TWAS hub - PHGDH

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.126	0.0380	1.3e-05	0.036	0.054	0.047	0.061	0.050	2.9e-05	3.5e-07	2.0e-06	6.0e-08	8.4e-07
2	GTEx	Esophagus Mucosa	0.116	0.0460	4.9e-03	0.014	NA	0.029	NA	0.024	3.8e-02	NA	4.6e-03	NA	9.9e-03
3	GTEx	Testis	0.310	0.0690	5.2e-06	0.345	NA	0.317	NA	0.333	4.5e-16	NA	1.2e-14	NA	2.0e-15
4	ROSMAP	Brain Pre-frontal Cortex	0.193	0.0550	3.5e-05	0.058	0.038	0.075	0.063	0.052	5.2e-08	9.1e-06	5.8e-10	1.6e-08	2.7e-07
5	YFS	Blood	0.274	0.0381	0.0e+00	0.097	0.152	0.169	0.152	0.146	4.1e-30	1.9e-47	6.9e-53	3.1e-47	1.8e-45
6	TCGA	Thyroid Carcinoma	0.140	0.0470	1.1e-07	0.072	0.094	0.079	NA	0.062	1.6e-07	2.0e-09	4.1e-08	NA	1.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Red Count	3.6	34.7	96.0	-3.4	-7.8	9.8	1.7	5.2	3.2
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	15.8	0.5	-0.8	0.7	1.4	0.3	4.0
Pain all over the body in last month	2.7	2.9	7.5	2.7	1.4	-0.7	2.1	-1.6	0.9
Family relationship satisfaction	2.7	3.3	8.2	0.9	1.9	-2.4	-0.3	-1.3	-2.9
Supplements: Fish oil (including cod liver oil)	2.6	3.4	7.1	2.4	1.2	-1.1	-0.6	-2.7	-2.1
Illnesses of father: None of the above (group 1)	2.5	3.1	9.5	1.6	0.4	-3.1	0.7	-1.7	-1.8
Commuting to job workplace: Walk	2.4	2.6	6.2	2.4	1.3	-1.0	1.0	-2.5	0.4
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	5.4	-2.3	1.2	-1.0	-2.0	1.4	1.7
Medication: Gliclazide	2.2	2.5	5.5	-2.3	-1.8	-0.0	-1.0	1.2	2.0
Serious illness, injury or assault to yourself	2.1	2.6	10.6	0.7	-0.6	3.3	1.9	0.5	0.4
Hair/balding pattern: Pattern 2	2.1	2.7	5.6	-1.2	-1.7	2.4	1.2	0.8	2.0
Breastfed as a baby	1.9	2.4	8.5	-2.9	0.6	0.1	-0.9	2.1	-0.5
Commuting to job workplace: Public transport	1.8	2.1	7.9	2.8	-0.2	-0.2	-0.9	-2.0	-0.2
Maternal smoking around birth	1.7	2.5	5.6	2.4	0.3	2.3	1.3	-1.5	-0.2
Stomach or abdominal pain in last month	1.7	2.1	7.9	1.0	-1.2	0.9	2.8	0.8	0.9
Handedness (chirality/laterality): Left-handed	1.7	2.1	3.6	1.9	1.9	-0.5	0.1	-1.2	-1.9
Ever taken oral contraceptive pill	1.7	1.9	6.2	-0.4	-1.7	-2.5	-1.2	0.3	0.6
Vitamin and mineral supplements	1.6	2.2	5.8	-1.6	-0.4	2.1	-0.3	2.4	-0.2
Relative age voice broke	1.6	2.4	4.4	-1.9	-1.2	2.1	-0.5	1.8	1.1
Happiness	1.6	1.9	7.2	0.6	0.1	-0.6	-1.6	-2.7	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	12.0	2.5	3.5	-1.7	-0.9	-2.5	-1.6
Chronic bronchitis/emphysema (mother)	1.6	1.9	5.3	2.3	0.2	-0.2	2.1	-1.2	-0.1
Financial situation satisfaction	1.6	2.0	4.0	1.4	0.5	-1.4	-0.9	-2.0	-1.7
Heart disease (siblings)	1.6	2.0	5.4	1.2	0.9	-1.0	-0.6	-1.7	-2.3
HbA1C	1.5	1.6	3.6	1.6	0.6	-0.7	1.9	-1.3	-1.0
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	4.4	-0.3	-0.3	1.4	0.8	2.1	2.1
Multivitamins +/- minerals	1.5	1.9	5.5	0.7	0.2	-2.3	-1.0	-2.0	-0.4
Alcohol usually taken with meals	1.5	2.4	8.4	-2.3	-0.1	-0.1	-0.0	2.9	-0.6
Blood clot in the leg (DVT)	1.5	2.0	4.1	-1.8	-2.0	1.3	-0.2	1.5	0.9
Mineral and other dietary supplements	1.5	2.0	4.5	-1.8	-0.3	1.2	0.9	2.1	1.5
Fractured/broken bones in last 5 years	1.5	1.9	4.4	0.1	-1.1	2.1	0.8	1.0	2.0
