[Hub]/) : Traits : Cardiovascular Disease : ← →

chr18:20,393,480-21,863,589

Best TWAS P=1.61e-11 · Best GWAS P=5.5e-11 conditioned to 0.409

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	6.5	-6.7	1.6e-11	-0.93	0.01	0.99	TRUE
10	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	6.4	-6.7	2.2e-11	-0.98	0.00	0.99	FALSE
19	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	-5.5	-6.5	6.9e-11	-0.83	0.03	0.89	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf8	0.07	0.05	lasso	5	0.03	9.5e-05	6.5	-6.5	7.7e-11	-0.98	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	-5.5	-6.5	1.1e-10	-0.89	0.40	0.60	FALSE
4	GTEx	Artery Tibial	C18orf8	0.18	0.12	lasso	3	0.10	1.5e-08	6.5	-6.5	1.1e-10	-0.99	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	6.6	-6.4	1.7e-10	-0.97	0.01	0.93	FALSE
13	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	6.4	-6.4	2.0e-10	-0.92	0.01	0.99	FALSE
5	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	-5.8	-6.4	2.1e-10	-0.86	0.04	0.92	FALSE
3	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	-5.8	-6.3	2.2e-10	-0.83	0.26	0.74	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	-5.5	-6.2	7.1e-10	-0.86	0.03	0.97	FALSE
8	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	-5.9	-5.9	2.9e-09	-0.71	0.09	0.82	FALSE
6	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	-5.5	-5.9	3.5e-09	-0.76	0.23	0.76	FALSE
7	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	-5.8	-5.9	4.3e-09	-0.82	0.04	0.95	FALSE
18	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	-4.3	-5.8	6.0e-09	-0.88	0.01	0.99	FALSE
17	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	-5.8	-5.7	9.1e-09	-0.79	0.45	0.55	FALSE
21	METSIM	Adipose	NPC1	0.06	0.05	enet	18	0.05	6.4e-08	-5.9	-5.7	1.2e-08	-0.80	0.04	0.96	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	NPC1	0.04	0.03	blup	70	0.05	9.4e-06	-5.6	-5.6	2.8e-08	-0.81	0.12	0.87	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	C18orf8	0.21	0.27	enet	6	0.23	6.9e-13	-5.2	-5.5	3.3e-08	-0.69	0.54	0.46	FALSE
11	GTEx	Esophagus Muscularis	NPC1	0.11	0.07	enet	4	0.09	7.3e-06	-5.6	-5.5	3.9e-08	-0.68	0.15	0.81	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	NPC1	0.03	0.03	blup	69	0.04	2.9e-09	-5.2	-5.4	5.3e-08	-0.84	0.05	0.95	FALSE
9	GTEx	Brain Frontal Cortex BA9	C18orf8	0.42	0.30	enet	12	0.08	3.4e-03	-5.3	-5.4	5.9e-08	-0.68	0.28	0.69	FALSE
14	GTEx	Pancreas	NPC1	0.33	0.14	lasso	7	0.12	1.1e-05	-5.2	-5.4	7.7e-08	-0.67	0.36	0.56	FALSE
12	GTEx	Lung	NPC1	0.11	0.06	enet	11	0.04	2.3e-04	-5.5	-5.3	9.8e-08	-0.68	0.39	0.61	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NPC1	0.08	0.07	lasso	3	0.08	5.2e-10	6.4	-5.3	1.4e-07	-0.91	0.01	0.99	FALSE
20	GTEx	Thyroid	NPC1	0.20	0.10	enet	25	0.13	2.3e-10	-5.1	-5.2	2.2e-07	-0.77	0.43	0.57	FALSE