Hub : Genes

EPM2A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0660	0.0290	4.0e-03	0.010	0.012	0.010	0.017	0.014	1.7e-02	1.1e-02	1.8e-02	3.1e-03	7.6e-03
2	GTEx	Brain Hypothalamus	0.2110	0.0990	5.4e-03	0.039	NA	0.041	NA	0.066	4.3e-02	NA	3.9e-02	NA	1.2e-02
3	GTEx	Esophagus Muscularis	0.1100	0.0390	3.5e-07	0.086	NA	0.104	NA	0.103	7.0e-06	NA	7.0e-07	NA	7.7e-07
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1860	0.0660	1.0e-05	0.151	NA	0.141	NA	0.146	1.2e-08	NA	4.0e-08	NA	2.0e-08
5	GTEx	Skin Sun Exposed Lower leg	0.0290	0.0150	4.7e-03	0.030	NA	0.014	NA	0.012	1.5e-03	NA	2.4e-02	NA	3.4e-02
6	GTEx	Spleen	0.1250	0.0570	2.0e-03	0.016	NA	0.019	NA	0.000	1.2e-01	NA	1.0e-01	NA	3.2e-01
7	GTEx	Testis	0.1360	0.0600	2.2e-04	0.139	NA	0.092	NA	0.132	9.7e-07	NA	6.9e-05	NA	1.8e-06
8	NTR	Blood	0.0168	0.0082	1.6e-04	0.018	0.010	0.016	0.012	0.017	1.5e-06	3.0e-04	3.3e-06	8.8e-05	2.7e-06
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0314	0.0319	8.7e-03	0.013	0.010	0.013	NA	-0.001	1.2e-02	2.1e-02	1.2e-02	NA	4.4e-01
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0377	0.0355	6.5e-04	0.038	0.017	0.022	NA	0.004	3.9e-05	4.5e-03	1.5e-03	NA	1.0e-01
11	TCGA	Liver Hepatocellular Carcinoma	0.2760	0.1470	2.5e-03	0.041	0.015	0.031	NA	0.027	5.1e-03	6.3e-02	1.3e-02	NA	1.9e-02
12	TCGA	Thyroid Carcinoma	0.2060	0.1410	1.1e-05	0.065	0.067	0.062	NA	0.061	5.9e-07	4.6e-07	1.2e-06	NA	1.3e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.5	2.4	5.2	-1.0	-1.4	-1.6	1.6	1.6	2.3	-1.7	1.1	0.9	1.4	1.6	1.7
Bipolar Disorder or Schizophrenia	0.3	0.7	4.6	-2.1	-0.4	-0.6	0.7	0.3	0.8	-0.4	0.1	-0.4	0.4	0.9	0.6
Depressed Affect (Nagel 2018)	0.7	1.5	9.7	-3.1	-0.9	-0.5	-1.2	-0.7	-0.0	0.3	-0.4	-0.7	-1.0	-0.5	-1.8
Depression (Nagel 2018)	2.9	4.3	9.8	-3.1	0.7	1.0	-2.9	-1.9	-1.8	1.1	-2.2	-1.9	-2.4	-1.8	-2.6
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.4	-1.1	-1.8	-1.3	0.5	0.2	0.7	-0.3	0.9	-0.5	0.4	0.7	-0.5
Neuroticism (Nagel 2018)	0.7	1.7	13.4	-3.7	-1.0	-0.7	-1.1	-0.5	-0.2	-0.1	-0.6	-1.0	-0.8	0.2	-1.4
Schizophrenia (2018)	0.4	0.8	3.8	-2.0	0.6	0.5	-0.5	-0.9	-0.7	0.8	-0.7	-1.3	-0.6	-0.2	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.6	2.5	-1.6	0.6	0.5	-0.5	-0.7	-1.2	0.4	-0.7	-0.8	-0.5	-0.6	-0.4
Worry (Nagel 2018)	0.7	1.6	10.0	-3.2	-0.7	-0.4	-1.2	-0.7	-0.8	-0.1	-1.0	-1.5	-1.0	0.1	-1.2
Alzheimer’s Disease (in mother)	1.3	1.5	3.8	-0.5	0.8	1.6	-0.9	-1.6	-1.4	1.9	-0.3	-0.9	-0.9	-0.8	-1.7
Alzheimer’s Disease (in father)	0.3	0.4	0.9	0.0	0.1	0.6	-0.3	-0.7	-0.6	0.9	-0.3	-0.7	-0.8	-0.8	-0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	2.3	-0.0	0.3	1.2	-0.4	-1.0	-1.1	1.5	0.2	-0.5	-0.5	-0.5	-0.9
Crohns Disease (2017)	0.2	0.5	2.6	0.9	0.9	-0.2	0.6	0.8	-0.4	-0.9	-0.2	0.3	0.4	0.3	1.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	0.7	0.9	-0.0	0.2	0.2	-0.5	-0.3	-0.4	-0.2	-0.1	0.1	0.8
Ulcerative Colitis (UC)	0.1	0.1	0.6	0.3	-0.1	-0.8	0.2	0.4	0.3	-0.6	0.0	0.2	0.0	0.1	0.3
Major Depression (MDD)	1.6	2.0	4.2	-1.5	-1.8	-1.5	1.0	1.3	1.2	-1.5	1.1	0.6	1.6	2.0	1.2
Reaction Time	1.9	3.7	9.3	-0.2	3.0	3.0	-1.6	-2.1	-2.1	2.3	-1.4	-0.7	-1.5	-1.6	-1.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	2.3	-0.2	-1.5	-0.9	0.3	-0.1	0.2	0.4	0.8	0.1	0.1	0.1	-0.9
Breast Cancer	1.2	2.9	4.5	0.6	-2.0	-2.0	1.8	1.8	1.7	-1.6	2.1	2.1	1.6	1.2	1.2
Ovarian Cancer	0.3	0.4	2.1	-0.9	-0.0	-0.1	-0.4	-0.0	-1.4	-0.4	-0.4	-1.3	-0.1	0.5	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	4.0	2.0	-0.7	-0.3	0.1	0.3	1.0	0.0	0.3	0.8	-0.2	-1.2	0.0
Bipolar Disorder (2011)	0.5	0.5	1.1	-1.1	0.5	0.7	-0.6	-0.6	-0.6	0.5	-0.3	-0.1	-0.9	-1.0	-0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	-1.1	-0.7	-0.2	-0.6	-0.4	0.2	0.1	0.1	-0.1	-0.8	-0.8	-1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.7	0.8	0.6	0.6	-0.7	-0.9	-0.3	1.2	-0.6	-1.3	-1.1	-0.9	-0.5
Crohns Disease (2012)	1.6	2.5	4.8	-0.5	-1.0	-1.6	1.5	2.0	1.2	-2.2	0.8	1.8	1.8	1.5	2.1
Mean Putamen Volume	0.6	0.7	1.5	0.0	-0.3	-0.8	0.6	1.1	0.2	-1.2	0.6	0.2	1.0	1.2	1.2
Fasting Glucose	1.6	1.9	2.9	0.6	0.8	1.5	-1.3	-1.7	-1.3	1.7	-1.3	-1.2	-1.4	-1.4	-1.7
HbA1C	0.5	0.5	1.1	0.5	-0.7	-0.8	0.5	0.8	1.0	-0.8	0.8	0.1	0.9	0.9	0.3
HDL Cholesterol	0.2	0.3	1.2	0.3	1.1	0.5	-0.5	-0.2	-0.8	-0.2	-0.8	-0.3	-0.3	-0.1	0.1
LDL Cholesterol	2.1	3.3	6.7	-1.1	1.3	1.7	-2.5	-1.7	-0.8	1.2	-2.2	-2.6	-2.1	-1.6	-2.0
