0.01	blup	232	0.02	4.3e-04	4.09	6.1	1.3e-09	-0.68	0.08	0.80	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	STX4	0.06	0.11	lasso	10	0.11	1.4e-13	5.38	-5.4	5.9e-08	0.46	1.00	0.00	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	KAT8	0.13	0.16	lasso	5	0.16	4.2e-20	-6.91	7.1	1.6e-12	-0.68	0.02	0.98	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	ZNF668	0.11	0.11	lasso	4	0.11	1.7e-14	-6.63	-6.4	1.4e-10	0.68	0.05	0.95	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	ZNF646	0.06	0.01	bslmm	233	0.01	1.1e-02	-6.75	5.7	1.1e-08	-0.64	0.04	0.95	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	VKORC1	0.05	0.02	enet	12	0.05	1.2e-06	4.34	-5.3	9.6e-08	0.56	0.68	0.28	FALSE
81	YFS	Blood	BCKDK	0.05	0.05	blup	237	0.07	4.4e-22	3.86	-5.4	6.1e-08	0.44	1.00	0.00	FALSE
82	YFS	Blood	HSD3B7	0.06	0.02	blup	220	0.03	8.9e-10	-7.03	-5.6	2.2e-08	0.52	0.02	0.98	FALSE
83	YFS	Blood	PRSS36	0.02	0.02	enet	8	0.02	1.1e-07	4.72	5.4	8.4e-08	-0.35	0.94	0.03	FALSE
84	YFS	Blood	ZNF668	0.10	0.12	bslmm	232	0.12	1.5e-36	-6.63	-6.7	2.9e-11	0.69	0.07	0.93	FALSE
85	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYST1	0.04	0.03	enet	4	0.03	1.2e-03	4.72	6.3	3.4e-10	-0.50	0.04	0.76	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD3B7	0.03	0.03	blup	31	0.04	5.2e-08	4.54	5.6	2.7e-08	-0.54	0.97	0.03	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	4.73	6.4	1.8e-10	-0.54	0.42	0.58	FALSE
88	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MYST1	0.26	0.01	blup	34	0.05	1.4e-03	-6.94	6.0	1.6e-09	-0.51	0.01	0.63	FALSE
89	The Cancer Genome Atlas	Glioblastoma Multiforme	MYST1	0.18	0.07	blup	35	0.11	4.2e-04	-6.63	6.7	1.8e-11	-0.68	0.02	0.90	FALSE
90	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	4.49	6.1	1.2e-09	-0.60	0.05	0.74	FALSE
91	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYST1	0.08	0.04	blup	34	0.07	7.2e-08	-6.94	6.1	8.6e-10	-0.54	0.02	0.98	FALSE
92	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF668	0.03	0.01	lasso	3	0.01	2.5e-02	-6.63	-6.6	3.9e-11	0.69	0.03	0.72	FALSE
93	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYST1	0.12	0.09	blup	34	0.10	2.8e-11	4.73	6.2	5.6e-10	-0.51	0.86	0.14	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VKORC1	0.03	0.04	lasso	3	0.04	3.2e-05	-6.56	6.8	9.6e-12	-0.71	0.02	0.98	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF668	0.02	0.02	blup	32	0.02	2.9e-03	-6.69	-7.1	1.3e-12	0.69	0.02	0.93	TRUE
96	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYST1	0.07	0.01	enet	6	0.04	1.6e-03	-7.03	6.2	7.6e-10	-0.60	0.01	0.88	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYST1	0.16	0.08	blup	34	0.12	1.5e-13	-6.95	6.6	4.1e-11	-0.57	0.01	0.99	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRSS53	0.07	0.04	enet	12	0.04	2.8e-05	5.42	-5.5	3.4e-08	0.45	0.44	0.33	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	VKORC1	0.05	0.02	blup	36	0.03	1.0e-04	-5.32	-5.2	2.1e-07	0.63	0.02	0.83	FALSE
100	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	-6.63	-7.0	2.4e-12	0.67	0.02	0.83	FALSE
101	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	VKORC1	0.10	0.03	enet	7	0.07	3.8e-04	-6.94	5.7	1.3e-08	-0.67	0.02	0.96	FALSE
102	The Cancer Genome Atlas	Lung Adenocarcinoma	MYST1	0.09	0.03	blup	33	0.03	1.4e-04	4.73	5.9	3.7e-09	-0.44	0.14	0.62	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYST1	0.08	0.08	enet	8	0.08	2.8e-09	4.72	5.2	2.2e-07	-0.36	0.99	0.01	FALSE
104	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD3B7	0.04	0.04	blup	31	0.05	3.6e-04	5.38	6.1	1.4e-09	-0.60	0.04	0.70	FALSE
105	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYST1	0.03	0.05	blup	34	0.03	2.1e-03	-6.63	7.1	1.6e-12	-0.69	0.02	0.92	FALSE
106	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STX1B	0.02	0.01	blup	32	0.01	5.5e-02	5.42	5.8	6.2e-09	-0.60	0.02	0.34	FALSE
107	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYST1	0.22	0.15	blup	36	0.21	2.1e-09	-7.03	6.5	6.6e-11	-0.59	0.01	0.99	FALSE
108	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSD3B7	0.09	0.12	blup	31	0.11	4.1e-05	4.63	5.5	5.1e-08	-0.57	0.20	0.55	FALSE
109	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MYST1	0.07	0.09	lasso	3	0.07	1.0e-03	4.64	5.8	8.8e-09	-0.43	0.03	0.66	FALSE
110	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYST1	0.19	0.12	blup	33	0.18	1.5e-18	-6.91	6.7	2.8e-11	-0.60	0.01	0.99	FALSE
111	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS36	0.17	0.13	blup	27	0.14	1.0e-14	4.64	5.7	1.3e-08	-0.47	0.95	0.05	FALSE
112	The Cancer Genome Atlas	Rectum Adenocarcinoma	MYST1	0.13	0.05	blup	35	0.06	1.9e-02	-7.03	7.1	1.3e-12	-0.66	0.01	0.63	FALSE
113	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYST1	0.04	0.02	blup	35	0.02	8.7e-03	4.72	6.5	7.2e-11	-0.56	0.02	0.47	FALSE
114	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYST1	0.13	0.06	blup	34	0.12	6.8e-05	-6.90	7.1	1.4e-12	-0.65	0.02	0.95	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	-6.99	6.8	8.4e-12	-0.59	0.01	0.99	FALSE