TWAS hub - PLIN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.667	0.1310	5.3e-03	0.192	NA	0.046	NA	0.010	1.2e-05	NA	2.5e-02	NA	1.8e-01
2	GTEx	Cells Transformed fibroblasts	0.080	0.0320	5.6e-03	0.022	NA	0.024	NA	0.033	8.8e-03	NA	6.1e-03	NA	1.5e-03
3	METSIM	Adipose	0.137	0.0342	1.6e-06	0.041	0.053	0.089	0.068	0.074	9.0e-07	2.0e-08	3.3e-13	2.0e-10	3.1e-11
4	NTR	Blood	0.118	0.0204	1.7e-16	0.042	0.075	0.090	0.101	0.090	1.7e-13	5.1e-23	2.3e-27	7.2e-31	1.6e-27
5	YFS	Blood	0.309	0.0301	0.0e+00	0.247	0.225	0.252	0.253	0.250	7.1e-80	4.8e-72	6.9e-82	5.3e-82	3.0e-81
6	TCGA	Cervical Squamous Cell Carcinoma	0.142	0.0640	7.6e-03	0.001	0.014	0.027	NA	0.004	2.8e-01	6.3e-02	1.7e-02	NA	1.9e-01
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.173	0.0508	3.0e-06	0.102	0.061	0.087	NA	0.098	1.7e-11	2.1e-07	5.5e-10	NA	4.2e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5	6	7
Hearing aid user	2.5	2.8	7.4	0.8	-1.7	-2.7	-1.9	1.5	1.6
Maternal smoking around birth	2.3	3.4	10.0	1.3	1.1	1.6	2.9	-0.1	-3.2
Medication: Lansoprazole	2.3	2.6	7.0	2.1	0.9	-1.3	-0.0	2.6	2.1
Body Mass Index (BMI) (2010)	2.1	2.9	11.5	-3.4	-1.6	-1.2	-2.0	-0.9	-0.2
Lupus	2.0	3.1	7.4	-1.0	-2.7	-2.2	-2.4	1.4	-1.1
Impedance of leg (right)	2.0	9.7	47.0	6.9	0.1	-2.0	0.2	4.0	0.4
Heart attack/myocardial infarction (self-reported)	2.0	2.6	6.3	2.3	-0.8	-1.7	-1.5	2.5	0.6
Impedance of leg (left)	1.8	8.9	42.1	6.5	0.4	-1.8	0.7	4.0	-0.0
Heart attack	1.8	2.3	5.3	2.1	-1.2	-1.5	-1.6	2.3	0.3
Eye problems/disorders: Glaucoma	1.7	2.0	6.0	-0.6	0.8	2.4	2.1	-1.1	-1.4
Fractured/broken bones in last 5 years	1.7	2.2	4.5	-0.4	1.8	2.0	2.1	-1.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.7	-1.9	1.3	2.0	2.2	-1.5	-1.1
Falls in the last year	1.6	2.2	6.4	0.1	2.3	0.9	2.5	1.3	1.1
Depression (self-reported)	1.6	2.0	6.4	1.3	0.7	0.5	2.5	-1.1	-1.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	6.2	0.4	2.5	1.3	1.6	-0.2	2.0
Medication: Co-codamol	1.5	1.7	4.5	-2.1	1.5	1.8	0.9	-1.0	-0.3
Glaucoma (self-reported)	1.5	1.8	6.6	-1.3	-0.1	2.6	1.5	-1.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	4.1	2.0	-0.6	-1.5	-0.5	2.0	1.2
Wears glasses or contact lenses	1.5	1.7	5.7	-0.7	-1.6	-1.4	-2.4	-1.1	-0.6
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.9	1.4	1.7	0.2	2.2	1.4	0.9
Medication: Metformin	1.4	2.0	5.5	2.4	-2.1	-1.5	-1.0	0.4	-0.6
Multivitamins +/- minerals	1.4	1.8	6.1	2.2	-0.4	-1.3	0.2	2.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.0	-1.7	-0.9	-1.7	-2.0	0.7	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	7.7	-2.8	-1.0	-0.6	-1.3	-0.6	-0.8
Medication: Aspirin	1.4	1.8	6.5	2.2	0.5	-0.9	-0.2	2.6	0.5
Ulcerative Colitis (UC)	1.3	2.5	7.0	-1.2	2.0	1.9	0.6	-1.0	2.7
Prostate Cancer	1.3	1.8	4.7	1.5	-1.7	-1.1	-2.2	1.1	0.6
Coronary Artery Disease (CAD)	1.3	1.5	4.1	2.0	0.2	1.0	0.8	-1.8	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.4	-2.1	0.9	-1.2	-0.5	-0.0	2.0
Mother’s age at death	1.3	1.6	3.9	-1.8	-0.2	1.4	0.2	-2.0	-1.5
Financial situation satisfaction	1.3	1.6	6.6	-2.6	1.0	-0.0	-1.0	0.2	1.6