Lupus	0.1	0.2	0.5	0.7	-0.0	0.6	0.5	-0.3	0.7	0.7	-0.0	-0.0	0.4	0.4	0.2
Neuroticism (2016)	0.7	1.1	7.9	-2.8	-0.6	-0.4	-0.6	-0.7	-0.5	0.4	-0.3	-0.8	-0.7	-0.1	-1.4
Primary Biliary Cirrhosis	0.1	0.2	0.8	-0.8	0.3	-0.1	-0.0	0.3	0.4	-0.5	0.1	0.9	0.0	-0.6	0.0
Rheumatoid Arthritis	0.2	0.2	0.8	0.2	0.4	0.1	0.4	0.6	0.4	-0.6	0.2	0.5	0.6	0.6	0.9
Schizophrenia (2014)	0.3	0.7	7.6	-2.8	0.1	-0.1	-0.1	-0.4	0.0	0.4	-0.4	-0.8	-0.2	0.1	-0.4
Triglycerides	0.3	0.5	1.5	-1.2	-0.9	-0.1	-0.4	-0.6	-0.0	0.5	0.0	-1.0	-0.6	-0.6	-1.2
Type 2 Diabetes (T2D) (2012)	5.1	5.9	9.6	2.0	3.1	3.0	-2.4	-2.2	-2.7	2.1	-2.6	-1.4	-2.5	-2.6	-1.8
Ulcerative Colitis	0.1	0.2	1.0	-1.0	0.2	-0.3	-0.4	0.1	0.4	-0.4	-0.2	-0.0	-0.2	0.1	-0.3
Blood Eosinophil Count	0.0	0.1	0.4	-0.4	-0.5	0.2	0.5	0.0	-0.2	0.4	0.6	-0.3	0.5	0.3	-0.0
Blood Platelet Count	0.2	1.9	5.0	-1.1	-1.6	-1.7	1.1	1.2	2.2	-1.0	1.5	1.7	1.2	0.4	0.7
Blood Red Count	0.1	0.6	4.9	2.2	0.1	0.3	-0.4	-0.4	-0.6	0.6	-0.5	-0.0	-0.3	-0.7	-0.3
Blood White Count	0.2	1.8	3.2	-1.8	1.0	1.2	-1.8	-1.4	-0.6	1.2	-1.1	-1.4	-1.2	-1.1	-1.6
Heel T-Score	2.8	22.0	31.5	1.8	-3.7	-4.5	5.2	5.3	5.1	-4.7	4.5	4.8	5.4	4.3	5.6
BMI	0.4	2.6	7.5	-0.6	-0.2	0.8	-1.6	-2.0	-0.5	2.1	-0.7	-0.9	-2.1	-2.4	-2.7
Height	1.5	28.1	65.0	-0.3	-4.7	-6.1	4.4	6.8	5.5	-8.1	3.4	3.6	5.1	5.4	6.3
Waist Hip Ratio (WHR)	1.3	5.8	9.7	1.1	1.8	2.6	-2.4	-2.9	-2.1	3.1	-2.2	-2.3	-2.4	-2.4	-2.8
Systolic Blood Pressure	0.6	2.9	6.6	-0.2	0.5	1.2	-1.7	-2.3	-1.0	2.2	-1.4	-2.0	-1.9	-1.5	-2.6
Smoking Status	0.1	0.3	0.7	-0.4	0.1	0.1	-0.7	-0.3	-0.8	-0.1	-0.9	-0.5	-0.8	-0.5	-0.5
Allergy or Eczema	0.1	0.2	1.3	0.5	-0.0	-0.2	-0.3	-0.3	-0.0	0.4	0.0	-0.1	-0.6	-1.2	-0.6
Cardiovascular Disease	3.2	10.6	16.7	-0.8	2.2	3.2	-3.7	-3.7	-2.8	3.4	-3.0	-2.5	-4.0	-4.0	-4.1
Hypothyroidism (self reported)	0.1	0.2	0.9	-1.0	0.0	0.1	-0.1	0.2	-0.1	-0.3	-0.3	-0.0	-0.6	-0.8	-0.0
Respiratory disease	0.1	0.3	0.9	0.9	-0.6	-0.7	0.3	0.4	0.5	-0.2	0.6	0.9	0.3	0.1	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.1	1.8	-0.1	0.3	0.7	0.4	0.5	0.3	1.2	1.7	0.1	-0.7	0.1
Lung FEV1/FVC ratio	0.8	4.0	7.3	-1.1	-1.3	-1.8	2.0	2.3	2.4	-2.2	1.3	1.7	2.3	2.1	2.7
Lung FVC	0.1	0.4	1.3	-0.3	1.0	0.0	-0.3	0.6	0.4	-1.1	-1.0	-0.2	0.0	0.2	1.0
Neuroticism	0.7	1.6	12.1	-3.5	-1.4	-0.9	-0.8	0.0	0.6	-0.8	-0.4	-0.9	-0.4	0.7	-1.0
Chronotype (morning person)	0.2	0.5	1.7	-1.3	0.9	0.8	-0.5	-0.7	-1.0	0.9	-0.5	-0.5	-0.4	-0.2	-0.6
Hair Pigment	0.1	1.5	3.1	0.7	-0.5	-0.9	1.4	1.4	1.3	-1.3	0.9	1.1	1.4	1.6	1.8
Tanning	2.5	30.1	40.1	-2.2	5.1	5.4	-6.2	-6.3	-4.8	6.1	-5.7	-5.2	-5.8	-5.5	-6.2
Hand grip strength (left)	0.1	0.4	2.1	-1.5	-0.4	-0.3	-0.1	-0.6	0.3	0.4	-0.1	-0.8	-0.3	0.1	-0.8
Number of treatments/medications taken	0.6	1.1	2.7	-1.2	0.1	-0.1	-1.6	-0.7	-0.8	0.0	-1.0	-0.7	-1.6	-1.4	-1.3
Average weekly spirits intake	0.2	0.2	1.2	1.1	0.1	0.4	0.0	-0.2	-0.5	0.4	-0.2	0.3	-0.1	-0.6	-0.2
Sensitivity / hurt feelings	0.2	0.3	0.8	-0.7	0.6	0.4	-0.4	0.1	-0.9	-0.2	-0.7	-0.4	0.2	0.6	0.3
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.5	-1.7	0.9	0.8	-2.1	-0.9	-0.8	0.4	-1.2	-0.9	-1.5	-1.1	-1.7
Hearing difficulty/problems: Yes	1.9	3.0	10.0	-3.2	-2.6	-2.3	0.8	1.3	1.9	-1.8	1.1	0.4	1.0	1.4	0.3
Relative age of first facial hair	2.4	4.9	8.2	0.8	-2.7	-2.5	2.0	2.6	2.6	-2.6	2.2	2.9	1.8	0.9	1.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	0.2	-1.0	-0.8	-0.1	0.2	-0.0	-0.4	0.5	0.9	-0.3	-0.6	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.8	0.5	0.4	0.4	-0.3	0.1	-0.9	-0.2	-0.1	0.4	-0.0	-0.3	-0.2
Ever had hysterectomy (womb removed)	6.6	7.5	11.2	-0.7	2.4	2.7	-3.0	-2.9	-3.2	2.6	-2.7	-2.1	-3.3	-3.4	-2.9
Systolic blood pressure, automated reading	0.1	0.2	0.6	-0.2	-0.6	-0.3	-0.2	-0.4	-0.2	0.2	-0.0	-0.8	-0.3	0.1	-0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.9	0.9	0.2	-0.2	0.2	0.5	0.5	-0.4	0.1	0.9	0.2	-0.5	0.5
Angina	0.3	0.4	1.6	-0.1	0.1	-0.2	0.3	0.6	1.1	-0.6	0.5	1.3	0.4	0.0	0.5
Medication for hormone replacement therapy	2.2	2.5	3.9	-0.6	1.3	1.6	-1.7	-1.6	-1.9	1.3	-1.5	-1.3	-1.9	-1.7	-2.0
Vitamin and mineral supplements	0.4	0.5	1.5	0.2	0.5	-0.0	0.3	0.6	-0.8	-0.7	-0.2	-0.3	1.0	1.2	1.1
Supplements: Zinc	1.5	1.7	4.2	1.0	1.1	1.9	-0.8	-1.7	-0.6	2.1	-0.9	-0.8	-1.1	-1.4	-1.3
Medication: Co-codamol	0.1	0.1	0.5	-0.7	-0.2	-0.1	0.1	0.4	0.4	-0.4	0.4	0.5	0.3	0.0	0.3
Medication: Metformin	0.5	0.7	1.9	1.4	1.2	0.7	0.1	0.7	-0.6	-0.4	0.1	1.3	0.1	-0.7	0.9
