[Hub]/) : Traits : Cardiovascular Disease :

chr17:42,413,481-43,570,226

Best TWAS P=2.45e-09 · Best GWAS P=1.25e-08 conditioned to 0.0128

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DCAKD 0.18 0.20 lasso 6 0.20 2.6e-23 5.2 -5.2 2.2e-07 -0.32 0.05 0.95 FALSE
2 CommonMind Brain Pre-frontal Cortex NMT1 0.07 0.05 bslmm 323 0.05 1.5e-06 2.9 5.5 3.5e-08 0.42 0.04 0.96 FALSE
3 GTEx Artery Tibial DCAKD 0.27 0.21 lasso 8 0.20 6.6e-16 5.2 -5.2 1.8e-07 -0.33 0.05 0.95 FALSE
4 GTEx Breast Mammary Tissue (Male) DCAKD 0.36 0.29 lasso 8 0.33 1.4e-08 5.1 -5.5 5.0e-08 -0.45 0.04 0.95 FALSE
5 GTEx Esophagus Mucosa DCAKD 0.33 0.32 enet 20 0.35 5.6e-24 5.2 -5.2 2.5e-07 -0.42 0.05 0.95 FALSE
6 GTEx Esophagus Muscularis DCAKD 0.27 0.29 lasso 5 0.30 2.1e-18 5.2 -5.2 2.2e-07 -0.36 0.05 0.95 FALSE
7 GTEx Heart Left Ventricle DCAKD 0.17 0.17 lasso 3 0.17 2.3e-09 5.2 -5.6 2.3e-08 -0.45 0.04 0.96 FALSE
8 GTEx Muscle Skeletal DCAKD 0.12 0.06 enet 16 0.07 9.9e-08 4.2 -5.5 4.7e-08 -0.55 0.02 0.98 FALSE
9 GTEx Nerve Tibial DCAKD 0.35 0.29 enet 21 0.30 1.6e-21 -5.6 -5.5 4.6e-08 -0.46 0.00 1.00 FALSE
10 GTEx Thyroid DCAKD 0.25 0.26 enet 17 0.27 9.4e-21 4.2 -5.2 1.7e-07 -0.54 0.16 0.83 FALSE
11 GTEx Whole Blood DCAKD 0.07 0.08 lasso 2 0.06 1.8e-06 5.2 -5.2 2.2e-07 -0.37 0.04 0.95 FALSE
12 METSIM Adipose NMT1 0.13 0.11 lasso 6 0.11 5.7e-16 5.1 5.2 2.5e-07 0.36 0.02 0.97 FALSE
13 NTR Blood DCAKD 0.02 0.01 enet 5 0.01 5.0e-05 -5.6 -5.3 8.7e-08 -0.45 0.02 0.98 FALSE
14 ROSMAP Brain Pre-frontal Cortex DCAKD 0.26 0.18 enet 27 0.24 8.8e-31 5.2 -5.1 3.1e-07 -0.37 0.05 0.95 FALSE
15 The Cancer Genome Atlas Esophageal Carcinoma LOC644172 0.19 0.12 lasso 3 0.05 8.2e-03 5.4 -5.2 1.8e-07 -0.28 0.01 0.67 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NMT1 0.05 0.04 lasso 2 0.04 1.5e-05 5.4 5.5 3.8e-08 0.50 0.01 0.98 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma NMT1 0.08 0.04 blup 83 0.05 3.5e-06 5.2 5.6 2.5e-08 0.41 0.03 0.97 FALSE
18 The Cancer Genome Atlas Lung Adenocarcinoma NMT1 0.04 0.00 blup 81 0.01 1.9e-02 5.5 5.3 1.5e-07 0.53 0.01 0.87 FALSE
19 The Cancer Genome Atlas Pancreatic Adenocarcinoma NMT1 0.23 0.08 blup 82 0.12 1.1e-05 -5.6 5.9 3.4e-09 0.71 0.01 0.98 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma NMT1 0.09 0.08 lasso 3 0.09 1.1e-09 -5.6 5.7 1.5e-08 0.54 0.01 0.99 FALSE
21 The Cancer Genome Atlas Thyroid Carcinoma DCAKD 0.12 0.13 lasso 8 0.13 5.5e-13 5.2 -5.2 1.6e-07 -0.34 0.03 0.97 FALSE
22 The Cancer Genome Atlas Thyroid Carcinoma HEXIM1 0.05 0.05 blup 47 0.04 8.5e-05 5.4 -5.7 9.3e-09 -0.77 0.02 0.97 FALSE
23 The Cancer Genome Atlas Thyroid Carcinoma NMT1 0.18 0.19 enet 20 0.20 3.8e-19 5.5 6.0 2.5e-09 0.63 0.01 0.99 TRUE