Hub : Genes

PHGDH

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.126 0.0380 1.3e-05 0.036 0.054 0.047 0.061 0.050 2.9e-05 3.5e-07 2.0e-06 6.0e-08 8.4e-07
2 GTEx Esophagus Mucosa 0.116 0.0460 4.9e-03 0.014 NA 0.029 NA 0.024 3.8e-02 NA 4.6e-03 NA 9.9e-03
3 GTEx Testis 0.310 0.0690 5.2e-06 0.345 NA 0.317 NA 0.333 4.5e-16 NA 1.2e-14 NA 2.0e-15
4 ROSMAP Brain Pre-frontal Cortex 0.193 0.0550 3.5e-05 0.058 0.038 0.075 0.063 0.052 5.2e-08 9.1e-06 5.8e-10 1.6e-08 2.7e-07
5 YFS Blood 0.274 0.0381 0.0e+00 0.097 0.152 0.169 0.152 0.146 4.1e-30 1.9e-47 6.9e-53 3.1e-47 1.8e-45
6 TCGA Thyroid Carcinoma 0.140 0.0470 1.1e-07 0.072 0.094 0.079 NA 0.062 1.6e-07 2.0e-09 4.1e-08 NA 1.1e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.4 1.1 -0.3 0.4 -1.0 0.4 0.7 -0.9
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 -0.2 -0.0 -0.2 -0.4 0.4 -0.3
Depressed Affect (Nagel 2018) 0.2 0.5 1.8 -0.8 -0.3 0.8 -0.1 1.3 -0.0
Depression (Nagel 2018) 0.9 1.3 3.9 1.5 -0.1 0.5 -0.9 -2.0 -1.0
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.2 0.4 0.1 0.2 0.1 0.1 0.3
Neuroticism (Nagel 2018) 0.3 0.8 1.8 1.2 -0.6 0.8 1.4 -0.5 -0.4
Schizophrenia (2018) 0.1 0.2 0.5 -0.1 -0.3 0.6 -0.7 -0.2 0.4
Schizophrenia vs Biploar Disorder 0.5 0.7 1.7 -0.6 -0.1 0.9 -0.8 0.8 1.3
Worry (Nagel 2018) 0.5 1.1 2.6 1.6 -1.0 0.4 1.5 -0.8 -0.5
Alzheimer’s Disease (in mother) 1.2 1.4 2.8 -1.7 -0.4 -0.5 -1.4 0.3 -1.7
Alzheimer’s Disease (in father) 0.8 0.9 2.3 -1.1 -0.1 0.9 1.5 0.9 -0.7
Alzheimer’s Disease (including proxy) 0.7 1.1 4.6 -2.1 -0.1 0.5 -0.3 0.7 -1.0
Crohns Disease (2017) 0.2 0.4 0.6 0.6 -0.3 -0.7 0.6 -0.8 -0.4
Irritable Bowel Disease (IBD) 0.1 0.2 0.9 -0.3 0.3 -0.9 -0.1 0.3 0.5
Ulcerative Colitis (UC) 0.5 0.9 2.0 -1.3 0.5 -0.6 -0.1 1.4 1.0
Major Depression (MDD) 0.7 0.8 2.0 0.6 0.5 0.4 1.4 -0.7 -1.2
Reaction Time 0.5 0.9 1.7 1.0 1.3 -0.8 1.0 0.4 -0.8
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.2 0.3 -1.1 -0.7 0.0 -0.3 -0.2
Breast Cancer 1.4 3.4 9.8 -1.8 -1.6 -3.1 -1.9 0.8 0.8
Ovarian Cancer 0.4 0.5 2.3 -0.4 1.5 -0.2 -0.5 0.5 -0.2
Prostate Cancer 0.3 0.4 0.8 -0.3 -0.8 -0.9 -0.6 0.9 0.1
Age at First Birth 0.9 1.4 3.3 -1.5 1.6 0.2 0.0 1.8 -0.2
Bipolar Disorder (2011) 0.8 0.8 2.2 -1.2 0.7 -1.5 -0.3 0.6 -0.2
Body Mass Index (BMI) (2010) 0.4 0.5 1.3 -1.1 0.2 -0.7 -1.1 -0.0 -0.1
Coronary Artery Disease (CAD) 0.3 0.3 1.5 -0.2 0.0 1.2 -0.1 -0.7 0.0
Crohns Disease (2012) 0.4 0.6 1.6 -0.9 -1.2 0.8 -0.1 0.6 -0.7
Mean Putamen Volume 0.6 0.7 1.5 1.0 0.8 1.2 0.9 0.3 0.4
Fasting Glucose 0.1 0.2 0.4 0.6 -0.0 0.6 -0.0 -0.5 0.1
HbA1C 1.5 1.6 3.6 1.6 0.6 -0.7 1.9 -1.3 -1.0
HDL Cholesterol 0.9 1.5 6.7 -0.2 -1.0 -0.4 1.1 0.4 2.6
LDL Cholesterol 0.6 0.9 5.1 -0.0 0.2 2.2 0.6 0.3 0.4
Lupus 0.1 0.2 0.5 -0.1 0.6 -0.1 0.7 0.4 0.4
Neuroticism (2016) 0.8 1.1 5.8 0.2 0.2 -0.1 2.4 0.1 -0.8
Primary Biliary Cirrhosis 1.3 1.8 3.8 -0.6 1.5 -1.9 -0.9 -0.7 -1.7
Rheumatoid Arthritis 1.3 1.7 4.0 0.8 1.5 -1.7 -0.2 -0.8 -2.0
Schizophrenia (2014) 0.2 0.3 1.2 -0.2 -0.5 0.6 -0.5 1.1 0.1
