Best TWAS P=2.99e-16 · Best GWAS P=6.17e-17 conditioned to 0.0211
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100507557 | 0.09 | 0.18 | enet | 22 | 0.21 | 1.3e-24 | -7.8 | -7.7 | 1.2e-14 | 0.87 | 0.59 | 0.41 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-545I5.3 | 0.16 | 0.01 | lasso | 17 | 0.01 | 4.1e-02 | -7.1 | -6.0 | 2.2e-09 | 0.74 | 0.24 | 0.69 | FALSE |
| 3 | GTEx | Adrenal Gland | RP11-545I5.3 | 0.08 | 0.09 | enet | 10 | 0.03 | 2.5e-02 | -7.6 | -7.8 | 8.8e-15 | 0.88 | 0.16 | 0.42 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-545I5.3 | 0.14 | 0.07 | lasso | 8 | 0.05 | 9.0e-05 | -8.0 | -8.2 | 3.0e-16 | 0.90 | 0.22 | 0.77 | TRUE |
| 5 | GTEx | Cells Transformed fibroblasts | FBXO30 | 0.04 | 0.04 | lasso | 1 | 0.04 | 4.6e-04 | -7.8 | 7.8 | 6.8e-15 | -0.86 | 0.24 | 0.23 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | RP11-545I5.3 | 0.04 | 0.03 | lasso | 2 | 0.03 | 2.0e-03 | 4.6 | -5.4 | 8.0e-08 | 0.63 | 0.14 | 0.67 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RP11-545I5.3 | 0.07 | 0.03 | lasso | 4 | 0.04 | 1.4e-03 | 4.6 | -5.3 | 1.3e-07 | 0.64 | 0.16 | 0.52 | FALSE |
| 8 | GTEx | Esophagus Muscularis | EPM2A | 0.11 | 0.09 | enet | 21 | 0.10 | 7.0e-07 | -6.6 | -6.1 | 1.3e-09 | 0.75 | 0.78 | 0.22 | FALSE |
| 9 | GTEx | Esophagus Muscularis | SHPRH | 0.19 | 0.02 | enet | 12 | 0.08 | 9.1e-06 | 4.4 | -5.7 | 9.7e-09 | 0.32 | 0.15 | 0.33 | FALSE |
| 10 | GTEx | Esophagus Muscularis | RP11-545I5.3 | 0.10 | 0.13 | lasso | 6 | 0.12 | 5.9e-08 | -7.6 | -7.8 | 4.7e-15 | 0.88 | 0.36 | 0.64 | FALSE |
| 11 | GTEx | Nerve Tibial | RP11-545I5.3 | 0.15 | 0.06 | enet | 31 | 0.06 | 7.0e-05 | -8.0 | -6.3 | 2.7e-10 | 0.74 | 0.25 | 0.75 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | EPM2A | 0.03 | 0.03 | enet | 10 | 0.01 | 2.4e-02 | -5.7 | 6.8 | 1.1e-11 | -0.83 | 0.24 | 0.53 | FALSE |
| 13 | GTEx | Spleen | EPM2A | 0.12 | 0.02 | enet | 23 | 0.02 | 1.0e-01 | -5.6 | 5.5 | 5.1e-08 | -0.65 | 0.15 | 0.33 | FALSE |
| 14 | GTEx | Testis | EPM2A | 0.14 | 0.14 | lasso | 3 | 0.13 | 1.8e-06 | -7.8 | -8.1 | 7.5e-16 | 0.91 | 0.12 | 0.86 | FALSE |
| 15 | GTEx | Thyroid | RP11-545I5.3 | 0.06 | 0.01 | lasso | 3 | 0.01 | 2.6e-02 | -4.0 | -6.3 | 2.6e-10 | 0.64 | 0.15 | 0.20 | FALSE |
| 16 | YFS | Blood | SHPRH | 0.01 | 0.01 | blup | 307 | 0.01 | 1.0e-04 | -7.6 | -7.4 | 1.4e-13 | 0.84 | 0.16 | 0.84 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FBXO30 | 0.02 | 0.02 | blup | 27 | 0.01 | 4.6e-04 | -7.8 | -6.7 | 1.5e-11 | 0.79 | 0.01 | 0.89 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EPM2A | 0.04 | 0.04 | enet | 9 | 0.02 | 1.5e-03 | -5.6 | 5.1 | 3.0e-07 | -0.69 | 0.07 | 0.86 | FALSE |
| 19 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | EPM2A | 0.28 | 0.04 | enet | 7 | 0.03 | 1.3e-02 | -7.7 | 5.4 | 7.3e-08 | -0.73 | 0.02 | 0.42 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | EPM2A | 0.21 | 0.07 | blup | 44 | 0.07 | 4.6e-07 | -5.6 | 6.3 | 3.0e-10 | -0.76 | 0.20 | 0.78 | FALSE |