Diabetes (father)	0.6	0.8	2.7	1.2	-0.9	-0.4	1.0	0.3	0.7	0.2	1.6	1.5	0.5	-0.0	-0.1
Diabetes (mother)	1.9	2.5	4.7	-0.9	1.3	1.7	-1.9	-1.7	-0.5	1.6	-1.2	-1.1	-1.9	-1.9	-2.2
Severe depression (siblings)	0.3	0.4	0.7	0.0	-0.7	-0.4	0.8	0.6	0.8	-0.6	0.4	0.6	0.6	0.6	0.5
Pack years adult smoking proportion	1.6	2.4	5.9	-2.4	0.0	0.7	-1.6	-1.8	-1.4	1.6	-0.8	-1.7	-1.5	-0.6	-2.4
Impedance of leg (right)	2.1	10.0	17.3	-0.3	3.1	3.3	-3.3	-3.6	-4.2	3.5	-3.2	-3.2	-3.1	-2.4	-3.3
Leg fat-free mass (left)	1.3	6.8	14.1	-0.1	-3.0	-2.8	2.5	2.9	3.8	-3.0	2.6	2.5	2.2	1.8	2.4
Trunk fat percentage	1.3	5.1	10.1	1.4	1.6	2.3	-2.1	-2.7	-1.9	3.2	-1.3	-1.2	-2.3	-2.9	-2.9
Hand grip strength (right)	0.2	0.5	1.3	-1.1	0.2	0.4	-0.4	-0.9	0.2	0.9	-0.6	-1.1	-0.6	-0.2	-1.0
Townsend deprivation index at recruitment	0.5	0.8	5.0	-2.2	-0.5	0.1	-0.4	-0.9	-0.7	0.8	-0.2	-0.7	-0.5	0.1	-1.0
Current tobacco smoking	2.9	4.8	8.1	-2.5	1.5	1.7	-2.4	-2.3	-2.2	1.6	-2.8	-2.7	-2.3	-1.5	-2.2
Average weekly fortified wine intake	0.1	0.1	0.3	0.5	-0.1	0.1	-0.0	-0.4	0.1	0.5	-0.0	-0.5	0.1	0.2	-0.5
Maternal smoking around birth	0.5	0.7	4.7	-2.2	-0.7	-0.3	-0.0	-0.1	0.8	-0.3	0.1	-1.1	0.2	1.2	-0.3
Fed-up feelings	0.2	0.4	1.8	-1.3	-1.1	-0.8	-0.0	0.1	0.9	-0.1	0.3	0.1	0.4	0.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	6.7	-2.4	1.1	1.0	-2.6	-1.4	-1.3	0.6	-1.9	-1.5	-2.0	-1.5	-1.9
Relative age voice broke	1.5	2.3	5.1	0.7	-1.8	-1.7	1.3	2.0	1.8	-2.2	1.1	1.8	0.9	0.3	1.2
Taking other prescription medications	0.4	0.5	1.3	-1.1	0.0	0.2	-1.2	-0.5	-0.7	0.3	-0.5	-0.2	-0.9	-1.0	-1.0
Age when periods started (menarche)	0.9	2.1	4.3	0.1	1.6	1.5	-1.6	-1.3	-2.0	1.0	-2.1	-1.9	-1.2	-0.7	-0.8
Bilateral oophorectomy (both ovaries removed)	5.9	6.8	15.1	-0.7	2.5	2.8	-2.3	-2.9	-3.9	2.6	-2.9	-3.5	-2.4	-1.3	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.6	13.8	1.4	-2.5	-3.3	2.8	3.7	2.9	-3.7	2.6	3.0	2.8	2.3	3.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	1.1	0.7	1.0	1.1	0.2	-0.3	-0.3	0.5	-0.0	0.0	-0.0	-0.1	0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.5	-0.7	-0.0	-0.1	-0.0	-0.1	0.1	0.1	-0.4	-0.2	0.4	0.5	0.3
Serious illness, injury or assault to yourself	6.5	7.9	12.1	-0.4	3.0	2.7	-3.5	-2.8	-3.0	2.3	-3.5	-1.8	-3.3	-3.4	-2.5
High blood pressure	1.8	4.9	8.6	0.2	1.6	2.2	-2.4	-2.3	-2.5	2.2	-1.7	-1.4	-2.8	-2.9	-2.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.7	1.3	-0.1	-0.0	-0.1	-0.2	0.1	0.3	0.1	0.2	-0.5	-1.2	-0.4
Multivitamins +/- minerals	1.0	1.3	3.2	-1.5	-0.1	0.4	-1.2	-1.3	-0.2	1.2	-0.7	-1.0	-1.5	-1.1	-1.8
Stomach or abdominal pain in last month	0.8	1.0	2.4	-1.6	0.7	0.5	-1.3	-1.0	-0.4	0.7	-1.0	-1.2	-1.1	-0.7	-1.1
Supplements: Glucosamine	0.9	1.2	2.3	0.4	-1.1	-1.3	0.9	1.3	1.5	-1.3	1.1	0.5	0.8	0.8	1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	3.4	-1.8	-0.8	-1.1	-0.0	0.5	0.2	-0.9	0.1	0.0	-0.0	0.0	-0.2
Medication: Atenolol	2.6	3.3	5.2	0.6	1.9	2.0	-1.9	-1.9	-1.8	1.7	-2.0	-1.3	-2.1	-2.3	-1.6
Medication: Levothyroxine sodium	0.1	0.2	0.7	-0.9	-0.4	-0.1	-0.2	-0.1	-0.5	0.1	-0.2	-0.6	-0.4	-0.4	-0.4
Sitting height	0.7	5.0	12.2	0.4	-1.7	-2.0	1.7	2.8	3.5	-3.1	1.9	2.9	1.7	0.8	2.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	0.3	0.3	0.0	0.3	-0.1	-0.7	0.2	0.1	0.1	0.2	0.2	0.2
High blood pressure (mother)	1.6	2.3	4.2	0.1	1.6	2.0	-1.6	-1.7	-1.1	1.8	-1.3	-0.3	-1.6	-1.9	-1.6
Body mass index (BMI)	0.4	1.5	3.8	0.2	0.4	1.1	-1.0	-1.6	-0.7	1.9	-0.4	-0.3	-1.3	-1.8	-1.9
Impedance of leg (left)	2.2	10.5	17.3	-0.1	3.1	3.5	-3.4	-3.6	-4.2	3.6	-3.2	-3.3	-3.1	-2.6	-3.4
Leg predicted mass (left)	1.3	7.0	14.4	-0.1	-3.0	-2.9	2.6	3.0	3.8	-3.1	2.6	2.5	2.3	1.9	2.4
Trunk fat mass	0.3	1.4	3.3	0.9	0.4	1.1	-1.0	-1.4	-0.6	1.7	-0.3	-0.4	-1.3	-1.8	-1.8
Waist circumference	0.2	0.8	2.0	1.4	0.0	0.8	-0.6	-1.0	-0.4	1.3	-0.0	-0.3	-0.8	-1.1	-1.3
Number of incorrect matches in round	0.3	0.6	1.6	-1.0	0.6	-0.2	-0.3	0.6	-0.2	-1.3	-0.9	-1.0	0.0	0.7	0.9
Past tobacco smoking	1.9	3.4	7.4	-2.1	1.9	1.8	-2.0	-2.1	-1.4	1.5	-2.4	-2.7	-1.5	-0.5	-1.4
Alcohol usually taken with meals	0.3	0.4	1.9	1.4	0.7	0.3	-0.7	0.2	0.0	-0.7	-0.8	0.3	-0.5	-0.7	0.2
Nervous feelings	1.4	2.6	4.9	-0.5	-1.9	-1.9	1.3	1.9	1.6	-2.2	1.4	1.1	1.5	2.0	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.4	-2.1	0.2	0.3	-1.7	-0.6	-0.6	0.0	-0.8	-0.7	-1.2	-0.6	-1.4