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	4.0	-1.8	-2.0	1.4	-0.4	1.3	0.5
Breast Cancer	1.4	3.4	9.8	-1.8	-1.6	-3.1	-1.9	0.8	0.8
Diabetes (father)	1.4	1.7	3.2	-1.3	1.8	-0.7	-1.8	0.2	1.3
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.4	1.5	-0.6	-2.5	0.6	-1.7	-1.3
Medication: Ventolin 100micrograms inhaler	1.4	1.7	6.0	-1.3	-2.4	0.8	-0.8	0.7	1.1
Basal cell carcinoma (self-reported)	1.4	1.7	7.2	-0.2	2.7	-1.1	-0.2	-0.7	-1.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.5	-1.6	-1.9	1.2	-0.1	1.0	1.4
Primary Biliary Cirrhosis	1.3	1.8	3.8	-0.6	1.5	-1.9	-0.9	-0.7	-1.7
Rheumatoid Arthritis	1.3	1.7	4.0	0.8	1.5	-1.7	-0.2	-0.8	-2.0
Hearing difficulty/problems: Yes	1.3	2.0	5.8	-2.4	-1.6	0.7	-0.7	1.0	1.2
High blood pressure (mother)	1.3	1.9	6.1	2.5	0.4	-0.0	1.4	-1.6	0.8
Peak expiratory flow (PEF)	1.3	3.0	6.9	2.6	1.3	-2.0	0.7	-1.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	7.3	1.4	2.7	-2.3	-0.6	-1.0	-0.7
Ever depressed for a whole week	1.3	1.6	4.5	-0.0	1.1	-2.0	0.3	0.1	-2.1
Alzheimer’s Disease (in mother)	1.2	1.4	2.8	-1.7	-0.4	-0.5	-1.4	0.3	-1.7
Age when periods started (menarche)	1.2	2.8	7.8	-1.3	-1.6	2.8	0.1	1.8	1.3
Supplements: Glucosamine	1.2	1.6	3.6	1.4	1.1	-1.9	0.1	-1.6	-0.3
Heart attack	1.2	1.6	4.0	-1.3	-2.0	1.0	0.2	0.9	1.4
Illnesses of mother	1.2	1.5	3.8	-2.0	-0.5	0.3	0.2	2.0	0.9
Height	1.1	22.0	99.6	3.1	10.0	-1.8	2.1	-2.2	-3.2
Waist Hip Ratio (WHR)	1.1	4.9	13.1	-1.3	-3.6	-0.0	-0.7	1.2	3.5
Nervous feelings	1.1	2.1	4.7	2.0	0.4	-0.9	0.4	-2.2	-1.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.9	10.1	2.1	3.2	-1.5	-0.6	-1.5	-1.9
Age at first live birth	1.1	2.0	6.5	-1.7	-1.1	0.5	0.8	2.6	0.6
Eye problems/disorders: None of the above	1.1	1.2	4.6	-0.5	-1.1	0.6	0.6	0.8	-2.2
Medication: Aspirin	1.1	1.4	3.2	0.8	-1.0	0.1	-0.6	-1.8	-1.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.1	0.6	1.1	-1.3	-1.2	-1.5	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.5	1.4	0.9	-0.0	0.8	-2.1	-0.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.4	1.4	-0.5	1.6	0.8	-0.2	1.0
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.9	-1.7	-0.8	-0.1	-1.2	1.2	-1.0
Medication: Atenolol	1.0	1.3	2.0	1.4	-0.8	0.8	1.2	-1.2	1.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.2	1.1	-0.9	-1.2	0.4	-1.0	-1.5
Standing height	1.0	9.4	36.5	2.9	6.0	-0.7	2.3	-1.4	-2.1
Hair/balding pattern: Pattern 4	1.0	2.4	5.5	0.0	2.0	-1.9	0.9	0.8	-2.3
Forced vital capacity (FVC), Best measure	1.0	3.8	9.7	1.8	3.1	-1.5	-1.3	-1.9	-1.4
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.3	-1.0	1.1	-1.2	0.1	1.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.6	-0.4	1.0	1.4	0.9	0.3	-1.6
Medication: Paracetamol	1.0	1.5	3.0	-1.7	-1.2	-0.2	-1.7	1.3	0.4
Depression (Nagel 2018)	0.9	1.3	3.9	1.5	-0.1	0.5	-0.9	-2.0	-1.0
Age at First Birth	0.9	1.4	3.3	-1.5	1.6	0.2	0.0	1.8	-0.2
HDL Cholesterol	0.9	1.5	6.7	-0.2	-1.0	-0.4	1.1	0.4	2.6
Ever had hysterectomy (womb removed)	0.9	1.0	3.4	1.1	0.2	0.2	1.9	-0.9	-0.8
Severe depression (siblings)	0.9	1.0	2.0	-0.3	1.4	-0.9	-1.0	0.4	-1.4
