Best TWAS P=2.03e-14 · Best GWAS P=6.75e-14 conditioned to 0.657
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | HAUS6 | 0.13 | 0.01 | lasso | 1 | 0.00 | 4.2e-01 | -5.4 | -5.2 | 2.0e-07 | -0.60 | 0.06 | 0.27 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PLIN2 | 0.08 | 0.02 | lasso | 4 | 0.03 | 1.5e-03 | 7.5 | 7.7 | 2.0e-14 | 0.91 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Esophagus Muscularis | HAUS6 | 0.22 | 0.09 | lasso | 4 | 0.11 | 4.6e-07 | 5.1 | -5.6 | 2.7e-08 | -0.36 | 0.78 | 0.06 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ADAMTSL1 | 0.07 | 0.00 | blup | 412 | 0.02 | 1.7e-03 | -6.6 | 6.3 | 2.3e-10 | 0.11 | 0.01 | 0.93 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HAUS6 | 0.06 | 0.02 | blup | 87 | 0.04 | 7.8e-06 | 5.1 | -5.8 | 4.8e-09 | -0.44 | 0.44 | 0.15 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FAM154A | 0.06 | 0.00 | blup | 174 | 0.01 | 1.3e-01 | 3.6 | -5.6 | 2.3e-08 | -0.46 | 0.19 | 0.13 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM154A | 0.08 | 0.04 | blup | 174 | 0.04 | 4.6e-05 | 5.8 | -6.5 | 1.0e-10 | -0.83 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | HAUS6 | 0.07 | 0.11 | blup | 87 | 0.11 | 6.8e-11 | 5.1 | -5.3 | 9.8e-08 | -0.28 | 1.00 | 0.00 | FALSE |