Hearing difficulty/problems with background noise	0.8	1.3	8.2	-2.9	-0.7	-0.3	-0.8	-1.0	-0.1	0.7	-0.4	-1.1	-0.8	-0.2	-1.5
Hair/balding pattern: Pattern 2	1.0	1.2	2.9	-0.8	-1.7	-1.7	1.1	1.0	0.5	-1.2	0.8	0.6	1.1	1.3	0.8
Had menopause	1.4	1.7	4.8	0.9	1.5	1.3	-1.3	-1.0	-2.2	1.1	-1.0	-0.8	-1.3	-1.6	-1.2
Had other major operations	1.7	2.1	5.5	-1.2	-2.3	-2.1	0.6	1.2	2.2	-1.4	1.4	1.7	0.5	-0.6	-0.2
Forced vital capacity (FVC)	0.4	1.6	5.5	-1.1	-0.8	-1.2	0.3	1.6	2.4	-2.2	-0.0	0.6	0.6	0.5	1.3
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.9	18.2	1.1	-2.8	-3.6	3.0	4.2	3.6	-4.3	2.9	3.5	3.0	2.4	3.9
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	5.0	-2.2	-2.2	-1.9	1.0	1.4	2.0	-1.6	1.3	0.8	1.4	1.6	0.5
Qualifications: None of the above	0.4	0.8	2.6	-1.0	0.9	0.9	-0.5	-1.0	-1.6	1.1	-0.8	-1.1	-0.0	0.3	-0.2
Financial difficulties in last 2 years	0.7	0.9	2.5	0.8	1.1	1.4	-0.8	-0.9	-0.3	1.1	-0.5	0.6	-0.9	-1.6	-0.8
Mouth/teeth dental problems	0.4	0.6	2.3	0.4	0.3	0.2	1.2	0.3	0.6	0.1	0.6	-0.6	0.8	1.5	1.1
Heart attack	0.2	0.2	0.8	0.3	0.6	0.5	-0.6	0.0	0.2	-0.1	-0.1	0.9	-0.4	-0.5	-0.3
Allergy	0.3	0.6	1.2	-1.0	1.1	1.1	-0.4	-0.7	-0.9	0.9	-0.6	-0.9	-0.2	0.5	-0.3
Pain all over the body in last month	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.2	0.0	0.1	-0.1	0.3	0.4	0.0	-0.1	-0.3
Diabetes (self-reported)	0.5	0.8	2.4	0.9	1.1	1.3	-0.7	-0.5	-0.8	0.8	-0.1	0.3	-1.1	-1.6	-0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	6.2	2.5	-0.3	-0.7	1.2	1.0	0.7	-0.7	1.3	1.4	0.6	-0.1	1.1
Medication: Ramipril	0.6	0.8	1.8	0.9	0.9	1.2	-0.8	-0.9	-0.6	0.9	-0.7	0.3	-1.1	-1.4	-0.8
Medication: Simvastatin	0.4	0.7	2.2	-0.3	0.4	0.6	-0.9	-0.6	-1.1	0.4	-0.3	0.1	-1.2	-1.5	-1.1
Fluid intelligence score	0.2	0.4	1.1	-0.8	-1.0	-0.5	-0.2	-0.5	-0.1	0.6	-0.0	-1.0	-0.3	0.1	-0.9
Illnesses of siblings	0.2	0.3	0.6	0.7	-0.8	-0.6	0.4	0.4	-0.4	-0.4	0.1	-0.5	0.6	0.8	0.4
Neuroticism score	0.7	1.4	11.0	-3.3	-1.1	-0.8	-1.1	-0.0	0.3	-0.8	-0.6	-0.8	-0.7	0.2	-1.0
Weight	0.1	0.6	1.7	0.3	-1.2	-0.7	0.5	0.6	1.3	-0.5	1.0	1.0	0.2	-0.3	-0.1
Impedance of arm (right)	0.3	1.2	4.0	2.0	1.6	1.3	-0.7	-1.0	-1.1	1.3	-0.9	-0.8	-0.6	-0.4	-0.4
Arm fat percentage (right)	0.7	2.7	6.8	1.1	1.0	1.6	-1.4	-2.1	-1.1	2.6	-0.6	-0.5	-1.6	-2.2	-2.4
Trunk fat-free mass	1.4	8.2	13.4	-1.2	-3.1	-3.1	2.6	3.4	3.6	-3.7	2.7	2.5	2.5	2.4	2.7
Hip circumference	0.3	1.1	2.7	1.2	-1.5	-0.9	1.0	1.0	1.1	-0.7	1.6	1.4	0.7	0.2	0.3
Time employed in main current job	0.4	0.5	1.7	0.1	0.2	-0.0	1.0	0.6	-0.3	-0.5	0.3	0.0	1.0	1.3	1.2
Alcohol intake versus 10 years previously	0.0	0.1	0.4	0.5	-0.1	-0.0	0.2	-0.1	-0.6	0.3	0.1	0.2	0.2	-0.0	0.1
Father’s age at death	0.3	0.5	2.1	1.5	1.0	0.4	0.1	0.1	-1.2	-0.0	-0.5	0.1	0.1	-0.3	0.7
Worrier / anxious feelings	1.0	1.8	7.6	-2.8	0.2	0.4	-1.9	-1.2	-0.4	0.5	-1.6	-1.2	-1.3	-0.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.8	-0.9	0.9	0.9	-1.3	-1.1	-0.6	1.0	-0.7	-0.3	-1.0	-1.3	-1.2
Falls in the last year	2.0	2.7	5.4	-0.3	-1.2	-1.4	1.4	2.3	1.6	-2.3	1.6	2.2	1.5	0.9	1.9
Hair/balding pattern: Pattern 3	0.5	0.7	2.0	1.4	0.6	0.8	-0.6	-0.6	-1.2	0.9	-0.6	-0.6	-0.8	-0.8	-0.6
Number of live births	0.2	0.3	1.2	-0.5	0.3	0.1	-0.3	-0.2	-0.8	-0.1	-0.6	-1.1	0.0	0.6	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	7.0	-0.7	-1.0	-1.3	0.9	1.9	2.6	-2.3	0.4	1.2	0.9	0.5	1.8
Pulse rate	0.4	0.7	1.6	1.3	-1.1	-0.9	1.2	0.6	-0.3	-0.5	0.6	0.2	0.7	0.8	0.9
Happiness	2.3	2.8	5.2	-0.5	0.9	1.1	-2.0	-1.8	-0.6	1.5	-1.8	-1.6	-2.3	-2.1	-2.3
Noisy workplace	0.1	0.2	0.5	0.7	-0.1	0.1	0.4	-0.3	0.1	0.6	0.5	0.2	0.5	0.5	-0.0
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.0	0.4	-1.9	-1.7	1.6	1.3	1.6	-1.0	2.0	1.6	1.3	1.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.7	-1.1	-1.3	-0.9	-0.3	0.3	0.9	-0.9	0.3	0.2	-0.1	0.1	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	0.5	0.3	0.3	-0.1	-0.1	-1.0	0.4	0.4	1.0	0.5	-0.3	-0.1
Asthma	0.5	1.0	2.9	1.7	-0.6	-0.9	0.8	1.1	1.2	-0.9	0.9	1.6	0.6	-0.2	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.1	-1.0	-1.5	-1.8	0.7	0.9	1.5	-1.1	0.6	0.3	0.5	0.7	0.6
Medication: Cholesterol lowering	1.9	3.0	6.1	0.6	0.9	1.6	-1.4	-2.1	-2.2	2.3	-1.0	-0.8	-2.0	-2.0	-2.5
Depression (self-reported)	0.7	0.8	2.6	-1.6	-0.8	-0.8	-1.2	-0.3	-0.1	-0.5	-0.6	-0.0	-1.0	-1.0	-1.3
Medication: Lansoprazole	0.9	1.0	2.0	0.3	-0.8	-0.7	1.3	1.1	1.1	-0.7	1.4	1.3	1.0	0.6	1.2
