Hub : Genes

PLIN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.667 0.1310 5.3e-03 0.192 NA 0.046 NA 0.010 1.2e-05 NA 2.5e-02 NA 1.8e-01
2 GTEx Cells Transformed fibroblasts 0.080 0.0320 5.6e-03 0.022 NA 0.024 NA 0.033 8.8e-03 NA 6.1e-03 NA 1.5e-03
3 METSIM Adipose 0.137 0.0342 1.6e-06 0.041 0.053 0.089 0.068 0.074 9.0e-07 2.0e-08 3.3e-13 2.0e-10 3.1e-11
4 NTR Blood 0.118 0.0204 1.7e-16 0.042 0.075 0.090 0.101 0.090 1.7e-13 5.1e-23 2.3e-27 7.2e-31 1.6e-27
5 YFS Blood 0.309 0.0301 0.0e+00 0.247 0.225 0.252 0.253 0.250 7.1e-80 4.8e-72 6.9e-82 5.3e-82 3.0e-81
6 TCGA Cervical Squamous Cell Carcinoma 0.142 0.0640 7.6e-03 0.001 0.014 0.027 NA 0.004 2.8e-01 6.3e-02 1.7e-02 NA 1.9e-01
7 TCGA Kidney Renal Clear Cell Carcinoma 0.173 0.0508 3.0e-06 0.102 0.061 0.087 NA 0.098 1.7e-11 2.1e-07 5.5e-10 NA 4.2e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.6 2.1 0.0 0.9 -0.2 1.4 0.8 -0.8 0.0
Bipolar Disorder or Schizophrenia 0.1 0.3 0.9 0.0 0.9 -0.3 0.3 0.2 0.8 0.1
Depressed Affect (Nagel 2018) 0.2 0.5 1.6 0.0 0.0 1.3 0.5 1.1 0.4 0.2
Depression (Nagel 2018) 0.1 0.2 1.0 0.0 -1.0 0.6 0.1 -0.1 -0.4 -0.2
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.7 0.0 -0.1 0.0 -0.1 0.8 0.5 0.4
Neuroticism (Nagel 2018) 0.1 0.3 0.9 0.0 0.4 -0.2 -0.9 -0.2 0.9 0.0
Schizophrenia (2018) 0.4 0.7 3.7 0.0 0.5 0.0 -0.8 -0.4 1.9 0.7
Schizophrenia vs Biploar Disorder 0.4 0.5 1.8 0.0 -0.2 1.3 0.8 1.0 -0.6 0.0
Worry (Nagel 2018) 0.7 1.4 3.2 0.0 0.4 -1.6 -1.8 -1.6 1.0 -0.4
Alzheimer’s Disease (in mother) 0.5 0.6 1.5 0.0 1.0 -0.8 -1.2 -0.5 0.4 -0.9
Alzheimer’s Disease (in father) 0.3 0.4 1.1 0.0 -1.0 0.5 -0.0 -0.2 1.1 -0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 1.5 0.0 0.1 -0.6 -1.1 -0.8 0.8 -1.2
Crohns Disease (2017) 0.5 1.1 3.7 0.0 -0.5 0.8 1.9 1.5 -0.1 -1.0
Irritable Bowel Disease (IBD) 1.1 2.5 6.6 0.0 -1.6 1.9 2.6 1.5 -1.2 1.2
Ulcerative Colitis (UC) 1.3 2.5 7.0 0.0 -1.2 2.0 1.9 0.6 -1.0 2.7
Major Depression (MDD) 1.0 1.3 4.3 0.0 -1.5 1.3 0.2 0.0 -2.1 0.6
Reaction Time 0.9 1.7 4.2 0.0 2.1 1.8 -0.7 0.3 1.9 0.6
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 0.0 0.3 -0.5 -0.6 0.5 0.7 -0.4
Breast Cancer 0.6 1.4 3.7 0.0 1.4 0.3 -1.1 -0.8 1.5 1.9
Ovarian Cancer 0.6 0.8 2.8 0.0 0.6 0.1 0.3 1.7 0.6 -1.4
Prostate Cancer 1.3 1.8 4.7 0.0 1.5 -1.7 -1.1 -2.2 1.1 0.6
Age at First Birth 0.5 0.7 1.3 0.0 -1.1 -0.8 -0.8 -0.8 1.1 0.5