Triglycerides 0.5 0.8 3.8 -0.0 -0.8 1.9 0.4 0.6 0.3
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.7 -0.2 -0.1 0.8 1.3 1.3 0.8
Ulcerative Colitis 0.8 1.2 4.4 -1.5 0.1 -0.3 -0.3 2.1 0.5
Blood Eosinophil Count 0.1 0.6 1.6 -0.6 0.5 1.3 0.2 -0.4 -1.1
Blood Platelet Count 0.1 0.9 2.7 1.6 0.0 -0.4 0.7 -0.3 1.4
Blood Red Count 3.6 34.7 96.0 -3.4 -7.8 9.8 1.7 5.2 3.2
Blood White Count 0.3 2.5 6.5 -0.5 0.4 -2.5 -2.1 -1.5 -1.2
Heel T-Score 0.1 0.8 2.4 0.7 -0.2 -1.5 -0.1 -0.1 1.4
BMI 0.2 1.2 2.3 1.3 -0.3 0.2 1.5 -0.8 -1.5
Height 1.1 22.0 99.6 3.1 10.0 -1.8 2.1 -2.2 -3.2
Waist Hip Ratio (WHR) 1.1 4.9 13.1 -1.3 -3.6 -0.0 -0.7 1.2 3.5
Systolic Blood Pressure 0.3 1.4 4.4 1.8 0.1 2.1 0.6 -0.1 0.2
Smoking Status 0.7 1.7 4.3 -1.1 -0.5 1.5 -1.5 2.1 0.2
Allergy or Eczema 0.4 1.2 4.6 -1.0 -0.5 -2.1 -0.4 0.3 -0.9
Cardiovascular Disease 0.4 1.4 4.4 1.0 0.9 2.1 1.2 0.5 0.6
Hypothyroidism (self reported) 0.6 1.4 2.8 -0.7 1.7 -1.6 -0.2 -0.4 -1.5
Respiratory disease 0.1 0.3 1.0 0.3 -0.1 0.2 -0.1 -1.0 -0.9
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.1 -1.0 0.7 -1.0 -0.0 -0.3 -1.1
Lung FEV1/FVC ratio 0.1 0.6 1.7 0.0 1.3 0.1 0.7 0.8 0.7
Lung FVC 0.2 1.1 3.3 -0.4 -0.2 -1.5 -1.8 -0.3 -0.8
Neuroticism 0.1 0.3 0.9 -0.8 -0.1 0.9 0.1 0.6 -0.4
Chronotype (morning person) 0.8 1.7 3.5 1.9 1.6 -0.3 1.4 -1.2 -0.9
Hair Pigment 0.1 2.7 7.5 0.4 -2.7 1.7 -1.0 -1.8 -1.2
Tanning 0.1 0.7 3.5 -0.1 0.3 0.1 1.9 -0.7 0.3
Hand grip strength (left) 0.5 1.4 2.8 1.7 1.1 1.4 0.7 -1.1 -0.9
Number of treatments/medications taken 0.2 0.4 1.4 0.2 -0.2 -0.1 -0.8 -1.2 -0.7
Average weekly spirits intake 0.2 0.2 0.9 -0.4 -0.9 -0.4 -0.3 -0.4 -0.0
Sensitivity / hurt feelings 0.6 1.0 3.0 -1.6 -0.5 0.4 -0.1 1.7 -0.3
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.1 0.6 1.1 -1.3 -1.2 -1.5 -1.3
Hearing difficulty/problems: Yes 1.3 2.0 5.8 -2.4 -1.6 0.7 -0.7 1.0 1.2
Relative age of first facial hair 0.8 1.6 4.0 0.4 -1.3 2.0 -0.9 -0.8 1.6
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 4.4 -0.3 -0.3 1.4 0.8 2.1 2.1
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.5 -0.2 0.1 -0.6 1.9 1.1 0.6
Ever had hysterectomy (womb removed) 0.9 1.0 3.4 1.1 0.2 0.2 1.9 -0.9 -0.8
Systolic blood pressure, automated reading 0.1 0.4 0.7 0.8 0.5 0.8 0.6 -0.1 -0.6
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 15.8 0.5 -0.8 0.7 1.4 0.3 4.0
Angina 0.3 0.5 1.2 -0.5 -1.1 -0.2 -0.6 -0.9 -0.1
Medication for hormone replacement therapy 0.4 0.5 0.9 -1.0 0.4 0.4 -0.5 0.7 -0.9
Vitamin and mineral supplements 1.6 2.2 5.8 -1.6 -0.4 2.1 -0.3 2.4 -0.2
Supplements: Zinc 0.3 0.3 0.5 -0.7 -0.3 -0.6 -0.7 0.0 -0.7
Medication: Co-codamol 0.8 0.9 1.9 -0.1 -1.1 0.2 1.3 1.4 0.6
Medication: Metformin 0.2 0.3 1.2 -0.1 0.3 0.6 1.1 0.4 0.4
Diabetes (father) 1.4 1.7 3.2 -1.3 1.8 -0.7 -1.8 0.2 1.3
Diabetes (mother) 0.3 0.4 1.0 0.2 1.0 -0.7 -0.2 -0.8 0.3
Severe depression (siblings) 0.9 1.0 2.0 -0.3 1.4 -0.9 -1.0 0.4 -1.4
Pack years adult smoking proportion 0.4 0.7 1.7 0.7 -1.3 0.6 0.9 0.2 -0.7
Impedance of leg (right) 0.1 0.6 1.5 -1.1 0.7 -0.1 -1.2 -0.2 0.6