Sitting height	0.9	6.5	19.9	2.7	4.5	-1.1	0.9	-1.4	-2.8
Chronic bronchitis/emphysema (father)	0.9	1.1	2.6	1.5	-1.6	0.7	0.5	-0.9	0.1
Had menopause	0.9	1.1	2.9	0.0	1.2	-1.7	0.3	-1.0	-1.1
Financial difficulties in last 2 years	0.9	1.2	3.0	0.4	-0.4	-1.7	-1.5	-0.6	-1.1
Medication: Ramipril	0.9	1.2	4.8	0.5	-0.8	2.2	1.1	-0.2	0.1
Trunk fat-free mass	0.9	5.2	10.8	2.9	3.3	-1.5	1.8	-1.2	-2.3
Alcohol intake versus 10 years previously	0.9	1.3	2.4	-1.1	-1.5	-1.5	0.0	-0.0	-1.5
Qualifications: A levels/AS levels or equivalent	0.9	1.9	7.2	1.3	-0.3	-2.7	-0.2	-1.6	-0.1
Prospective memory result	0.9	1.1	2.0	-0.7	-1.4	1.4	0.2	0.7	1.2
Trunk predicted mass	0.9	5.1	10.5	2.9	3.2	-1.4	1.9	-1.1	-2.1
Pulse wave reflection index	0.9	1.2	3.5	-1.9	-0.3	-0.8	0.5	-0.1	1.6
Arm fat-free mass (right)	0.9	4.4	10.0	2.5	3.2	-1.3	2.1	-0.6	-1.9
Number of full brothers	0.9	1.1	2.3	1.4	-1.5	-0.4	1.0	-1.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.5	0.1	0.3	-1.2	-2.1	-0.1	0.3
Medication: Omeprazole	0.9	1.0	2.6	-0.2	0.0	1.0	0.8	1.4	1.6
Arm predicted mass (right)	0.9	4.7	11.7	2.5	3.4	-1.3	2.1	-0.7	-1.9
Comparative height size at age 10	0.9	5.1	16.7	2.6	4.1	0.8	1.3	-1.9	-1.1
Medication: Aspirin	0.9	1.2	2.0	1.0	-1.1	1.0	-0.7	-1.4	-1.3
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-0.5	0.4	0.7	1.5	1.2	-1.3
Back pain experienced in last month	0.9	1.3	3.2	-1.4	0.2	1.8	-0.2	1.4	-1.0
Osteoarthritis (self-reported)	0.9	1.2	2.9	-0.8	1.7	-0.4	-1.2	-0.7	-1.2
Arm fat-free mass (left)	0.9	4.7	9.4	3.1	2.6	-1.0	2.0	-1.3	-2.2
Number of operations (self-reported)	0.9	1.4	4.0	0.3	0.8	-1.1	-1.4	-0.6	-2.0
Average weekly beer plus cider intake	0.9	1.3	2.5	0.8	1.3	-0.5	-1.6	-1.6	-0.2
Irritability	0.9	1.5	2.2	0.1	1.5	-0.8	-1.5	-1.5	-1.4
Alzheimer’s Disease (in father)	0.8	0.9	2.3	-1.1	-0.1	0.9	1.5	0.9	-0.7
Bipolar Disorder (2011)	0.8	0.8	2.2	-1.2	0.7	-1.5	-0.3	0.6	-0.2
Neuroticism (2016)	0.8	1.1	5.8	0.2	0.2	-0.1	2.4	0.1	-0.8
Ulcerative Colitis	0.8	1.2	4.4	-1.5	0.1	-0.3	-0.3	2.1	0.5
Chronotype (morning person)	0.8	1.7	3.5	1.9	1.6	-0.3	1.4	-1.2	-0.9
Relative age of first facial hair	0.8	1.6	4.0	0.4	-1.3	2.0	-0.9	-0.8	1.6
Medication: Co-codamol	0.8	0.9	1.9	-0.1	-1.1	0.2	1.3	1.4	0.6
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.8	-0.2	0.8	1.1	1.7	1.1	0.3
Qualifications: CSEs or equivalent	0.8	1.0	3.2	0.8	-0.6	1.4	1.8	-0.3	0.3
Hearing difficulty/problems with background noise	0.8	1.3	4.0	-2.0	-1.0	0.0	-1.1	0.4	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	4.0	-1.3	-0.6	0.5	-0.2	2.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	6.9	-0.5	0.5	-2.6	-0.6	0.2	-0.1
Medication: Ibuprofen	0.8	1.0	3.1	-1.6	-0.4	-0.0	-0.3	1.8	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	4.3	-0.0	0.7	2.1	-0.8	0.6	-0.4
Whole body fat-free mass	0.8	4.3	9.2	2.6	3.0	-1.1	1.9	-0.8	-2.1
Friendships satisfaction	0.8	1.0	4.0	-0.7	0.9	-0.7	-2.0	-0.2	0.1
Whole body water mass	0.8	4.4	9.3	2.7	3.0	-0.9	2.0	-0.8	-2.1
High cholesterol (Self-reported)	0.8	1.4	5.7	0.3	-0.8	2.4	1.4	0.4	-0.3
