Best TWAS P=7.1e-30 · Best GWAS P=3.65e-38 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | RP11-385F7.1 | 0.35 | 0.32 | lasso | 4 | 0.30 | 1.5e-09 | 9.2 | -9.2 | 4.1e-20 | 0.37 | 0.98 | 0.00 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | RP11-385F7.1 | 0.22 | 0.06 | enet | 40 | 0.10 | 3.1e-04 | -4.6 | -7.1 | 9.8e-13 | 0.46 | 0.06 | 0.39 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CD2AP | 0.12 | 0.04 | lasso | 7 | 0.04 | 1.1e-03 | 9.2 | 6.3 | 3.1e-10 | -0.10 | 0.64 | 0.01 | TRUE |
| 4 | GTEx | Colon Transverse | RP11-385F7.1 | 0.15 | 0.03 | enet | 7 | 0.05 | 2.1e-03 | 9.1 | -8.4 | 4.5e-17 | 0.29 | 0.24 | 0.52 | TRUE |
| 5 | GTEx | Esophagus Mucosa | RP11-385F7.1 | 0.20 | 0.10 | lasso | 20 | 0.07 | 1.6e-05 | 9.1 | -11.2 | 3.0e-29 | 0.56 | 0.35 | 0.64 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RP11-385F7.1 | 0.13 | 0.06 | lasso | 4 | 0.06 | 2.1e-04 | 9.1 | -9.0 | 2.0e-19 | 0.33 | 0.69 | 0.06 | FALSE |
| 7 | GTEx | Lung | RP11-385F7.1 | 0.11 | 0.04 | lasso | 5 | 0.03 | 1.8e-03 | 9.2 | -7.9 | 2.5e-15 | 0.25 | 0.84 | 0.01 | FALSE |
| 8 | GTEx | Pituitary | RP11-385F7.1 | 0.26 | 0.21 | lasso | 5 | 0.16 | 7.7e-05 | 9.2 | -9.2 | 4.1e-20 | 0.36 | 0.20 | 0.20 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | RP11-385F7.1 | 0.09 | 0.05 | enet | 6 | 0.05 | 6.1e-05 | 9.2 | -9.6 | 1.1e-21 | 0.43 | 0.27 | 0.43 | FALSE |
| 10 | GTEx | Thyroid | RP11-385F7.1 | 0.23 | 0.20 | lasso | 3 | 0.19 | 2.0e-14 | 9.2 | -8.5 | 2.4e-17 | 0.30 | 1.00 | 0.00 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPR111 | 0.03 | 0.01 | lasso | 2 | 0.02 | 2.5e-05 | -10.6 | 11.1 | 2.1e-28 | -0.64 | 0.44 | 0.31 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPR115 | 0.01 | 0.00 | blup | 90 | 0.01 | 7.2e-03 | -5.2 | 8.9 | 4.3e-19 | -0.67 | 0.12 | 0.55 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | GPR111 | 0.13 | 0.08 | blup | 97 | 0.11 | 5.0e-07 | -10.5 | 10.1 | 4.3e-24 | -0.84 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Esophageal Carcinoma | GPR111 | 0.19 | 0.14 | lasso | 2 | 0.14 | 3.9e-05 | -10.7 | 11.4 | 7.1e-30 | -0.86 | 0.38 | 0.43 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GPR111 | 0.10 | 0.16 | enet | 17 | 0.16 | 9.4e-18 | -10.6 | 10.7 | 8.7e-27 | -0.78 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GPR115 | 0.06 | 0.11 | lasso | 8 | 0.13 | 2.5e-14 | -10.7 | 9.8 | 8.4e-23 | -0.77 | 0.02 | 0.98 | TRUE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GPR111 | 0.04 | 0.08 | lasso | 1 | 0.05 | 6.7e-04 | -10.7 | 10.7 | 1.1e-26 | -0.81 | 0.30 | 0.04 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | GPR111 | 0.02 | 0.01 | blup | 94 | 0.02 | 1.1e-03 | -7.8 | 9.2 | 5.0e-20 | -0.79 | 0.07 | 0.55 | FALSE |
| 19 | The Cancer Genome Atlas | Rectum Adenocarcinoma | GPR111 | 0.22 | 0.09 | blup | 94 | 0.14 | 4.5e-04 | -8.0 | 9.1 | 1.2e-19 | -0.73 | 0.12 | 0.71 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GPR111 | 0.03 | 0.04 | lasso | 1 | 0.03 | 2.4e-03 | -10.6 | 10.6 | 4.2e-26 | -0.80 | 0.25 | 0.28 | FALSE |
| 21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | GPR115 | 0.08 | 0.09 | blup | 90 | 0.06 | 3.4e-03 | -8.0 | 9.4 | 3.8e-21 | -0.71 | 0.06 | 0.76 | FALSE |