Leg fat-free mass (left) 0.5 2.6 5.2 2.2 2.3 -0.4 1.6 -0.4 -1.7
Trunk fat percentage 0.1 0.2 0.4 -0.5 0.5 0.6 0.2 0.5 -0.4
Hand grip strength (right) 0.3 0.9 2.0 1.3 1.1 -0.0 -0.1 -1.4 -0.8
Townsend deprivation index at recruitment 0.2 0.2 0.7 -0.7 -0.2 -0.8 -0.2 -0.3 -0.3
Current tobacco smoking 0.7 1.1 3.4 -0.4 -0.9 1.9 -0.6 1.4 0.1
Average weekly fortified wine intake 0.5 0.6 1.8 -0.0 0.5 -1.0 0.8 -0.2 1.3
Maternal smoking around birth 1.7 2.5 5.6 2.4 0.3 2.3 1.3 -1.5 -0.2
Fed-up feelings 0.3 0.6 3.0 -0.0 1.7 -0.1 -0.2 -0.0 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 4.5 1.4 0.9 -0.0 0.8 -2.1 -0.2
Relative age voice broke 1.6 2.4 4.4 -1.9 -1.2 2.1 -0.5 1.8 1.1
Taking other prescription medications 0.3 0.5 0.9 -0.9 -0.7 -0.5 -0.2 -0.5 1.0
Age when periods started (menarche) 1.2 2.8 7.8 -1.3 -1.6 2.8 0.1 1.8 1.3
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.8 -0.2 0.8 1.1 1.7 1.1 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 2.0 1.4 -0.5 -1.2 0.6 -1.1 0.9
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.4 1.4 -0.5 1.6 0.8 -0.2 1.0
Qualifications: CSEs or equivalent 0.8 1.0 3.2 0.8 -0.6 1.4 1.8 -0.3 0.3
Serious illness, injury or assault to yourself 2.1 2.6 10.6 0.7 -0.6 3.3 1.9 0.5 0.4
High blood pressure 0.2 0.5 2.1 1.0 -0.2 1.4 0.3 -0.2 0.2
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.5 -1.3 -0.9 -2.1 -0.4 0.1 -0.3
Multivitamins +/- minerals 1.5 1.9 5.5 0.7 0.2 -2.3 -1.0 -2.0 -0.4
Stomach or abdominal pain in last month 1.7 2.1 7.9 1.0 -1.2 0.9 2.8 0.8 0.9
Supplements: Glucosamine 1.2 1.6 3.6 1.4 1.1 -1.9 0.1 -1.6 -0.3
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.9 -1.7 -0.8 -0.1 -1.2 1.2 -1.0
Medication: Atenolol 1.0 1.3 2.0 1.4 -0.8 0.8 1.2 -1.2 1.2
Medication: Levothyroxine sodium 0.3 0.5 2.3 -1.5 0.5 -0.2 -0.1 0.3 -0.6
Sitting height 0.9 6.5 19.9 2.7 4.5 -1.1 0.9 -1.4 -2.8
Chronic bronchitis/emphysema (father) 0.9 1.1 2.6 1.5 -1.6 0.7 0.5 -0.9 0.1
High blood pressure (mother) 1.3 1.9 6.1 2.5 0.4 -0.0 1.4 -1.6 0.8
Body mass index (BMI) 0.1 0.5 1.1 0.8 -0.7 -0.5 0.5 -0.2 -1.1
Impedance of leg (left) 0.2 0.8 1.8 -1.1 1.0 -0.4 -1.4 -0.4 0.4
Leg predicted mass (left) 0.5 2.7 5.4 2.2 2.3 -0.4 1.7 -0.4 -1.7
Trunk fat mass 0.1 0.5 1.5 0.4 1.2 0.2 0.7 0.2 -0.8
Waist circumference 0.1 0.3 0.9 0.7 -0.5 -0.5 1.0 0.0 0.0
Number of incorrect matches in round 0.5 0.8 1.5 0.7 1.0 0.3 1.2 -1.2 0.6
Past tobacco smoking 0.2 0.4 1.1 0.3 -0.4 0.9 0.3 -0.3 1.1
Alcohol usually taken with meals 1.5 2.4 8.4 -2.3 -0.1 -0.1 -0.0 2.9 -0.6
Nervous feelings 1.1 2.1 4.7 2.0 0.4 -0.9 0.4 -2.2 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.4 0.2 -0.1 0.6 -1.2 0.0 0.0
Hearing difficulty/problems with background noise 0.8 1.3 4.0 -2.0 -1.0 0.0 -1.1 0.4 -1.3
Hair/balding pattern: Pattern 2 2.1 2.7 5.6 -1.2 -1.7 2.4 1.2 0.8 2.0
Had menopause 0.9 1.1 2.9 0.0 1.2 -1.7 0.3 -1.0 -1.1
Had other major operations 0.7 0.9 1.9 1.3 0.1 0.1 0.7 -1.4 -1.1