Bipolar Disorder (2011) 0.9 0.9 3.0 0.0 0.9 -0.0 1.7 1.5 0.0 0.0
Body Mass Index (BMI) (2010) 2.1 2.9 11.5 0.0 -3.4 -1.6 -1.2 -2.0 -0.9 -0.2
Coronary Artery Disease (CAD) 1.3 1.5 4.1 0.0 2.0 0.2 1.0 0.8 -1.8 -1.2
Crohns Disease (2012) 0.5 0.8 3.1 0.0 0.9 -0.1 1.2 1.7 -0.7 0.0
Mean Putamen Volume 1.1 1.3 4.0 0.0 1.2 0.2 0.8 1.5 -0.9 -2.0
Fasting Glucose 0.8 1.0 3.1 0.0 0.6 -1.6 0.0 -0.5 -0.9 -1.8
HbA1C 0.5 0.5 2.0 0.0 -0.4 -0.4 -0.4 -0.9 -1.4 -0.4
HDL Cholesterol 0.2 0.4 1.2 0.0 0.7 0.6 0.1 1.1 0.7 0.2
LDL Cholesterol 0.7 1.1 4.1 0.0 2.0 1.0 -0.3 0.7 0.9 -1.1
Lupus 2.0 3.1 7.4 0.0 -1.0 -2.7 -2.2 -2.4 1.4 -1.1
Neuroticism (2016) 0.2 0.3 1.1 0.0 0.1 0.4 -0.3 1.0 -0.7 -0.7
Primary Biliary Cirrhosis 0.1 0.2 0.7 0.0 0.4 0.2 0.8 -0.2 0.7 0.0
Rheumatoid Arthritis 0.1 0.1 0.8 0.0 -0.3 -0.2 -0.0 -0.3 0.1 -0.9
Schizophrenia (2014) 0.0 0.1 0.2 0.0 0.4 0.2 0.1 0.3 0.5 -0.4
Triglycerides 0.1 0.2 0.8 0.0 -0.4 0.4 0.4 -0.3 -0.3 0.9
Type 2 Diabetes (T2D) (2012) 0.8 1.0 3.9 0.0 2.0 -1.3 0.4 -0.4 0.7 -0.7
Ulcerative Colitis 0.7 1.1 2.7 0.0 -1.2 0.7 1.5 0.8 -1.6 0.0
Blood Eosinophil Count 0.2 1.6 6.5 0.0 1.0 2.5 -0.3 1.9 0.7 0.0
Blood Platelet Count 0.7 7.9 25.9 0.0 1.1 -3.5 -3.7 -5.1 1.1 1.3
Blood Red Count 0.1 0.7 2.0 0.0 0.5 -0.3 -1.4 -0.9 -1.3 -0.1
Blood White Count 0.2 1.6 6.9 0.0 -0.2 1.8 0.4 2.6 0.8 0.0
Heel T-Score 0.5 4.1 8.8 0.0 -1.5 -1.9 -2.1 -3.0 2.3 2.0
BMI 0.3 1.9 12.0 0.0 -3.5 0.4 -0.2 -0.1 -0.9 0.6
Height 0.6 10.8 58.5 0.0 7.7 -0.4 1.8 3.0 0.7 -2.1
Waist Hip Ratio (WHR) 0.9 3.9 10.1 0.0 1.5 -0.6 -3.2 -2.8 1.7 1.8
Systolic Blood Pressure 0.2 0.8 3.8 0.0 1.2 -0.4 -0.1 0.5 0.3 -2.0
Smoking Status 0.1 0.2 0.4 0.0 0.5 0.5 -0.6 -0.0 0.5 -0.0
Allergy or Eczema 0.2 0.4 1.4 0.0 -1.0 -0.5 0.0 -0.5 1.2 0.1
Cardiovascular Disease 0.1 0.3 1.2 0.0 0.4 0.3 -0.4 0.2 0.5 1.1
Hypothyroidism (self reported) 0.4 1.0 3.4 0.0 0.5 1.5 0.2 1.8 1.0 0.1
Respiratory disease 0.1 0.3 1.4 0.0 0.1 -0.1 -0.8 0.1 0.1 -1.2
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.7 0.0 0.5 -1.9 -1.0 -1.7 0.3 0.2
Lung FEV1/FVC ratio 0.1 0.6 1.7 0.0 -1.1 0.3 -0.5 -0.5 -1.0 1.3
Lung FVC 0.2 0.9 3.7 0.0 1.0 -1.9 -0.3 -1.1 -0.5 -0.4
Neuroticism 0.1 0.3 0.7 0.0 0.0 -0.3 -0.8 -0.6 0.6 0.7
Chronotype (morning person) 0.6 1.4 5.1 0.0 -0.8 -2.3 -0.8 -1.7 -0.2 -0.8
Hair Pigment 0.1 2.7 11.2 0.0 0.7 1.7 -0.6 1.0 3.4 1.8
Tanning 0.1 0.7 1.7 0.0 -1.1 -1.3 -0.6 -0.9 -0.4 -0.8