Medication: Atorvastatin	0.8	1.0	2.3	-0.7	-0.5	1.5	-1.2	-1.0	0.8
Myopia	0.8	1.2	2.8	-1.6	-1.7	0.3	-0.1	1.0	0.9
Arm predicted mass (left)	0.8	4.2	7.8	2.6	2.8	-1.1	1.7	-1.0	-2.4
Alzheimer’s Disease (including proxy)	0.7	1.1	4.6	-2.1	-0.1	0.5	-0.3	0.7	-1.0
Major Depression (MDD)	0.7	0.8	2.0	0.6	0.5	0.4	1.4	-0.7	-1.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	-0.2	-0.1	0.8	1.3	1.3	0.8
Smoking Status	0.7	1.7	4.3	-1.1	-0.5	1.5	-1.5	2.1	0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.5	-0.2	0.1	-0.6	1.9	1.1	0.6
Current tobacco smoking	0.7	1.1	3.4	-0.4	-0.9	1.9	-0.6	1.4	0.1
Had other major operations	0.7	0.9	1.9	1.3	0.1	0.1	0.7	-1.4	-1.1
Forced vital capacity (FVC)	0.7	2.7	7.9	1.2	2.8	-1.4	-1.2	-1.1	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.6	-0.7	0.9	0.8	-0.1	1.6	0.2
Birth weight of first child	0.7	1.3	3.5	1.7	-0.3	0.3	1.0	-1.9	0.2
Headache pain in last month	0.7	1.1	2.9	-0.7	-0.2	-1.3	-0.1	1.3	-1.7
Medication: Amlodipine	0.7	1.0	2.6	1.4	0.0	0.9	1.6	-0.6	0.0
Shortness of breath walking on level ground	0.7	0.8	2.7	-1.6	-0.6	0.4	-1.2	0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.5	1.1	-0.6	1.6	0.5	-0.6	0.6
Emphysema/chronic bronchitis	0.7	0.8	2.5	0.4	0.9	-1.6	-0.2	-1.0	-0.7
Medication for pain relief, constipation, heartburn	0.7	1.2	2.3	1.5	0.8	-1.1	1.1	-1.5	-0.2
Medication: Blood pressure	0.7	1.3	4.5	1.2	-0.4	2.1	1.3	-0.1	0.1
Suffer from ‘nerves’	0.7	1.0	2.8	1.5	-0.4	-0.9	0.4	-1.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.3	0.9	-1.5	0.3	1.1	-0.7	0.5
Guilty feelings	0.7	1.1	2.9	0.8	-1.2	0.3	-0.9	-1.7	-0.9
Wears glasses or contact lenses	0.7	0.7	1.2	-1.1	0.5	-1.0	0.8	1.0	0.5
Basal metabolic rate	0.7	4.1	8.5	2.5	2.9	-0.8	1.9	-0.8	-2.2
Supplements: Calcium	0.7	0.8	1.9	-0.6	0.8	-1.4	0.1	0.6	1.1
Alcohol drinker status: Previous	0.7	0.8	2.3	1.5	-0.3	0.7	0.4	-1.3	0.4
Mean Putamen Volume	0.6	0.7	1.5	1.0	0.8	1.2	0.9	0.3	0.4
LDL Cholesterol	0.6	0.9	5.1	-0.0	0.2	2.2	0.6	0.3	0.4
Hypothyroidism (self reported)	0.6	1.4	2.8	-0.7	1.7	-1.6	-0.2	-0.4	-1.5
Sensitivity / hurt feelings	0.6	1.0	3.0	-1.6	-0.5	0.4	-0.1	1.7	-0.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.5	-1.3	-0.9	-2.1	-0.4	0.1	-0.3
Illnesses of siblings	0.6	0.8	2.7	0.4	-0.6	-0.1	0.9	0.9	1.6
Medication: Cholesterol lowering	0.6	0.9	4.1	0.5	-0.9	2.0	0.4	-0.2	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	-0.6	0.8	-1.5	-0.5	-0.0	-0.6
Loud music exposure frequency	0.6	0.7	1.3	0.7	0.7	-0.6	-0.4	-1.1	-1.1
Medication: Paracetamol	0.6	1.0	2.2	-1.3	-0.6	0.1	-1.5	1.1	0.6
Birth weight	0.6	1.2	3.8	0.5	0.8	1.6	2.0	-0.5	0.3
High blood pressure (siblings)	0.6	0.9	3.7	-0.4	0.5	0.5	-1.9	-0.4	-0.9
Pulse wave peak to peak time	0.6	0.7	2.1	1.4	0.4	0.0	-0.6	-0.7	-1.0
Health satisfaction	0.6	0.8	2.3	0.4	0.3	-0.9	-1.2	-1.5	-0.1
Migraine (self-reported)	0.6	0.8	2.0	-1.4	-0.6	-0.8	0.4	1.0	-0.6
Heart disease (mother)	0.6	0.8	1.9	0.4	-0.6	1.3	0.6	-0.2	1.4
Supplements: Vitamin C	0.6	0.7	1.9	1.4	-0.4	-0.4	0.1	-1.2	-0.8