Impedance of whole body	1.3	6.8	29.9	5.5	1.0	-1.1	1.3	3.7	-0.3
Alcohol usually taken with meals	1.2	1.9	5.8	0.6	-2.4	-2.0	-1.3	0.1	-1.2
Length of working week for main job	1.2	1.3	6.0	-2.5	-1.2	-0.7	-1.2	0.1	-0.2
Number of full brothers	1.2	1.6	4.9	-2.2	-1.6	-0.3	-0.7	-1.0	-1.4
Number of children fathered	1.2	1.3	7.2	0.1	-1.3	0.2	0.1	-0.4	-2.7
Medication: Ibuprofen	1.2	1.4	3.9	-2.0	-0.4	-1.2	-1.3	0.7	1.4
Family relationship satisfaction	1.2	1.5	3.6	-1.7	-0.7	-1.4	-1.9	0.5	1.2
Supplements: Vitamin C	1.2	1.5	2.9	1.0	1.4	0.1	1.6	1.4	1.7
Friendships satisfaction	1.2	1.4	8.3	-0.3	0.5	-0.6	-1.0	0.0	2.9
Medication: Gliclazide	1.2	1.4	5.0	1.3	-0.9	-2.2	-0.5	1.4	0.3
Irritable Bowel Disease (IBD)	1.1	2.5	6.6	-1.6	1.9	2.6	1.5	-1.2	1.2
Mean Putamen Volume	1.1	1.3	4.0	1.2	0.2	0.8	1.5	-0.9	-2.0
Breastfed as a baby	1.1	1.3	5.8	-2.4	0.4	-0.2	-1.3	-0.1	1.3
Medication: Omeprazole	1.1	1.3	5.1	-0.3	-1.2	-2.3	-1.5	0.1	-0.5
Long-standing illness, disability or infirmity	1.1	1.7	3.7	1.1	-1.7	-1.9	-0.4	0.7	-1.9
Medication: Atorvastatin	1.1	1.3	3.8	0.1	-1.7	-1.5	-1.9	0.2	-0.4
Age started oral contraceptive pill	1.1	1.3	3.0	-0.9	1.1	1.7	1.6	-0.7	1.2
Major Depression (MDD)	1.0	1.3	4.3	-1.5	1.3	0.2	0.0	-2.1	0.6
Medication: Atenolol	1.0	1.2	4.0	2.0	0.9	0.2	1.1	0.5	1.5
Chronic bronchitis/emphysema (father)	1.0	1.1	2.8	0.4	1.0	1.3	1.5	-1.7	0.2
Diabetes (self-reported)	1.0	1.5	3.6	1.3	-1.9	-1.3	-1.6	0.8	-0.1
Worry too long after embarrassment	1.0	1.6	4.0	1.0	-2.0	-1.6	-1.6	1.1	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	6.1	0.2	-0.5	0.5	1.5	-0.6	-2.5
Wheeze or whistling in the chest in last year	1.0	1.7	7.3	0.9	1.0	-1.3	0.6	2.7	0.8
Angina (self-reported)	1.0	1.3	3.7	1.9	0.4	1.0	1.3	1.5	-0.5
Illnesses of siblings: Diabetes	1.0	1.2	3.2	-0.9	-0.9	-1.6	-1.8	0.7	0.9
Ever had bowel cancer screening	1.0	1.1	5.1	-0.1	-1.3	0.4	0.7	-0.6	-2.2
Diabetes diagnosed by doctor	1.0	1.7	3.4	1.4	-1.9	-1.6	-1.7	0.8	0.0
Medication: Bendroflumethiazide	1.0	1.6	5.5	-0.6	-1.8	-0.9	-2.3	0.3	1.1
Reaction Time	0.9	1.7	4.2	2.1	1.8	-0.7	0.3	1.9	0.6
Bipolar Disorder (2011)	0.9	0.9	3.0	0.9	-0.0	1.7	1.5	0.0	0.0
Waist Hip Ratio (WHR)	0.9	3.9	10.1	1.5	-0.6	-3.2	-2.8	1.7	1.8
Angina	0.9	1.2	3.6	1.9	0.2	0.8	1.1	1.7	-0.3
Average weekly fortified wine intake	0.9	1.1	5.2	2.3	-0.1	-0.8	0.6	0.7	-0.9
Relative age voice broke	0.9	1.3	3.8	1.0	0.7	0.3	2.0	1.3	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	6.0	-1.1	-1.7	-0.7	-2.4	1.7	1.2
Financial difficulties in last 2 years	0.9	1.2	6.2	-2.5	1.0	0.3	0.1	-0.9	0.6
Number of live births	0.9	1.2	4.0	-1.8	2.0	0.6	-0.1	-0.9	-0.1
Medication: Cholesterol lowering	0.9	1.4	4.3	1.9	-0.9	-2.1	-1.1	0.0	-0.0
Eye problems/disorders: None of the above	0.9	1.1	2.4	1.4	-0.8	-1.5	-0.5	1.6	0.2
Emphysema/chronic bronchitis	0.9	1.0	2.9	0.3	-0.0	-1.7	-0.8	1.2	1.3
Medication for pain relief, constipation, heartburn	0.9	1.5	4.3	-1.0	0.1	2.1	0.8	-2.0	-0.4
Medication: Seretide 50 evohaler	0.9	1.0	2.6	1.6	1.1	-1.4	0.0	1.2	0.4
Suffer from ‘nerves’	0.9	1.4	7.6	2.8	0.1	0.1	1.2	0.8	0.3
