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chr7:148,013,258-151,772,124

Best TWAS P=6.5e-40 · Best GWAS P=2.63e-125 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ABCF2	0.12	0.07	bslmm	557	0.08	6.9e-10	-7.81	-5.5	5.0e-08	-0.01	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GIMAP2	0.07	0.00	blup	479	0.02	9.3e-04	-11.43	-6.5	6.2e-11	-0.02	0.10	0.03	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NUB1	0.15	0.08	lasso	6	0.13	4.7e-16	-5.06	-5.3	1.2e-07	0.03	1.00	0.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TMEM176A	0.07	0.04	lasso	8	0.03	7.0e-05	9.73	11.2	3.5e-29	0.06	0.64	0.08	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TMEM176B	0.13	0.01	enet	25	0.08	7.3e-10	8.76	6.8	8.2e-12	0.08	0.91	0.01	FALSE
6	GTEx	Adipose Subcutaneous	NUB1	0.17	0.09	lasso	4	0.12	8.9e-10	6.47	6.7	2.0e-11	-0.06	0.99	0.00	FALSE
7	GTEx	Adrenal Gland	ZNF786	0.36	0.20	lasso	12	0.26	5.2e-10	6.47	-5.2	2.2e-07	-0.08	0.98	0.00	TRUE
8	GTEx	Artery Aorta	NUB1	0.30	0.23	lasso	4	0.23	7.9e-13	-5.35	6.9	4.9e-12	-0.07	1.00	0.00	FALSE
9	GTEx	Artery Aorta	FASTK	0.17	0.14	lasso	3	0.12	4.4e-07	5.26	5.6	2.1e-08	0.09	0.89	0.00	FALSE
10	GTEx	Artery Coronary	NUB1	0.29	0.09	lasso	6	0.12	6.6e-05	-4.26	6.7	1.6e-11	-0.05	0.18	0.16	FALSE
11	GTEx	Artery Coronary	CHPF2	0.43	0.02	lasso	8	0.04	1.5e-02	-7.44	5.2	2.3e-07	0.02	0.06	0.05	FALSE
12	GTEx	Artery Coronary	RP11-148K1.12	0.31	-0.01	enet	16	0.00	2.2e-01	9.82	-12.3	5.9e-35	-0.02	0.02	0.78	FALSE
13	GTEx	Artery Tibial	NUB1	0.27	0.15	lasso	7	0.15	5.6e-12	-5.35	6.9	5.3e-12	-0.06	1.00	0.00	FALSE
14	GTEx	Brain Cerebellar Hemisphere	KCNH2	0.34	0.09	lasso	5	0.12	5.0e-04	5.39	-6.8	9.4e-12	0.01	0.12	0.07	FALSE
15	GTEx	Brain Cerebellar Hemisphere	GIMAP4	0.50	0.00	lasso	11	0.00	2.4e-01	4.57	8.0	1.6e-15	0.00	0.05	0.06	FALSE
16	GTEx	Brain Cerebellar Hemisphere	FASTK	0.46	0.03	lasso	8	0.07	9.3e-03	5.26	6.5	7.9e-11	0.00	0.06	0.06	TRUE
17	GTEx	Brain Cerebellum	KCNH2	0.35	0.20	enet	24	0.28	4.8e-09	-13.05	-9.4	8.3e-21	-0.01	0.87	0.06	FALSE
18	GTEx	Brain Hypothalamus	RP4-800G7.2	0.32	0.16	lasso	7	0.10	2.4e-03	-7.09	-5.7	1.2e-08	0.31	0.13	0.07	TRUE
19	GTEx	Breast Mammary Tissue (Male)	ZBED6CL	0.40	-0.01	enet	21	0.16	1.3e-04	0.33	5.2	2.0e-07	0.06	0.04	0.06	TRUE
20	GTEx	Breast Mammary Tissue (Male)	RP4-800G7.2	0.02	-0.01	enet	5	-0.01	8.6e-01	-4.72	-6.2	7.1e-10	0.13	0.03	0.06	TRUE
21	GTEx	Cells Transformed fibroblasts	NUB1	0.10	0.02	lasso	3	0.02	6.1e-03	-5.15	6.1	1.0e-09	-0.06	0.53	0.06	TRUE
22	GTEx	Cells Transformed fibroblasts	CHPF2	0.12	0.03	enet	10	0.00	1.8e-01	-7.44	8.1	4.7e-16	0.01	0.28	0.04	FALSE
23	GTEx	Colon Sigmoid	NUB1	0.21	0.21	lasso	2	0.15	4.5e-06	-5.35	5.4	7.2e-08	-0.08	0.63	0.04	FALSE
24	GTEx	Colon Sigmoid	ZNF783	0.17	0.02	enet	8	0.01	1.0e-01	4.81	6.3	3.2e-10	0.12	0.18	0.07	FALSE
25	GTEx	Colon Sigmoid	RP4-800G7.2	0.17	0.06	lasso	4	0.06	3.9e-03	4.81	7.3	3.3e-13	0.06	0.32	0.05	FALSE
26	GTEx	Esophagus Mucosa	RP4-800G7.2	0.19	0.16	lasso	2	0.14	1.2e-09	5.85	5.3	1.1e-07	-0.04	1.00	0.00	TRUE
27	GTEx	Esophagus Muscularis	FASTK	0.17	0.17	lasso	3	0.16	9.2e-10	5.26	5.1	2.9e-07	0.09	1.00	0.00	FALSE
28	GTEx	Heart Atrial Appendage	TMEM176B	0.37	0.06	enet	15	0.23	1.1e-10	1.06	-8.5	1.8e-17	0.05	0.58	0.05	FALSE
29	GTEx	Heart Left Ventricle	FASTK	0.26	0.04	enet	8	0.04	3.0e-03	5.26	7.7	1.9e-14	0.04	0.12	0.04	FALSE
