TWAS hub - LAP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0480	0.0180	1.2e-04	0.063	0.032	0.037	0.037	0.053	4.0e-08	7.3e-05	2.4e-05	2.6e-05	4.8e-07
2	GTEx	Cells Transformed fibroblasts	0.1960	0.0530	2.1e-09	0.124	NA	0.114	NA	0.134	1.6e-09	NA	7.4e-09	NA	3.0e-10
3	GTEx	Spleen	0.1520	0.0600	2.5e-03	0.158	NA	0.095	NA	0.148	7.3e-05	NA	2.0e-03	NA	1.3e-04
4	GTEx	Testis	0.2830	0.0710	1.9e-08	0.189	NA	0.190	NA	0.194	8.5e-09	NA	7.7e-09	NA	5.1e-09
5	GTEx	Whole Blood	0.0570	0.0240	1.9e-03	0.016	NA	0.016	NA	0.014	1.0e-02	NA	1.1e-02	NA	1.8e-02
6	NTR	Blood	0.0564	0.0138	1.4e-15	0.072	0.058	0.069	0.072	0.073	3.4e-22	5.3e-18	2.8e-21	3.6e-22	1.6e-22
7	ROSMAP	Brain Pre-frontal Cortex	0.1191	0.0333	4.4e-10	0.093	0.068	0.079	0.082	0.097	5.2e-12	4.0e-09	2.4e-10	1.0e-10	1.9e-12
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0860	0.0587	1.4e-05	0.056	0.041	0.032	NA	0.049	6.4e-07	2.1e-05	1.5e-04	NA	3.3e-06
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0415	0.0191	3.2e-08	0.081	0.073	0.081	NA	0.078	2.0e-09	1.3e-08	1.9e-09	NA	4.0e-09
10	TCGA	Brain Lower Grade Glioma	0.0253	0.0159	5.9e-04	0.028	0.029	0.028	NA	0.025	3.8e-04	2.4e-04	3.6e-04	NA	6.3e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0169	0.0127	7.7e-03	0.019	0.009	0.005	NA	0.010	2.9e-03	2.8e-02	8.8e-02	NA	2.2e-02
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0350	0.0250	6.5e-03	0.020	0.020	-0.003	NA	0.018	1.5e-02	1.5e-02	6.3e-01	NA	2.0e-02
13	TCGA	Stomach Adenocarcinoma	0.0670	0.0370	1.1e-05	0.027	0.058	0.050	NA	0.030	4.8e-03	5.3e-05	1.5e-04	NA	3.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Pulse wave peak to peak time	8.6	10.2	12.1	-2.9	-3.5	-3.4	-3.1	-3.2	-2.9	-3.1	-3.5	-2.9	-3.0	-3.4	-3.4	-3.1
Height	6.4	123.4	158.8	-11.0	-11.8	-10.5	-10.9	-10.6	-10.2	-10.2	-10.7	-10.6	-11.2	-12.3	-11.5	-12.6
Pulse wave Arterial Stiffness index	6.1	7.1	8.7	2.3	2.9	2.9	2.6	2.7	2.4	2.6	3.0	2.4	2.5	2.9	2.9	2.6
Unable to work because of sickness or disability	5.2	6.7	8.6	2.8	2.8	2.5	2.7	2.6	2.4	2.7	2.5	2.7	2.2	2.9	2.8	2.1
Blood Platelet Count	5.0	58.4	65.6	7.9	8.0	7.2	7.8	7.5	7.5	7.5	7.4	7.7	7.3	8.0	8.1	7.5
Birth weight	4.9	10.7	13.6	-3.2	-3.4	-3.3	-3.4	-3.1	-3.2	-3.2	-2.9	-3.2	-3.3	-3.7	-3.0	-3.6
High cholesterol (Self-reported)	4.6	8.1	10.8	2.8	3.0	2.6	3.0	2.7	2.8	2.7	2.6	2.8	2.7	3.3	2.9	3.1
Ulcerative Colitis	4.5	6.6	11.7	2.7	2.6	3.4	2.5	2.9	2.6	2.8	0.0	2.5	2.5	2.4	2.3	2.6
Type 2 Diabetes (T2D) (2012)	4.4	5.1	6.2	2.1	1.9	2.2	2.2	2.2	2.4	2.2	2.3	2.3	2.5	2.2	2.4	2.4
Mouth/teeth dental problems: Dentures	4.4	7.4	8.8	-2.9	-2.7	-2.6	-2.9	-2.8	-2.7	-2.9	-2.5	-3.0	-2.7	-2.7	-2.4	-2.5
Systolic Blood Pressure	4.3	21.7	24.7	4.7	4.9	4.4	4.6	4.7	4.6	4.5	4.8	4.5	4.7	4.8	4.5	5.0
Smoking status: Previous	4.3	6.4	7.2	2.7	2.6	2.6	2.5	2.6	2.7	2.5	2.4	2.5	2.5	2.5	2.5	2.2
Standing height	4.2	42.1	53.4	-6.5	-7.0	-6.2	-6.4	-6.2	-6.0	-6.0	-6.2	-6.1	-6.5	-7.2	-6.6	-7.3
Pain type(s) experienced in last month: Hip pain	4.1	5.2	7.6	2.0	2.6	2.1	2.3	2.3	2.0	2.0	2.4	2.1	2.0	2.8	2.3	2.5
Heart disease (siblings)	4.1	5.0	7.4	2.0	2.6	2.4	2.1	2.1	2.0	2.0	2.1	2.0	2.0	2.7	2.5	2.3
Trunk fat-free mass	4.0	23.2	30.6	-4.7	-5.2	-4.8	-4.5	-4.7	-4.3	-4.4	-4.7	-4.5	-5.0	-5.2	-5.0	-5.5
Medication: Atorvastatin	4.0	4.9	6.2	2.4	2.1	2.1	2.3	2.3	2.4	2.2	2.5	2.2	2.3	1.9	1.6	2.2
Diabetes (mother)	3.9	5.0	6.9	-2.5	-2.0	-1.7	-2.5	-2.2	-2.6	-2.4	-2.3	-2.5	-2.3	-1.9	-2.0	-1.9
Hair/balding pattern: Pattern 3	3.9	5.7	6.4	2.3	2.5	2.4	2.4	2.4	2.3	2.4	2.3	2.4	2.3	2.5	2.5	2.4
Trunk predicted mass	3.9	22.5	30.1	-4.6	-5.1	-4.7	-4.5	-4.6	-4.2	-4.3	-4.6	-4.4	-4.9	-5.1	-5.0	-5.5
Diverticular disease/diverticulitis (self-reported)	3.7	4.4	6.1	2.0	2.1	2.1	2.1	2.0	1.8	2.0	1.8	2.1	2.2	2.4	2.1	2.5
Emphysema/chronic bronchitis	3.7	4.2	5.5	2.2	2.1	1.7	2.1	2.1	1.8	2.0	2.3	2.1	1.9	2.0	2.3	1.8
Comparative height size at age 10	3.7	20.1	23.5	-4.5	-4.8	-4.4	-4.6	-4.3	-4.2	-4.3	-4.1	-4.3	-4.6	-4.8	-4.6	-4.8
Whole body water mass	3.6	20.5	26.8	-4.4	-4.8	-4.5	-4.3	-4.4	-4.0	-4.2	-4.4	-4.2	-4.8	-4.8	-4.6	-5.2
Supplements: Calcium	3.6	4.0	4.6	2.0	2.1	2.0	2.0	2.0	1.7	2.1	1.8	2.1	1.8	2.1	2.1	1.9
Health satisfaction	3.5	4.5	6.0	2.3	2.1	1.7	2.4	1.9	2.2	2.2	1.5	2.3	2.1	2.5	2.1	2.0
Whole body fat-free mass	3.5	20.2	26.6	-4.4	-4.8	-4.4	-4.3	-4.4	-4.0	-4.2	-4.4	-4.2	-4.7	-4.8	-4.5	-5.2
Basal metabolic rate	3.4	18.9	24.7	-4.2	-4.6	-4.3	-4.1	-4.3	-3.9	-4.0	-4.4	-4.1	-4.6	-4.5	-4.3	-5.0
Arm predicted mass (right)	3.3	16.9	20.7	-4.0	-4.5	-4.0	-3.9	-4.1	-3.6	-3.7	-4.2	-3.9	-4.2	-4.5	-4.2	-4.5
