Best TWAS P=2.18e-12 · Best GWAS P=1.77e-12 conditioned to 7.15e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | EFCAB7 | 0.27 | 0.04 | lasso | 4 | 0.06 | 1.2e-02 | -4.9 | 5.3 | 1.4e-07 | -0.01 | 0.15 | 0.05 | FALSE |
| 2 | GTEx | Brain Cerebellum | EFCAB7 | 0.33 | 0.09 | lasso | 10 | 0.09 | 1.5e-03 | -3.7 | 5.5 | 3.9e-08 | 0.05 | 0.22 | 0.06 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | INADL | 0.15 | 0.06 | lasso | 5 | 0.05 | 1.7e-04 | 6.6 | -6.5 | 7.3e-11 | -0.03 | 0.00 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Muscularis | TM2D1 | 0.12 | 0.03 | lasso | 3 | 0.04 | 3.2e-03 | 5.5 | 7.0 | 2.2e-12 | -0.04 | 0.06 | 0.58 | TRUE |
| 5 | GTEx | Prostate | EFCAB7 | 0.28 | 0.07 | lasso | 7 | 0.08 | 5.1e-03 | -5.2 | 5.3 | 9.6e-08 | -0.02 | 0.13 | 0.12 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | TM2D1 | 0.08 | 0.02 | bslmm | 500 | 0.02 | 6.0e-04 | 4.5 | 6.4 | 1.3e-10 | 0.02 | 0.43 | 0.02 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | ITGB3BP | 0.15 | 0.10 | lasso | 2 | 0.08 | 2.6e-05 | -5.3 | 5.3 | 1.4e-07 | 0.05 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ITGB3BP | 0.08 | 0.07 | blup | 52 | 0.07 | 1.4e-08 | -5.3 | 5.5 | 5.0e-08 | 0.01 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ITGB3BP | 0.03 | 0.02 | blup | 52 | 0.02 | 6.9e-03 | -5.3 | 5.2 | 2.1e-07 | 0.05 | 0.01 | 0.83 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DLEU2L | 0.13 | 0.09 | enet | 8 | 0.07 | 5.3e-04 | -5.1 | 5.2 | 1.5e-07 | 0.03 | 0.00 | 0.90 | FALSE |