30	GTEx	Lung	NUB1	0.12	0.05	lasso	3	0.01	2.6e-02	-5.35	5.8	5.5e-09	-0.08	0.15	0.05	FALSE
31	GTEx	Lung	CHPF2	0.11	0.00	lasso	1	0.00	2.0e-01	-7.81	7.8	5.7e-15	0.01	0.36	0.02	TRUE
32	GTEx	Nerve Tibial	NUB1	0.22	0.15	lasso	3	0.17	2.3e-12	-5.35	6.3	3.2e-10	-0.07	1.00	0.00	FALSE
33	GTEx	Skin Sun Exposed Lower leg	NUB1	0.20	0.12	enet	26	0.13	5.9e-11	-5.15	8.3	9.6e-17	-0.04	1.00	0.00	TRUE
34	GTEx	Skin Sun Exposed Lower leg	ZNF425	0.11	0.01	enet	19	0.03	9.0e-04	5.22	6.9	5.2e-12	-0.30	0.24	0.07	TRUE
35	GTEx	Small Intestine Terminal Ileum	ZNF786	0.31	0.20	lasso	7	0.20	3.6e-05	5.38	-5.7	1.5e-08	-0.09	0.45	0.03	TRUE
36	GTEx	Spleen	CHPF2	0.46	0.16	lasso	5	0.25	4.8e-07	5.93	7.3	3.6e-13	0.02	0.27	0.10	FALSE
37	GTEx	Spleen	ZNF783	0.32	-0.01	enet	34	0.05	2.4e-02	3.84	6.9	6.4e-12	0.13	0.09	0.05	TRUE
38	GTEx	Stomach	ZNF786	0.20	0.12	enet	16	0.09	6.8e-05	4.03	-5.2	1.6e-07	-0.07	0.82	0.03	FALSE
39	GTEx	Uterus	GIMAP4	0.32	-0.01	enet	42	0.02	1.4e-01	4.16	-8.6	1.1e-17	0.02	0.06	0.06	FALSE
40	METSIM	Adipose	AOC1	0.17	0.08	enet	26	0.11	3.2e-16	9.43	12.9	3.7e-38	-0.02	0.52	0.48	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	TMEM176A	0.25	0.17	enet	19	0.20	1.5e-25	8.76	11.5	1.6e-30	0.04	1.00	0.00	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	TMEM176B	0.21	0.10	enet	21	0.13	1.0e-16	8.76	8.0	9.9e-16	0.06	1.00	0.00	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	PDIA4	0.15	0.14	bslmm	378	0.14	5.3e-17	-6.72	-6.0	1.7e-09	0.34	1.00	0.00	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	TMUB1	0.05	0.01	bslmm	511	0.01	7.2e-03	3.64	-5.5	3.4e-08	-0.02	0.09	0.04	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	ZNF212	0.12	0.07	bslmm	375	0.09	3.0e-11	-2.81	-5.5	4.6e-08	0.16	1.00	0.00	FALSE
46	YFS	Blood	CHPF2	0.03	0.01	enet	18	0.01	1.1e-05	-7.44	7.9	2.9e-15	0.04	0.89	0.00	FALSE
47	YFS	Blood	FASTK	0.04	0.01	blup	515	0.02	1.9e-07	5.26	9.6	1.0e-21	0.01	1.00	0.00	TRUE
48	YFS	Blood	GIMAP7	0.07	0.04	enet	51	0.06	6.7e-18	4.19	-6.5	6.1e-11	0.09	1.00	0.00	TRUE
49	YFS	Blood	PDIA4	0.05	0.05	lasso	2	0.05	4.4e-17	-7.44	-7.4	1.9e-13	0.35	1.00	0.00	TRUE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM176A	0.06	0.01	blup	60	0.03	1.0e-03	9.81	12.6	1.5e-36	0.01	0.06	0.17	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM176A	0.04	0.01	blup	60	0.04	4.0e-08	9.81	9.8	8.2e-23	0.04	0.12	0.16	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM176B	0.08	0.01	blup	72	0.06	1.6e-12	5.34	5.4	5.8e-08	0.05	0.85	0.00	TRUE
53	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WDR86	0.12	0.06	blup	78	0.07	2.3e-04	-3.23	6.0	2.1e-09	-0.06	0.01	0.96	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	EZH2	0.09	0.05	enet	9	0.03	1.0e-02	-5.45	-5.6	2.7e-08	-0.02	0.03	0.04	TRUE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC4A2	0.13	0.00	blup	54	0.03	4.5e-03	-2.21	5.8	6.0e-09	-0.01	0.01	0.08	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	WDR86	0.09	0.02	enet	7	0.04	1.8e-03	-6.96	5.9	4.1e-09	-0.06	0.01	0.46	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHPF2	0.03	0.04	lasso	1	0.02	2.5e-03	-7.39	7.4	1.5e-13	0.03	0.01	0.96	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUB1	0.04	0.00	blup	86	0.02	3.6e-03	-2.61	-5.5	5.2e-08	0.05	0.03	0.27	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM176A	0.22	0.01	blup	60	0.14	1.7e-15	3.52	10.3	1.1e-24	