Prospective memory result	0.4	0.5	1.4	-1.1	-0.8	-0.8	0.5	0.3	0.4	-0.6	0.1	-0.0	0.7	1.2	0.5
Lung cancer (father)	0.8	1.0	5.9	-0.8	-0.2	0.1	-0.4	-1.1	-0.6	1.0	-0.9	-2.4	-0.5	0.8	-0.4
Illnesses of mother	3.9	4.9	9.4	-0.2	-2.8	-3.1	2.5	2.5	1.5	-2.2	2.5	1.6	2.2	1.8	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	10.5	-1.2	-1.4	-1.6	1.5	2.5	3.2	-2.9	1.0	1.8	1.7	1.2	2.5
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	0.2	-0.6	-0.4	0.8	0.6	-0.4	-0.3	0.6	0.4	0.6	0.6	0.7
Impedance of arm (left)	0.4	1.7	2.8	1.7	1.6	1.4	-1.2	-1.4	-1.4	1.5	-1.3	-1.2	-1.0	-0.9	-1.0
Arm fat mass (right)	0.2	0.8	2.5	0.5	-0.1	0.6	-0.6	-1.1	-0.2	1.4	0.1	0.1	-1.0	-1.6	-1.6
Trunk predicted mass	1.5	8.6	13.8	-1.2	-3.1	-3.2	2.7	3.4	3.7	-3.7	2.7	2.5	2.6	2.5	2.8
Standing height	1.1	11.3	23.5	-0.1	-3.3	-3.6	2.9	4.3	4.0	-4.8	2.7	2.6	3.0	2.9	3.6
Length of working week for main job	0.7	0.8	3.0	-1.6	-0.8	-0.1	-0.6	-0.5	0.8	0.6	0.3	0.1	-0.9	-1.1	-1.7
Exposure to tobacco smoke at home	0.7	0.8	3.4	-1.9	-1.3	-0.9	0.6	0.4	1.4	-0.4	0.6	-0.1	0.0	0.5	0.1
Breastfed as a baby	0.1	0.1	0.6	-0.2	-0.1	0.1	0.3	0.1	0.3	0.1	0.8	0.6	0.2	0.2	-0.2
Tense / ‘highly strung’	0.6	1.0	8.0	-2.8	-0.4	-0.4	-1.0	-0.0	0.0	-0.7	-0.6	-0.8	-0.8	-0.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.0	-1.3	-1.7	-1.2	1.3	1.0	1.6	-0.9	1.7	1.1	1.5	1.7	0.7
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.3	0.7	0.0	0.3	0.3	-0.3	-0.4	0.2	0.0	0.3	0.6	0.7
Birth weight of first child	0.4	0.7	2.0	-0.7	0.3	0.5	-1.0	-0.9	-0.8	0.6	-0.9	-1.4	-1.0	-0.3	-1.0
Peak expiratory flow (PEF)	1.0	2.3	4.7	-0.6	-1.5	-1.5	1.4	1.8	2.2	-1.9	1.1	0.9	1.5	1.6	1.8
Pulse wave reflection index	0.6	0.8	1.9	-1.1	1.4	1.2	-0.7	-0.7	-0.9	0.7	-1.1	-1.0	-0.2	0.1	0.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.5	-0.5	-1.2	-0.9	0.5	0.4	1.0	-0.5	0.5	0.1	0.8	1.0	0.3
Loud music exposure frequency	1.2	1.4	3.2	-1.4	-1.8	-1.4	1.0	1.0	1.1	-1.2	0.9	0.4	1.1	1.3	0.9
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.3	-0.7	-2.3	-1.9	1.0	1.1	2.3	-1.2	1.4	1.2	0.7	0.7	-0.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.4	-0.5	-1.8	-1.3	0.3	0.6	1.6	-0.7	1.1	1.6	0.3	-0.4	-0.7
Blood clot in the leg (DVT)	0.2	0.3	1.5	-1.2	-0.5	-0.6	-0.1	0.3	-0.6	-0.7	-0.0	-0.4	0.3	0.5	0.3
Medication: Paracetamol	0.6	1.0	2.2	1.0	0.8	1.0	-1.0	-1.0	-0.4	1.3	-0.5	0.8	-0.9	-1.5	-1.2
Headache pain in last month	0.3	0.6	3.5	-1.9	-0.3	-0.3	-0.3	0.3	1.4	-0.6	0.2	0.7	-0.1	-0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	3.7	-1.3	-1.0	-1.4	1.0	1.5	1.6	-1.7	0.6	0.2	1.6	1.7	1.9
Glaucoma (self-reported)	1.4	1.6	4.1	-0.5	0.9	0.9	-1.4	-1.1	-1.0	0.9	-1.4	-1.0	-2.0	-2.0	-1.3
Gout (self-reported)	0.7	0.9	1.6	-0.1	-1.0	-1.3	0.9	1.0	1.0	-1.1	0.5	0.7	1.1	1.2	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	1.0	-1.0	0.1	0.2	-0.0	-0.1	-0.4	0.2	-0.2	-0.3	-0.4	-0.4	-0.1
Medication: Amlodipine	0.2	0.3	1.3	0.4	-0.4	0.1	-0.3	-0.2	-0.0	0.2	0.4	0.7	-0.7	-1.2	-1.0
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.7	0.4	-1.3	-1.3	1.6	0.9	1.1	-0.7	1.2	0.3	1.7	1.9	1.3
Birth weight	1.7	3.6	5.7	-0.2	2.2	2.4	-2.3	-1.8	-1.7	1.8	-1.7	-1.2	-2.2	-2.4	-1.8
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.9	0.4	0.5	1.1	-0.9	-1.3	-0.6	1.4	-0.6	-0.8	-1.0	-0.7	-1.2
High blood pressure (siblings)	0.1	0.2	1.2	-0.5	0.3	0.4	0.2	0.2	1.1	-0.1	0.4	0.7	0.1	-0.0	0.3
Forced vital capacity (FVC), Best measure	1.0	3.7	9.0	-1.6	-1.5	-1.8	1.2	2.5	3.0	-3.0	0.9	1.6	1.5	1.2	2.0
Body fat percentage	1.6	6.1	11.9	1.0	1.7	2.5	-2.4	-3.0	-2.2	3.5	-1.6	-1.4	-2.6	-3.1	-3.3
Leg fat percentage (right)	2.1	7.5	14.7	0.4	1.8	2.8	-2.6	-3.4	-2.8	3.8	-1.8	-1.8	-2.9	-3.2	-3.6
Arm fat-free mass (right)	0.7	3.7	7.2	-1.3	-2.5	-2.2	1.5	2.2	2.7	-2.6	1.8	1.7	1.4	1.0	1.5
Exposure to tobacco smoke outside home	0.5	0.7	1.8	-1.0	-0.7	-0.3	-0.6	-0.9	-0.0	0.8	-0.4	-1.3	-1.1	-0.7	-1.3
Comparative body size at age 10	0.5	1.3	2.5	0.7	0.5	1.0	-1.1	-1.3	-1.0	1.0	-1.3	-0.8	-1.4	-1.6	-1.6
Number of full brothers	0.8	1.0	3.4	-0.7	-0.1	0.4	-0.9	-1.0	-0.9	1.1	-0.2	0.2	-1.3	-1.8	-1.6
Worry too long after embarrassment	0.3	0.5	1.5	-1.2	0.2	0.4	-0.8	-0.6	-0.6	0.5	-0.9	-1.1	-0.6	-0.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	14.1	-3.8	-2.2	-1.0	0.0	-0.2	1.2	0.2	1.1	-0.2	0.1	0.6	-1.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	0.4	-0.8	-0.6	0.1	-0.2	-0.2	0.4	0.6	0.6	0.1	-0.1	-0.7