Forced vital capacity (FVC) 0.7 2.7 7.9 1.2 2.8 -1.4 -1.2 -1.1 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.7 1.6 0.0 -0.5 1.0 -1.2 1.4
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.2 1.1 -0.9 -1.2 0.4 -1.0 -1.5
Qualifications: None of the above 0.3 0.6 1.3 -0.9 0.3 1.1 -0.2 0.9 0.8
Financial difficulties in last 2 years 0.9 1.2 3.0 0.4 -0.4 -1.7 -1.5 -0.6 -1.1
Mouth/teeth dental problems 0.3 0.4 1.1 0.6 -0.4 -0.4 1.1 -0.9 -0.3
Heart attack 1.2 1.6 4.0 -1.3 -2.0 1.0 0.2 0.9 1.4
Allergy 0.4 0.8 3.4 0.7 0.9 1.8 0.4 0.1 -0.2
Pain all over the body in last month 2.7 2.9 7.5 2.7 1.4 -0.7 2.1 -1.6 0.9
Diabetes (self-reported) 0.2 0.3 0.9 -0.9 -0.2 -0.5 -0.2 -0.3 0.5
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 1.5 -0.1 -0.2 -1.2 -0.0 -0.6 -0.4
Medication: Ramipril 0.9 1.2 4.8 0.5 -0.8 2.2 1.1 -0.2 0.1
Medication: Simvastatin 0.4 0.7 1.6 -0.4 -1.1 0.6 1.3 0.7 -0.1
Fluid intelligence score 0.2 0.4 1.7 0.5 -1.3 -0.6 0.1 -0.2 -0.1
Illnesses of siblings 0.6 0.8 2.7 0.4 -0.6 -0.1 0.9 0.9 1.6
Neuroticism score 0.4 0.8 2.2 -1.5 0.1 -0.6 -1.0 0.7 -0.8
Weight 0.5 2.3 4.6 1.8 2.1 -0.7 1.3 -0.7 -1.9
Impedance of arm (right) 0.3 1.4 3.3 -1.0 0.3 1.8 -1.3 0.2 1.5
Arm fat percentage (right) 0.1 0.2 0.4 -0.5 -0.4 0.3 -0.4 0.5 -0.6
Trunk fat-free mass 0.9 5.2 10.8 2.9 3.3 -1.5 1.8 -1.2 -2.3
Hip circumference 0.4 1.8 3.4 1.7 1.4 -0.1 1.4 -0.9 -1.8
Time employed in main current job 0.5 0.6 1.6 0.8 0.8 0.1 0.0 -1.2 -0.8
Alcohol intake versus 10 years previously 0.9 1.3 2.4 -1.1 -1.5 -1.5 0.0 -0.0 -1.5
Father’s age at death 0.4 0.6 1.6 -0.9 -0.6 -1.3 -0.7 -0.1 0.5
Worrier / anxious feelings 0.3 0.5 1.0 0.5 -0.7 -1.0 0.8 -0.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.1 0.7 -0.0 0.0 -0.6 -0.1 1.0
Falls in the last year 0.2 0.3 1.0 -0.2 -0.4 0.5 -0.4 1.0 0.6
Hair/balding pattern: Pattern 3 0.3 0.5 1.3 0.1 0.9 -1.1 0.2 0.7 -0.3
Number of live births 0.5 0.7 2.1 -0.0 1.2 -0.9 -0.0 0.3 1.5
Forced expiratory volume in 1-second (FEV1) 1.1 3.9 10.1 2.1 3.2 -1.5 -0.6 -1.5 -1.9
Pulse rate 0.4 0.7 2.5 -0.8 -0.8 0.6 -0.2 1.6 0.3
Happiness 1.6 1.9 7.2 0.6 0.1 -0.6 -1.6 -2.7 -1.1
Noisy workplace 0.2 0.2 0.5 -0.4 -0.3 -0.5 -0.6 0.2 0.7
Qualifications: A levels/AS levels or equivalent 0.9 1.9 7.2 1.3 -0.3 -2.7 -0.2 -1.6 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.6 -0.7 0.9 0.8 -0.1 1.6 0.2
Mouth/teeth dental problems: Dentures 0.1 0.1 0.4 0.3 0.7 0.6 -0.0 0.2 0.0
Asthma 0.2 0.3 0.6 -0.3 -0.5 -0.6 -0.7 -0.8 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 4.0 -1.3 -0.6 0.5 -0.2 2.0 -0.2
Medication: Cholesterol lowering 0.6 0.9 4.1 0.5 -0.9 2.0 0.4 -0.2 -0.2
Depression (self-reported) 0.1 0.1 0.4 0.6 0.4 0.1 -0.4 -0.0 -0.1
Medication: Lansoprazole 0.4 0.4 1.4 0.1 0.8 0.1 0.6 0.1 1.2
Prospective memory result 0.9 1.1 2.0 -0.7 -1.4 1.4 0.2 0.7 1.2
Lung cancer (father) 0.5 0.5 1.3 0.8 0.5 -0.8 0.5 -1.1 -0.3
Illnesses of mother 1.2 1.5 3.8 -2.0 -0.5 0.3 0.2 2.0 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.1 12.0 2.5 3.5 -1.7 -0.9 -2.5 -1.6
Pulse wave Arterial Stiffness index 0.5 0.6 1.9 -1.4 -0.0 -0.1 0.8 0.7 0.9