Had major operations	0.9	1.0	3.8	0.3	-1.4	0.2	0.1	-1.9	-1.1
Average weekly red wine intake	0.9	1.3	3.6	-1.4	1.3	0.6	1.1	-1.9	0.4
Commuting to job workplace: Walk	0.9	1.0	2.7	0.5	1.6	-0.4	0.6	1.2	1.4
Commuting to job workplace: Public transport	0.9	1.1	2.3	-0.6	1.2	1.0	1.0	-1.2	1.5
Alcohol drinker status: Previous	0.9	1.0	3.9	-0.3	-2.0	-1.1	-1.2	0.3	-0.2
Fasting Glucose	0.8	1.0	3.1	0.6	-1.6	0.0	-0.5	-0.9	-1.8
Type 2 Diabetes (T2D) (2012)	0.8	1.0	3.9	2.0	-1.3	0.4	-0.4	0.7	-0.7
Number of treatments/medications taken	0.8	1.4	4.0	2.0	0.6	-1.9	0.2	1.1	0.8
Average weekly spirits intake	0.8	1.1	2.6	-0.2	1.3	1.6	1.3	-0.9	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	-1.4	-0.2	-1.3	-0.5	-1.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.2	-0.8	-1.3	-0.8	-0.3	1.5	-1.0
Sitting height	0.8	5.6	23.8	4.9	-0.7	1.7	2.8	-0.9	-1.9
Hair/balding pattern: Pattern 2	0.8	1.0	3.2	-0.7	-0.6	0.9	-0.2	-1.4	-1.8
Mouth/teeth dental problems	0.8	1.2	3.2	1.0	1.3	1.4	1.8	0.6	-0.0
Standing height	0.8	7.9	31.1	5.6	0.1	2.0	4.1	-0.5	-1.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	6.5	-2.5	0.7	1.4	0.1	-0.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.7	1.9	1.6	-0.1	1.8	1.0	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.0	0.8	-0.3	-1.7	-0.6	1.4	-0.0
Osteoarthritis (self-reported)	0.8	1.0	4.7	-2.2	0.4	-0.0	-0.4	-1.4	0.3
Supplements: Calcium	0.8	0.8	3.7	-1.9	-0.5	0.2	-0.2	-1.2	0.4
Worry (Nagel 2018)	0.7	1.4	3.2	0.4	-1.6	-1.8	-1.6	1.0	-0.4
LDL Cholesterol	0.7	1.1	4.1	2.0	1.0	-0.3	0.7	0.9	-1.1
Ulcerative Colitis	0.7	1.1	2.7	-1.2	0.7	1.5	0.8	-1.6	0.0
Blood Platelet Count	0.7	7.9	25.9	1.1	-3.5	-3.7	-5.1	1.1	1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	4.8	0.3	-0.4	-0.8	0.6	-0.8	-2.2
Severe depression (siblings)	0.7	0.8	1.9	-1.1	-1.4	0.7	-0.7	-0.0	-1.2
Medication: Levothyroxine sodium	0.7	1.2	4.7	1.1	0.9	-0.2	1.2	2.2	0.5
High blood pressure (mother)	0.7	1.0	2.5	1.4	0.9	0.3	1.6	0.4	1.2
Number of incorrect matches in round	0.7	1.2	4.4	0.1	2.1	0.7	1.4	1.1	0.8
Medication: Ramipril	0.7	0.9	4.3	2.1	1.0	0.1	0.4	0.6	0.4
Prospective memory result	0.7	0.8	2.2	-0.7	1.5	1.2	0.9	-0.6	0.7
Illnesses of mother	0.7	0.8	3.3	-1.8	-0.6	0.7	-0.6	-0.2	-1.1
Impedance of arm (left)	0.7	3.4	13.5	3.7	1.3	-0.7	1.2	2.6	-0.5
Forced vital capacity (FVC), Best measure	0.7	2.7	14.0	3.7	-1.2	0.7	1.2	-0.8	-0.8
Neck or shoulder pain in last month	0.7	1.0	3.2	1.1	-0.5	-1.4	0.4	1.8	-0.7
Migraine (self-reported)	0.7	0.8	4.0	1.0	0.0	0.2	0.8	2.0	-0.4
Heart disease (mother)	0.7	0.9	3.2	1.8	0.2	0.9	0.8	1.2	-0.1
Medication: Aspirin	0.7	0.9	3.2	1.4	0.6	-0.4	-0.3	1.8	0.6
Mineral and other dietary supplements	0.7	0.9	2.7	-0.6	-1.6	-0.8	-1.2	-0.1	-1.1
Breast Cancer	0.6	1.4	3.7	1.4	0.3	-1.1	-0.8	1.5	1.9
Ovarian Cancer	0.6	0.8	2.8	0.6	0.1	0.3	1.7	0.6	-1.4
Height	0.6	10.8	58.5	7.7	-0.4	1.8	3.0	0.7	-2.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.7	0.5	-1.9	-1.0	-1.7	0.3	0.2
Chronotype (morning person)	0.6	1.4	5.1	-0.8	-2.3	-0.8	-1.7	-0.2	-0.8
Vitamin and mineral supplements	0.6	0.8	2.3	-1.5	0.4	1.2	-0.1	-1.3	-0.1