Number of children fathered	3.0	3.4	5.6	-1.4	2.2	1.9	-2.4	-1.7	-1.7	1.2	-2.2	-1.5	-2.0	-1.9	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.3	-0.4	-0.5	-1.1	-0.1	0.8	0.0	-1.0	0.0	0.1	0.2	0.0	0.4
Age at first live birth	1.3	2.3	5.9	0.4	0.7	1.5	-1.3	-1.7	-0.8	1.8	-1.1	-0.5	-2.0	-2.4	-2.2
Pulse wave peak to peak time	0.1	0.2	0.4	-0.2	0.5	0.2	-0.6	-0.2	0.6	-0.1	-0.6	-0.3	-0.4	-0.4	-0.3
Health satisfaction	1.4	1.9	4.1	-0.9	0.5	0.9	-1.6	-1.4	-0.9	1.2	-1.3	-0.9	-1.9	-2.0	-1.8
Shortness of breath walking on level ground	0.8	1.0	3.5	0.2	-0.5	-0.4	0.9	1.0	1.5	-0.6	1.4	1.9	0.9	0.4	0.8
Qualifications: College or University degree	1.0	3.2	7.0	2.1	0.1	-0.8	1.4	2.2	2.6	-2.2	1.3	2.5	1.3	0.7	2.1
Eye problems/disorders: None of the above	0.3	0.3	1.5	0.2	1.2	1.1	-0.4	-0.4	-0.8	0.4	-0.5	-0.1	0.1	0.2	-0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.3	-0.7	-1.1	-0.4	0.2	-0.2	0.4	0.2	0.6	0.0	-0.1	0.1	-0.8
Emphysema/chronic bronchitis	1.0	1.1	2.8	-0.2	-1.2	-1.6	1.0	1.0	0.7	-1.3	0.5	0.3	1.0	1.7	1.1
Medication for pain relief, constipation, heartburn	1.2	2.1	3.5	0.6	-1.2	-1.3	1.8	1.7	0.6	-1.6	1.6	0.7	1.8	1.9	1.7
Neck or shoulder pain in last month	1.0	1.5	3.8	-0.5	-1.5	-1.7	0.6	1.3	2.0	-1.3	1.3	1.5	0.5	0.3	0.6
Medication: Blood pressure	0.7	1.1	2.1	1.3	0.9	1.3	-0.9	-1.0	-0.7	1.1	-0.3	0.4	-1.3	-1.5	-1.4
Angina (self-reported)	0.2	0.3	1.3	-0.1	0.3	-0.0	0.2	0.5	1.0	-0.5	0.3	1.1	0.4	0.0	0.6
Migraine (self-reported)	0.3	0.3	0.8	-0.0	-0.6	-0.3	0.3	0.4	0.9	-0.3	0.8	0.5	0.8	0.9	0.0
Medication: Ibuprofen	0.7	0.9	3.4	-0.9	-1.6	-1.8	0.3	0.7	1.3	-0.9	0.4	-0.1	0.3	0.5	0.2
Medication: Allopurinol	1.6	2.1	3.9	-0.4	-1.9	-2.0	1.5	1.5	1.3	-1.4	1.4	1.1	1.5	1.7	1.2
Medication: Omeprazole	0.5	0.5	1.1	-0.9	0.3	0.4	-1.0	-0.8	0.1	0.8	-0.6	-0.4	-0.7	-1.0	-1.0
Medication: Seretide 50 evohaler	0.9	1.1	2.8	-1.1	-1.2	-1.7	0.5	1.0	1.2	-1.4	0.5	0.3	0.9	0.9	0.8
Mean time to correctly identify matches	1.7	3.3	8.7	0.6	2.9	2.6	-1.5	-1.7	-2.4	1.9	-1.3	-0.5	-1.5	-1.6	-1.3
Heart disease (mother)	0.6	0.8	3.0	-1.7	0.1	0.1	-0.7	-0.8	0.0	0.3	-1.1	-1.7	-0.4	0.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.5	-1.4	-0.6	-0.8	0.5	0.6	0.5	-0.8	0.4	-0.5	1.2	1.9	0.9
Whole body fat mass	0.4	1.5	3.8	0.5	0.3	1.0	-1.1	-1.5	-0.7	1.8	-0.3	-0.5	-1.4	-1.8	-1.9
Leg fat mass (right)	0.6	2.5	5.8	0.3	0.6	1.5	-1.5	-2.0	-1.2	2.3	-0.7	-0.8	-1.8	-2.2	-2.4
Arm predicted mass (right)	0.9	4.6	8.5	-1.4	-2.7	-2.5	1.7	2.5	2.9	-2.8	2.0	1.8	1.6	1.3	1.7
Pulse rate, automated reading	0.1	0.5	1.5	-0.6	-0.4	0.0	-0.5	-0.8	-0.7	0.9	0.1	-0.5	-0.7	-0.7	-1.2
Alcohol intake frequency.	1.2	2.8	5.0	-0.0	-1.3	-1.6	2.1	1.7	0.8	-1.4	2.2	1.7	2.0	1.8	1.9
Comparative height size at age 10	0.9	4.8	10.2	-0.2	-2.2	-2.7	1.7	2.7	2.4	-3.2	1.7	1.4	2.0	2.3	2.2
Number of full sisters	1.3	1.6	5.3	-1.3	-0.1	0.6	-0.8	-1.5	-1.4	1.4	-0.7	-2.3	-1.2	-0.2	-1.7
Suffer from ‘nerves’	0.6	1.0	4.8	-2.2	0.1	0.1	-1.1	-0.3	-1.0	-0.5	-1.2	-1.6	-0.7	0.3	-0.4
Overall health rating	1.0	2.2	4.8	-2.2	0.1	0.2	-2.2	-1.1	-0.4	0.5	-1.3	-0.8	-2.1	-2.0	-2.0
Chest pain or discomfort	0.3	0.4	1.1	-1.0	0.5	0.0	-0.5	0.4	0.8	-0.8	-0.3	0.8	-0.8	-0.7	0.2
Had major operations	0.1	0.2	0.7	-0.3	-0.5	-0.0	-0.1	-0.4	0.4	0.5	0.4	0.1	-0.2	-0.1	-0.8
Age at last live birth	0.1	0.1	0.4	0.3	-0.2	0.1	0.1	-0.2	0.3	0.3	0.1	0.4	-0.4	-0.6	-0.4
Family relationship satisfaction	4.5	5.5	8.0	-1.5	2.0	2.1	-2.7	-2.5	-2.3	2.3	-2.6	-2.8	-2.6	-1.9	-2.6
Leg pain on walking	0.3	0.3	1.4	0.7	0.7	0.4	-0.4	-0.4	0.1	0.6	-0.2	0.5	-0.6	-1.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	-0.7	0.4	-0.5	0.5	1.1	0.8	-1.3	0.2	0.9	0.6	0.5	1.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.7	-1.6	-0.6	-0.2	-0.4	-0.5	-0.3	0.4	-0.3	-1.1	0.0	0.6	-0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	0.8	-0.4	-0.4	1.3	0.5	0.3	-0.1	0.5	-0.5	1.2	1.5	1.1
Medication: Aspirin	1.9	2.6	3.8	-0.5	1.5	2.0	-1.8	-1.8	-1.6	1.7	-1.3	-1.0	-1.9	-1.6	-1.9
Supplements: Vitamin C	1.5	1.8	2.9	0.4	-1.5	-1.6	1.3	1.6	1.5	-1.7	1.4	1.6	1.0	0.5	1.1
Knee pain experienced in last month	0.2	0.3	1.4	-0.8	-0.7	-0.7	0.1	0.2	1.2	-0.2	0.4	0.4	0.1	-0.1	0.0
Hypertension (Self-reported)	2.3	6.4	10.7	0.3	2.0	2.6	-2.9	-2.5	-2.9	2.3	-2.1	-1.6	-3.1	-3.3	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.7	0.9	0.6	-1.1	-1.0	-0.1	0.9	-1.0	-0.4	-0.5	-0.9	-0.7
