Best TWAS P=1.31e-08 · Best GWAS P=7.5e-09 conditioned to 0.00208
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ESYT2 | 0.07 | 0.03 | blup | 465 | 0.05 | 7.5e-07 | -2.1 | 5.2 | 1.5e-07 | 0.76 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Nerve Tibial | ESYT2 | 0.13 | 0.07 | enet | 3 | 0.07 | 1.3e-05 | 5.3 | -5.3 | 1.0e-07 | -0.61 | 0.10 | 0.89 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ESYT2 | 0.13 | 0.05 | lasso | 7 | 0.03 | 8.0e-04 | 5.3 | -5.7 | 1.4e-08 | -0.57 | 0.10 | 0.69 | TRUE |
| 4 | NTR | Blood | ESYT2 | 0.06 | 0.09 | enet | 26 | 0.09 | 5.4e-27 | 5.3 | 5.3 | 9.6e-08 | 0.84 | 0.09 | 0.91 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ESYT2 | 0.02 | 0.03 | lasso | 2 | 0.02 | 4.1e-03 | 5.4 | 5.7 | 1.3e-08 | 0.80 | 0.05 | 0.55 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WDR60 | 0.11 | 0.09 | enet | 12 | 0.13 | 2.7e-09 | 3.6 | -5.2 | 2.6e-07 | -0.60 | 0.58 | 0.40 | FALSE |