Best TWAS P=9.33e-216 · Best GWAS P=1.34e-223 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | GPR126 | 0.06 | 0.04 | lasso | 4 | 0.04 | 6.1e-04 | -30.7 | 31.4 | 9.3e-216 | -0.97 | 0.02 | 0.96 | TRUE |
2 | GTEx | Colon Transverse | GPR126 | 0.13 | -0.01 | lasso | 7 | 0.00 | 4.2e-01 | -12.2 | -10.7 | 7.0e-27 | 0.32 | 0.07 | 0.38 | TRUE |
3 | METSIM | Adipose | GPR126 | 0.05 | 0.01 | blup | 429 | 0.02 | 1.9e-04 | -16.2 | 25.9 | 2.3e-147 | -0.74 | 0.14 | 0.86 | TRUE |
4 | METSIM | Adipose | VTA1 | 0.03 | 0.03 | lasso | 5 | 0.02 | 9.8e-04 | -12.3 | -10.3 | 1.2e-24 | 0.04 | 0.62 | 0.01 | TRUE |
5 | NTR | Blood | HIVEP2 | 0.02 | 0.01 | blup | 424 | 0.01 | 2.6e-03 | -11.8 | -19.0 | 1.7e-80 | 0.40 | 0.34 | 0.05 | TRUE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GPR126 | 0.06 | 0.00 | blup | 69 | 0.01 | 4.6e-02 | -1.9 | -8.9 | 3.9e-19 | 0.42 | 0.02 | 0.07 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NMBR | 0.03 | 0.03 | blup | 46 | 0.02 | 3.6e-05 | 14.1 | -15.0 | 6.6e-51 | 0.13 | 0.84 | 0.08 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NMBR | 0.04 | 0.04 | enet | 9 | 0.03 | 1.7e-04 | 13.0 | -12.3 | 5.7e-35 | 0.11 | 0.37 | 0.07 | TRUE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | VTA1 | 0.03 | 0.02 | blup | 66 | 0.02 | 1.7e-03 | 14.8 | -14.6 | 4.5e-48 | 0.08 | 0.22 | 0.11 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NMBR | 0.07 | 0.05 | blup | 46 | 0.05 | 1.4e-06 | 14.2 | -11.6 | 3.2e-31 | 0.10 | 0.98 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VTA1 | 0.03 | 0.00 | enet | 8 | 0.00 | 1.1e-01 | 14.8 | -8.4 | 6.5e-17 | 0.15 | 0.09 | 0.13 | TRUE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | NMBR | 0.06 | 0.04 | blup | 46 | 0.05 | 1.1e-05 | 14.2 | -9.1 | 1.2e-19 | 0.08 | 0.91 | 0.00 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | VTA1 | 0.03 | 0.04 | enet | 3 | 0.01 | 1.2e-02 | 13.0 | -12.5 | 6.2e-36 | 0.07 | 0.19 | 0.08 | FALSE |
14 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NMBR | 0.09 | 0.01 | blup | 46 | 0.04 | 3.4e-02 | 13.8 | -16.7 | 7.1e-63 | 0.11 | 0.01 | 0.67 | TRUE |