Illnesses of father: Heart disease	1.6	2.2	4.0	-1.3	-1.6	-1.6	1.2	1.7	1.5	-2.0	1.3	1.1	1.6	1.5	1.3
Illnesses of siblings: Diabetes	0.9	1.1	2.9	0.5	0.6	1.0	-0.9	-1.0	-1.0	1.2	-0.5	0.1	-1.3	-1.7	-1.5
Smoking status: Previous	2.6	4.0	10.3	2.4	-1.8	-1.7	2.2	2.0	1.7	-1.2	2.9	3.2	1.7	0.4	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.1	9.9	-0.4	-2.6	-2.7	2.0	2.6	3.2	-2.9	1.6	1.9	1.9	1.6	2.4
Whole body fat-free mass	1.4	8.1	14.4	-0.9	-3.2	-3.2	2.6	3.3	3.8	-3.5	2.7	2.5	2.5	2.1	2.6
Leg fat-free mass (right)	1.6	8.5	17.3	0.1	-3.2	-3.1	2.8	3.3	4.2	-3.4	2.9	2.8	2.6	2.0	2.8
Arm fat percentage (left)	0.8	3.1	7.5	1.0	1.0	1.7	-1.5	-2.2	-1.2	2.7	-0.7	-0.6	-1.8	-2.4	-2.5
Average weekly red wine intake	0.6	0.8	2.6	-1.1	0.8	0.4	-1.3	-0.4	-0.3	-0.1	-1.6	-0.8	-1.1	-1.0	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.9	-0.1	0.5	0.0	-0.3	-0.3	-1.7	0.2	-0.9	-1.3	0.0	0.1	0.4
Mood swings	0.8	1.5	8.2	-2.9	-2.0	-1.6	-0.3	0.4	0.6	-1.0	0.4	-0.3	0.1	0.6	-0.8
Loneliness, isolation	1.0	1.4	8.5	-2.9	-1.0	-1.0	-1.0	-0.1	0.8	-0.7	-0.5	-0.8	-0.9	-0.2	-1.4
Long-standing illness, disability or infirmity	0.3	0.5	1.5	-1.2	-0.7	-0.7	-0.5	0.6	0.9	-1.0	0.3	0.8	-0.4	-0.6	-0.2
Ever had bowel cancer screening	1.4	1.6	4.1	-0.2	-2.0	-1.9	0.9	1.3	1.0	-1.6	1.5	1.3	0.9	0.6	0.5
Diabetes diagnosed by doctor	0.5	0.8	2.2	1.4	1.0	1.2	-0.5	-0.5	-0.5	1.0	0.1	0.7	-0.8	-1.5	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	2.6	-1.6	-0.4	-0.5	0.2	0.4	0.1	-0.7	0.3	0.2	-0.1	0.2	0.3
Friendships satisfaction	5.6	6.9	11.0	-2.4	1.3	1.8	-2.9	-3.1	-1.9	2.6	-2.6	-3.3	-3.0	-2.3	-3.3
Qualifications: nursing, teaching	2.6	4.0	7.1	-0.5	-2.4	-2.6	1.9	2.2	2.7	-2.4	1.9	1.8	1.6	1.6	1.3
Commuting to job workplace: Walk	5.0	5.4	8.6	1.0	-2.4	-2.5	2.7	2.3	2.4	-2.0	2.9	2.0	2.6	2.4	2.2
Eye problems/disorders: Cataract	0.2	0.2	1.1	0.0	-0.6	-1.0	0.3	0.6	-0.0	-0.8	0.2	-0.2	0.0	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.3	0.3	0.2	-0.0	-1.0	-0.4	-0.4	0.1	-0.6	0.2	-1.2	-1.5	-0.8
Medication for cholesterol	2.7	4.1	5.6	0.5	-1.8	-2.2	2.2	2.2	2.3	-1.9	2.0	1.9	2.4	2.2	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.5	-1.3	0.6	0.7	-1.7	-1.2	-1.0	0.7	-1.6	-1.6	-1.9	-1.5	-1.4
Back pain experienced in last month	0.8	1.2	4.5	-2.1	-1.2	-1.5	0.0	1.2	0.4	-1.6	0.4	0.1	0.6	0.9	0.7
Mineral and other dietary supplements	0.8	1.0	5.2	2.3	0.8	0.3	0.7	0.8	0.1	-0.5	0.2	1.4	0.8	0.2	1.5
Breast cancer (self-reported)	1.4	1.7	3.8	-0.8	1.9	1.5	-1.3	-1.1	-1.2	1.0	-1.7	-2.0	-1.0	-0.6	-0.3
Asthma (self-reported)	0.5	1.0	3.4	1.8	-0.5	-0.8	0.7	1.1	1.1	-0.9	0.8	1.6	0.6	-0.2	0.9
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.0	0.5	-0.7	-0.7	0.3	-0.1	0.3	0.4	0.1
Osteoarthritis (self-reported)	0.1	0.2	0.6	0.1	-0.8	-0.7	0.3	0.1	0.3	0.0	0.6	-0.1	0.2	0.6	0.0
Medication: Aspirin	1.8	2.3	3.6	-0.8	1.4	1.7	-1.9	-1.6	-1.5	1.4	-1.3	-1.1	-1.9	-1.5	-1.9
Medication: Gliclazide	0.4	0.5	2.5	0.3	1.6	1.0	-0.4	-0.5	-0.7	0.5	-0.8	-0.0	-0.1	-0.2	0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	1.1	1.1	0.5	0.0	0.2	0.3	0.3	-0.2	-0.0	0.7	-0.0	-0.2	0.5
Smoking status: Current	2.0	3.2	6.6	-2.0	1.4	1.4	-2.0	-1.7	-2.0	1.0	-2.6	-2.3	-1.9	-1.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.6	-0.2	-0.8	-1.5	1.1	1.9	2.2	-2.1	0.5	1.2	1.5	1.2	2.1
Whole body water mass	1.4	8.2	14.6	-1.0	-3.2	-3.2	2.6	3.3	3.8	-3.6	2.7	2.5	2.5	2.2	2.6
Leg predicted mass (right)	1.5	8.1	16.8	0.1	-3.1	-3.0	2.7	3.2	4.1	-3.3	2.8	2.8	2.5	2.0	2.7
Arm fat mass (left)	0.2	0.8	2.5	0.6	-0.0	0.6	-0.7	-1.0	-0.1	1.4	0.1	0.1	-1.0	-1.6	-1.6
Number of self-reported non-cancer illnesses	0.6	1.0	3.2	-1.1	-0.7	0.0	-1.1	-0.7	-0.6	0.5	-0.1	-0.3	-1.3	-1.6	-1.8
Average weekly champagne plus white wine intake	0.2	0.3	1.0	-0.6	-1.0	-0.8	-0.0	0.2	0.7	-0.4	0.1	-0.6	-0.4	-0.2	-0.5
Miserableness	0.3	0.5	3.7	-1.9	-0.7	-0.6	-0.8	-0.1	0.5	-0.2	-0.3	-0.1	-0.3	-0.1	-0.9
Guilty feelings	1.2	1.8	5.2	-2.3	-1.5	-1.7	0.6	1.2	2.2	-1.5	1.0	0.7	0.7	0.9	0.6
Wears glasses or contact lenses	0.5	0.5	3.2	1.8	0.8	0.8	-0.0	-0.6	-0.7	0.9	0.1	-0.2	0.0	0.1	-0.2
Ever taken oral contraceptive pill	2.0	2.3	4.7	1.0	1.5	2.2	-1.1	-1.8	-1.4	2.0	-1.5	-1.9	-1.2	-0.6	-1.0
Hearing aid user	0.1	0.1	0.3	-0.5	0.0	-0.1	-0.2	0.1	-0.0	-0.5	-0.1	-0.3	-0.2	0.1	-0.2
Mother’s age at death	1.0	1.2	3.5	1.5	1.9	1.6	-0.9	-0.7	-0.9	0.5	-1.3	-0.7	-1.0	-0.9	-0.0