Pack years adult smoking proportion	0.6	0.9	4.0	0.9	-0.2	-0.3	1.0	0.3	-2.0
Qualifications: CSEs or equivalent	0.6	0.8	3.8	2.0	0.8	0.1	1.0	0.2	-0.2
Had other major operations	0.6	0.7	1.7	0.4	-1.1	-1.3	-0.9	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.1	0.0	-1.8	-0.7	-1.7	1.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.7	-0.6	-1.6	-0.2	-1.3	0.8	0.2
Impedance of arm (right)	0.6	3.0	12.7	3.6	1.0	-0.6	1.0	2.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.7	1.9	0.1	-1.0	1.0	1.1	-0.4
Happiness	0.6	0.7	1.7	-1.2	-0.2	-0.7	-1.1	0.4	1.3
Tense / ‘highly strung’	0.6	1.0	1.9	-1.4	-0.9	-1.4	-1.4	0.4	-0.8
Loud music exposure frequency	0.6	0.7	3.2	-0.1	-0.7	-0.7	0.3	0.6	-1.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.3	-1.8	0.5	0.0	0.2	0.2	1.0
Exposure to tobacco smoke outside home	0.6	0.8	2.4	0.6	1.0	1.0	1.6	-0.2	1.1
Comparative body size at age 10	0.6	1.7	5.9	-2.4	0.1	0.8	-1.3	-1.9	0.6
Pulse wave peak to peak time	0.6	0.7	1.3	1.2	1.0	0.8	1.1	0.7	0.0
Mouth/teeth dental problems: Loose teeth	0.6	0.8	3.2	0.9	-0.7	-0.4	-0.1	0.8	-1.8
Medication: Blood pressure	0.6	1.0	3.8	2.0	-1.0	-1.1	-0.5	1.0	-0.4
Leg pain on walking	0.6	0.8	2.8	-0.3	-1.7	-1.2	-0.3	0.6	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.8	-0.4	0.1	-0.2	-0.7	1.3	1.7
Knee pain experienced in last month	0.6	0.9	3.3	-1.8	-1.2	0.2	-0.7	-0.8	0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.4	-1.0	-0.4	0.6	0.2	-1.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.9	-0.6	-0.8	-1.7	-1.6	0.2	0.0
Average weekly champagne plus white wine intake	0.6	0.8	2.2	0.5	-1.1	-0.7	-0.7	1.5	0.9
Illnesses of father: High blood pressure	0.6	0.7	1.4	0.4	-0.9	-0.3	-1.2	1.1	-1.1
Alcohol drinker status: Never	0.6	0.7	1.9	1.4	-1.2	-0.9	0.5	0.7	0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	1.0	-0.8	-1.2	-0.5	0.4	-0.9
Crohns Disease (2017)	0.5	1.1	3.7	-0.5	0.8	1.9	1.5	-0.1	-1.0
Age at First Birth	0.5	0.7	1.3	-1.1	-0.8	-0.8	-0.8	1.1	0.5
Crohns Disease (2012)	0.5	0.8	3.1	0.9	-0.1	1.2	1.7	-0.7	0.0
HbA1C	0.5	0.5	2.0	-0.4	-0.4	-0.4	-0.9	-1.4	-0.4
Heel T-Score	0.5	4.1	8.8	-1.5	-1.9	-2.1	-3.0	2.3	2.0
Sensitivity / hurt feelings	0.5	0.8	2.7	0.4	1.2	-0.2	0.7	1.6	1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.3	-1.5	0.8	1.1	0.5	-0.5	0.7
Medication for hormone replacement therapy	0.5	0.6	1.9	0.6	-0.9	-0.8	-0.3	0.6	-1.4
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.2	-0.9	-0.5	-0.9	-1.0	1.8	1.0
Had menopause	0.5	0.6	3.6	-0.4	-0.2	1.9	0.8	-0.4	-0.1
Forced vital capacity (FVC)	0.5	1.8	6.9	2.6	-1.4	0.9	1.0	-0.7	-1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.5	-1.6	1.4	0.5	0.3	-0.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.5	0.2	0.9	1.2	1.0	-1.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	9.5	3.1	-0.6	0.4	1.0	-0.7	0.2
Birth weight of first child	0.5	0.9	3.1	0.5	0.4	1.1	0.9	-1.7	-0.9
High blood pressure (siblings)	0.5	0.7	2.9	-0.2	-0.0	0.9	0.9	-1.7	-0.7
Qualifications: College or University degree	0.5	1.6	4.3	0.7	-1.8	-2.1	-1.3	-0.3	-1.2
