Best TWAS P=1.07e-25 · Best GWAS P=3.33e-25 conditioned to 0.799
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WDR78 | 0.13 | 0.14 | lasso | 3 | 0.14 | 1.7e-16 | -7.95 | 8.0 | 1.9e-15 | -0.73 | 0.83 | 0.17 | FALSE |
| 2 | GTEx | Artery Aorta | MIER1 | 0.18 | 0.07 | lasso | 7 | 0.10 | 3.7e-06 | -2.40 | -7.2 | 4.4e-13 | 0.76 | 0.04 | 0.95 | FALSE |
| 3 | GTEx | Artery Tibial | WDR78 | 0.14 | 0.09 | lasso | 8 | 0.09 | 2.1e-07 | -10.13 | 10.5 | 1.1e-25 | -0.91 | 0.02 | 0.98 | TRUE |
| 4 | GTEx | Artery Tibial | MIER1 | 0.12 | 0.08 | lasso | 4 | 0.07 | 6.3e-06 | -10.17 | -10.2 | 2.7e-24 | 0.85 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | MIER1 | 0.12 | 0.07 | lasso | 2 | 0.05 | 8.5e-04 | -10.37 | -10.4 | 2.2e-25 | 1.00 | 0.01 | 0.97 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | MIER1 | 0.21 | -0.01 | lasso | 6 | 0.00 | 4.3e-01 | -7.95 | -8.7 | 2.8e-18 | 0.80 | 0.04 | 0.56 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | MIER1 | 0.19 | 0.09 | lasso | 7 | 0.10 | 3.1e-08 | -7.95 | -9.0 | 2.2e-19 | 0.87 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Esophagus Muscularis | MIER1 | 0.14 | 0.05 | enet | 9 | 0.04 | 2.5e-03 | -10.13 | -10.3 | 5.0e-25 | 0.80 | 0.03 | 0.92 | FALSE |
| 9 | GTEx | Nerve Tibial | WDR78 | 0.13 | 0.07 | lasso | 5 | 0.06 | 7.5e-05 | -10.12 | 9.3 | 1.2e-20 | -0.82 | 0.03 | 0.97 | FALSE |
| 10 | GTEx | Nerve Tibial | DIRAS3 | 0.18 | 0.01 | lasso | 6 | 0.05 | 1.3e-04 | -3.92 | 5.2 | 2.0e-07 | -0.01 | 0.05 | 0.90 | TRUE |
| 11 | GTEx | Testis | WDR78 | 0.45 | 0.42 | lasso | 6 | 0.40 | 5.0e-19 | -10.13 | -10.2 | 1.8e-24 | 0.85 | 0.03 | 0.97 | FALSE |
| 12 | GTEx | Thyroid | WDR78 | 0.12 | 0.11 | lasso | 3 | 0.09 | 2.4e-07 | -9.93 | 10.4 | 4.0e-25 | -0.91 | 0.02 | 0.98 | FALSE |
| 13 | METSIM | Adipose | MIER1 | 0.05 | 0.05 | enet | 19 | 0.04 | 2.8e-07 | -7.95 | -9.7 | 3.5e-22 | 0.83 | 0.03 | 0.97 | FALSE |
| 14 | NTR | Blood | MIER1 | 0.03 | 0.01 | bslmm | 573 | 0.01 | 2.7e-05 | -10.09 | -6.8 | 1.3e-11 | 0.57 | 0.04 | 0.96 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WDR78 | 0.02 | 0.01 | blup | 86 | 0.02 | 2.4e-04 | -10.11 | 8.1 | 8.5e-16 | -0.70 | 0.01 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C1orf141 | 0.12 | 0.06 | blup | 70 | 0.08 | 2.9e-09 | 1.19 | 5.4 | 5.9e-08 | -0.12 | 1.00 | 0.00 | TRUE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL23R | 0.25 | 0.07 | lasso | 8 | 0.05 | 1.0e-02 | -5.12 | -5.2 | 2.6e-07 | 0.48 | 0.02 | 0.67 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | MIER1 | 0.19 | 0.05 | blup | 58 | 0.06 | 1.7e-06 | -10.37 | -7.5 | 5.7e-14 | 0.78 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC35D1 | 0.13 | 0.10 | enet | 16 | 0.20 | 9.2e-19 | -6.98 | -6.2 | 5.9e-10 | 0.64 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR78 | 0.10 | 0.00 | blup | 86 | 0.07 | 1.6e-07 | -0.67 | 6.0 | 1.4e-09 | -0.54 | 0.04 | 0.91 | FALSE |