Best TWAS P=2.45e-08 · Best GWAS P=3.73e-08 conditioned to 0.151
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | RP11-378A13.1 | 0.18 | 0.14 | lasso | 6 | 0.13 | 4.6e-05 | 5.2 | -5.3 | 1.5e-07 | -0.98 | 0.02 | 0.94 | FALSE |
| 2 | GTEx | Testis | PNKD | 0.20 | 0.19 | lasso | 3 | 0.19 | 1.2e-08 | 5.0 | -5.2 | 2.2e-07 | -0.97 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Testis | TMBIM1 | 0.27 | 0.13 | enet | 20 | 0.15 | 2.7e-07 | 4.3 | -5.6 | 2.5e-08 | -0.85 | 0.02 | 0.98 | TRUE |
| 4 | METSIM | Adipose | TMBIM1 | 0.14 | 0.15 | lasso | 11 | 0.14 | 1.3e-20 | 5.5 | -5.2 | 1.6e-07 | -0.99 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TMBIM1 | 0.10 | 0.04 | blup | 49 | 0.06 | 3.0e-03 | 5.0 | -5.2 | 1.6e-07 | -0.98 | 0.03 | 0.77 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | TMBIM1 | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 5.5 | -5.4 | 6.4e-08 | -0.98 | 0.01 | 0.83 | FALSE |