Mean time to correctly identify matches	0.5	0.9	2.3	1.0	1.5	-0.3	-0.0	1.5	0.9
Comparative height size at age 10	0.5	2.8	11.4	3.4	-2.1	0.1	0.0	-1.0	-1.7
Medication for cholesterol	0.5	0.8	2.8	-0.4	-0.6	1.0	0.8	-1.7	-0.6
Breast cancer (self-reported)	0.5	0.6	2.5	-1.6	1.0	0.6	0.1	-0.5	0.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	2.2	0.7	-0.8	-1.5	-0.1	-0.1	-0.7
Myopia	0.5	0.8	3.4	-0.3	0.6	-1.0	-0.6	-0.2	1.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.2	-0.7	-0.8	-1.5	-1.1	-0.1	-0.2
Pack years of smoking	0.5	0.8	3.8	0.6	-0.4	-0.3	1.0	-0.1	-2.0
Bipolar Disorder (2018)	0.4	0.6	2.1	0.9	-0.2	1.4	0.8	-0.8	0.0
Schizophrenia (2018)	0.4	0.7	3.7	0.5	0.0	-0.8	-0.4	1.9	0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	-0.2	1.3	0.8	1.0	-0.6	0.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	0.1	-0.6	-1.1	-0.8	0.8	-1.2
Hypothyroidism (self reported)	0.4	1.0	3.4	0.5	1.5	0.2	1.8	1.0	0.1
Relative age of first facial hair	0.4	0.7	2.5	1.6	0.7	-0.5	1.0	0.9	-0.5
Ever had hysterectomy (womb removed)	0.4	0.4	2.1	-0.9	-0.0	-0.2	-0.1	-0.4	-1.4
Systolic blood pressure, automated reading	0.4	1.2	4.9	2.2	0.7	0.3	1.4	0.1	-0.9
Taking other prescription medications	0.4	0.6	1.6	1.2	-0.1	-0.4	1.3	-0.1	-0.9
Medication: Simvastatin	0.4	0.7	3.8	2.0	0.7	-0.3	0.3	-0.2	0.2
Time employed in main current job	0.4	0.5	2.8	-0.0	-0.2	-0.2	0.2	0.8	-1.7
Alcohol intake versus 10 years previously	0.4	0.7	2.5	-0.2	-1.1	-0.6	0.2	0.8	-1.6
Asthma	0.4	0.7	1.8	1.3	1.1	-0.8	0.8	0.8	-0.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	-1.1	0.1	-1.5	0.3	1.2	1.4
Peak expiratory flow (PEF)	0.4	1.0	3.1	1.2	-0.1	1.1	1.2	-1.7	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	0.5	0.4	0.5	1.1	1.4	-0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	-0.7	0.5	0.3	-0.2	-1.1	-1.1
Headache pain in last month	0.4	0.7	1.6	0.1	0.1	-0.5	1.3	1.2	-1.2
Age at first live birth	0.4	0.6	1.7	0.5	-1.2	-0.7	-0.3	-0.6	-1.3
Pulse rate, automated reading	0.4	1.2	3.5	-0.8	1.7	0.7	0.6	-1.9	0.6
Number of full sisters	0.4	0.5	2.3	-0.4	-1.5	-0.7	-0.8	-0.2	0.2
Age at last live birth	0.4	0.6	2.2	-0.3	-0.2	-1.5	-1.0	0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.4	1.5	0.6	1.0	1.1	-1.3	0.4
Leg fat-free mass (right)	0.4	1.9	5.2	-2.0	0.4	1.6	1.2	-2.3	-0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.9	0.9	0.4	1.1	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.1	0.2	-1.3	-1.0	-1.5	-0.5	0.6
Leg predicted mass (right)	0.4	2.0	5.3	-2.0	0.4	1.6	1.2	-2.3	-0.6
Medication: Lisinopril	0.4	0.5	1.3	1.1	0.3	0.3	0.4	1.0	-0.7
Number of operations (self-reported)	0.4	0.5	1.7	-0.8	-1.0	-0.0	-0.3	-0.6	-1.3
Pain experienced in last month	0.4	0.7	2.5	0.4	-0.5	-0.0	-1.6	-1.4	0.4
Alzheimer’s Disease (in father)	0.3	0.4	1.1	-1.0	0.5	-0.0	-0.2	1.1	-0.5
BMI	0.3	1.9	12.0	-3.5	0.4	-0.2	-0.1	-0.9	0.6
Hearing difficulty/problems: Yes	0.3	0.5	1.6	0.7	-1.2	-0.5	-0.5	0.5	0.9
Diabetes (father)	0.3	0.3	0.9	0.7	-0.9	-0.0	-0.4	0.3	-0.8
Leg fat-free mass (left)	0.3	1.4	4.6	-1.7	0.4	1.3	0.9	-2.1	-0.4