Hand grip strength (left) 0.2 0.6 2.0 0.0 -0.6 0.7 -0.8 -0.1 -1.4 1.0
Number of treatments/medications taken 0.8 1.4 4.0 0.0 2.0 0.6 -1.9 0.2 1.1 0.8
Average weekly spirits intake 0.8 1.1 2.6 0.0 -0.2 1.3 1.6 1.3 -0.9 0.8
Sensitivity / hurt feelings 0.5 0.8 2.7 0.0 0.4 1.2 -0.2 0.7 1.6 1.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.3 0.0 -1.5 0.8 1.1 0.5 -0.5 0.7
Hearing difficulty/problems: Yes 0.3 0.5 1.6 0.0 0.7 -1.2 -0.5 -0.5 0.5 0.9
Relative age of first facial hair 0.4 0.7 2.5 0.0 1.6 0.7 -0.5 1.0 0.9 -0.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 4.8 0.0 0.3 -0.4 -0.8 0.6 -0.8 -2.2
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.5 0.0 -0.6 -0.7 0.5 0.1 0.6 -0.1
Ever had hysterectomy (womb removed) 0.4 0.4 2.1 0.0 -0.9 -0.0 -0.2 -0.1 -0.4 -1.4
Systolic blood pressure, automated reading 0.4 1.2 4.9 0.0 2.2 0.7 0.3 1.4 0.1 -0.9
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.1 0.0 -1.4 -0.2 -1.3 -0.5 -1.5 0.5
Angina 0.9 1.2 3.6 0.0 1.9 0.2 0.8 1.1 1.7 -0.3
Medication for hormone replacement therapy 0.5 0.6 1.9 0.0 0.6 -0.9 -0.8 -0.3 0.6 -1.4
Vitamin and mineral supplements 0.6 0.8 2.3 0.0 -1.5 0.4 1.2 -0.1 -1.3 -0.1
Supplements: Zinc 0.1 0.1 0.4 0.0 0.3 -0.6 0.0 0.1 0.4 0.5
Medication: Co-codamol 1.5 1.7 4.5 0.0 -2.1 1.5 1.8 0.9 -1.0 -0.3
Medication: Metformin 1.4 2.0 5.5 0.0 2.4 -2.1 -1.5 -1.0 0.4 -0.6
Diabetes (father) 0.3 0.3 0.9 0.0 0.7 -0.9 -0.0 -0.4 0.3 -0.8
Diabetes (mother) 0.1 0.1 0.4 0.0 0.0 -0.6 -0.1 0.3 0.6 -0.3
Severe depression (siblings) 0.7 0.8 1.9 0.0 -1.1 -1.4 0.7 -0.7 -0.0 -1.2
Pack years adult smoking proportion 0.6 0.9 4.0 0.0 0.9 -0.2 -0.3 1.0 0.3 -2.0
Impedance of leg (right) 2.0 9.7 47.0 0.0 6.9 0.1 -2.0 0.2 4.0 0.4
Leg fat-free mass (left) 0.3 1.4 4.6 0.0 -1.7 0.4 1.3 0.9 -2.1 -0.4
Trunk fat percentage 0.3 1.3 4.9 0.0 1.3 2.2 -0.5 1.0 1.0 0.6
Hand grip strength (right) 0.2 0.5 1.1 0.0 0.2 0.9 -1.0 0.2 -0.6 1.1
Townsend deprivation index at recruitment 0.3 0.5 1.4 0.0 -0.6 -0.2 -0.8 0.7 0.5 -1.2
Current tobacco smoking 0.1 0.2 0.5 0.0 0.3 0.0 -0.1 0.7 0.6 -0.4
Average weekly fortified wine intake 0.9 1.1 5.2 0.0 2.3 -0.1 -0.8 0.6 0.7 -0.9
Maternal smoking around birth 2.3 3.4 10.0 0.0 1.3 1.1 1.6 2.9 -0.1 -3.2
Fed-up feelings 0.3 0.5 1.4 0.0 -0.3 1.2 0.9 0.5 -0.6 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.9 0.0 -0.4 0.8 -0.8 -0.3 -0.1 1.0
