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chr17:44,788,310-48,139,500

Best TWAS P=6.2e-18 · Best GWAS P=6.23e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
56	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF652	0.05	0.02	blup	55	0.02	2.5e-03	9.6	-8.6	6.2e-18	-0.87	0.01	0.97	TRUE
17	GTEx	Cells Transformed fibroblasts	RP11-463M16.4	0.10	0.00	enet	21	0.01	2.8e-02	-5.7	8.2	2.1e-16	0.29	0.28	0.06	TRUE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF652	0.03	0.03	enet	5	0.03	2.6e-04	6.9	-7.7	1.1e-14	-0.90	0.03	0.93	TRUE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOSR2	0.01	0.01	blup	77	0.01	7.4e-03	7.0	7.0	3.5e-12	-0.12	0.07	0.05	TRUE
8	GTEx	Artery Aorta	AC091133.1	0.10	0.07	lasso	5	0.07	1.2e-04	-5.4	6.9	4.9e-12	-0.01	0.54	0.04	TRUE
63	The Cancer Genome Atlas	Thyroid Carcinoma	GNGT2	0.11	0.06	blup	48	0.05	1.3e-05	7.2	6.7	2.6e-11	0.66	0.00	1.00	TRUE
26	GTEx	Pituitary	NPEPPS	0.20	0.10	enet	10	0.05	2.6e-02	5.1	6.6	3.3e-11	-0.06	0.11	0.14	TRUE
13	GTEx	Cells EBV-transformed lymphocytes	UBE2Z	0.16	0.01	enet	25	0.10	3.5e-04	-5.9	-6.6	4.4e-11	-0.12	0.27	0.08	TRUE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNF8	0.05	0.06	blup	47	0.06	1.0e-06	-6.2	6.5	9.0e-11	-0.08	0.07	0.93	TRUE
14	GTEx	Cells EBV-transformed lymphocytes	AC002558.1	0.28	0.04	enet	22	0.07	2.2e-03	4.5	-6.5	9.7e-11	0.05	0.07	0.16	TRUE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF652	0.06	0.03	lasso	4	0.02	1.6e-03	7.2	-6.4	1.4e-10	-0.76	0.22	0.54	TRUE
36	METSIM	Adipose	UBE2Z	0.06	0.06	enet	16	0.04	3.2e-06	-5.9	-5.9	3.2e-09	0.06	1.00	0.00	TRUE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100272146	0.04	0.03	enet	19	0.03	1.1e-04	-5.0	5.2	2.0e-07	0.06	0.00	0.96	TRUE
38	YFS	Blood	GNGT2	0.13	0.13	lasso	5	0.12	1.1e-38	7.2	7.6	3.7e-14	0.76	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GNGT2	0.15	0.05	enet	4	0.08	3.4e-04	7.2	7.4	1.3e-13	0.71	0.00	0.99	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	GNGT2	0.04	0.04	lasso	3	0.03	2.8e-04	7.2	7.3	3.4e-13	0.72	0.00	0.99	FALSE
55	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GNGT2	0.16	0.07	lasso	5	0.07	4.8e-04	7.2	7.2	4.5e-13	0.73	0.00	0.92	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GNGT2	0.06	0.04	lasso	2	0.04	3.5e-05	7.2	7.2	4.8e-13	0.72	0.00	0.99	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	GNGT2	0.04	0.04	lasso	4	0.03	1.3e-07	7.2	7.2	8.3e-13	0.71	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNGT2	0.09	0.07	blup	48	0.06	2.7e-07	7.2	7.0	1.8e-12	0.72	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	GNGT2	0.08	0.06	enet	7	0.08	3.9e-09	7.2	7.0	2.6e-12	0.66	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNF8	0.08	0.07	lasso	5	0.08	9.3e-10	-5.4	6.8	8.1e-12	-0.08	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GNGT2	0.07	0.05	lasso	3	0.05	3.3e-06	7.2	6.8	1.4e-11	0.72	0.00	1.00	FALSE
