TWAS
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Traits
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Cardiovascular Disease
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chr19:1,163,934-2,560,423
Best TWAS P=4.69e-09 · Best GWAS P=2.65e-09 conditioned to 1
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
CTB-31O20.6
0.16
0.07
lasso
5
0.05
7.8e-04
-5.9
-5.9
4.7e-09
0.99
0.01
0.99
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
KLF16
0.12
0.08
bslmm
372
0.08
1.0e-10
-4.8
-5.4
6.3e-08
0.43
0.58
0.41
FALSE