[Hub]/) : Traits : Cardiovascular Disease : ← →

chr11:110,776,537-112,491,227

Best TWAS P=5.14e-11 · Best GWAS P=5.45e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C11orf1	0.06	0.06	lasso	5	0.05	4.4e-07	6.6	-6.6	5.1e-11	-1.00	0.02	0.98	TRUE
6	GTEx	Skin Sun Exposed Lower leg	C11orf1	0.06	0.05	lasso	2	0.02	9.6e-03	6.4	-6.4	1.2e-10	-0.98	0.02	0.96	FALSE
5	GTEx	Skin Sun Exposed Lower leg	CRYAB	0.07	0.04	lasso	10	0.02	1.3e-02	6.4	6.3	2.3e-10	0.98	0.02	0.96	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf1	0.07	0.06	enet	3	0.08	7.0e-09	5.8	-6.1	1.1e-09	-0.90	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	SIK2	0.05	0.06	lasso	1	0.05	2.6e-06	5.9	5.9	3.7e-09	0.75	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	FDXACB1	0.08	0.07	lasso	3	0.05	5.6e-04	5.8	-5.9	4.5e-09	-0.95	0.00	0.97	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	C11orf1	0.04	0.02	lasso	2	0.03	2.1e-04	5.8	-5.8	5.6e-09	-0.96	0.00	1.00	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRYAB	0.03	0.02	lasso	1	0.01	2.2e-03	5.8	5.8	6.0e-09	0.96	0.00	0.96	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	FDXACB1	0.13	0.05	lasso	1	0.05	2.4e-06	5.8	-5.8	6.0e-09	-0.96	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FDXACB1	0.03	0.02	lasso	1	0.02	5.9e-03	5.8	-5.8	6.0e-09	-0.96	0.00	0.89	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	CRYAB	0.12	0.10	lasso	5	0.07	7.7e-05	5.8	5.8	7.5e-09	0.96	0.02	0.98	FALSE
3	GTEx	Muscle Skeletal	C11orf1	0.04	0.05	lasso	4	0.02	3.5e-03	5.8	-5.8	7.7e-09	-0.96	0.03	0.95	FALSE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	C11orf1	0.11	0.07	enet	2	0.08	3.4e-05	5.8	-5.7	1.1e-08	-0.94	0.00	0.98	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	HSPB2	0.03	0.01	blup	5	0.03	2.3e-04	5.8	5.5	3.4e-08	0.81	0.00	0.93	FALSE
15	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C11orf1	0.09	0.01	blup	5	0.03	2.0e-02	-4.0	-5.5	4.1e-08	-0.75	0.00	0.26	FALSE
2	GTEx	Esophagus Mucosa	SIK2	0.13	0.03	lasso	4	0.02	2.2e-02	4.9	5.4	5.6e-08	0.67	0.10	0.68	FALSE
7	GTEx	Testis	PPP2R1B	0.34	0.21	lasso	10	0.36	1.5e-16	6.2	-5.4	7.0e-08	-0.84	0.03	0.97	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	SIK2	0.04	0.01	blup	35	0.01	6.7e-03	5.9	5.2	1.6e-07	0.71	0.01	0.94	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf1	0.04	0.03	blup	5	0.02	1.8e-03	5.8	-5.2	2.5e-07	-0.85	0.00	0.87	FALSE