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chr4:16,767,708-18,710,299

Best TWAS P=0 · Best GWAS P=5.93e-278 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM184B	0.14	0.25	enet	21	0.24	2.0e-28	-12.3	12.4	3.2e-35	-0.14	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LAP3	0.05	0.06	lasso	2	0.05	4.8e-07	-10.4	-11.0	3.1e-28	0.11	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MED28	0.07	0.09	enet	9	0.11	7.1e-13	-12.4	13.6	2.1e-42	-0.18	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	24.9	24.1	5.2e-128	-0.23	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	24.9	26.5	1.8e-154	-0.34	0.39	0.27	FALSE
6	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	-32.5	37.9	0.0e+00	-0.79	0.10	0.60	TRUE
7	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	27.0	30.0	4.4e-198	-0.35	1.00	0.00	FALSE
8	GTEx	Brain Cerebellum	LCORL	0.18	-0.01	enet	11	-0.01	6.6e-01	-2.9	-6.0	2.5e-09	0.02	0.06	0.17	FALSE
9	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	25.0	31.0	2.6e-211	-0.51	0.08	0.80	FALSE
10	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	-30.7	33.7	1.8e-249	-0.75	0.03	0.69	FALSE
11	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	24.9	24.9	6.0e-137	-0.26	0.06	0.11	FALSE
12	GTEx	Cells Transformed fibroblasts	LAP3	0.20	0.12	lasso	6	0.13	3.0e-10	-12.2	-11.8	4.0e-32	0.13	1.00	0.00	FALSE
13	GTEx	Colon Transverse	MED28	0.13	0.05	lasso	3	0.02	5.8e-02	-10.4	10.6	2.0e-26	-0.11	0.20	0.04	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	QDPR	0.25	0.07	enet	18	0.12	4.6e-05	-1.4	7.7	1.2e-14	0.01	0.28	0.04	TRUE
15	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	25.0	27.5	2.3e-166	-0.35	0.14	0.35	FALSE
16	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	24.9	24.8	9.7e-136	-0.25	0.99	0.00	FALSE
17	GTEx	Muscle Skeletal	MED28	0.05	0.03	enet	8	0.02	3.1e-03	-12.2	12.3	9.2e-35	-0.14	0.56	0.02	FALSE
18	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	24.9	27.7	2.0e-169	-0.35	0.99	0.00	TRUE
19	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	24.9	22.4	2.2e-111	-0.37	0.08	0.22	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	23.9	27.4	5.7e-165	-0.34	0.63	0.06	FALSE
21	GTEx	Skin Sun Exposed Lower leg	QDPR	0.11	0.04	enet	22	0.08	4.8e-07	-1.4	10.4	2.8e-25	-0.29	0.25	0.45	FALSE
22	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	25.0	26.6	5.8e-156	-0.27	1.00	0.00	FALSE
23	GTEx	Spleen	LAP3	0.15	0.16	lasso	3	0.15	1.3e-04	-8.7	-10.5	5.5e-26	0.13	0.39	0.05	FALSE
24	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	24.9	35.9	8.5e-283	-0.65	0.05	0.60	FALSE
25	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	26.8	28.9	3.0e-184	-0.24	0.19	0.05	FALSE
26	GTEx	Testis	LAP3	0.28	0.19	lasso	3	0.19	5.1e-09	-10.5	-10.9	6.7e-28	0.10	1.00	0.00	FALSE
27	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	24.9	34.2	9.3e-257	-0.53	0.25	0.56	FALSE
28	GTEx	Whole Blood	LAP3	0.06	0.02	enet	7	0.02	1.1e-02	-10.4	-10.6	2.3e-26	0.12	0.70	0.01	FALSE
29	METSIM	Adipose	QDPR	0.05	0.00	bslmm	466	0.01	2.4e-02	3.6	5.8	5.5e-09	-0.19	0.10	0.04	FALSE
30	NTR	Blood	LAP3	0.06	0.07	lasso	5	0.07	1.6e-22	-10.5	-10.2	1.3e-24	0.10	1.00	0.00	FALSE
