Best TWAS P=2.19e-19 · Best GWAS P=7.45e-19 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP11-337C18.9 | 0.13 | 0.13 | lasso | 2 | 0.13 | 2.4e-05 | -6.2 | -5.7 | 1.1e-08 | 0.51 | 0.22 | 0.64 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-337C18.9 | 0.07 | 0.02 | lasso | 6 | 0.02 | 1.5e-02 | -6.2 | -6.3 | 2.9e-10 | 0.50 | 0.25 | 0.15 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | CHD1L | 0.20 | -0.01 | enet | 4 | -0.01 | 5.3e-01 | -8.9 | 9.0 | 2.2e-19 | -1.00 | 0.00 | 0.95 | TRUE |
| 4 | GTEx | Brain Cortex | ACP6 | 0.60 | 0.39 | enet | 31 | 0.53 | 4.5e-17 | -3.4 | 5.2 | 2.0e-07 | 0.02 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Frontal Cortex BA9 | ACP6 | 0.66 | 0.41 | lasso | 6 | 0.54 | 9.7e-17 | -5.5 | 5.1 | 3.0e-07 | 0.01 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | FMO5 | 0.08 | 0.00 | lasso | 9 | 0.02 | 7.6e-03 | -4.4 | -6.5 | 6.8e-11 | 0.75 | 0.10 | 0.33 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | ACP6 | 0.53 | 0.27 | enet | 10 | 0.36 | 6.1e-14 | -5.5 | 5.3 | 1.1e-07 | 0.00 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Lung | CHD1L | 0.09 | 0.05 | enet | 6 | 0.04 | 3.2e-04 | -5.3 | 5.7 | 1.1e-08 | -0.40 | 0.54 | 0.11 | FALSE |
| 9 | GTEx | Prostate | ACP6 | 0.29 | 0.33 | lasso | 3 | 0.32 | 6.9e-09 | -5.6 | 5.5 | 3.7e-08 | 0.02 | 0.72 | 0.02 | FALSE |
| 10 | METSIM | Adipose | FMO5 | 0.06 | 0.04 | blup | 375 | 0.05 | 1.8e-07 | -4.5 | -6.0 | 2.4e-09 | 0.66 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ACP6 | 0.09 | 0.05 | blup | 31 | 0.05 | 3.0e-05 | -3.4 | 7.5 | 4.8e-14 | 0.04 | 0.11 | 0.20 | TRUE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | ACP6 | 0.18 | 0.14 | enet | 15 | 0.15 | 6.7e-09 | -3.4 | 5.8 | 8.1e-09 | 0.04 | 0.88 | 0.11 | FALSE |
| 13 | The Cancer Genome Atlas | Glioblastoma Multiforme | ACP6 | 0.11 | 0.04 | blup | 31 | 0.07 | 2.8e-03 | -3.5 | 5.4 | 7.5e-08 | 0.02 | 0.02 | 0.16 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ACP6 | 0.07 | 0.02 | blup | 31 | 0.04 | 1.1e-05 | -3.5 | 6.2 | 5.3e-10 | 0.03 | 0.85 | 0.07 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ACP6 | 0.23 | 0.19 | blup | 30 | 0.17 | 6.5e-10 | -3.5 | 5.4 | 6.4e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ACP6 | 0.17 | 0.09 | blup | 31 | 0.08 | 1.3e-04 | -3.5 | 5.8 | 6.5e-09 | 0.02 | 0.40 | 0.03 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ACP6 | 0.04 | 0.01 | blup | 31 | 0.02 | 2.7e-03 | -3.5 | 5.3 | 1.0e-07 | 0.02 | 0.05 | 0.26 | FALSE |