Average weekly red wine intake	0.6	0.8	3.5	-0.2	-0.2	0.6	0.9	1.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.6	1.2	0.7	-1.0	-1.3	-1.6	-0.6
Hearing aid user	0.6	0.7	1.9	-1.0	-1.4	0.4	0.9	0.4	0.4
Mother’s age at death	0.6	0.7	1.9	0.3	0.9	-0.2	-0.6	1.0	-1.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.3	-0.3	-0.0	-0.5	-1.5	-1.0	0.7
Commuting to job workplace: Cycle	0.6	0.8	1.4	0.7	-0.2	-1.1	-0.4	-1.2	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	-0.2	0.4	0.8	0.6	1.2	1.3
Pain experienced in last month	0.6	1.1	2.5	-0.3	-1.5	1.0	-0.8	-0.1	1.6
Pack years of smoking	0.6	0.9	2.6	0.6	-1.6	0.9	0.9	0.2	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	-0.6	-0.1	0.9	-0.8	0.8	1.3
Worry (Nagel 2018)	0.5	1.1	2.6	1.6	-1.0	0.4	1.5	-0.8	-0.5
Ulcerative Colitis (UC)	0.5	0.9	2.0	-1.3	0.5	-0.6	-0.1	1.4	1.0
Reaction Time	0.5	0.9	1.7	1.0	1.3	-0.8	1.0	0.4	-0.8
Triglycerides	0.5	0.8	3.8	-0.0	-0.8	1.9	0.4	0.6	0.3
Hand grip strength (left)	0.5	1.4	2.8	1.7	1.1	1.4	0.7	-1.1	-0.9
Leg fat-free mass (left)	0.5	2.6	5.2	2.2	2.3	-0.4	1.6	-0.4	-1.7
Average weekly fortified wine intake	0.5	0.6	1.8	-0.0	0.5	-1.0	0.8	-0.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.0	1.4	-0.5	-1.2	0.6	-1.1	0.9
Leg predicted mass (left)	0.5	2.7	5.4	2.2	2.3	-0.4	1.7	-0.4	-1.7
Number of incorrect matches in round	0.5	0.8	1.5	0.7	1.0	0.3	1.2	-1.2	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.7	1.6	0.0	-0.5	1.0	-1.2	1.4
Weight	0.5	2.3	4.6	1.8	2.1	-0.7	1.3	-0.7	-1.9
Time employed in main current job	0.5	0.6	1.6	0.8	0.8	0.1	0.0	-1.2	-0.8
Number of live births	0.5	0.7	2.1	-0.0	1.2	-0.9	-0.0	0.3	1.5
Lung cancer (father)	0.5	0.5	1.3	0.8	0.5	-0.8	0.5	-1.1	-0.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	-1.4	-0.0	-0.1	0.8	0.7	0.9
Length of working week for main job	0.5	0.6	1.7	1.0	0.3	-0.3	0.6	-1.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	2.0	-1.3	1.4	-1.2	-0.5	-0.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.8	-1.1	-1.3	0.3	-0.3	0.9	0.5
Number of children fathered	0.5	0.5	1.4	-0.3	-0.7	1.2	-0.2	0.7	0.9
Neck or shoulder pain in last month	0.5	0.7	2.3	0.1	-1.3	-0.2	0.3	0.4	-1.5
Medication: Allopurinol	0.5	0.6	1.1	-1.0	-0.9	0.8	-1.0	0.6	-0.1
Alcohol intake frequency.	0.5	1.1	4.3	1.3	-0.2	-0.3	-0.6	-2.1	0.0
Overall health rating	0.5	1.1	2.2	-1.4	-0.9	-0.8	-1.1	0.2	1.5
Had major operations	0.5	0.6	1.9	0.1	0.6	1.4	1.0	0.2	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.1	-0.7	1.4	-0.2	-0.1	-0.8	0.3
Knee pain experienced in last month	0.5	0.7	2.4	-0.3	1.5	-0.7	-0.8	-0.6	-0.5
Smoking status: Previous	0.5	0.7	1.5	-0.4	0.7	-1.2	-0.8	0.0	-1.2
Leg fat-free mass (right)	0.5	2.9	6.0	2.3	2.4	-0.4	1.8	-0.5	-1.6
Qualifications: nursing, teaching	0.5	0.8	2.4	-0.3	-0.4	0.5	0.1	1.5	1.4
Smoking status: Current	0.5	0.9	2.5	-0.4	-0.6	1.6	-0.5	1.4	-0.0
Leg predicted mass (right)	0.5	2.7	5.5	2.2	2.4	-0.4	1.8	-0.5	-1.6
Alcohol drinker status: Never	0.5	0.6	1.9	0.9	0.6	0.1	0.7	-1.4	0.6
Unable to work because of sickness or disability	0.5	0.6	1.3	1.1	1.2	-0.0	-0.2	-0.5	-1.0