Hypothyroidism/myxoedema (self-reported)	3.2	6.2	8.7	-2.6	-2.7	-2.3	-2.6	-2.5	-2.2	-2.5	-2.2	-2.6	-2.5	-2.9	-2.5	-2.1
Arm fat-free mass (right)	3.2	16.3	21.0	-3.9	-4.4	-3.9	-3.8	-4.0	-3.5	-3.7	-4.2	-3.8	-4.2	-4.3	-4.1	-4.6
Schizophrenia vs Biploar Disorder	3.1	4.1	6.3	-2.0	-2.1	-2.5	-2.0	-2.3	-2.1	-2.3	0.0	-2.1	-1.9	-2.1	-1.9	-1.8
Medication: Levothyroxine sodium	3.1	5.2	7.6	-2.3	-2.5	-1.8	-2.4	-2.2	-2.0	-2.2	-2.0	-2.4	-2.4	-2.8	-2.4	-2.1
Leg fat-free mass (right)	3.1	16.7	21.3	-4.1	-4.3	-4.0	-4.0	-4.1	-3.8	-3.9	-4.1	-4.0	-4.4	-4.1	-3.9	-4.6
Leg predicted mass (right)	3.1	16.7	21.3	-4.0	-4.3	-4.0	-4.0	-4.1	-3.8	-3.9	-4.0	-4.0	-4.4	-4.2	-3.9	-4.6
Ever taken oral contraceptive pill	3.1	3.4	4.5	1.9	1.8	1.5	2.1	2.0	2.0	2.1	1.9	2.1	1.8	1.5	1.7	1.5
Arm fat-free mass (left)	3.1	15.5	19.7	-3.9	-4.3	-3.9	-3.7	-3.9	-3.5	-3.6	-4.0	-3.7	-4.1	-4.2	-3.9	-4.4
Arm predicted mass (left)	3.1	15.6	20.0	-3.9	-4.3	-3.8	-3.8	-3.9	-3.5	-3.6	-4.0	-3.8	-4.1	-4.2	-4.0	-4.5
Leg fat-free mass (left)	3.0	16.1	21.1	-4.0	-4.2	-3.9	-3.9	-4.0	-3.7	-3.8	-4.0	-3.9	-4.3	-4.1	-3.9	-4.6
Leg predicted mass (left)	3.0	15.7	20.8	-3.9	-4.2	-3.9	-3.8	-3.9	-3.6	-3.7	-3.9	-3.8	-4.3	-4.1	-3.8	-4.6
Hypothyroidism (self reported)	2.9	6.7	7.6	-2.7	-2.6	-2.4	-2.7	-2.5	-2.5	-2.6	-2.3	-2.7	-2.7	-2.8	-2.6	-2.5
Medication: Cholesterol lowering	2.9	4.5	5.7	1.9	2.3	2.3	2.0	2.2	1.9	1.9	2.3	1.9	2.2	2.2	2.0	2.4
Osteoporosis (self-reported)	2.9	3.6	5.3	1.9	2.0	1.3	1.9	1.7	1.9	1.8	1.8	1.9	1.8	2.2	2.3	1.8
Systolic blood pressure, automated reading	2.6	7.6	10.2	3.0	3.0	2.2	2.9	2.5	2.8	2.6	2.5	2.8	2.7	3.2	2.7	2.9
Lupus	2.5	3.8	5.3	-2.1	-1.9	-1.7	-2.3	-2.1	-2.0	-2.3	-1.7	-2.3	-1.8	-1.8	-1.6	-1.6
Schizophrenia (2014)	2.5	5.6	7.6	-2.4	-2.5	-2.4	-2.3	-2.4	-2.3	-2.4	0.0	-2.3	-2.6	-2.5	-2.6	-2.8
Medication for hormone replacement therapy	2.5	2.8	3.4	1.6	1.7	1.8	1.6	1.7	1.8	1.7	1.7	1.6	1.5	1.7	1.3	1.6
Mouth/teeth dental problems	2.5	3.8	4.8	2.1	1.8	1.5	2.1	1.8	2.0	2.1	1.5	2.2	2.1	1.9	2.0	2.0
Pulse wave reflection index	2.5	3.1	3.8	1.8	1.8	1.5	1.8	1.8	1.8	1.7	2.0	1.7	1.7	1.8	1.5	1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.3	8.3	-2.5	-2.7	-1.8	-2.6	-2.0	-2.3	-2.1	-1.9	-2.2	-2.2	-2.9	-2.3	-2.3
Financial difficulties in last 2 years	2.4	3.2	4.2	1.6	1.9	1.8	1.9	2.0	2.0	2.0	2.1	1.8	1.8	1.4	1.5	1.6
Birth weight of first child	2.4	4.3	6.9	-1.8	-2.2	-2.2	-1.9	-1.9	-1.8	-1.8	-1.9	-1.8	-2.0	-2.5	-2.3	-2.6
Bipolar Disorder (2011)	2.3	2.2	3.2	-1.6	-1.6	-1.3	-1.5	-1.5	-1.4	-1.5	0.0	-1.6	-1.6	-1.5	-1.8	-1.7
Schizophrenia (2018)	2.2	4.6	6.1	-2.2	-2.2	-2.4	-2.1	-2.2	-2.2	-2.2	0.0	-2.0	-2.4	-2.2	-2.3	-2.5
Hand grip strength (right)	2.2	5.9	8.0	-2.5	-2.6	-2.0	-2.5	-2.3	-2.5	-2.3	-2.4	-2.4	-2.2	-2.8	-2.4	-2.5
Tinnitus: Yes, now most or all of the time	2.2	2.6	3.7	1.5	1.6	1.9	1.5	1.6	1.6	1.7	1.6	1.5	1.5	1.6	1.7	1.8
Sitting height	2.1	14.9	22.1	-3.9	-4.2	-3.7	-3.8	-3.6	-3.6	-3.4	-3.6	-3.6	-4.0	-4.3	-3.7	-4.7
Past tobacco smoking	2.1	3.8	4.7	-2.0	-2.0	-2.2	-1.8	-2.0	-2.0	-1.9	-2.0	-1.9	-2.0	-1.7	-2.0	-1.8
Illnesses of father: Heart disease	2.1	3.0	4.3	1.8	1.6	1.5	1.9	1.8	1.7	1.7	2.0	1.8	1.5	1.4	2.1	1.6
Hearing difficulty/problems with background noise	2.0	3.2	4.1	1.6	1.7	1.5	2.0	1.8	1.6	1.9	1.6	1.9	2.0	1.9	1.5	2.0
Medication: Ramipril	2.0	2.5	3.5	1.4	1.7	1.7	1.6	1.8	1.3	1.6	1.9	1.6	1.6	1.4	1.2	1.7
Weight	2.0	9.8	12.0	-3.1	-3.3	-3.2	-3.0	-3.3	-2.8	-3.0	-3.5	-3.0	-3.5	-2.9	-2.8	-3.5
Guilty feelings	2.0	2.9	3.8	-1.5	-1.6	-2.0	-1.6	-1.8	-1.9	-1.7	-2.0	-1.6	-1.8	-1.2	-1.8	-1.8
Ulcerative Colitis (UC)	1.9	3.6	8.4	1.7	1.9	2.9	1.5	2.1	1.8	2.0	1.7	1.6	2.1	1.6	1.5	1.8
Primary Biliary Cirrhosis	1.9	2.8	3.9	1.7	1.6	2.0	1.5	1.7	1.6	1.7	1.6	1.5	1.8	1.6	1.3	2.0
Chronotype (morning person)	1.9	4.3	5.9	-2.1	-2.2	-1.7	-2.3	-2.1	-2.1	-2.0	-2.4	-2.2	-1.8	-2.1	-2.2	-1.8
Average weekly fortified wine intake	1.9	2.2	2.8	-1.3	-1.5	-1.6	-1.3	-1.5	-1.5	-1.5	-1.6	-1.4	-1.5	-1.5	-1.6	-1.7
Heart attack	1.9	2.4	3.2	1.2	1.8	1.7	1.5	1.6	1.4	1.5	1.8	1.3	1.4	1.7	1.5	1.4
Noisy workplace	1.9	2.4	4.7	1.5	1.7	0.9	1.6	1.4	1.3	1.3	1.3	1.6	1.5	2.2	1.9	1.6
Frequency of depressed mood in last 2 weeks	1.8	2.5	3.6	1.9	1.5	1.4	1.9	1.7	1.8	1.8	1.5	1.8	1.5	1.5	0.7	1.3
Severe depression (siblings)	1.8	2.0	3.2	-1.0	-1.3	-1.6	-1.2	-1.5	-1.5	-1.4	-1.7	-1.2	-1.5	-1.1	-1.4	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	4.9	1.7	1.8	1.7	1.7	1.6	1.5	1.8	1.5	1.7	1.5	2.2	1.7	1.8
Pulse rate	1.8	3.1	4.4	1.7	1.8	1.5	1.9	1.9	1.7	1.8	2.1	1.9	1.6	1.5	1.9	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	8.1	-2.4	-2.5	-2.3	-2.5	-2.3	-2.4	-2.3	-2.3	-2.3	-2.3	-2.8	-1.9	-2.5