Relative age voice broke 0.9 1.3 3.8 0.0 1.0 0.7 0.3 2.0 1.3 -1.4
Taking other prescription medications 0.4 0.6 1.6 0.0 1.2 -0.1 -0.4 1.3 -0.1 -0.9
Age when periods started (menarche) 0.1 0.4 1.1 0.0 1.1 0.2 -0.6 0.9 0.0 0.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 0.0 -0.2 -0.2 0.2 0.3 0.7 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 6.0 0.0 -1.1 -1.7 -0.7 -2.4 1.7 1.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 0.0 0.4 -0.4 0.9 0.2 -0.8 -0.6
Qualifications: CSEs or equivalent 0.6 0.8 3.8 0.0 2.0 0.8 0.1 1.0 0.2 -0.2
Serious illness, injury or assault to yourself 0.3 0.4 1.0 0.0 -0.9 -0.1 -0.1 0.2 -1.0 0.8
High blood pressure 0.2 0.5 0.9 0.0 0.6 -0.2 -0.7 -0.9 0.8 0.9
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.2 0.0 -0.9 -0.5 -0.9 -1.0 1.8 1.0
Multivitamins +/- minerals 1.4 1.8 6.1 0.0 2.2 -0.4 -1.3 0.2 2.5 -0.2
Stomach or abdominal pain in last month 0.3 0.4 1.5 0.0 0.0 0.5 0.7 1.2 0.8 -0.0
Supplements: Glucosamine 0.1 0.1 0.3 0.0 0.1 0.1 -0.5 -0.3 0.4 0.4
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.2 0.0 -0.8 -1.3 -0.8 -0.3 1.5 -1.0
Medication: Atenolol 1.0 1.2 4.0 0.0 2.0 0.9 0.2 1.1 0.5 1.5
Medication: Levothyroxine sodium 0.7 1.2 4.7 0.0 1.1 0.9 -0.2 1.2 2.2 0.5
Sitting height 0.8 5.6 23.8 0.0 4.9 -0.7 1.7 2.8 -0.9 -1.9
Chronic bronchitis/emphysema (father) 1.0 1.1 2.8 0.0 0.4 1.0 1.3 1.5 -1.7 0.2
High blood pressure (mother) 0.7 1.0 2.5 0.0 1.4 0.9 0.3 1.6 0.4 1.2
Body mass index (BMI) 0.3 1.4 6.5 0.0 -2.5 1.3 0.2 -0.2 -1.0 0.9
Impedance of leg (left) 1.8 8.9 42.1 0.0 6.5 0.4 -1.8 0.7 4.0 -0.0
Leg predicted mass (left) 0.3 1.5 4.6 0.0 -1.7 0.4 1.3 0.9 -2.1 -0.4
Trunk fat mass 0.2 0.9 3.4 0.0 1.1 1.9 -0.0 1.3 0.2 0.2
Waist circumference 0.1 0.2 0.4 0.0 -0.6 0.7 -0.6 -0.2 -0.4 0.3
Number of incorrect matches in round 0.7 1.2 4.4 0.0 0.1 2.1 0.7 1.4 1.1 0.8
Past tobacco smoking 0.1 0.2 0.5 0.0 -0.0 0.1 0.7 0.4 0.5 0.7
Alcohol usually taken with meals 1.2 1.9 5.8 0.0 0.6 -2.4 -2.0 -1.3 0.1 -1.2
Nervous feelings 0.1 0.2 1.1 0.0 0.2 -0.5 -0.4 -0.4 1.0 0.0
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 4.7 0.0 -1.9 1.3 2.0 2.2 -1.5 -1.1
Hearing difficulty/problems with background noise 0.3 0.4 0.8 0.0 0.8 -0.8 -0.9 0.3 0.7 0.2
Hair/balding pattern: Pattern 2 0.8 1.0 3.2 0.0 -0.7 -0.6 0.9 -0.2 -1.4 -1.8
Had menopause 0.5 0.6 3.6 0.0 -0.4 -0.2 1.9 0.8 -0.4 -0.1