Ovarian Cancer	0.4	0.5	2.3	-0.4	1.5	-0.2	-0.5	0.5	-0.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-1.1	0.2	-0.7	-1.1	-0.0	-0.1
Crohns Disease (2012)	0.4	0.6	1.6	-0.9	-1.2	0.8	-0.1	0.6	-0.7
Allergy or Eczema	0.4	1.2	4.6	-1.0	-0.5	-2.1	-0.4	0.3	-0.9
Cardiovascular Disease	0.4	1.4	4.4	1.0	0.9	2.1	1.2	0.5	0.6
Medication for hormone replacement therapy	0.4	0.5	0.9	-1.0	0.4	0.4	-0.5	0.7	-0.9
Pack years adult smoking proportion	0.4	0.7	1.7	0.7	-1.3	0.6	0.9	0.2	-0.7
Allergy	0.4	0.8	3.4	0.7	0.9	1.8	0.4	0.1	-0.2
Medication: Simvastatin	0.4	0.7	1.6	-0.4	-1.1	0.6	1.3	0.7	-0.1
Neuroticism score	0.4	0.8	2.2	-1.5	0.1	-0.6	-1.0	0.7	-0.8
Hip circumference	0.4	1.8	3.4	1.7	1.4	-0.1	1.4	-0.9	-1.8
Father’s age at death	0.4	0.6	1.6	-0.9	-0.6	-1.3	-0.7	-0.1	0.5
Pulse rate	0.4	0.7	2.5	-0.8	-0.8	0.6	-0.2	1.6	0.3
Medication: Lansoprazole	0.4	0.4	1.4	0.1	0.8	0.1	0.6	0.1	1.2
Impedance of arm (left)	0.4	1.8	4.5	-1.3	1.1	1.6	-0.6	0.5	2.1
Glaucoma (self-reported)	0.4	0.5	1.3	0.0	-0.5	-1.1	-0.9	0.6	-0.1
Worry too long after embarrassment	0.4	0.7	3.4	-0.1	-1.8	0.5	0.0	-0.0	0.7
Angina (self-reported)	0.4	0.5	1.3	-0.3	-1.0	-0.4	-0.8	-1.1	-0.3
Illnesses of father: Heart disease	0.4	0.6	1.9	-0.8	0.0	0.5	-1.4	0.7	0.5
Long-standing illness, disability or infirmity	0.4	0.7	2.1	1.4	-0.5	0.6	-0.6	-0.8	0.5
Eye problems/disorders: Cataract	0.4	0.5	2.3	-0.4	-0.3	0.2	-0.3	0.5	1.5
Breast cancer (self-reported)	0.4	0.5	1.1	0.3	-0.3	0.4	1.1	-0.8	1.0
Osteoporosis (self-reported)	0.4	0.4	1.9	-0.2	-0.6	-0.1	-0.5	0.3	1.4
Average weekly champagne plus white wine intake	0.4	0.5	1.0	-0.9	0.0	1.0	-0.6	0.6	0.7
Miserableness	0.4	0.7	1.7	0.5	1.3	-0.8	-0.2	0.8	-1.1
Medication: Blood pressure	0.4	0.8	3.1	0.8	0.7	-0.7	-0.3	-1.8	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	-0.7	1.2	0.2	0.8	-0.7	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	0.5	0.6	-0.2	-0.2	-0.8	-1.1
Age started oral contraceptive pill	0.4	0.5	1.7	-0.4	-0.1	-0.6	0.9	0.3	1.3
Bipolar Disorder (2018)	0.3	0.4	1.1	-0.3	0.4	-1.0	0.4	0.7	-0.9
Neuroticism (Nagel 2018)	0.3	0.8	1.8	1.2	-0.6	0.8	1.4	-0.5	-0.4
Prostate Cancer	0.3	0.4	0.8	-0.3	-0.8	-0.9	-0.6	0.9	0.1
Coronary Artery Disease (CAD)	0.3	0.3	1.5	-0.2	0.0	1.2	-0.1	-0.7	0.0
Blood White Count	0.3	2.5	6.5	-0.5	0.4	-2.5	-2.1	-1.5	-1.2
Systolic Blood Pressure	0.3	1.4	4.4	1.8	0.1	2.1	0.6	-0.1	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.1	-1.0	0.7	-1.0	-0.0	-0.3	-1.1
Angina	0.3	0.5	1.2	-0.5	-1.1	-0.2	-0.6	-0.9	-0.1
Supplements: Zinc	0.3	0.3	0.5	-0.7	-0.3	-0.6	-0.7	0.0	-0.7
Diabetes (mother)	0.3	0.4	1.0	0.2	1.0	-0.7	-0.2	-0.8	0.3
Hand grip strength (right)	0.3	0.9	2.0	1.3	1.1	-0.0	-0.1	-1.4	-0.8
Fed-up feelings	0.3	0.6	3.0	-0.0	1.7	-0.1	-0.2	-0.0	-0.8
Taking other prescription medications	0.3	0.5	0.9	-0.9	-0.7	-0.5	-0.2	-0.5	1.0
Medication: Levothyroxine sodium	0.3	0.5	2.3	-1.5	0.5	-0.2	-0.1	0.3	-0.6
Qualifications: None of the above	0.3	0.6	1.3	-0.9	0.3	1.1	-0.2	0.9	0.8
Mouth/teeth dental problems	0.3	0.4	1.1	0.6	-0.4	-0.4	1.1	-0.9	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.5	-0.1	-0.2	-1.2	-0.0	-0.6	-0.4