Eye problems/disorders: Cataract	1.8	2.1	2.8	1.6	1.5	1.4	1.4	1.4	1.2	1.4	1.5	1.4	1.6	1.5	1.2	1.7
Alzheimer’s Disease (including proxy)	1.7	2.4	3.8	1.5	1.2	1.6	1.5	1.4	1.6	1.9	1.1	1.6	1.9	1.3	1.5	1.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.6	1.4	1.6	1.9	1.5	1.5	1.2	1.5	1.4	1.4	1.0	1.9	1.7	0.9
Forced vital capacity (FVC), Best measure	1.7	6.2	9.5	-2.5	-2.7	-2.7	-2.5	-2.4	-2.4	-2.4	-2.3	-2.3	-2.2	-3.1	-2.2	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	2.7	-1.4	-1.2	-1.5	-1.4	-1.5	-1.7	-1.6	-1.3	-1.5	-1.4	-0.7	-1.3	-0.8
Ever smoked	1.7	2.9	4.2	1.6	1.7	2.0	1.5	1.9	1.8	1.7	2.0	1.6	1.8	1.2	1.7	1.7
Alzheimer’s Disease (in mother)	1.6	1.9	3.5	1.4	1.0	1.3	1.4	1.2	1.6	1.5	0.7	1.5	1.9	1.1	0.9	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	3.7	1.9	1.5	0.7	1.7	1.4	1.7	1.5	1.4	1.8	1.6	1.4	0.8	1.5
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.9	-1.5	-1.2	-0.6	-1.7	-1.2	-1.5	-1.5	-1.1	-1.7	-1.0	-1.3	-1.4	-0.7
Prospective memory result	1.6	1.9	3.0	1.1	1.3	1.6	1.4	1.5	1.5	1.4	1.7	1.3	1.5	0.8	1.2	1.4
Qualifications: College or University degree	1.5	4.8	7.4	-2.1	-2.4	-2.5	-2.0	-2.1	-1.9	-2.0	-2.2	-2.0	-1.8	-2.7	-2.5	-2.3
Diastolic blood pressure, automated reading	1.5	4.7	7.4	2.4	2.4	1.6	2.3	1.9	2.1	2.0	1.9	2.2	2.0	2.7	2.3	2.2
Bipolar Disorder or Schizophrenia	1.4	3.5	4.9	-1.9	-2.0	-1.9	-1.9	-1.8	-1.7	-1.8	0.0	-1.8	-1.9	-2.1	-2.2	-2.1
Fed-up feelings	1.4	2.5	3.1	1.7	1.7	1.3	1.7	1.6	1.6	1.6	1.7	1.7	1.3	1.8	1.7	1.3
Falls in the last year	1.4	1.9	3.9	1.1	1.7	1.6	1.3	1.3	1.1	1.2	1.2	1.1	1.1	2.0	1.5	1.4
Illnesses of father: None of the above (group 1)	1.4	1.8	2.2	-1.3	-1.1	-1.4	-1.4	-1.3	-1.3	-1.4	-1.1	-1.3	-1.5	-1.2	-1.5	-1.4
Average weekly champagne plus white wine intake	1.4	1.9	3.4	-1.3	-1.5	-1.8	-1.3	-1.6	-1.3	-1.4	-1.8	-1.3	-1.0	-1.1	-1.2	-0.9
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.7	1.0	1.6	1.5	1.4	1.4	1.3	1.3	1.6	1.2	1.3	1.5	1.3	1.2
Depression (Nagel 2018)	1.3	1.9	3.3	1.8	1.5	0.9	1.6	1.3	1.6	1.4	0.0	1.6	1.6	1.5	0.7	1.5
Rheumatoid Arthritis	1.3	1.8	3.3	-1.2	-1.2	-1.2	-1.2	-1.2	-1.4	-1.3	-1.2	-1.3	-1.5	-1.3	-1.5	-1.8
Cardiovascular Disease	1.3	4.4	5.8	2.0	2.2	2.0	2.1	2.0	2.0	2.0	1.9	2.0	2.1	2.4	2.0	2.3
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.1	1.8	1.3	1.1	1.4	1.3	1.5	1.5	1.2	1.6	1.0	1.4	0.8	0.7
Mean time to correctly identify matches	1.3	2.6	3.2	1.7	1.5	1.7	1.7	1.7	1.8	1.8	1.6	1.8	1.7	1.2	1.2	1.4
Osteoarthritis (self-reported)	1.3	1.7	3.1	-1.3	-1.1	-0.9	-1.3	-1.4	-1.6	-1.3	-1.6	-1.4	-1.7	-0.6	-0.8	-1.6
Intelligence (Savage-Jansen 2018)	1.2	3.8	6.2	-2.1	-2.2	-2.0	-1.8	-1.8	-1.7	-1.7	0.0	-1.7	-2.0	-2.5	-2.4	-2.3
Medication: Co-codamol	1.2	1.4	2.2	1.0	1.3	1.5	1.1	1.4	1.2	1.1	1.5	1.0	1.1	1.0	0.7	1.1
Diabetes (father)	1.2	1.5	2.3	-1.2	-1.5	-1.0	-1.3	-1.2	-1.2	-1.2	-1.5	-1.2	-0.8	-1.4	-1.2	-0.7
Alcohol usually taken with meals	1.2	2.0	3.1	1.6	1.4	0.9	1.8	1.1	1.4	1.5	0.8	1.7	1.2	1.7	1.7	1.0
Nervous feelings	1.2	2.3	3.2	1.7	1.6	1.2	1.7	1.5	1.4	1.6	1.4	1.6	1.3	1.8	1.5	1.2
Age at first live birth	1.2	2.1	3.5	-1.5	-1.5	-1.5	-1.4	-1.4	-1.5	-1.4	-1.2	-1.4	-1.5	-1.5	-1.3	-1.9
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.1	-1.1	-1.1	-1.2	-1.2	-1.3	-1.4	-1.4	-1.4	-1.3	-1.2	-1.0	-1.3	-1.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.9	-0.8	-1.2	-1.7	-0.9	-1.4	-1.0	-1.2	-1.7	-0.9	-1.0	-0.8	-1.1	-1.1
Age started oral contraceptive pill	1.2	1.5	2.1	-1.4	-1.2	-0.8	-1.5	-1.2	-1.1	-1.2	-1.3	-1.4	-1.0	-1.3	-1.3	-1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.7	3.7	-1.5	-1.7	-1.9	-1.4	-1.6	-1.5	-1.5	-1.9	-1.4	-1.6	-1.7	-1.8	-1.8
Number of treatments/medications taken	1.1	1.9	2.7	1.5	1.5	1.3	1.6	1.4	1.3	1.4	1.4	1.5	1.0	1.6	1.1	1.2
Stomach or abdominal pain in last month	1.1	1.3	1.9	1.2	1.1	1.1	1.2	1.1	0.9	1.1	1.2	1.2	1.0	1.2	1.4	1.4
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	1.9	-1.1	-1.0	-1.4	-1.0	-1.2	-1.1	-1.2	-1.2	-1.1	-1.3	-0.9	-1.1	-1.3
Alzheimer’s Disease (in father)	1.0	1.1	1.8	0.9	1.0	1.3	0.9	1.1	1.0	1.1	1.0	0.9	1.1	0.9	1.3	0.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.3	-0.8	-0.8	-1.1	-0.9	-1.1	-1.0	-1.0	-1.1	-1.0	-1.5	-0.7	-1.4	-1.8
Had menopause	1.0	1.3	2.4	0.9	1.1	1.5	1.0	1.1	1.2	1.1	0.9	0.9	1.2	1.1	1.4	1.2
Number of children fathered	1.0	1.1	1.6	1.1	1.0	0.7	1.1	0.9	1.1	0.9	0.7	1.1	1.1	1.3	1.2	1.3
Loneliness, isolation	1.0	1.4	2.5	1.3	1.0	1.2	1.3	1.4	1.4	1.6	1.2	1.4	1.0	0.8	0.4	0.4
