Best TWAS P=6.99e-29 · Best GWAS P=1.37e-35 conditioned to 2e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | ZNF697 | 0.28 | 0.01 | enet | 31 | 0.10 | 1.2e-03 | 3.9 | 6.8 | 1.0e-11 | -0.31 | 0.06 | 0.40 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ZNF697 | 0.08 | 0.02 | enet | 16 | 0.03 | 3.6e-03 | 3.7 | 5.9 | 3.7e-09 | -0.44 | 0.10 | 0.51 | FALSE |
| 3 | GTEx | Esophagus Mucosa | PHGDH | 0.12 | 0.01 | enet | 24 | 0.03 | 4.6e-03 | -12.4 | 10.0 | 1.9e-23 | -0.73 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ZNF697 | 0.14 | 0.03 | lasso | 9 | 0.07 | 1.5e-05 | -8.9 | 10.0 | 1.3e-23 | -0.66 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Lung | ZNF697 | 0.18 | 0.06 | enet | 15 | 0.04 | 3.6e-04 | 4.0 | 5.8 | 8.8e-09 | -0.26 | 0.95 | 0.03 | FALSE |
| 6 | GTEx | Testis | RP11-418J17.1 | 0.17 | 0.00 | enet | 30 | 0.00 | 3.9e-01 | -3.9 | -6.0 | 1.7e-09 | -0.06 | 0.09 | 0.06 | TRUE |
| 7 | NTR | Blood | ZNF697 | 0.04 | 0.02 | bslmm | 363 | 0.02 | 2.3e-08 | 1.4 | 5.2 | 2.1e-07 | -0.38 | 0.86 | 0.11 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | ZNF697 | 0.32 | 0.22 | lasso | 12 | 0.25 | 4.3e-32 | 3.9 | 6.5 | 7.4e-11 | -0.27 | 1.00 | 0.00 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | RP5-871G17.5 | 0.07 | 0.02 | blup | 407 | 0.03 | 1.4e-04 | -2.8 | -5.7 | 1.1e-08 | 0.19 | 0.86 | 0.01 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | GAPDHP23 | 0.13 | 0.04 | blup | 393 | 0.09 | 5.8e-12 | 1.1 | -7.8 | 6.0e-15 | 0.45 | 0.99 | 0.01 | FALSE |
| 11 | YFS | Blood | ZNF697 | 0.02 | 0.00 | enet | 12 | 0.01 | 1.8e-04 | -12.5 | 8.1 | 4.5e-16 | -0.69 | 0.00 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNF697 | 0.08 | 0.07 | blup | 55 | 0.08 | 1.7e-09 | -10.9 | 11.2 | 7.0e-29 | -0.82 | 0.00 | 1.00 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF697 | 0.05 | 0.06 | blup | 55 | 0.05 | 1.2e-06 | 4.0 | 7.8 | 6.0e-15 | -0.35 | 0.98 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF697 | 0.06 | 0.03 | blup | 55 | 0.06 | 1.5e-07 | 3.9 | 9.6 | 8.4e-22 | -0.54 | 0.54 | 0.44 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF697 | 0.07 | 0.02 | blup | 56 | 0.06 | 2.7e-07 | -12.5 | 10.4 | 3.1e-25 | -0.70 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ZNF697 | 0.09 | 0.04 | blup | 56 | 0.03 | 1.6e-02 | 3.9 | 9.3 | 1.4e-20 | -0.49 | 0.03 | 0.43 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBX15 | 0.07 | 0.02 | blup | 92 | 0.05 | 2.2e-06 | 3.6 | 5.9 | 3.6e-09 | -0.05 | 0.39 | 0.57 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF697 | 0.07 | 0.03 | blup | 56 | 0.05 | 1.7e-05 | 3.9 | 7.3 | 3.8e-13 | -0.47 | 0.83 | 0.08 | FALSE |