Financial situation satisfaction	1.5	1.8	4.3	0.1	0.4	1.1	-1.2	-1.7	-0.2	1.8	-1.0	-0.7	-1.8	-1.9	-2.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.9	-1.0	-0.7	-0.5	-0.1	0.2	0.5	-0.3	0.3	0.1	0.2	0.1	-0.5
Commuting to job workplace: Public transport	0.2	0.3	1.0	-0.0	-0.0	-0.4	-0.0	0.6	1.0	-0.9	0.3	0.7	0.3	0.1	0.3
Eye problems/disorders: Glaucoma	1.9	2.2	4.2	-0.4	1.2	1.4	-1.4	-1.6	-1.4	1.6	-1.5	-1.2	-1.9	-2.0	-1.6
Medication: Blood pressure	3.4	6.5	13.9	0.2	1.9	2.5	-2.9	-2.5	-2.6	2.2	-2.4	-1.7	-3.3	-3.7	-2.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.4	-1.5	-0.8	-0.6	-0.5	0.2	0.1	-0.4	0.4	0.1	-0.3	-0.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	7.0	-2.6	-1.5	-1.4	-0.2	0.2	0.6	-0.7	0.5	-0.9	0.1	0.8	-0.8
High cholesterol (Self-reported)	1.4	2.5	5.1	0.2	1.2	1.8	-1.4	-1.8	-2.3	2.0	-1.3	-1.0	-1.6	-1.6	-1.7
Medication: Bendroflumethiazide	3.1	4.8	7.5	1.6	2.7	2.6	-2.2	-2.0	-2.5	1.9	-1.7	-0.7	-2.5	-2.7	-2.1
Medication: Paracetamol	0.6	1.0	2.4	0.4	0.6	0.8	-1.2	-1.1	-0.5	1.1	-0.7	0.4	-1.2	-1.5	-1.6
Medication: Lisinopril	0.8	1.0	2.9	1.7	-0.6	-0.5	0.5	0.8	1.6	-0.7	0.8	1.7	0.2	-0.9	0.1
Medication: Atorvastatin	1.0	1.3	5.1	2.3	1.3	1.6	-0.4	-0.9	-1.4	1.2	-0.9	-0.4	-0.4	-0.5	-0.3
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.9	-0.7	0.1	-0.1	-0.5	0.6	0.7	0.1	-0.5	-0.3	-0.3	-0.8
Alcohol drinker status: Never	0.6	0.7	2.4	-0.9	-0.6	-0.7	0.9	0.5	-0.4	-0.3	0.8	-0.5	1.1	1.6	0.9
Ever smoked	0.5	0.8	2.5	1.4	-0.9	-0.8	0.8	1.1	0.5	-0.8	1.0	1.6	0.3	-0.3	0.3
Basal metabolic rate	0.9	5.2	10.2	-0.6	-2.7	-2.5	2.0	2.6	3.2	-2.8	2.3	2.1	1.9	1.6	1.9
Leg fat percentage (left)	2.0	7.4	14.6	0.6	1.8	2.8	-2.5	-3.3	-2.7	3.8	-1.8	-1.8	-2.8	-3.2	-3.6
Arm fat-free mass (left)	0.6	3.1	6.1	-0.9	-2.2	-2.0	1.5	2.0	2.5	-2.2	1.7	1.6	1.3	0.9	1.4
Number of operations (self-reported)	0.6	0.9	2.4	-0.6	0.1	0.4	-1.1	-1.0	-0.6	1.1	-0.3	-0.5	-1.1	-1.6	-1.5
Average weekly beer plus cider intake	0.5	0.7	2.0	-1.3	-0.7	-0.3	-0.4	-0.7	-1.4	0.8	-0.0	-1.3	-0.3	0.1	-1.0
Irritability	0.7	1.2	4.8	-2.2	-0.9	-0.4	-1.2	-1.0	-0.2	0.6	-0.6	-1.3	-1.0	-0.6	-1.6
Risk taking	0.5	0.8	4.5	-2.1	-1.4	-1.2	0.0	-0.2	0.2	0.1	0.5	-0.8	0.0	0.3	-0.6
Ever had prostate specific antigen (PSA) test	4.4	5.1	8.2	0.9	-1.2	-2.0	2.1	2.7	2.9	-2.8	2.0	1.9	2.4	2.6	2.7
Fractured/broken bones in last 5 years	2.7	3.4	6.9	-0.8	2.3	2.6	-1.7	-2.2	-1.6	2.2	-1.7	-1.7	-1.6	-1.4	-1.6
Age started oral contraceptive pill	0.5	0.6	2.8	1.7	0.5	0.3	0.4	0.7	0.7	-0.5	0.3	1.0	0.6	0.1	0.9
Diastolic blood pressure, automated reading	0.3	0.8	2.5	-0.6	-1.3	-1.3	0.6	0.7	1.6	-0.8	0.8	0.8	0.5	0.3	0.4
Ever depressed for a whole week	0.8	0.9	3.4	-1.8	-1.1	-1.3	0.0	0.6	0.8	-1.2	0.1	-0.9	0.3	1.3	0.1
Unable to work because of sickness or disability	0.9	1.1	3.6	-1.9	-1.6	-1.1	0.6	0.8	1.0	-0.8	1.1	0.9	0.9	0.7	0.0
Commuting to job workplace: Cycle	0.5	0.6	2.2	0.4	1.3	1.5	-0.6	-0.5	-0.6	0.5	-0.8	-0.1	-0.6	-0.8	-0.4
Myopia	0.6	0.8	2.6	1.6	0.2	-0.1	0.2	1.0	1.0	-1.1	0.2	1.6	-0.1	-0.7	0.7
Vascular/heart problems diagnosed by doctor	1.6	4.4	7.7	0.1	-1.7	-2.2	2.5	2.2	2.1	-2.0	1.6	1.1	2.6	2.8	2.8
Cholesterol lowering medication	0.3	0.4	1.2	0.4	1.1	0.8	-0.7	-0.2	-0.8	0.0	-0.6	-0.1	-0.6	-0.9	0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	-1.0	0.2	0.2	-0.6	-0.4	0.6	0.5	-0.3	0.0	-0.2	-0.8	-0.4
Pain experienced in last month	1.1	1.8	4.8	0.5	1.5	1.5	-1.1	-1.1	-2.2	0.9	-1.7	-1.4	-1.3	-1.2	-0.8
Supplements: Calcium	0.2	0.2	0.9	-0.9	-0.2	-0.5	-0.3	0.4	0.2	-0.9	-0.1	0.0	0.1	0.1	0.3
Basal cell carcinoma (self-reported)	0.1	0.2	1.2	-0.2	0.2	0.4	-0.1	-0.1	-1.1	0.1	0.3	0.2	-0.4	-0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.2	0.9	0.7	-1.0	-0.2	-0.1	-0.0	-0.4	0.7	-0.8	-0.9	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.4	-1.2	-0.7	-0.6	-0.0	0.2	-0.4	-0.5	0.2	-0.4	0.3	0.5	0.2
Heart disease (siblings)	0.4	0.5	1.2	-0.2	0.5	0.3	-1.0	-0.5	-0.2	0.4	-0.5	-0.1	-1.1	-1.1	-1.0
Alcohol drinker status: Previous	0.9	1.0	2.3	0.2	-1.0	-1.0	1.1	1.1	1.1	-0.8	1.5	1.3	1.0	0.4	0.9
Pack years of smoking	1.5	2.2	5.7	-2.2	0.0	0.6	-1.4	-1.8	-1.5	1.6	-0.6	-1.7	-1.4	-0.4	-2.4
Impedance of whole body	1.1	5.5	8.1	1.2	2.5	2.6	-2.4	-2.5	-2.9	2.7	-2.3	-2.1	-2.2	-2.0	-2.3
Leg fat mass (left)	0.6	2.4	5.6	0.3	0.6	1.5	-1.5	-1.9	-1.0	2.2	-0.7	-0.8	-1.7	-2.2	-2.4
Arm predicted mass (left)	0.8	3.8	7.0	-0.8	-2.5	-2.2	1.7	2.3	2.6	-2.4	2.0	1.9	1.6	1.1	1.6