Mineral and other dietary supplements	1.0	1.3	1.7	1.0	1.1	1.0	1.1	1.1	1.3	1.2	1.3	1.2	1.1	1.1	1.2	1.1
Supplements: Zinc	0.9	1.0	1.7	0.8	0.9	1.1	1.0	0.9	0.9	1.0	0.8	0.9	1.3	0.8	1.1	1.3
Forced vital capacity (FVC)	0.9	3.4	6.0	-2.0	-2.1	-1.9	-1.9	-1.7	-1.8	-1.7	-1.6	-1.8	-1.5	-2.5	-1.7	-1.7
Fluid intelligence score	0.9	1.9	3.3	-1.1	-1.4	-1.6	-1.1	-1.4	-1.2	-1.1	-1.8	-1.1	-1.4	-1.3	-1.5	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.1	1.2	1.2	0.9	1.1	0.9	1.0	0.9	0.7	1.0	1.0	1.4	0.7	1.2
Irritable Bowel Disease (IBD)	0.8	1.9	3.9	1.2	1.5	2.0	1.1	1.4	1.1	1.4	1.2	1.1	1.3	1.5	1.3	1.3
Reaction Time	0.8	1.6	2.1	1.4	1.1	1.3	1.4	1.5	1.3	1.5	1.5	1.4	1.3	0.7	0.9	1.0
Hand grip strength (left)	0.8	2.1	4.3	-1.6	-1.7	-0.9	-1.5	-1.2	-1.5	-1.3	-1.3	-1.4	-1.2	-2.1	-1.7	-1.4
Medication: Metformin	0.8	1.2	1.9	1.1	1.2	1.1	0.9	1.1	1.1	0.9	1.2	1.0	1.2	1.2	0.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.5	-1.8	-1.8	-1.5	-1.7	-1.5	-1.6	-1.5	-1.5	-1.6	-1.3	-2.1	-1.3	-1.4
Headache pain in last month	0.8	1.4	2.2	-1.3	-1.1	-1.2	-1.2	-1.3	-1.5	-1.2	-1.1	-1.3	-1.2	-1.0	-1.1	-0.7
Neck or shoulder pain in last month	0.8	1.1	2.0	0.8	1.1	1.2	1.0	1.0	1.0	1.1	0.9	0.9	1.0	1.4	1.1	1.4
Long-standing illness, disability or infirmity	0.8	1.2	2.8	1.4	1.4	0.5	1.2	1.0	0.8	0.9	1.2	1.2	0.5	1.7	1.0	0.9
Medication for cholesterol	0.8	1.2	1.8	-1.0	-1.2	-1.0	-1.3	-1.1	-1.2	-1.1	-1.0	-1.1	-0.8	-1.3	-0.9	-0.8
Eye problems/disorders: Glaucoma	0.8	0.9	2.1	0.9	0.8	1.4	0.9	1.1	0.9	1.2	0.7	1.0	1.2	0.6	0.3	0.8
Myopia	0.8	1.2	2.6	-0.7	-1.0	-1.6	-0.9	-1.2	-1.0	-1.2	-1.0	-1.0	-1.2	-0.9	-0.8	-1.4
Ovarian Cancer	0.7	1.0	2.0	0.7	1.0	1.4	0.9	1.0	0.7	0.9	1.2	0.7	0.8	1.1	1.4	0.8
Coronary Artery Disease (CAD)	0.7	0.8	2.7	0.7	1.1	0.1	0.8	0.5	0.5	0.9	0.0	0.9	0.9	1.6	1.2	1.2
Maternal smoking around birth	0.7	1.1	2.4	0.9	1.4	1.1	0.8	1.0	0.5	0.7	1.2	0.8	0.5	1.5	1.4	0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.1	-1.1	-1.4	-1.0	-1.0	-1.1	-0.7	-0.8	-1.3	-0.9	-1.2	-1.3	-1.1	-1.3
Pulse rate, automated reading	0.7	2.3	3.6	1.6	1.6	1.2	1.5	1.4	1.4	1.3	1.6	1.5	1.2	1.9	1.8	1.4
Mood swings	0.7	1.3	1.9	-1.4	-1.0	-0.8	-1.3	-1.0	-1.2	-1.1	-1.1	-1.3	-1.2	-1.0	-1.2	-1.2
Crohns Disease (2012)	0.6	1.0	2.5	0.8	1.2	0.7	0.9	0.8	0.8	0.8	0.0	0.9	0.9	1.6	1.5	1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.3	1.1	1.4	0.8	0.9	0.9	0.8	0.7	0.8	0.9	1.2	1.5	0.7	1.5
Qualifications: CSEs or equivalent	0.6	0.8	2.2	0.5	0.9	1.0	0.6	0.8	0.6	0.7	1.0	0.5	0.6	1.1	1.5	1.4
Trunk fat mass	0.6	2.8	4.6	-1.6	-1.8	-1.8	-1.5	-1.9	-1.3	-1.5	-2.1	-1.5	-2.0	-1.2	-1.3	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.4	1.1	1.1	0.6	1.1	0.9	1.0	0.9	0.8	1.1	0.9	1.2	0.5	1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.2	0.9	1.0	0.9	1.0	0.9	0.9	1.1	0.9	1.0	0.8	0.6	0.7	0.5
Illnesses of siblings	0.6	0.8	1.4	-0.9	-1.0	-0.8	-1.0	-0.8	-0.8	-0.8	-0.6	-0.9	-0.7	-1.2	-1.1	-0.9
Hip circumference	0.6	2.7	4.3	-1.6	-1.7	-1.8	-1.4	-1.9	-1.4	-1.5	-2.1	-1.5	-1.9	-1.3	-1.1	-1.9
Depression (self-reported)	0.6	0.7	1.3	1.1	0.9	0.3	1.1	0.8	0.8	0.9	0.9	1.1	0.5	1.0	0.8	0.5
Lung cancer (father)	0.6	0.7	2.0	-0.5	-0.7	-1.4	-0.6	-0.8	-0.7	-0.7	-0.7	-0.5	-0.9	-0.5	-0.9	-1.1
Glaucoma (self-reported)	0.6	0.7	1.3	0.8	0.7	1.1	0.8	0.9	0.8	0.9	0.5	0.9	1.1	0.7	0.3	0.8
Family relationship satisfaction	0.6	0.7	1.2	0.9	0.7	0.7	0.9	0.7	1.1	0.9	0.6	0.8	0.8	0.8	0.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.7	0.9	1.3	0.5	0.9	0.7	0.7	0.6	0.8	0.8	0.7	1.3	1.1	0.9
Asthma (self-reported)	0.6	1.1	1.6	-1.0	-0.9	-1.1	-1.1	-1.1	-1.0	-1.1	-0.9	-1.1	-1.2	-0.7	-1.2	-1.1
Mother’s age at death	0.6	0.7	1.3	1.1	0.7	0.6	0.9	0.8	1.1	1.0	0.6	1.0	0.9	0.5	1.0	0.8
Pack years of smoking	0.6	0.9	1.6	1.1	0.9	0.6	1.1	0.8	1.2	0.9	0.8	1.0	0.8	1.3	0.9	1.1
Multivitamins +/- minerals	0.5	0.6	1.2	1.1	0.6	0.8	0.9	0.9	0.9	0.9	0.4	0.9	0.8	0.4	0.1	0.6
High blood pressure (mother)	0.5	0.7	1.5	-0.9	-0.5	-0.6	-1.1	-0.9	-1.2	-1.2	-0.8	-1.1	-0.6	-0.2	-0.3	0.0
Exposure to tobacco smoke outside home	0.5	0.6	1.1	0.8	0.9	0.8	0.7	0.7	0.6	0.7	0.6	0.7	0.7	1.0	0.8	1.0
Medication: Omeprazole	0.5	0.5	1.0	-0.6	-0.6	-0.8	-0.5	-0.8	-0.8	-0.8	-0.8	-0.6	-1.0	-0.5	-0.5	-1.0
Heart disease (mother)	0.5	0.6	1.1	0.8	0.7	0.4	1.1	0.7	1.0	0.9	0.5	1.0	0.6	0.9	0.3	0.5
Whole body fat mass	0.5	2.2	3.7	-1.4	-1.5	-1.6	-1.3	-1.7	-1.2	-1.4	-1.9	-1.3	-1.8	-1.0	-1.1	-1.7
Suffer from ‘nerves’	0.5	0.7	1.4	-0.6	-1.0	-0.9	-0.8	-0.9	-0.8	-0.7	-1.0	-0.7	-0.9	-0.8	-1.2	-0.9