Impedance of arm (left) 0.4 1.8 4.5 -1.3 1.1 1.6 -0.6 0.5 2.1
Arm fat mass (right) 0.1 0.4 1.3 0.6 0.4 -0.3 0.5 -0.0 -1.1
Trunk predicted mass 0.9 5.1 10.5 2.9 3.2 -1.4 1.9 -1.1 -2.1
Standing height 1.0 9.4 36.5 2.9 6.0 -0.7 2.3 -1.4 -2.1
Length of working week for main job 0.5 0.6 1.7 1.0 0.3 -0.3 0.6 -1.3 0.3
Exposure to tobacco smoke at home 0.1 0.2 0.5 0.1 0.2 0.7 -0.4 0.5 0.2
Breastfed as a baby 1.9 2.4 8.5 -2.9 0.6 0.1 -0.9 2.1 -0.5
Tense / ‘highly strung’ 0.3 0.5 1.3 -0.8 0.6 0.8 0.1 0.4 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.5 -0.3 -1.2 0.7 -0.4 -0.4 -0.2
Hair/balding pattern: Pattern 4 1.0 2.4 5.5 0.0 2.0 -1.9 0.9 0.8 -2.3
Birth weight of first child 0.7 1.3 3.5 1.7 -0.3 0.3 1.0 -1.9 0.2
Peak expiratory flow (PEF) 1.3 3.0 6.9 2.6 1.3 -2.0 0.7 -1.8 -1.4
Pulse wave reflection index 0.9 1.2 3.5 -1.9 -0.3 -0.8 0.5 -0.1 1.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.4 -0.6 0.8 -1.5 -0.5 -0.0 -0.6
Loud music exposure frequency 0.6 0.7 1.3 0.7 0.7 -0.6 -0.4 -1.1 -1.1
Qualifications: O levels/GCSEs or equivalent 1.4 2.3 6.4 1.5 -0.6 -2.5 0.6 -1.7 -1.3
Mouth/teeth dental problems: Bleeding gums 2.2 2.8 5.4 -2.3 1.2 -1.0 -2.0 1.4 1.7
Blood clot in the leg (DVT) 1.5 2.0 4.1 -1.8 -2.0 1.3 -0.2 1.5 0.9
Medication: Paracetamol 0.6 1.0 2.2 -1.3 -0.6 0.1 -1.5 1.1 0.6
Headache pain in last month 0.7 1.1 2.9 -0.7 -0.2 -1.3 -0.1 1.3 -1.7
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 6.9 -0.5 0.5 -2.6 -0.6 0.2 -0.1
Glaucoma (self-reported) 0.4 0.5 1.3 0.0 -0.5 -1.1 -0.9 0.6 -0.1
Gout (self-reported) 0.3 0.5 0.9 -0.6 -0.3 0.9 -0.6 0.9 -0.6
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 2.0 -1.3 1.4 -1.2 -0.5 -0.1 -0.9
Medication: Amlodipine 0.7 1.0 2.6 1.4 0.0 0.9 1.6 -0.6 0.0
Medication: Ventolin 100micrograms inhaler 1.4 1.7 6.0 -1.3 -2.4 0.8 -0.8 0.7 1.1
Birth weight 0.6 1.2 3.8 0.5 0.8 1.6 2.0 -0.5 0.3
Chronic bronchitis/emphysema (mother) 1.6 1.9 5.3 2.3 0.2 -0.2 2.1 -1.2 -0.1
High blood pressure (siblings) 0.6 0.9 3.7 -0.4 0.5 0.5 -1.9 -0.4 -0.9
Forced vital capacity (FVC), Best measure 1.0 3.8 9.7 1.8 3.1 -1.5 -1.3 -1.9 -1.4
Body fat percentage 0.0 0.2 0.4 -0.6 0.4 0.2 -0.1 0.3 -0.6
Leg fat percentage (right) 0.2 0.6 1.3 -0.8 -0.3 -0.9 -1.2 -0.1 -0.9
Arm fat-free mass (right) 0.9 4.4 10.0 2.5 3.2 -1.3 2.1 -0.6 -1.9
Exposure to tobacco smoke outside home 0.2 0.3 0.9 -0.1 0.1 0.9 0.0 -0.0 -1.0
Comparative body size at age 10 0.3 0.9 2.4 0.1 -1.2 1.1 1.6 0.3 0.7
Number of full brothers 0.9 1.1 2.3 1.4 -1.5 -0.4 1.0 -1.1 -0.3
Worry too long after embarrassment 0.4 0.7 3.4 -0.1 -1.8 0.5 0.0 -0.0 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.8 -1.1 -1.3 0.3 -0.3 0.9 0.5
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 0.5 -0.4 -0.7 0.7 0.2 0.9
Number of children fathered 0.5 0.5 1.4 -0.3 -0.7 1.2 -0.2 0.7 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 4.5 0.1 0.3 -1.2 -2.1 -0.1 0.3
Age at first live birth 1.1 2.0 6.5 -1.7 -1.1 0.5 0.8 2.6 0.6
Pulse wave peak to peak time 0.6 0.7 2.1 1.4 0.4 0.0 -0.6 -0.7 -1.0