Trunk fat percentage	0.3	1.3	4.9	1.3	2.2	-0.5	1.0	1.0	0.6
Townsend deprivation index at recruitment	0.3	0.5	1.4	-0.6	-0.2	-0.8	0.7	0.5	-1.2
Fed-up feelings	0.3	0.5	1.4	-0.3	1.2	0.9	0.5	-0.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.4	0.8	-0.8	-0.3	-0.1	1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.4	-0.4	0.9	0.2	-0.8	-0.6
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.9	-0.1	-0.1	0.2	-1.0	0.8
Stomach or abdominal pain in last month	0.3	0.4	1.5	0.0	0.5	0.7	1.2	0.8	-0.0
Body mass index (BMI)	0.3	1.4	6.5	-2.5	1.3	0.2	-0.2	-1.0	0.9
Leg predicted mass (left)	0.3	1.5	4.6	-1.7	0.4	1.3	0.9	-2.1	-0.4
Hearing difficulty/problems with background noise	0.3	0.4	0.8	0.8	-0.8	-0.9	0.3	0.7	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.7	0.3	0.7	0.8	0.9	0.0	0.6
Allergy	0.3	0.7	3.0	0.2	0.6	0.9	0.5	-1.7	-0.9
Illnesses of siblings	0.3	0.5	1.3	1.0	0.5	0.6	0.5	1.1	0.5
Trunk fat-free mass	0.3	1.7	6.4	-0.0	-0.6	1.5	1.2	-2.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	4.3	2.1	-0.6	0.7	0.9	-0.7	-0.2
Noisy workplace	0.3	0.4	1.2	-1.1	-0.4	0.8	0.5	-0.5	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	-0.6	-1.0	-0.7	-0.8	-0.6	-0.2
Trunk predicted mass	0.3	1.6	6.1	-0.0	-0.7	1.5	1.2	-2.5	-1.1
Medication: Paracetamol	0.3	0.5	2.2	1.5	-0.0	-0.9	0.2	0.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	1.0	-0.1	-0.9	0.3	0.4	-0.4
Birth weight	0.3	0.7	2.4	-0.2	-0.3	-1.6	-0.6	0.8	1.0
Body fat percentage	0.3	1.1	5.2	0.8	2.3	-0.3	0.9	0.7	0.8
Health satisfaction	0.3	0.4	0.9	-0.8	-0.9	-0.5	-0.7	-0.1	-0.9
Shortness of breath walking on level ground	0.3	0.3	0.7	-0.4	-0.8	-0.7	-0.4	0.1	-0.8
Alcohol intake frequency.	0.3	0.7	2.1	0.8	-1.4	-1.0	-0.1	0.8	-0.8
Overall health rating	0.3	0.7	3.6	0.2	-0.0	-1.9	-0.7	0.7	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.7	1.3	-0.4	0.2	0.0	0.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	0.6	-1.0	0.7	0.1	0.1	-1.1
Illnesses of father: Heart disease	0.3	0.4	1.2	-0.2	-1.1	-0.8	-1.1	0.4	0.1
Whole body fat-free mass	0.3	1.6	6.1	-0.9	-0.2	1.5	1.1	-2.5	-0.8
Arm fat percentage (left)	0.3	1.1	5.5	-1.2	2.3	-0.1	0.3	-0.1	0.9
Eye problems/disorders: Cataract	0.3	0.3	1.0	-0.5	0.3	0.2	-0.9	-0.0	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.2	-1.0	-0.6	0.1	0.8	-0.1
Back pain experienced in last month	0.3	0.5	1.7	-0.1	0.1	-0.4	1.0	1.3	0.7
Asthma (self-reported)	0.3	0.6	1.8	1.3	0.8	-0.9	0.6	0.9	-0.4
Osteoporosis (self-reported)	0.3	0.4	0.9	0.8	0.1	-0.9	-0.5	-0.9	0.1
Whole body water mass	0.3	1.5	5.5	-0.8	-0.2	1.6	1.2	-2.4	-0.8
Number of self-reported non-cancer illnesses	0.3	0.5	1.6	0.8	-0.4	-1.3	0.2	0.9	-0.8
High cholesterol (Self-reported)	0.3	0.5	2.7	0.6	-0.4	0.0	0.1	-1.6	-0.6
Medication: Paracetamol	0.3	0.5	1.4	1.2	0.3	-0.1	1.1	0.5	-0.8
Average weekly beer plus cider intake	0.3	0.5	1.0	-1.0	0.6	1.0	-0.3	0.3	-0.9
Irritability	0.3	0.5	2.2	0.9	0.2	-0.6	-0.5	1.5	0.3
Risk taking	0.3	0.4	1.8	-1.4	0.4	0.4	0.8	-0.3	0.1
Ever depressed for a whole week	0.3	0.4	1.2	-1.1	0.5	0.3	0.3	-0.8	0.7