28	GTEx	Skin Sun Exposed Lower leg	GOSR2	0.04	0.03	lasso	6	0.01	4.0e-02	7.0	6.7	1.5e-11	-0.12	0.09	0.76	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNF8	0.01	0.01	blup	47	0.01	9.1e-03	-5.9	6.6	3.5e-11	-0.09	0.05	0.28	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOSR2	0.05	0.03	blup	77	0.03	3.7e-03	6.5	6.6	5.3e-11	-0.10	0.04	0.52	FALSE
43	The Cancer Genome Atlas	Glioblastoma Multiforme	GNGT2	0.22	0.00	blup	47	0.00	3.1e-01	7.2	6.5	6.1e-11	0.76	0.00	0.61	FALSE
22	GTEx	Muscle Skeletal	UBE2Z	0.06	0.02	lasso	8	0.03	9.8e-04	-5.7	6.5	7.7e-11	-0.08	0.77	0.01	FALSE
19	GTEx	Esophagus Muscularis	SNF8	0.08	0.03	lasso	3	0.01	5.7e-02	-6.2	6.5	1.1e-10	-0.08	0.12	0.04	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	UBE2Z	0.11	0.07	lasso	6	0.04	1.8e-03	-6.2	6.5	1.1e-10	-0.08	0.11	0.04	FALSE
23	GTEx	Muscle Skeletal	EFCAB13	0.04	0.01	lasso	5	0.01	1.4e-02	-1.2	6.3	3.7e-10	-0.07	0.12	0.11	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP5G1	0.07	0.05	lasso	3	0.06	4.7e-08	-6.8	6.3	3.8e-10	0.00	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Glioblastoma Multiforme	SNF8	0.09	0.06	blup	47	0.07	4.3e-03	-5.9	6.2	4.4e-10	-0.07	0.07	0.33	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF652	0.09	0.01	enet	12	0.05	5.5e-04	7.5	-6.2	4.8e-10	-0.55	0.02	0.46	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNF8	0.03	0.01	blup	47	0.03	1.0e-02	-5.8	6.2	4.9e-10	-0.07	0.04	0.49	FALSE
21	GTEx	Heart Left Ventricle	ATP5G1	0.24	0.22	lasso	4	0.22	9.3e-12	-5.7	6.2	5.4e-10	-0.05	1.00	0.00	FALSE
34	GTEx	Thyroid	GNGT2	0.16	0.09	enet	25	0.08	8.1e-07	7.2	6.2	5.8e-10	0.68	0.50	0.49	FALSE
10	GTEx	Brain Cortex	WNT3	0.29	0.17	enet	18	0.10	1.0e-03	-5.1	6.1	8.2e-10	-0.08	0.05	0.36	FALSE
5	GTEx	Adipose Subcutaneous	EFCAB13	0.11	0.03	enet	20	0.08	8.4e-07	-1.2	6.1	1.3e-09	-0.06	0.24	0.47	FALSE
4	CommonMind	Brain Pre-frontal Cortex	UBE2Z	0.05	0.08	lasso	2	0.08	9.8e-10	-5.9	6.0	1.9e-09	-0.07	1.00	0.00	FALSE
35	GTEx	Whole Blood	UBE2Z	0.08	0.01	lasso	6	0.02	4.9e-03	-5.9	-6.0	2.5e-09	0.03	0.84	0.01	FALSE