Impedance of arm (right)	0.3	1.4	3.3	-1.0	0.3	1.8	-1.3	0.2	1.5
Worrier / anxious feelings	0.3	0.5	1.0	0.5	-0.7	-1.0	0.8	-0.5	-0.6
Hair/balding pattern: Pattern 3	0.3	0.5	1.3	0.1	0.9	-1.1	0.2	0.7	-0.3
Tense / ‘highly strung’	0.3	0.5	1.3	-0.8	0.6	0.8	0.1	0.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	-0.3	-1.2	0.7	-0.4	-0.4	-0.2
Gout (self-reported)	0.3	0.5	0.9	-0.6	-0.3	0.9	-0.6	0.9	-0.6
Comparative body size at age 10	0.3	0.9	2.4	0.1	-1.2	1.1	1.6	0.3	0.7
Qualifications: College or University degree	0.3	0.9	3.3	-0.4	-0.8	-0.2	0.1	1.8	1.1
Medication: Seretide 50 evohaler	0.3	0.4	1.3	-0.1	-0.4	0.6	0.4	1.2	0.4
Pulse rate, automated reading	0.3	0.9	2.0	0.2	-1.4	0.9	0.3	0.7	1.4
Chest pain or discomfort	0.3	0.4	1.5	0.8	-1.2	-0.0	0.2	0.2	0.6
Age at last live birth	0.3	0.4	1.3	0.1	0.1	-0.5	1.1	0.7	-0.5
Leg pain on walking	0.3	0.3	0.9	0.1	0.9	0.3	-0.9	-0.3	-0.3
Hypertension (Self-reported)	0.3	0.8	2.5	1.2	0.2	1.6	0.7	-0.6	0.4
Mood swings	0.3	0.5	1.3	-1.1	-0.4	-0.7	-0.5	0.7	-0.4
Loneliness, isolation	0.3	0.3	0.7	-0.8	0.5	-0.3	-0.7	0.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	-0.4	0.9	0.2	0.9	-0.1	-1.1
Medication: Bendroflumethiazide	0.3	0.5	2.2	-0.6	-0.2	0.4	0.1	0.2	1.5
Illnesses of father: High blood pressure	0.3	0.3	0.7	0.4	0.5	0.6	0.4	0.9	0.4
Risk taking	0.3	0.4	1.8	0.2	-0.7	1.3	0.4	-0.5	-0.2
Impedance of whole body	0.3	1.3	2.8	-1.5	0.8	1.1	-0.9	0.4	1.7
Depressed Affect (Nagel 2018)	0.2	0.5	1.8	-0.8	-0.3	0.8	-0.1	1.3	-0.0
Crohns Disease (2017)	0.2	0.4	0.6	0.6	-0.3	-0.7	0.6	-0.8	-0.4
Schizophrenia (2014)	0.2	0.3	1.2	-0.2	-0.5	0.6	-0.5	1.1	0.1
BMI	0.2	1.2	2.3	1.3	-0.3	0.2	1.5	-0.8	-1.5
Lung FVC	0.2	1.1	3.3	-0.4	-0.2	-1.5	-1.8	-0.3	-0.8
Number of treatments/medications taken	0.2	0.4	1.4	0.2	-0.2	-0.1	-0.8	-1.2	-0.7
Average weekly spirits intake	0.2	0.2	0.9	-0.4	-0.9	-0.4	-0.3	-0.4	-0.0
Medication: Metformin	0.2	0.3	1.2	-0.1	0.3	0.6	1.1	0.4	0.4
Townsend deprivation index at recruitment	0.2	0.2	0.7	-0.7	-0.2	-0.8	-0.2	-0.3	-0.3
High blood pressure	0.2	0.5	2.1	1.0	-0.2	1.4	0.3	-0.2	0.2
Impedance of leg (left)	0.2	0.8	1.8	-1.1	1.0	-0.4	-1.4	-0.4	0.4
Past tobacco smoking	0.2	0.4	1.1	0.3	-0.4	0.9	0.3	-0.3	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	0.2	-0.1	0.6	-1.2	0.0	0.0
Diabetes (self-reported)	0.2	0.3	0.9	-0.9	-0.2	-0.5	-0.2	-0.3	0.5
Fluid intelligence score	0.2	0.4	1.7	0.5	-1.3	-0.6	0.1	-0.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	0.7	-0.0	0.0	-0.6	-0.1	1.0
Falls in the last year	0.2	0.3	1.0	-0.2	-0.4	0.5	-0.4	1.0	0.6
Noisy workplace	0.2	0.2	0.5	-0.4	-0.3	-0.5	-0.6	0.2	0.7
Asthma	0.2	0.3	0.6	-0.3	-0.5	-0.6	-0.7	-0.8	0.4
Leg fat percentage (right)	0.2	0.6	1.3	-0.8	-0.3	-0.9	-1.2	-0.1	-0.9
Exposure to tobacco smoke outside home	0.2	0.3	0.9	-0.1	0.1	0.9	0.0	-0.0	-1.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.5	-0.4	-0.7	0.7	0.2	0.9
Mean time to correctly identify matches	0.2	0.3	0.8	-0.0	0.9	-0.5	0.6	0.3	-0.7
Whole body fat mass	0.2	0.7	1.9	0.7	1.1	-0.1	0.6	-0.1	-1.4
