Best TWAS P=8.89e-13 · Best GWAS P=4.07e-14 conditioned to 0.00206
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | RP11-819C21.1 | 0.37 | 0.16 | enet | 23 | 0.24 | 8.8e-07 | -2.3 | -5.1 | 2.9e-07 | -0.47 | 0.37 | 0.18 | FALSE |
| 2 | GTEx | Brain Cerebellum | RP11-819C21.1 | 0.18 | 0.08 | enet | 2 | 0.02 | 8.8e-02 | 6.8 | -6.2 | 6.9e-10 | -0.76 | 0.06 | 0.48 | FALSE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-819C21.1 | 0.39 | 0.17 | enet | 26 | 0.23 | 1.0e-06 | -3.6 | -5.7 | 1.0e-08 | -0.61 | 0.14 | 0.79 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | RP11-819C21.1 | 0.14 | 0.09 | enet | 12 | 0.09 | 2.6e-05 | 6.8 | -5.9 | 4.0e-09 | -0.67 | 0.15 | 0.80 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | RP11-819C21.1 | 0.15 | -0.01 | lasso | 1 | -0.01 | 7.0e-01 | 6.8 | -6.8 | 8.8e-12 | -0.80 | 0.04 | 0.19 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | RP11-819C21.1 | 0.11 | 0.06 | lasso | 8 | 0.05 | 2.1e-04 | 5.8 | -5.9 | 3.5e-09 | -0.60 | 0.82 | 0.10 | FALSE |
| 7 | GTEx | Heart Left Ventricle | CWF19L2 | 0.10 | 0.07 | lasso | 4 | 0.05 | 1.4e-03 | 5.7 | 6.5 | 6.3e-11 | 0.69 | 0.46 | 0.29 | FALSE |
| 8 | GTEx | Muscle Skeletal | CWF19L2 | 0.08 | 0.05 | lasso | 3 | 0.05 | 1.1e-05 | 6.8 | 7.2 | 8.9e-13 | 0.80 | 0.04 | 0.96 | TRUE |
| 9 | GTEx | Ovary | RP11-819C21.1 | 0.31 | 0.11 | enet | 28 | 0.22 | 3.9e-06 | 5.5 | -5.5 | 3.8e-08 | -0.69 | 0.05 | 0.86 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-819C21.1 | 0.27 | 0.10 | lasso | 5 | 0.19 | 9.4e-11 | -4.0 | -6.4 | 1.9e-10 | -0.81 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Testis | CWF19L2 | 0.20 | 0.09 | lasso | 6 | 0.09 | 1.0e-04 | 6.8 | 7.1 | 1.1e-12 | 0.72 | 0.34 | 0.46 | FALSE |
| 12 | GTEx | Thyroid | RP11-819C21.1 | 0.14 | 0.11 | enet | 21 | 0.13 | 3.0e-10 | -4.0 | -5.2 | 1.6e-07 | -0.62 | 0.46 | 0.54 | FALSE |
| 13 | GTEx | Whole Blood | RP11-819C21.1 | 0.06 | 0.03 | lasso | 2 | 0.01 | 4.8e-02 | 5.5 | -5.6 | 2.3e-08 | -0.53 | 0.15 | 0.30 | FALSE |
| 14 | METSIM | Adipose | CWF19L2 | 0.08 | 0.03 | blup | 517 | 0.05 | 6.5e-08 | 6.8 | 5.4 | 6.3e-08 | 0.62 | 0.26 | 0.74 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | CWF19L2 | 0.11 | 0.01 | blup | 105 | 0.02 | 3.0e-02 | -2.6 | 5.5 | 2.9e-08 | 0.62 | 0.06 | 0.09 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CWF19L2 | 0.05 | 0.00 | blup | 106 | 0.01 | 3.4e-02 | 2.3 | 5.6 | 2.3e-08 | 0.71 | 0.03 | 0.05 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CWF19L2 | 0.08 | 0.00 | blup | 106 | 0.03 | 3.0e-04 | -4.2 | 5.1 | 2.8e-07 | 0.66 | 0.39 | 0.09 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CWF19L2 | 0.13 | 0.01 | enet | 9 | 0.04 | 1.4e-02 | -3.5 | 5.2 | 2.6e-07 | 0.65 | 0.03 | 0.34 | FALSE |