Had other major operations 0.6 0.7 1.7 0.0 0.4 -1.1 -1.3 -0.9 0.7 0.6
Forced vital capacity (FVC) 0.5 1.8 6.9 0.0 2.6 -1.4 0.9 1.0 -0.7 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.1 0.0 0.0 -1.8 -0.7 -1.7 1.5 0.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.7 0.0 0.3 0.7 0.8 0.9 0.0 0.6
Qualifications: None of the above 0.1 0.3 1.3 0.0 -1.1 -0.1 0.6 -0.3 -0.3 -0.0
Financial difficulties in last 2 years 0.9 1.2 6.2 0.0 -2.5 1.0 0.3 0.1 -0.9 0.6
Mouth/teeth dental problems 0.8 1.2 3.2 0.0 1.0 1.3 1.4 1.8 0.6 -0.0
Heart attack 1.8 2.3 5.3 0.0 2.1 -1.2 -1.5 -1.6 2.3 0.3
Allergy 0.3 0.7 3.0 0.0 0.2 0.6 0.9 0.5 -1.7 -0.9
Pain all over the body in last month 0.1 0.1 0.3 0.0 0.2 0.5 0.4 0.3 -0.2 0.1
Diabetes (self-reported) 1.0 1.5 3.6 0.0 1.3 -1.9 -1.3 -1.6 0.8 -0.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.7 0.0 -0.6 -1.6 -0.2 -1.3 0.8 0.2
Medication: Ramipril 0.7 0.9 4.3 0.0 2.1 1.0 0.1 0.4 0.6 0.4
Medication: Simvastatin 0.4 0.7 3.8 0.0 2.0 0.7 -0.3 0.3 -0.2 0.2
Fluid intelligence score 0.1 0.2 0.6 0.0 -0.4 -0.7 -0.7 -0.3 0.5 -0.4
Illnesses of siblings 0.3 0.5 1.3 0.0 1.0 0.5 0.6 0.5 1.1 0.5
Neuroticism score 0.1 0.2 0.7 0.0 0.5 0.1 -0.6 -0.2 0.8 0.4
Weight 0.2 0.8 2.2 0.0 -0.0 1.2 1.0 1.5 -1.1 0.1
Impedance of arm (right) 0.6 3.0 12.7 0.0 3.6 1.0 -0.6 1.0 2.4 -0.5
Arm fat percentage (right) 0.2 1.0 4.6 0.0 -1.1 2.1 -0.3 0.1 -0.2 0.9
Trunk fat-free mass 0.3 1.7 6.4 0.0 -0.0 -0.6 1.5 1.2 -2.5 -1.1
Hip circumference 0.2 0.9 2.4 0.0 -0.5 1.2 1.0 1.6 -0.6 -0.7
Time employed in main current job 0.4 0.5 2.8 0.0 -0.0 -0.2 -0.2 0.2 0.8 -1.7
Alcohol intake versus 10 years previously 0.4 0.7 2.5 0.0 -0.2 -1.1 -0.6 0.2 0.8 -1.6
Father’s age at death 0.0 0.0 0.2 0.0 -0.1 0.2 -0.4 -0.1 0.2 -0.3
Worrier / anxious feelings 0.2 0.4 0.8 0.0 -0.6 -0.6 -0.8 -0.9 0.7 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 3.7 0.0 1.9 0.1 -1.0 1.0 1.1 -0.4
Falls in the last year 1.6 2.2 6.4 0.0 0.1 2.3 0.9 2.5 1.3 1.1
Hair/balding pattern: Pattern 3 0.2 0.3 1.1 0.0 -0.0 -0.3 -0.4 -1.1 -0.7 -0.0
Number of live births 0.9 1.2 4.0 0.0 -1.8 2.0 0.6 -0.1 -0.9 -0.1
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 4.3 0.0 2.1 -0.6 0.7 0.9 -0.7 -0.2
Pulse rate 0.1 0.2 0.7 0.0 0.2 0.3 -0.5 -0.8 -0.3 0.8
Happiness 0.6 0.7 1.7 0.0 -1.2 -0.2 -0.7 -1.1 0.4 1.3