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.3	0.9	1.0	1.0	-0.1	-0.3
Commuting to job workplace: Cycle	0.3	0.3	1.4	-0.1	0.4	-0.7	0.0	0.7	1.2
Cholesterol lowering medication	0.3	0.4	1.3	0.4	0.2	-0.1	-0.7	1.2	1.0
Heart disease (siblings)	0.3	0.4	1.9	-1.4	-0.4	0.2	-0.4	-0.7	-0.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.6	0.0	1.3	0.5	1.1	0.4	0.2
HDL Cholesterol	0.2	0.4	1.2	0.7	0.6	0.1	1.1	0.7	0.2
Neuroticism (2016)	0.2	0.3	1.1	0.1	0.4	-0.3	1.0	-0.7	-0.7
Blood Eosinophil Count	0.2	1.6	6.5	1.0	2.5	-0.3	1.9	0.7	0.0
Blood White Count	0.2	1.6	6.9	-0.2	1.8	0.4	2.6	0.8	0.0
Systolic Blood Pressure	0.2	0.8	3.8	1.2	-0.4	-0.1	0.5	0.3	-2.0
Allergy or Eczema	0.2	0.4	1.4	-1.0	-0.5	0.0	-0.5	1.2	0.1
Lung FVC	0.2	0.9	3.7	1.0	-1.9	-0.3	-1.1	-0.5	-0.4
Hand grip strength (left)	0.2	0.6	2.0	-0.6	0.7	-0.8	-0.1	-1.4	1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.6	-0.7	0.5	0.1	0.6	-0.1
Hand grip strength (right)	0.2	0.5	1.1	0.2	0.9	-1.0	0.2	-0.6	1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.2	-0.2	0.2	0.3	0.7	-0.8
High blood pressure	0.2	0.5	0.9	0.6	-0.2	-0.7	-0.9	0.8	0.9
Trunk fat mass	0.2	0.9	3.4	1.1	1.9	-0.0	1.3	0.2	0.2
Weight	0.2	0.8	2.2	-0.0	1.2	1.0	1.5	-1.1	0.1
Arm fat percentage (right)	0.2	1.0	4.6	-1.1	2.1	-0.3	0.1	-0.2	0.9
Hip circumference	0.2	0.9	2.4	-0.5	1.2	1.0	1.6	-0.6	-0.7
Worrier / anxious feelings	0.2	0.4	0.8	-0.6	-0.6	-0.8	-0.9	0.7	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	-0.0	-0.3	-0.4	-1.1	-0.7	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.9	-0.7	-1.0	-0.7	-0.5	0.0	0.4
Lung cancer (father)	0.2	0.3	1.2	-0.5	-1.1	-0.1	0.3	0.2	-0.6
Arm fat mass (right)	0.2	0.6	2.8	-0.7	1.7	0.4	0.7	-0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.4	-0.1	-0.4	-0.8	-0.2	-0.5	-1.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.0	0.2	0.5	0.4	0.8	0.9
Gout (self-reported)	0.2	0.3	0.6	-0.6	0.2	-0.6	-0.7	0.8	0.5
Medication: Amlodipine	0.2	0.3	0.6	-0.1	0.7	0.5	0.0	-0.8	-0.6
Leg fat percentage (right)	0.2	0.7	2.0	0.9	1.4	-0.6	-0.0	0.6	1.2
Arm fat-free mass (right)	0.2	0.8	2.8	-0.3	-0.1	1.3	1.0	-1.7	-0.4
Medication: Allopurinol	0.2	0.3	1.3	0.3	0.4	-0.6	-0.1	1.2	-0.0
Whole body fat mass	0.2	0.9	4.0	0.4	2.0	0.5	1.3	-0.4	0.4
Arm predicted mass (right)	0.2	0.9	2.6	-0.5	-0.2	1.4	1.1	-1.6	-0.3
Chest pain or discomfort	0.2	0.2	1.0	0.1	0.5	-0.2	0.4	1.0	0.3
Smoking status: Previous	0.2	0.3	0.8	-0.3	0.3	-0.5	-0.3	-0.9	-0.6
Mood swings	0.2	0.3	1.4	0.0	1.2	-0.1	0.5	0.7	0.6
Loneliness, isolation	0.2	0.2	0.7	-0.3	-0.0	-0.8	-0.3	0.3	0.8
Arm fat mass (left)	0.2	0.9	3.5	-0.8	1.9	0.7	0.9	-0.6	0.5
Miserableness	0.2	0.4	1.2	0.2	0.8	0.4	1.1	0.2	-0.8
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.8	-0.5	-0.6	-0.4	0.5	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.9	-0.3	-0.4	0.4	0.3	-0.3
Basal metabolic rate	0.2	1.2	4.2	-0.6	0.1	1.4	1.2	-2.0	-0.6
Leg fat percentage (left)	0.2	0.6	2.3	0.6	1.5	-0.4	0.4	0.5	1.0
Arm fat-free mass (left)	0.2	1.1	3.3	0.0	-0.4	1.6	1.1	-1.8	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	-0.5	0.2	0.8	1.1	-1.3	-0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.9	0.3	0.3	0.4	0.1	1.0	0.8