-0.03	0.92	0.02	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM176B	0.21	0.11	blup	72	0.15	2.4e-16	3.52	8.1	6.0e-16	0.00	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABP1	0.16	0.19	lasso	4	0.20	9.3e-22	-12.45	12.1	1.1e-33	-0.02	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHPF2	0.07	0.03	blup	51	0.05	8.6e-07	5.69	8.4	2.9e-17	0.01	0.17	0.73	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FASTK	0.03	0.02	lasso	2	0.02	2.2e-03	5.26	5.3	1.3e-07	0.09	0.00	0.98	TRUE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM176A	0.19	0.05	lasso	6	0.13	2.6e-14	-12.45	13.1	6.3e-39	-0.04	0.06	0.94	FALSE
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM176B	0.04	0.02	lasso	2	0.02	1.5e-03	7.20	8.9	5.8e-19	-0.01	0.05	0.51	TRUE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM176A	0.17	0.05	blup	60	0.07	5.1e-05	-4.82	10.8	3.0e-27	-0.04	0.36	0.26	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHPF2	0.03	0.02	blup	51	0.02	8.1e-04	-7.44	6.3	2.8e-10	0.01	0.01	0.93	FALSE
68	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABP1	0.26	0.20	enet	10	0.17	1.4e-08	-11.49	-11.9	1.6e-32	0.03	0.97	0.03	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF786	0.15	0.15	blup	29	0.16	5.7e-08	3.52	-5.7	1.4e-08	-0.09	0.99	0.00	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM176A	0.09	0.06	blup	60	0.06	2.5e-07	-4.86	7.8	7.9e-15	0.01	0.92	0.01	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM176B	0.06	0.01	blup	72	0.03	7.7e-05	3.49	8.9	6.7e-19	0.03	0.08	0.16	FALSE
72	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ATG9B	0.08	0.03	lasso	3	0.03	2.5e-03	-2.21	-9.4	7.1e-21	0.06	0.01	0.86	TRUE
73	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ABP1	0.13	0.03	blup	102	0.05	4.4e-03	16.79	-7.9	2.2e-15	-0.06	0.00	0.94	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHPF2	0.06	0.02	lasso	5	0.02	1.3e-03	-7.81	8.7	4.1e-18	0.00	0.01	0.98	TRUE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	EZH2	0.05	0.02	blup	54	0.03	6.5e-04	-5.45	-6.0	1.6e-09	0.01	0.05	0.03	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM176A	0.15	0.01	blup	60	0.04	6.1e-05	14.15	8.9	4.5e-19	0.02	0.06	0.69	FALSE
77	The Cancer Genome Atlas	Rectum Adenocarcinoma	TMEM176A	0.36	0.09	lasso	4	0.10	2.4e-03	1.06	6.5	7.0e-11	0.06	0.02	0.05	FALSE
78	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM176A	0.13	0.05	blup	60	0.04	1.3e-03	-4.82	7.6	2.9e-14	-0.05	0.03	0.03	FALSE
79	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM176A	0.15	0.00	lasso	10	0.02	5.7e-02	14.15	13.2	6.5e-40	0.02	0.01	0.31	TRUE
80	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM176B	0.17	0.12	enet	8	0.11	9.4e-05	3.49	6.8	8.3e-12	-0.02	0.34	0.06	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	CHPF2	0.03	0.03	blup	51	0.03	1.2e-03	-7.39	8.3	6.7e-17	0.01	0.01	0.97	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	SMARCD3	0.07	0.01	blup	71	0.03	1.1e-03	3.45	5.2	1.7e-07	-0.05	0.01	0.04	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM176A	0.32	0.09	blup	60	0.11	6.7e-11	1.06	9.6	6.0e-22	0.00	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM176B	0.33	0.10	enet	22	0.14	3.2e-13	1.06	7.3	3.9e-13	0.02	1.00	0.00	FALSE
85	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF786	0.20	0.06	blup	29	0.09	1.4e-03	3.84	-7.3	2.9e-13	0.02	0.05	0.08	TRUE