31	NTR	Blood	MED28	0.09	0.18	lasso	2	0.18	3.7e-54	-12.2	12.5	4.1e-36	-0.15	1.00	0.00	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	LAP3	0.12	0.09	lasso	6	0.10	1.9e-12	-10.4	-10.2	1.3e-24	0.10	1.00	0.00	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	FAM184B	0.17	0.14	enet	31	0.18	5.1e-23	-12.4	-16.9	2.4e-64	0.25	1.00	0.00	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	MED28	0.02	0.01	bslmm	411	0.00	1.9e-01	-12.5	16.1	1.8e-58	-0.29	0.22	0.03	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	-30.8	31.1	2.5e-212	-0.83	0.04	0.88	TRUE
36	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	27.0	27.0	1.9e-160	-0.25	0.84	0.03	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	MED28	0.02	0.01	enet	4	0.01	4.0e-03	-9.9	10.1	3.5e-24	-0.09	0.04	0.73	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	NCAPG	0.03	0.04	enet	5	0.04	8.1e-09	1.1	-10.6	4.8e-26	0.55	0.95	0.04	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	NCAPG	0.08	0.04	blup	34	0.09	1.1e-05	-31.1	-26.3	1.7e-152	0.83	0.06	0.91	TRUE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM184B	0.02	0.03	lasso	2	0.02	2.6e-03	-12.7	-12.9	6.6e-38	0.16	0.24	0.03	TRUE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LAP3	0.09	0.06	lasso	2	0.05	3.3e-06	-10.4	-10.7	1.2e-26	0.13	0.39	0.59	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	-30.8	-29.8	5.2e-195	0.83	0.99	0.00	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LAP3	0.04	0.08	enet	5	0.08	1.9e-09	-10.4	-10.6	4.7e-26	0.10	0.07	0.93	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	27.0	36.0	2.9e-284	-0.63	0.16	0.59	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	LAP3	0.03	0.03	blup	36	0.03	2.4e-04	-9.9	-11.2	3.8e-29	0.11	0.08	0.83	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	MED28	0.07	0.06	lasso	2	0.06	4.5e-07	-12.3	11.5	2.3e-30	-0.11	0.05	0.95	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	-31.1	-31.1	5.3e-212	0.86	0.03	0.54	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MED28	0.08	0.05	blup	34	0.05	2.9e-03	-12.4	12.9	4.4e-38	-0.16	0.02	0.76	TRUE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	MED28	0.02	0.01	blup	34	0.01	8.5e-03	-12.2	12.2	2.3e-34	-0.14	0.03	0.81	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	NCAPG	0.06	0.02	blup	34	0.04	1.0e-05	-31.1	-19.2	1.5e-82	0.67	0.13	0.05	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LAP3	0.02	0.02	lasso	4	0.01	2.2e-02	-12.3	-12.3	1.4e-34	0.13	0.02	0.81	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED28	0.03	0.02	blup	34	0.03	2.3e-04	-10.5	11.5	7.7e-31	-0.12	0.04	0.93	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LAP3	0.04	0.02	blup	36	0.02	1.5e-02	-12.4	-11.5	2.3e-30	0.14	0.01	0.72	TRUE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MED28	0.10	0.12	enet	8	0.12	1.6e-05	-12.3	12.1	1.7e-33	-0.12	0.03	0.93	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	24.9	33.1	4.1e-240	-0.56	0.28	0.22	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED28	0.06	0.05	enet	3	0.07	1.7e-07	-12.4	11.1	1.1e-28	-0.13	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCAPG	0.02	0.02	blup	34	0.02	3.4e-03	-28.5	-25.6	1.5e-144	0.75	0.01	0.88	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	LAP3	0.07	0.03	blup	36	0.06	5.3e-05	-9.0	-12.6	2.2e-36	0.15	0.02	0.97	FALSE
59	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED28	0.08	0.05	lasso	3	0.05	8.7e-03	-10.4	11.5	2.1e-30	-0.13	0.02	0.69	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	26.8	34.1	2.6e-255	-0.64	0.13	0.80	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	MED28	0.03	0.03	blup	34	0.02	3.4e-03	-12.3	12.1	1.0e-33	-0.13	0.02	0.68	FALSE