Arm predicted mass (left)	0.2	1.1	3.1	0.0	-0.4	1.8	1.3	-1.7	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.9	-0.3	0.3	0.2	0.8	0.1
Depression (Nagel 2018)	0.1	0.2	1.0	-1.0	0.6	0.1	-0.1	-0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.1	0.0	-0.1	0.8	0.5	0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.9	0.4	-0.2	-0.9	-0.2	0.9	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.3	-0.5	-0.6	0.5	0.7	-0.4
Primary Biliary Cirrhosis	0.1	0.2	0.7	0.4	0.2	0.8	-0.2	0.7	0.0
Rheumatoid Arthritis	0.1	0.1	0.8	-0.3	-0.2	-0.0	-0.3	0.1	-0.9
Triglycerides	0.1	0.2	0.8	-0.4	0.4	0.4	-0.3	-0.3	0.9
Blood Red Count	0.1	0.7	2.0	0.5	-0.3	-1.4	-0.9	-1.3	-0.1
Smoking Status	0.1	0.2	0.4	0.5	0.5	-0.6	-0.0	0.5	-0.0
Cardiovascular Disease	0.1	0.3	1.2	0.4	0.3	-0.4	0.2	0.5	1.1
Respiratory disease	0.1	0.3	1.4	0.1	-0.1	-0.8	0.1	0.1	-1.2
Lung FEV1/FVC ratio	0.1	0.6	1.7	-1.1	0.3	-0.5	-0.5	-1.0	1.3
Neuroticism	0.1	0.3	0.7	0.0	-0.3	-0.8	-0.6	0.6	0.7
Hair Pigment	0.1	2.7	11.2	0.7	1.7	-0.6	1.0	3.4	1.8
Tanning	0.1	0.7	1.7	-1.1	-1.3	-0.6	-0.9	-0.4	-0.8
Supplements: Zinc	0.1	0.1	0.4	0.3	-0.6	0.0	0.1	0.4	0.5
Diabetes (mother)	0.1	0.1	0.4	0.0	-0.6	-0.1	0.3	0.6	-0.3
Current tobacco smoking	0.1	0.2	0.5	0.3	0.0	-0.1	0.7	0.6	-0.4
Age when periods started (menarche)	0.1	0.4	1.1	1.1	0.2	-0.6	0.9	0.0	0.4
Supplements: Glucosamine	0.1	0.1	0.3	0.1	0.1	-0.5	-0.3	0.4	0.4
Waist circumference	0.1	0.2	0.4	-0.6	0.7	-0.6	-0.2	-0.4	0.3
Past tobacco smoking	0.1	0.2	0.5	-0.0	0.1	0.7	0.4	0.5	0.7
Nervous feelings	0.1	0.2	1.1	0.2	-0.5	-0.4	-0.4	1.0	0.0
Qualifications: None of the above	0.1	0.3	1.3	-1.1	-0.1	0.6	-0.3	-0.3	-0.0
Pain all over the body in last month	0.1	0.1	0.3	0.2	0.5	0.4	0.3	-0.2	0.1
Fluid intelligence score	0.1	0.2	0.6	-0.4	-0.7	-0.7	-0.3	0.5	-0.4
Neuroticism score	0.1	0.2	0.7	0.5	0.1	-0.6	-0.2	0.8	0.4
Pulse rate	0.1	0.2	0.7	0.2	0.3	-0.5	-0.8	-0.3	0.8
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.1	0.1	-0.0	-0.0	0.6	0.3
Pulse wave reflection index	0.1	0.2	0.4	-0.6	-0.7	-0.3	0.3	-0.5	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.5	0.1	0.7	0.0	0.5	-0.0	-0.1
Leg fat mass (right)	0.1	0.3	1.7	0.2	1.3	0.0	0.5	-0.1	0.6
Hypertension (Self-reported)	0.1	0.2	0.4	0.6	-0.2	-0.4	-0.6	0.3	0.5
Qualifications: nursing, teaching	0.1	0.2	0.5	0.6	0.5	-0.3	0.7	-0.2	-0.2
Smoking status: Current	0.1	0.1	0.2	0.0	-0.2	-0.5	0.4	0.5	-0.2
Guilty feelings	0.1	0.2	0.4	0.0	0.0	-0.6	-0.5	-0.6	0.3
Medication: Blood pressure	0.1	0.2	0.8	-0.2	0.9	0.4	-0.2	0.3	0.5
Ever smoked	0.1	0.2	0.7	0.8	0.2	-0.2	0.4	0.3	-0.8
Diastolic blood pressure, automated reading	0.1	0.3	2.0	0.0	0.2	-1.4	-0.5	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.7	-0.0	0.8	-0.0	0.4	0.2	-0.1
Leg fat mass (left)	0.1	0.4	1.9	0.1	1.4	0.3	0.9	-0.1	0.3
Schizophrenia (2014)	0.0	0.1	0.2	0.4	0.2	0.1	0.3	0.5	-0.4
Father’s age at death	0.0	0.0	0.2	-0.1	0.2	-0.4	-0.1	0.2	-0.3

Hub : Genes

PLIN2

Models

Trait associations