Leg pain on walking	0.5	0.6	1.0	0.9	0.8	0.5	1.0	0.5	0.7	0.7	0.2	0.8	0.8	1.0	0.8	0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	0.7	0.8	0.6	0.6	0.5	0.5	0.4	0.5	0.6	0.9	1.1	1.0	1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	1.1	0.7	0.0	1.1	0.6	0.8	0.8	0.6	1.1	0.6	0.9	0.7	0.6
Medication: Aspirin	0.5	0.6	2.3	0.5	0.7	0.8	0.6	0.7	0.7	0.5	1.0	0.5	1.0	0.7	0.5	1.5
Irritability	0.5	0.8	1.7	1.0	1.0	0.2	1.1	0.8	0.8	0.8	0.7	1.1	0.9	1.3	0.8	0.8
Blood Eosinophil Count	0.4	2.8	3.4	-1.9	-1.6	-1.4	-1.8	-1.7	-1.7	-1.8	-1.8	-1.8	-1.5	-1.3	-1.8	-1.6
Sensitivity / hurt feelings	0.4	0.7	1.7	1.1	0.8	0.0	1.2	0.6	0.7	0.9	0.3	1.1	0.6	1.3	0.9	0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.1	0.8	0.8	0.4	1.0	0.9	0.6	0.9	0.8	1.0	0.9	0.7	0.3	0.8
Vitamin and mineral supplements	0.4	0.5	1.1	-1.1	-0.8	-0.5	-0.8	-0.7	-0.7	-0.7	-0.5	-0.8	-0.6	-0.8	-0.4	-0.6
Townsend deprivation index at recruitment	0.4	0.6	1.1	-0.7	-0.9	-0.5	-0.7	-0.6	-0.6	-0.5	-0.8	-0.6	-1.0	-0.9	-1.0	-1.0
Relative age voice broke	0.4	0.6	1.0	-0.7	-0.5	-0.7	-0.7	-0.7	-0.8	-0.9	-0.7	-0.8	-0.6	-0.7	-1.0	-1.0
Medication: Atenolol	0.4	0.5	0.8	-0.8	-0.6	-0.0	-0.8	-0.7	-0.7	-0.8	-0.7	-0.9	-0.8	-0.5	-0.5	-0.5
Waist circumference	0.4	1.4	2.2	-0.9	-1.3	-1.4	-0.9	-1.4	-0.7	-1.1	-1.5	-1.0	-1.5	-0.8	-0.9	-1.3
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	0.6	0.6	0.8	0.8	0.8	0.7	0.8	0.6	0.8	0.9	0.7	0.5	0.8
Neuroticism score	0.4	0.8	1.9	-0.5	-0.8	-1.2	-0.5	-0.8	-0.8	-0.6	-1.1	-0.5	-1.0	-0.5	-1.2	-1.4
Illnesses of mother	0.4	0.5	1.2	0.7	0.7	0.5	0.7	0.8	0.8	0.8	1.1	0.8	0.3	0.5	1.0	0.2
Arm fat mass (right)	0.4	1.6	2.8	-1.2	-1.3	-1.4	-1.1	-1.5	-1.0	-1.2	-1.7	-1.1	-1.6	-0.8	-0.8	-1.5
High blood pressure (siblings)	0.4	0.6	1.8	0.5	0.9	0.4	0.7	0.5	0.6	0.5	0.4	0.6	0.7	1.2	1.4	1.0
Worry too long after embarrassment	0.4	0.7	1.2	-0.6	-1.1	-1.1	-0.5	-0.8	-0.8	-0.6	-0.9	-0.6	-0.7	-1.0	-1.0	-1.1
Migraine (self-reported)	0.4	0.5	1.2	0.6	0.8	0.3	0.8	0.5	0.8	0.6	0.5	0.7	0.7	0.8	1.0	1.1
Arm fat mass (left)	0.4	1.6	2.8	-1.1	-1.3	-1.4	-1.0	-1.5	-1.0	-1.2	-1.7	-1.1	-1.6	-0.7	-0.8	-1.5
Cholesterol lowering medication	0.4	0.5	1.3	0.5	0.7	0.7	0.8	0.6	0.5	0.7	0.5	0.7	0.4	1.2	1.0	0.8
Worry (Nagel 2018)	0.3	0.7	2.0	-0.4	-0.8	-1.4	-0.5	-1.0	-0.7	-0.7	0.0	-0.5	-0.9	-0.4	-1.1	-1.2
Mean Putamen Volume	0.3	0.4	0.6	0.7	0.7	0.7	0.6	0.7	0.7	0.6	0.6	0.6	0.4	0.6	0.6	0.3
Fasting Glucose	0.3	0.3	0.8	0.6	0.2	0.8	0.6	0.0	0.6	0.6	0.9	0.6	0.4	0.2	0.8	0.6
HDL Cholesterol	0.3	0.5	0.9	-0.7	-0.6	-0.7	-0.7	-0.8	-0.8	-0.8	-0.9	-0.7	-0.9	-0.1	-0.6	-1.0
Smoking Status	0.3	0.8	1.3	0.8	0.9	1.1	0.7	1.0	0.9	0.9	1.0	0.8	1.0	0.7	0.9	1.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-0.4	-0.5	-0.2	-0.6	-0.7	-0.6	-0.6	-1.0	-0.7	-0.6	-0.5	-0.6	-0.6
Impedance of leg (right)	0.3	1.4	2.0	1.1	1.1	1.2	1.1	1.2	1.1	1.3	1.2	1.3	1.4	1.0	1.1	1.4
Current tobacco smoking	0.3	0.5	0.8	-0.9	-0.7	-0.7	-0.8	-0.7	-0.8	-0.7	-0.5	-0.8	-0.8	-0.7	-0.4	-0.5
Taking other prescription medications	0.3	0.4	0.9	-0.4	-0.5	-0.9	-0.4	-0.6	-0.6	-0.5	-0.5	-0.4	-0.9	-0.5	-0.8	-0.9
Impedance of leg (left)	0.3	1.5	2.8	1.1	1.1	1.3	1.0	1.2	1.1	1.2	1.1	1.2	1.5	1.1	1.2	1.7
Pain all over the body in last month	0.3	0.3	0.5	0.5	0.6	0.7	0.6	0.6	0.5	0.6	0.7	0.6	0.1	0.6	0.6	-0.0
Father’s age at death	0.3	0.5	0.8	0.9	0.5	0.6	0.9	0.6	0.8	0.8	0.4	0.9	0.8	0.3	0.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	-0.3	-0.6	-0.6	-0.4	-0.3	-0.1	-0.2	-0.2	-0.3	-0.5	-1.1	-1.0	-1.0
Medication: Lansoprazole	0.3	0.3	0.7	0.4	0.7	0.8	0.5	0.7	0.4	0.6	0.7	0.5	0.4	0.6	0.5	0.5
Tense / ‘highly strung’	0.3	0.5	1.7	-0.4	-0.6	-0.8	-0.3	-0.5	-0.4	-0.4	-0.6	-0.3	-0.6	-0.7	-1.3	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.5	-0.5	-0.7	-0.7	-0.5	-0.6	-0.7	-0.7	-0.2	-0.6	-0.7	-0.7	-0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	-0.5	-1.0	-1.0	-0.5	-0.8	-0.5	-0.5	-1.0	-0.4	-0.6	-0.7	-0.8	-0.6
Gout (self-reported)	0.3	0.4	0.6	0.8	0.8	0.8	0.7	0.8	0.5	0.7	0.6	0.8	0.6	0.5	0.5	0.5
Medication: Amlodipine	0.3	0.4	0.8	-0.5	-0.5	-0.5	-0.5	-0.5	-0.7	-0.6	-0.4	-0.6	-0.7	-0.6	-0.9	-0.8
Comparative body size at age 10	0.3	0.7	1.1	-0.9	-0.9	-0.7	-1.0	-0.9	-1.1	-1.0	-0.6	-1.0	-0.9	-0.7	-0.5	-0.5
Medication: Blood pressure	0.3	0.5	0.9	0.5	0.9	0.7	0.5	0.6	0.4	0.4	1.0	0.4	0.6	0.7	0.8	0.9
Leg fat mass (right)	0.3	1.0	2.0	-0.9	-1.0	-1.0	-0.8	-1.2	-0.7	-0.9	-1.4	-0.9	-1.3	-0.5	-0.7	-1.1
Number of full sisters	0.3	0.4	0.9	0.4	0.6	0.5	0.4	0.7	0.5	0.5	1.0	0.5	0.5	0.5	0.8	0.7
Friendships satisfaction	0.3	0.3	1.0	0.7	0.6	0.0	0.8	0.3	0.7	0.6	0.2	0.7	0.3	1.0	0.7	0.4
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	0.8	0.8	0.7	0.8	0.7	0.7	0.7	0.7	0.7	0.2	0.9	0.5	0.3