Health satisfaction 0.6 0.8 2.3 0.4 0.3 -0.9 -1.2 -1.5 -0.1
Shortness of breath walking on level ground 0.7 0.8 2.7 -1.6 -0.6 0.4 -1.2 0.5 -0.1
Qualifications: College or University degree 0.3 0.9 3.3 -0.4 -0.8 -0.2 0.1 1.8 1.1
Eye problems/disorders: None of the above 1.1 1.2 4.6 -0.5 -1.1 0.6 0.6 0.8 -2.2
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.5 1.1 -0.6 1.6 0.5 -0.6 0.6
Emphysema/chronic bronchitis 0.7 0.8 2.5 0.4 0.9 -1.6 -0.2 -1.0 -0.7
Medication for pain relief, constipation, heartburn 0.7 1.2 2.3 1.5 0.8 -1.1 1.1 -1.5 -0.2
Neck or shoulder pain in last month 0.5 0.7 2.3 0.1 -1.3 -0.2 0.3 0.4 -1.5
Medication: Blood pressure 0.7 1.3 4.5 1.2 -0.4 2.1 1.3 -0.1 0.1
Angina (self-reported) 0.4 0.5 1.3 -0.3 -1.0 -0.4 -0.8 -1.1 -0.3
Migraine (self-reported) 0.6 0.8 2.0 -1.4 -0.6 -0.8 0.4 1.0 -0.6
Medication: Ibuprofen 0.8 1.0 3.1 -1.6 -0.4 -0.0 -0.3 1.8 -0.2
Medication: Allopurinol 0.5 0.6 1.1 -1.0 -0.9 0.8 -1.0 0.6 -0.1
Medication: Omeprazole 0.9 1.0 2.6 -0.2 0.0 1.0 0.8 1.4 1.6
Medication: Seretide 50 evohaler 0.3 0.4 1.3 -0.1 -0.4 0.6 0.4 1.2 0.4
Mean time to correctly identify matches 0.2 0.3 0.8 -0.0 0.9 -0.5 0.6 0.3 -0.7
Heart disease (mother) 0.6 0.8 1.9 0.4 -0.6 1.3 0.6 -0.2 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 4.3 -0.0 0.7 2.1 -0.8 0.6 -0.4
Whole body fat mass 0.2 0.7 1.9 0.7 1.1 -0.1 0.6 -0.1 -1.4
Leg fat mass (right) 0.2 0.8 2.7 0.5 0.8 -1.0 -0.2 -0.4 -1.6
Arm predicted mass (right) 0.9 4.7 11.7 2.5 3.4 -1.3 2.1 -0.7 -1.9
Pulse rate, automated reading 0.3 0.9 2.0 0.2 -1.4 0.9 0.3 0.7 1.4
Alcohol intake frequency. 0.5 1.1 4.3 1.3 -0.2 -0.3 -0.6 -2.1 0.0
Comparative height size at age 10 0.9 5.1 16.7 2.6 4.1 0.8 1.3 -1.9 -1.1
Number of full sisters 0.2 0.3 0.6 -0.5 0.2 0.4 -0.6 0.5 0.8
Suffer from ‘nerves’ 0.7 1.0 2.8 1.5 -0.4 -0.9 0.4 -1.7 0.4
Overall health rating 0.5 1.1 2.2 -1.4 -0.9 -0.8 -1.1 0.2 1.5
Chest pain or discomfort 0.3 0.4 1.5 0.8 -1.2 -0.0 0.2 0.2 0.6
Had major operations 0.5 0.6 1.9 0.1 0.6 1.4 1.0 0.2 -0.7
Age at last live birth 0.3 0.4 1.3 0.1 0.1 -0.5 1.1 0.7 -0.5
Family relationship satisfaction 2.7 3.3 8.2 0.9 1.9 -2.4 -0.3 -1.3 -2.9
Leg pain on walking 0.3 0.3 0.9 0.1 0.9 0.3 -0.9 -0.3 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.3 0.9 -1.5 0.3 1.1 -0.7 0.5
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.3 -1.0 1.1 -1.2 0.1 1.5 -0.9
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.1 -0.7 1.4 -0.2 -0.1 -0.8 0.3
Medication: Aspirin 0.9 1.2 2.0 1.0 -1.1 1.0 -0.7 -1.4 -1.3
Supplements: Vitamin C 0.6 0.7 1.9 1.4 -0.4 -0.4 0.1 -1.2 -0.8
Knee pain experienced in last month 0.5 0.7 2.4 -0.3 1.5 -0.7 -0.8 -0.6 -0.5
Hypertension (Self-reported) 0.3 0.8 2.5 1.2 0.2 1.6 0.7 -0.6 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.5 -0.6 0.5 -0.4 0.0 0.7 0.6
Illnesses of father: Heart disease 0.4 0.6 1.9 -0.8 0.0 0.5 -1.4 0.7 0.5
Illnesses of siblings: Diabetes 0.9 1.1 2.3 -0.5 0.4 0.7 1.5 1.2 -1.3