Leg fat mass (right)	0.2	0.8	2.7	0.5	0.8	-1.0	-0.2	-0.4	-1.6
Number of full sisters	0.2	0.3	0.6	-0.5	0.2	0.4	-0.6	0.5	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	-0.6	0.5	-0.4	0.0	0.7	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.3	0.4	-0.3	-0.0	0.8	0.1
Medication for cholesterol	0.2	0.4	0.7	0.7	0.1	-0.9	0.5	0.5	0.7
Asthma (self-reported)	0.2	0.4	0.7	-0.6	-0.5	-0.3	-0.8	-0.9	0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.7	-0.7	-0.3	-0.4	0.2	0.4
Ever smoked	0.2	0.3	0.9	-0.1	-0.5	-1.0	0.0	0.9	-0.1
Leg fat percentage (left)	0.2	0.6	1.2	-0.6	-0.3	-1.0	-0.9	-0.2	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.4	-0.6	0.2	-1.6	-0.1	0.6	-0.1
Leg fat mass (left)	0.2	0.9	3.3	0.7	0.7	-0.9	0.1	-0.5	-1.8
Schizophrenia (2018)	0.1	0.2	0.5	-0.1	-0.3	0.6	-0.7	-0.2	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.9	-0.3	0.3	-0.9	-0.1	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.2	0.3	-1.1	-0.7	0.0	-0.3	-0.2
Fasting Glucose	0.1	0.2	0.4	0.6	-0.0	0.6	-0.0	-0.5	0.1
Lupus	0.1	0.2	0.5	-0.1	0.6	-0.1	0.7	0.4	0.4
Blood Eosinophil Count	0.1	0.6	1.6	-0.6	0.5	1.3	0.2	-0.4	-1.1
Blood Platelet Count	0.1	0.9	2.7	1.6	0.0	-0.4	0.7	-0.3	1.4
Heel T-Score	0.1	0.8	2.4	0.7	-0.2	-1.5	-0.1	-0.1	1.4
Respiratory disease	0.1	0.3	1.0	0.3	-0.1	0.2	-0.1	-1.0	-0.9
Lung FEV1/FVC ratio	0.1	0.6	1.7	0.0	1.3	0.1	0.7	0.8	0.7
Neuroticism	0.1	0.3	0.9	-0.8	-0.1	0.9	0.1	0.6	-0.4
Hair Pigment	0.1	2.7	7.5	0.4	-2.7	1.7	-1.0	-1.8	-1.2
Tanning	0.1	0.7	3.5	-0.1	0.3	0.1	1.9	-0.7	0.3
Systolic blood pressure, automated reading	0.1	0.4	0.7	0.8	0.5	0.8	0.6	-0.1	-0.6
Impedance of leg (right)	0.1	0.6	1.5	-1.1	0.7	-0.1	-1.2	-0.2	0.6
Trunk fat percentage	0.1	0.2	0.4	-0.5	0.5	0.6	0.2	0.5	-0.4
Body mass index (BMI)	0.1	0.5	1.1	0.8	-0.7	-0.5	0.5	-0.2	-1.1
Trunk fat mass	0.1	0.5	1.5	0.4	1.2	0.2	0.7	0.2	-0.8
Waist circumference	0.1	0.3	0.9	0.7	-0.5	-0.5	1.0	0.0	0.0
Arm fat percentage (right)	0.1	0.2	0.4	-0.5	-0.4	0.3	-0.4	0.5	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	0.3	0.7	0.6	-0.0	0.2	0.0
Depression (self-reported)	0.1	0.1	0.4	0.6	0.4	0.1	-0.4	-0.0	-0.1
Arm fat mass (right)	0.1	0.4	1.3	0.6	0.4	-0.3	0.5	-0.0	-1.1
Exposure to tobacco smoke at home	0.1	0.2	0.5	0.1	0.2	0.7	-0.4	0.5	0.2
Ever had bowel cancer screening	0.1	0.2	0.7	0.4	0.2	0.3	0.8	-0.2	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.4	-0.4	-0.0	-0.0	-0.0	-0.6	-0.3
Arm fat mass (left)	0.1	0.5	1.5	0.8	0.6	-0.3	0.8	-0.1	-1.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	0.8	0.4	-0.2	-0.1	-0.4	-0.1
Medication: Lisinopril	0.1	0.1	0.4	-0.1	0.5	0.1	0.1	-0.6	0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.9	-0.1	-0.0	0.5	-0.9	0.9	0.1
Cholesterol lowering medication	0.1	0.2	0.8	0.0	0.1	0.4	0.9	-0.3	0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.2	-0.0	-0.2	-0.4	0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.4	0.1	0.2	0.1	0.1	0.3
Body fat percentage	0.0	0.2	0.4	-0.6	0.4	0.2	-0.1	0.3	-0.6
Arm fat percentage (left)	0.0	0.1	0.4	-0.5	-0.0	0.1	-0.0	0.6	-0.3

Hub : Genes

PHGDH

Models

Trait associations