Medication: Blood pressure	0.3	0.6	1.0	-0.8	-0.6	-0.6	-0.6	-0.6	-0.7	-0.7	-0.6	-0.8	-1.0	-0.6	-0.9	-1.0
Commuting to job workplace: Cycle	0.3	0.4	1.4	-0.6	-0.6	-0.3	-0.4	-0.2	-0.5	-0.3	-0.2	-0.4	-0.4	-1.2	-1.0	-1.0
Leg fat mass (left)	0.3	1.2	2.4	-1.0	-1.2	-1.1	-1.0	-1.4	-0.9	-1.1	-1.5	-1.0	-1.4	-0.7	-0.8	-1.1
Age at First Birth	0.2	0.3	0.7	-0.7	-0.6	-0.8	-0.4	-0.8	-0.5	-0.8	-0.3	-0.7	-0.3	-0.4	-0.0	-0.1
BMI	0.2	1.3	2.4	-1.0	-1.2	-1.3	-1.1	-1.5	-1.0	-1.2	-1.5	-1.1	-1.3	-0.6	-0.5	-0.8
Allergy or Eczema	0.2	0.4	1.1	-0.3	-0.5	-0.8	-0.3	-0.6	-0.4	-0.4	-0.9	-0.3	-0.5	-0.6	-1.0	-1.1
Lung FVC	0.2	1.1	2.4	-1.0	-1.1	-1.6	-0.8	-1.0	-1.0	-1.0	-0.9	-0.8	-0.7	-1.5	-1.0	-0.8
Neuroticism	0.2	0.5	1.1	-0.3	-0.5	-1.0	-0.4	-0.7	-0.7	-0.5	-1.0	-0.3	-0.7	-0.1	-0.9	-1.0
Pack years adult smoking proportion	0.2	0.4	0.7	0.7	0.4	0.2	0.7	0.4	0.8	0.5	0.5	0.7	0.4	0.8	0.5	0.7
Age when periods started (menarche)	0.2	0.4	1.0	0.4	0.7	1.0	0.5	0.8	0.4	0.5	1.0	0.5	0.6	0.2	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-0.7	-0.5	-0.3	-1.0	-0.7	-0.7	-0.9	-0.6	-0.9	-0.5	-0.2	-0.5	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.4	-0.3	-0.6	-0.2	-0.4	-0.6	-0.4	-0.4	-0.3	-0.8	0.0	-0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	-0.7	-0.6	-0.6	-1.0	-0.9	-0.7	-0.9	-0.7	-0.9	-0.6	-0.4	-0.6	0.2
Qualifications: None of the above	0.2	0.5	0.9	0.5	0.9	0.6	0.7	0.7	0.6	0.6	0.7	0.7	0.4	0.9	0.7	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.6	-0.4	-0.8	-0.6	-0.6	-0.6	-0.7	-0.6	-0.6	-0.5	-0.4	-0.7	-0.5
Asthma	0.2	0.4	0.7	-0.6	-0.6	-0.6	-0.7	-0.7	-0.7	-0.7	-0.6	-0.7	-0.8	-0.4	-0.8	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	-0.5	-0.8	-0.5	-0.7	-0.6	-0.6	-0.7	-0.6	-0.7	-0.6	-1.0	-1.1	-0.6
Peak expiratory flow (PEF)	0.2	0.4	0.6	-0.8	-0.6	-0.7	-0.8	-0.7	-0.7	-0.8	-0.7	-0.8	-0.4	-0.5	-0.1	-0.2
Loud music exposure frequency	0.2	0.2	0.4	-0.4	-0.3	0.4	-0.6	-0.1	-0.5	-0.3	0.2	-0.6	-0.6	-0.5	-0.5	-0.5
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.5	-0.6	0.1	-0.6	-0.4	-0.4	-0.4	-0.4	-0.6	-0.7	-0.4	-0.0	-0.6
Number of full brothers	0.2	0.2	0.8	-0.3	-0.2	-0.9	-0.3	-0.6	-0.3	-0.6	-0.5	-0.4	-0.5	0.1	-0.2	-0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.4	-0.3	-0.6	-0.5	-0.5	-0.5	-0.6	-0.3	-0.5	-0.7	-0.4	-0.8	-0.6
Medication: Ibuprofen	0.2	0.2	0.4	0.3	0.3	0.5	0.5	0.3	0.4	0.4	0.2	0.4	0.5	0.5	0.4	0.6
Alcohol intake frequency.	0.2	0.4	0.7	-0.6	-0.5	-0.7	-0.6	-0.7	-0.6	-0.6	-0.7	-0.6	-0.7	-0.6	-0.9	-0.5
Medication: Aspirin	0.2	0.2	1.1	0.2	0.2	0.5	0.2	0.4	0.4	0.3	0.7	0.2	0.6	0.1	0.1	1.0
Ever had bowel cancer screening	0.2	0.2	0.5	-0.5	-0.0	-0.1	-0.5	-0.4	-0.6	-0.7	-0.4	-0.7	-0.5	0.1	-0.6	-0.7
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.7	0.7	0.3	0.5	0.4	0.3	0.3	0.3	0.5	0.4	1.0	0.1	0.6
Commuting to job workplace: Walk	0.2	0.2	0.4	0.5	0.5	0.2	0.3	0.4	0.4	0.3	0.5	0.4	0.4	0.5	0.5	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.6	0.5	0.5	0.4	0.6	0.3	0.3	0.9	0.4	0.6	0.4	0.2	0.6
Breast cancer (self-reported)	0.2	0.2	0.6	0.1	0.3	0.6	0.3	0.4	0.4	0.5	0.5	0.4	0.4	0.3	0.5	0.8
Smoking status: Current	0.2	0.4	0.6	-0.8	-0.6	-0.5	-0.8	-0.6	-0.7	-0.6	-0.3	-0.7	-0.7	-0.6	-0.3	-0.3
Wears glasses or contact lenses	0.2	0.3	0.8	-0.3	-0.5	-0.9	-0.3	-0.6	-0.4	-0.5	-0.7	-0.3	-0.4	-0.4	-0.4	-0.5
Average weekly beer plus cider intake	0.2	0.3	0.8	0.2	0.6	0.8	0.3	0.7	0.2	0.4	0.9	0.3	0.3	0.6	0.7	0.3
Bipolar Disorder (2018)	0.1	0.1	0.6	-0.4	-0.5	-0.1	-0.4	-0.1	-0.1	-0.2	0.0	-0.4	-0.2	-0.7	-0.7	-0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	0.5	0.5	0.3	0.4	0.5	0.4	0.5	0.0	0.5	0.2	0.6	0.2	0.1
Crohns Disease (2017)	0.1	0.2	0.6	0.1	0.6	0.4	0.2	0.2	0.1	0.2	0.3	0.1	0.1	0.8	0.6	0.4
Major Depression (MDD)	0.1	0.1	0.4	-0.0	-0.3	-0.7	0.0	-0.6	-0.3	-0.2	0.0	-0.1	-0.3	0.2	-0.1	-0.1
Breast Cancer	0.1	0.3	0.5	-0.6	-0.6	-0.3	-0.4	-0.5	-0.5	-0.5	-0.7	-0.5	-0.6	-0.4	-0.7	-0.3
Prostate Cancer	0.1	0.1	0.5	-0.2	0.1	0.7	-0.3	0.1	0.0	-0.1	0.1	-0.3	-0.2	0.2	-0.3	-0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.6	-0.6	-0.4	0.4	-0.5	-0.0	-0.2	-0.1	0.0	-0.4	-0.1	-0.8	-0.2	-0.2
HbA1C	0.1	0.1	0.4	-0.0	-0.1	0.1	-0.1	-0.5	0.0	-0.3	-0.6	-0.3	0.0	0.4	-0.5	0.1
Neuroticism (2016)	0.1	0.1	0.3	0.5	0.2	0.3	0.4	0.3	0.4	0.5	0.2	0.4	0.3	0.3	0.2	0.2
Triglycerides	0.1	0.1	0.4	0.6	0.1	0.1	0.5	0.4	0.3	0.3	0.3	0.6	0.4	-0.1	-0.2	0.2
Blood White Count	0.1	0.7	1.1	-0.8	-0.8	-1.0	-0.8	-1.0	-1.0	-1.1	-0.8	-0.9	-0.8	-0.6	-0.5	-0.6
Heel T-Score	0.1	0.5	1.1	-1.0	-0.2	-0.2	-0.9	-0.8	-1.0	-1.1	-0.7	-1.1	-0.3	0.4	-0.1	0.6