Smoking status: Previous 0.5 0.7 1.5 -0.4 0.7 -1.2 -0.8 0.0 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 7.3 1.4 2.7 -2.3 -0.6 -1.0 -0.7
Whole body fat-free mass 0.8 4.3 9.2 2.6 3.0 -1.1 1.9 -0.8 -2.1
Leg fat-free mass (right) 0.5 2.9 6.0 2.3 2.4 -0.4 1.8 -0.5 -1.6
Arm fat percentage (left) 0.0 0.1 0.4 -0.5 -0.0 0.1 -0.0 0.6 -0.3
Average weekly red wine intake 0.6 0.8 3.5 -0.2 -0.2 0.6 0.9 1.9 0.4
Handedness (chirality/laterality): Left-handed 1.7 2.1 3.6 1.9 1.9 -0.5 0.1 -1.2 -1.9
Mood swings 0.3 0.5 1.3 -1.1 -0.4 -0.7 -0.5 0.7 -0.4
Loneliness, isolation 0.3 0.3 0.7 -0.8 0.5 -0.3 -0.7 0.1 -0.8
Long-standing illness, disability or infirmity 0.4 0.7 2.1 1.4 -0.5 0.6 -0.6 -0.8 0.5
Ever had bowel cancer screening 0.1 0.2 0.7 0.4 0.2 0.3 0.8 -0.2 0.1
Diabetes diagnosed by doctor 0.1 0.1 0.4 -0.4 -0.0 -0.0 -0.0 -0.6 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 -0.3 0.4 -0.3 -0.0 0.8 0.1
Friendships satisfaction 0.8 1.0 4.0 -0.7 0.9 -0.7 -2.0 -0.2 0.1
Qualifications: nursing, teaching 0.5 0.8 2.4 -0.3 -0.4 0.5 0.1 1.5 1.4
Commuting to job workplace: Walk 2.4 2.6 6.2 2.4 1.3 -1.0 1.0 -2.5 0.4
Eye problems/disorders: Cataract 0.4 0.5 2.3 -0.4 -0.3 0.2 -0.3 0.5 1.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.2 -0.4 0.9 0.2 0.9 -0.1 -1.1
Medication for cholesterol 0.2 0.4 0.7 0.7 0.1 -0.9 0.5 0.5 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.6 -0.4 1.0 1.4 0.9 0.3 -1.6
Back pain experienced in last month 0.9 1.3 3.2 -1.4 0.2 1.8 -0.2 1.4 -1.0
Mineral and other dietary supplements 1.5 2.0 4.5 -1.8 -0.3 1.2 0.9 2.1 1.5
Breast cancer (self-reported) 0.4 0.5 1.1 0.3 -0.3 0.4 1.1 -0.8 1.0
Asthma (self-reported) 0.2 0.4 0.7 -0.6 -0.5 -0.3 -0.8 -0.9 0.2
Osteoporosis (self-reported) 0.4 0.4 1.9 -0.2 -0.6 -0.1 -0.5 0.3 1.4
Osteoarthritis (self-reported) 0.9 1.2 2.9 -0.8 1.7 -0.4 -1.2 -0.7 -1.2
Medication: Aspirin 1.1 1.4 3.2 0.8 -1.0 0.1 -0.6 -1.8 -1.7
Medication: Gliclazide 2.2 2.5 5.5 -2.3 -1.8 -0.0 -1.0 1.2 2.0
Illnesses of father: None of the above (group 1) 2.5 3.1 9.5 1.6 0.4 -3.1 0.7 -1.7 -1.8
Smoking status: Current 0.5 0.9 2.5 -0.4 -0.6 1.6 -0.5 1.4 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.6 1.2 0.7 -1.0 -1.3 -1.6 -0.6
Whole body water mass 0.8 4.4 9.3 2.7 3.0 -0.9 2.0 -0.8 -2.1
Leg predicted mass (right) 0.5 2.7 5.5 2.2 2.4 -0.4 1.8 -0.5 -1.6
Arm fat mass (left) 0.1 0.5 1.5 0.8 0.6 -0.3 0.8 -0.1 -1.2
Number of self-reported non-cancer illnesses 0.1 0.2 0.6 0.8 0.4 -0.2 -0.1 -0.4 -0.1
Average weekly champagne plus white wine intake 0.4 0.5 1.0 -0.9 0.0 1.0 -0.6 0.6 0.7
Miserableness 0.4 0.7 1.7 0.5 1.3 -0.8 -0.2 0.8 -1.1
Guilty feelings 0.7 1.1 2.9 0.8 -1.2 0.3 -0.9 -1.7 -0.9
Wears glasses or contact lenses 0.7 0.7 1.2 -1.1 0.5 -1.0 0.8 1.0 0.5
Ever taken oral contraceptive pill 1.7 1.9 6.2 -0.4 -1.7 -2.5 -1.2 0.3 0.6
Hearing aid user 0.6 0.7 1.9 -1.0 -1.4 0.4 0.9 0.4 0.4
Mother’s age at death 0.6 0.7 1.9 0.3 0.9 -0.2 -0.6 1.0 -1.4
Financial situation satisfaction 1.6 2.0 4.0 1.4 0.5 -1.4 -0.9 -2.0 -1.7
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.3 -0.3 -0.0 -0.5 -1.5 -1.0 0.7