7	GTEx	Artery Aorta	SNF8	0.12	0.12	lasso	6	0.10	2.3e-06	-5.4	5.9	3.6e-09	-0.02	0.87	0.01	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNF8	0.11	0.12	lasso	4	0.12	1.4e-13	-5.4	5.9	3.8e-09	-0.07	0.26	0.74	FALSE
25	GTEx	Ovary	ATP5G1	0.15	0.08	enet	13	0.09	2.8e-03	-4.4	5.9	3.9e-09	-0.06	0.22	0.04	FALSE
12	GTEx	Brain Cortex	ARL17A	0.35	0.20	lasso	6	0.25	1.7e-07	4.2	5.9	4.0e-09	-0.09	0.11	0.05	FALSE
29	GTEx	Skin Sun Exposed Lower leg	UBE2Z	0.14	0.11	lasso	9	0.14	6.3e-12	-5.1	5.8	5.1e-09	-0.05	1.00	0.00	FALSE
16	GTEx	Cells Transformed fibroblasts	SNF8	0.12	0.10	lasso	3	0.12	5.1e-09	-5.4	5.8	6.5e-09	-0.06	1.00	0.00	FALSE
33	GTEx	Thyroid	SNF8	0.11	0.08	lasso	3	0.07	2.5e-06	-5.7	5.8	6.7e-09	-0.04	0.97	0.00	FALSE
30	GTEx	Testis	GOSR2	0.11	0.00	enet	2	0.00	2.8e-01	-5.7	5.7	9.9e-09	-0.12	0.10	0.24	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	UBE2Z	0.13	0.09	lasso	4	0.12	2.7e-11	-5.3	5.7	1.0e-08	-0.07	0.17	0.83	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTLL6	0.03	0.00	blup	59	0.02	2.7e-03	-4.1	-5.7	1.3e-08	-0.02	0.02	0.82	FALSE
32	GTEx	Testis	RP11-156P1.3	0.17	0.03	lasso	7	0.04	7.7e-03	6.0	5.7	1.4e-08	-0.04	0.05	0.58	FALSE
15	GTEx	Cells Transformed fibroblasts	GOSR2	0.14	0.10	enet	11	0.08	9.9e-07	-5.7	5.7	1.5e-08	-0.11	1.00	0.00	FALSE
18	GTEx	Esophagus Muscularis	ATP5G1	0.09	0.06	lasso	5	0.05	4.5e-04	-5.6	5.6	1.7e-08	-0.04	0.33	0.04	FALSE
37	METSIM	Adipose	ZNF652	0.05	0.03	lasso	8	0.05	6.2e-08	-2.1	-5.6	1.7e-08	-0.69	0.75	0.25	FALSE
11	GTEx	Brain Cortex	ATP5G1	0.16	0.15	lasso	2	0.14	1.3e-04	-5.6	5.6	2.5e-08	-0.03	0.18	0.06	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	SNF8	0.16	0.18	lasso	7	0.18	5.9e-17	-5.4	5.4	6.2e-08	-0.06	0.64	0.36	FALSE
9	GTEx	Brain Cerebellum	ATP5G1	0.22	0.26	lasso	3	0.24	8.2e-08	-5.1	5.4	7.6e-08	-0.04	0.90	0.00	FALSE
24	GTEx	Nerve Tibial	UBE2Z	0.12	0.04	enet	16	0.05	1.5e-04	-5.4	5.4	7.8e-08	-0.06	0.90	0.00	FALSE
20	GTEx	Heart Atrial Appendage	ATP5G1	0.22	0.10	enet	6	0.13	1.3e-06	-5.4	5.4	8.2e-08	-0.03	0.96	0.00	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	CALCOCO2	0.03	0.00	blup	50	0.01	1.9e-02	3.6	5.3	1.1e-07	0.00	0.03	0.76	FALSE
6	GTEx	Adipose Subcutaneous	ITGB3	0.13	0.04	enet	33	0.09	3.6e-08	-1.6	5.3	1.3e-07	-0.06	0.48	0.37	FALSE
31	GTEx	Testis	SNF8	0.23	0.11	lasso	5	0.08	1.6e-04	-5.4	5.2	1.8e-07	-0.03	0.73	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TBKBP1	0.03	0.00	blup	415	0.01	5.4e-02	3.8	-5.2	2.1e-07	0.01	0.14	0.43	FALSE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C17orf57	0.16	0.13	blup	73	0.09	3.7e-04	-2.7	5.1	3.1e-07	0.02	0.08	0.64	FALSE