Waist Hip Ratio (WHR)	0.1	0.4	0.8	-0.3	-0.9	-0.7	-0.6	-0.6	-0.3	-0.6	-0.6	-0.5	-0.5	-0.7	-0.9	-0.4
Tanning	0.1	0.8	1.1	0.9	0.6	0.7	1.0	1.0	1.1	1.0	1.0	1.0	1.0	0.5	0.8	0.7
Average weekly spirits intake	0.1	0.1	0.4	-0.3	-0.1	-0.5	-0.3	-0.4	-0.4	-0.4	-0.6	-0.3	-0.3	-0.0	-0.1	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.5	0.3	0.6	0.6	0.3	0.3	0.3	0.2	0.0	0.2	0.2	0.7	0.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.3	0.4	0.5	0.3	0.3	0.2	0.3	0.2	0.2	0.4	0.5	0.4	0.7
Angina	0.1	0.2	0.6	-0.1	0.6	0.7	0.1	0.3	0.1	0.0	0.5	-0.0	0.1	0.8	0.7	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.6	-0.3	-0.3	-0.1	-0.4	-0.3	-0.2	-0.2	-0.6	-0.3	-0.1	-0.4	-0.8	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.9	-0.1	-0.3	-0.4	-0.1	-0.4	-0.1	-0.1	-0.6	-0.1	-0.6	-0.2	-0.7	-1.0
Supplements: Glucosamine	0.1	0.1	0.4	-0.2	-0.1	0.1	-0.2	-0.2	-0.4	-0.3	-0.4	-0.3	-0.5	-0.1	-0.1	-0.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.7	0.1	0.5	0.2	0.0	0.0	-0.2	0.0	0.0	-0.1	-0.2	0.9	0.2	-0.0
Number of incorrect matches in round	0.1	0.1	0.4	0.1	0.0	0.6	0.2	0.4	0.4	0.4	0.5	0.2	0.3	-0.4	-0.1	0.2
Had other major operations	0.1	0.2	0.8	0.1	0.4	0.9	0.1	0.4	0.2	0.3	0.4	0.2	0.2	0.3	0.6	0.4
Medication: Simvastatin	0.1	0.2	0.7	-0.1	0.5	0.6	0.2	0.3	-0.1	0.2	0.3	0.1	0.2	0.8	0.8	0.7
Time employed in main current job	0.1	0.1	0.3	-0.4	-0.2	-0.5	-0.3	-0.3	-0.4	-0.4	-0.2	-0.3	-0.5	-0.1	-0.1	-0.5
Worrier / anxious feelings	0.1	0.2	0.8	0.4	0.5	-0.1	0.5	0.1	0.1	0.3	-0.0	0.4	0.2	0.9	0.6	-0.0
Number of live births	0.1	0.2	0.5	0.1	0.4	0.1	0.4	0.2	0.3	0.2	0.2	0.3	0.4	0.6	0.7	0.7
Happiness	0.1	0.1	0.4	0.4	0.0	0.0	0.4	0.1	0.6	0.3	-0.0	0.3	0.1	-0.0	-0.2	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.4	-0.7	-0.6	-0.3	-0.6	-0.3	-0.4	-0.7	-0.3	-0.4	-0.4	-0.5	-0.5
Length of working week for main job	0.1	0.1	0.3	0.1	0.3	0.2	0.1	0.2	0.1	0.0	0.4	0.1	0.3	0.2	0.5	0.5
Exposure to tobacco smoke at home	0.1	0.1	0.5	-0.0	0.4	0.7	0.1	0.4	0.1	0.2	0.6	0.0	-0.0	0.2	-0.0	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.6	0.5	0.0	0.6	0.3	0.3	0.4	0.2	0.5	-0.1	0.6	0.4	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.3	0.4	-0.4	0.3	-0.1	-0.1	-0.1	0.1	0.2	-0.3	0.7	-0.1	0.0
Shortness of breath walking on level ground	0.1	0.2	1.1	0.2	0.5	0.2	0.3	0.1	0.1	0.1	-0.0	0.2	0.1	1.1	0.8	0.4
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.0	0.3	-0.1	0.2	0.1	0.4	0.1	0.4	0.2	0.1	0.2	0.6	0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.2	-0.4	-0.2	-0.3	-0.3	-0.3	-0.2	-0.2	-0.1	0.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.1	0.1	-0.5	-0.1	-0.2	-0.2	-0.2	-0.3	-0.0	-0.3	0.2	0.3	-0.6
Angina (self-reported)	0.1	0.2	0.6	-0.1	0.5	0.5	0.1	0.2	-0.0	-0.1	0.4	-0.1	-0.0	0.8	0.6	0.4
Overall health rating	0.1	0.3	1.1	0.4	0.7	0.2	0.5	0.4	0.3	0.4	0.4	0.5	0.4	1.0	0.7	0.7
Had major operations	0.1	0.1	0.3	0.1	0.3	0.4	0.3	0.2	0.1	0.3	-0.2	0.2	-0.1	0.6	-0.4	-0.4
Age at last live birth	0.1	0.1	0.3	-0.2	-0.3	-0.6	-0.1	-0.2	-0.2	-0.2	0.1	-0.0	-0.3	-0.5	-0.0	-0.4
Hypertension (Self-reported)	0.1	0.3	0.6	0.4	0.7	0.7	0.5	0.5	0.4	0.4	0.5	0.4	0.3	0.7	0.5	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.5	-0.1	-0.0	-0.3	-0.3	-0.7	-0.4	-0.4	-0.4	-0.5	0.1	0.2	-0.3
Illnesses of siblings: Diabetes	0.1	0.2	0.8	-0.1	0.1	0.8	0.1	0.4	0.2	0.3	0.3	0.0	0.5	0.2	0.3	0.9
Average weekly red wine intake	0.1	0.2	0.4	-0.6	-0.3	0.0	-0.4	-0.4	-0.5	-0.5	-0.5	-0.6	-0.4	-0.2	0.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.3	-0.2	0.5	-0.2	0.0	-0.4	-0.1	-0.2	-0.2	-0.3	-0.3	-0.1	-0.5
Back pain experienced in last month	0.1	0.2	0.5	-0.5	-0.3	-0.3	-0.3	-0.6	-0.4	-0.4	-0.7	-0.5	-0.5	0.1	-0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.3	-0.4	-0.6	-0.3	-0.4	-0.5	-0.3	-0.3	-0.2	-0.2	-0.8	0.0	-0.3
Miserableness	0.1	0.1	0.5	-0.1	-0.2	-0.5	-0.2	-0.2	-0.3	-0.2	-0.1	-0.1	-0.5	-0.1	-0.6	-0.7
Hearing aid user	0.1	0.1	0.5	-0.5	-0.3	-0.2	-0.3	-0.1	-0.4	-0.1	-0.1	-0.2	-0.0	-0.6	-0.7	-0.0
Financial situation satisfaction	0.1	0.2	0.6	0.5	0.4	0.2	0.5	0.5	0.5	0.5	0.8	0.5	0.1	0.1	0.1	-0.0
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.2	0.4	0.6	0.4	0.3	0.4	0.2	0.4	0.2	0.4	0.6	0.4	0.7
Medication: Lisinopril	0.1	0.1	0.2	0.4	0.3	0.2	0.3	0.3	0.3	0.3	0.5	0.3	0.1	-0.0	0.3	-0.1
Alcohol drinker status: Never	0.1	0.2	0.3	0.5	0.5	-0.0	0.5	0.2	0.4	0.4	0.4	0.4	0.4	0.3	0.5	0.5
Number of operations (self-reported)	0.1	0.1	0.3	-0.1	0.1	-0.4	0.1	-0.2	-0.4	-0.1	-0.6	-0.0	-0.2	0.5	-0.1	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.4	0.4	0.1	0.5	0.3	0.4	0.4	0.1	0.4	0.3	0.4	0.1	0.2