Commuting to job workplace: Public transport 1.8 2.1 7.9 2.8 -0.2 -0.2 -0.9 -2.0 -0.2
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 0.7 -0.7 -0.3 -0.4 0.2 0.4
Medication: Blood pressure 0.4 0.8 3.1 0.8 0.7 -0.7 -0.3 -1.8 0.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.5 -0.7 1.2 0.2 0.8 -0.7 -0.4
Supplements: Fish oil (including cod liver oil) 2.6 3.4 7.1 2.4 1.2 -1.1 -0.6 -2.7 -2.1
High cholesterol (Self-reported) 0.8 1.4 5.7 0.3 -0.8 2.4 1.4 0.4 -0.3
Medication: Bendroflumethiazide 0.3 0.5 2.2 -0.6 -0.2 0.4 0.1 0.2 1.5
Medication: Paracetamol 1.0 1.5 3.0 -1.7 -1.2 -0.2 -1.7 1.3 0.4
Medication: Lisinopril 0.1 0.1 0.4 -0.1 0.5 0.1 0.1 -0.6 0.4
Medication: Atorvastatin 0.8 1.0 2.3 -0.7 -0.5 1.5 -1.2 -1.0 0.8
Illnesses of father: High blood pressure 0.3 0.3 0.7 0.4 0.5 0.6 0.4 0.9 0.4
Alcohol drinker status: Never 0.5 0.6 1.9 0.9 0.6 0.1 0.7 -1.4 0.6
Ever smoked 0.2 0.3 0.9 -0.1 -0.5 -1.0 0.0 0.9 -0.1
Basal metabolic rate 0.7 4.1 8.5 2.5 2.9 -0.8 1.9 -0.8 -2.2
Leg fat percentage (left) 0.2 0.6 1.2 -0.6 -0.3 -1.0 -0.9 -0.2 -1.1
Arm fat-free mass (left) 0.9 4.7 9.4 3.1 2.6 -1.0 2.0 -1.3 -2.2
Number of operations (self-reported) 0.9 1.4 4.0 0.3 0.8 -1.1 -1.4 -0.6 -2.0
Average weekly beer plus cider intake 0.9 1.3 2.5 0.8 1.3 -0.5 -1.6 -1.6 -0.2
Irritability 0.9 1.5 2.2 0.1 1.5 -0.8 -1.5 -1.5 -1.4
Risk taking 0.3 0.4 1.8 0.2 -0.7 1.3 0.4 -0.5 -0.2
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.3 0.5 0.6 -0.2 -0.2 -0.8 -1.1
Fractured/broken bones in last 5 years 1.5 1.9 4.4 0.1 -1.1 2.1 0.8 1.0 2.0
Age started oral contraceptive pill 0.4 0.5 1.7 -0.4 -0.1 -0.6 0.9 0.3 1.3
Diastolic blood pressure, automated reading 0.1 0.3 0.9 -0.1 -0.0 0.5 -0.9 0.9 0.1
Ever depressed for a whole week 1.3 1.6 4.5 -0.0 1.1 -2.0 0.3 0.1 -2.1
Unable to work because of sickness or disability 0.5 0.6 1.3 1.1 1.2 -0.0 -0.2 -0.5 -1.0
Commuting to job workplace: Cycle 0.6 0.8 1.4 0.7 -0.2 -1.1 -0.4 -1.2 -1.1
Myopia 0.8 1.2 2.8 -1.6 -1.7 0.3 -0.1 1.0 0.9
Vascular/heart problems diagnosed by doctor 0.2 0.5 2.4 -0.6 0.2 -1.6 -0.1 0.6 -0.1
Cholesterol lowering medication 0.1 0.2 0.8 0.0 0.1 0.4 0.9 -0.3 0.2
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.6 -0.2 0.4 0.8 0.6 1.2 1.3
Pain experienced in last month 0.6 1.1 2.5 -0.3 -1.5 1.0 -0.8 -0.1 1.6
Supplements: Calcium 0.7 0.8 1.9 -0.6 0.8 -1.4 0.1 0.6 1.1
Basal cell carcinoma (self-reported) 1.4 1.7 7.2 -0.2 2.7 -1.1 -0.2 -0.7 -1.1
Heart attack/myocardial infarction (self-reported) 1.4 1.8 3.5 -1.6 -1.9 1.2 -0.1 1.0 1.4
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 4.0 -1.8 -2.0 1.4 -0.4 1.3 0.5
Heart disease (siblings) 1.6 2.0 5.4 1.2 0.9 -1.0 -0.6 -1.7 -2.3
Alcohol drinker status: Previous 0.7 0.8 2.3 1.5 -0.3 0.7 0.4 -1.3 0.4
Pack years of smoking 0.6 0.9 2.6 0.6 -1.6 0.9 0.9 0.2 -0.9
Impedance of whole body 0.3 1.3 2.8 -1.5 0.8 1.1 -0.9 0.4 1.7
Leg fat mass (left) 0.2 0.9 3.3 0.7 0.7 -0.9 0.1 -0.5 -1.8
Arm predicted mass (left) 0.8 4.2 7.8 2.6 2.8 -1.1 1.7 -1.0 -2.4