Ever depressed for a whole week	0.1	0.1	0.3	0.2	0.4	0.2	0.3	0.3	0.2	0.3	0.3	0.2	-0.2	0.5	0.2	-0.3
Pain experienced in last month	0.1	0.1	0.3	0.4	0.2	0.5	0.2	0.6	0.4	0.4	0.5	0.4	0.4	-0.3	-0.1	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.6	-0.5	-0.4	0.3	-0.4	-0.1	-0.5	-0.2	-0.1	-0.5	-0.4	-0.8	-0.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.3	-0.4	0.2	-0.4	-0.2	-0.3	-0.2	-0.2	-0.4	-0.5	-0.3	-0.0	-0.5
Impedance of whole body	0.1	0.7	1.2	0.7	0.8	0.9	0.6	0.8	0.6	0.8	0.8	0.8	1.0	0.9	1.0	1.1
Neuroticism (Nagel 2018)	0.0	0.1	0.6	0.0	0.0	-0.8	-0.1	-0.0	-0.2	0.2	0.0	0.1	-0.4	0.2	-0.2	-0.5
LDL Cholesterol	0.0	0.1	0.3	-0.1	-0.4	-0.2	-0.1	-0.1	-0.2	-0.2	-0.1	0.0	-0.2	-0.4	-0.6	-0.4
Blood Red Count	0.0	0.3	0.5	-0.5	-0.6	-0.7	-0.5	-0.6	-0.4	-0.4	-0.6	-0.4	-0.5	-0.5	0.0	-0.5
Respiratory disease	0.0	0.0	0.2	-0.1	-0.2	-0.3	-0.1	-0.2	-0.1	-0.1	-0.0	-0.1	-0.4	-0.0	-0.2	-0.3
Lung FEV1/FVC ratio	0.0	0.1	0.3	-0.1	0.2	0.2	0.1	-0.1	-0.2	-0.2	-0.4	-0.1	-0.3	-0.5	0.4	-0.3
Hair Pigment	0.0	0.1	0.6	-0.3	0.4	0.1	-0.2	0.1	-0.2	-0.3	-0.1	-0.2	-0.3	0.7	0.8	0.2
Relative age of first facial hair	0.0	0.1	0.2	0.3	0.4	0.1	0.4	0.4	0.3	0.4	0.2	0.4	0.1	0.1	0.1	-0.4
Trunk fat percentage	0.0	0.2	0.8	-0.3	-0.4	-0.4	-0.2	-0.6	-0.1	-0.3	-0.9	-0.2	-0.6	0.2	0.2	-0.4
High blood pressure	0.0	0.1	0.4	0.2	0.5	0.3	0.4	0.3	0.2	0.2	0.2	0.2	0.1	0.7	0.3	0.3
Body mass index (BMI)	0.0	0.2	0.6	-0.3	-0.3	-0.5	-0.2	-0.6	-0.2	-0.4	-0.8	-0.3	-0.7	0.3	0.0	-0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.2	-0.0	-0.2	-0.3	-0.1	-0.2	-0.1	-0.0	-0.2	-0.1	-0.3	-0.3	-0.1	-0.4
Allergy	0.0	0.1	0.2	-0.2	-0.2	-0.3	-0.3	-0.2	-0.2	-0.3	-0.2	-0.3	0.2	-0.3	0.1	0.4
Diabetes (self-reported)	0.0	0.0	0.1	0.2	0.1	-0.0	0.0	-0.1	0.0	-0.1	-0.2	-0.0	0.1	0.4	-0.4	0.4
Impedance of arm (right)	0.0	0.0	0.2	-0.3	0.1	0.0	-0.3	0.0	-0.4	-0.2	0.2	-0.2	-0.0	0.1	0.2	0.1
Arm fat percentage (right)	0.0	0.1	0.3	-0.1	-0.0	-0.3	0.0	-0.4	-0.0	-0.2	-0.5	-0.1	-0.6	0.5	0.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.2	0.1	0.1	0.2	0.3	0.0	0.2	0.3	-0.2	0.2	0.1	0.5	0.3	0.2
Impedance of arm (left)	0.0	0.1	0.2	0.0	0.3	0.2	-0.0	0.2	-0.1	0.1	0.2	0.1	0.2	0.4	0.5	0.3
Breastfed as a baby	0.0	0.1	0.2	0.4	0.4	0.1	0.2	0.2	0.2	0.0	0.0	0.2	0.1	0.5	0.2	-0.2
Medication: Paracetamol	0.0	0.0	0.1	0.1	0.1	0.1	0.2	-0.0	0.3	0.2	-0.0	0.1	0.0	0.3	0.1	0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.2	-0.2	0.2	0.3	0.1	0.3	0.1	0.1	0.4	0.0	0.1	-0.2	0.1	0.2
Body fat percentage	0.0	0.1	0.6	-0.1	-0.2	-0.3	-0.1	-0.5	-0.0	-0.2	-0.8	-0.1	-0.6	0.4	0.2	-0.3
Leg fat percentage (right)	0.0	0.2	0.7	0.3	0.3	0.2	0.5	0.0	0.5	0.3	-0.2	0.4	-0.1	0.8	0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.2	0.0	0.1	0.5	0.1	0.1	0.3	0.2	-0.1	-0.0	0.4	0.1	-0.2	0.4
Medication: Allopurinol	0.0	0.0	0.1	0.0	0.0	0.2	-0.0	0.0	-0.3	-0.0	-0.2	0.0	-0.1	0.0	-0.1	-0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.2	-0.0	-0.1	0.4	-0.1	0.0	-0.0	0.1	-0.3	0.0	-0.2	-0.0	-0.5	-0.1
Chest pain or discomfort	0.0	0.1	0.2	0.2	0.2	-0.3	0.2	-0.0	-0.2	-0.1	-0.0	0.1	-0.3	0.4	-0.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.2	-0.2	-0.0	-0.2	-0.1	-0.2	0.1	0.0	0.3	0.2
Supplements: Vitamin C	0.0	0.1	0.1	-0.1	0.1	0.0	-0.1	-0.3	-0.2	-0.4	-0.2	-0.3	-0.4	0.4	0.2	-0.1
Knee pain experienced in last month	0.0	0.1	0.4	-0.2	0.1	-0.1	-0.2	-0.2	-0.3	-0.3	-0.3	-0.2	-0.2	0.6	0.2	-0.1
Arm fat percentage (left)	0.0	0.1	0.4	-0.0	-0.0	-0.3	0.0	-0.4	0.0	-0.2	-0.7	-0.1	-0.5	0.6	0.4	-0.2
Qualifications: nursing, teaching	0.0	0.0	0.2	0.2	-0.1	-0.0	0.0	-0.1	0.1	0.1	-0.5	0.1	0.2	0.3	0.3	-0.0
Medication: Gliclazide	0.0	0.0	0.1	0.1	0.2	-0.0	0.1	0.1	0.1	0.0	0.2	0.1	0.0	0.3	-0.1	0.0
Commuting to job workplace: Public transport	0.0	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.1	-0.0	0.1	-0.2	0.1	-0.2	0.1	-0.0	-0.2
Medication: Paracetamol	0.0	0.1	0.2	0.2	0.2	0.1	0.4	0.1	0.4	0.3	0.1	0.2	0.2	0.4	0.0	0.4
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.0	-0.1	0.3	-0.0	0.0	-0.2	0.0	-0.2	-0.1	0.2	-0.1	0.3	0.0
Leg fat percentage (left)	0.0	0.2	0.7	0.3	0.3	0.2	0.4	-0.0	0.5	0.2	-0.3	0.3	-0.0	0.9	0.6	0.4
Risk taking	0.0	0.0	0.1	-0.3	-0.2	-0.0	-0.2	-0.1	-0.2	-0.2	-0.0	-0.3	0.0	-0.3	-0.3	0.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.1	-0.5	-0.4	-0.3	-0.2	-0.1	-0.2	-0.1	-0.1	-0.0	-0.6	-0.2	-0.1
Alcohol drinker status: Previous	0.0	0.0	0.1	0.0	0.1	0.0	-0.1	-0.1	0.1	-0.0	-0.2	-0.0	0.1	0.2	0.1	0.2

Hub : Genes

LAP3

Models

Trait associations