Noisy workplace 0.3 0.4 1.2 0.0 -1.1 -0.4 0.8 0.5 -0.5 -0.2
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.5 0.0 -1.6 1.4 0.5 0.3 -0.5 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.5 0.0 0.2 0.9 1.2 1.0 -1.0 0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 0.9 0.0 -0.7 -1.0 -0.7 -0.5 0.0 0.4
Asthma 0.4 0.7 1.8 0.0 1.3 1.1 -0.8 0.8 0.8 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 4.0 0.0 -1.7 -0.9 -1.7 -2.0 0.7 1.3
Medication: Cholesterol lowering 0.9 1.4 4.3 0.0 1.9 -0.9 -2.1 -1.1 0.0 -0.0
Depression (self-reported) 1.6 2.0 6.4 0.0 1.3 0.7 0.5 2.5 -1.1 -1.9
Medication: Lansoprazole 2.3 2.6 7.0 0.0 2.1 0.9 -1.3 -0.0 2.6 2.1
Prospective memory result 0.7 0.8 2.2 0.0 -0.7 1.5 1.2 0.9 -0.6 0.7
Lung cancer (father) 0.2 0.3 1.2 0.0 -0.5 -1.1 -0.1 0.3 0.2 -0.6
Illnesses of mother 0.7 0.8 3.3 0.0 -1.8 -0.6 0.7 -0.6 -0.2 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 9.5 0.0 3.1 -0.6 0.4 1.0 -0.7 0.2
Pulse wave Arterial Stiffness index 0.3 0.4 1.0 0.0 -0.6 -1.0 -0.7 -0.8 -0.6 -0.2
Impedance of arm (left) 0.7 3.4 13.5 0.0 3.7 1.3 -0.7 1.2 2.6 -0.5
Arm fat mass (right) 0.2 0.6 2.8 0.0 -0.7 1.7 0.4 0.7 -0.6 0.4
Trunk predicted mass 0.3 1.6 6.1 0.0 -0.0 -0.7 1.5 1.2 -2.5 -1.1
Standing height 0.8 7.9 31.1 0.0 5.6 0.1 2.0 4.1 -0.5 -1.9
Length of working week for main job 1.2 1.3 6.0 0.0 -2.5 -1.2 -0.7 -1.2 0.1 -0.2
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.0 -0.1 0.1 -0.0 -0.0 0.6 0.3
Breastfed as a baby 1.1 1.3 5.8 0.0 -2.4 0.4 -0.2 -1.3 -0.1 1.3
Tense / ‘highly strung’ 0.6 1.0 1.9 0.0 -1.4 -0.9 -1.4 -1.4 0.4 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.4 0.0 -0.1 -0.4 -0.8 -0.2 -0.5 -1.2
Hair/balding pattern: Pattern 4 0.4 1.0 2.2 0.0 -1.1 0.1 -1.5 0.3 1.2 1.4
Birth weight of first child 0.5 0.9 3.1 0.0 0.5 0.4 1.1 0.9 -1.7 -0.9
Peak expiratory flow (PEF) 0.4 1.0 3.1 0.0 1.2 -0.1 1.1 1.2 -1.7 0.1
Pulse wave reflection index 0.1 0.2 0.4 0.0 -0.6 -0.7 -0.3 0.3 -0.5 0.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.8 0.0 0.5 0.4 0.5 1.1 1.4 -0.1
Loud music exposure frequency 0.6 0.7 3.2 0.0 -0.1 -0.7 -0.7 0.3 0.6 -1.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.8 0.0 0.0 0.2 0.5 0.4 0.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.3 0.0 -0.7 0.5 0.3 -0.2 -1.1 -1.1
Blood clot in the leg (DVT) 0.1 0.1 0.5 0.0 0.1 0.7 0.0 0.5 -0.0 -0.1
Medication: Paracetamol 0.3 0.5 2.2 0.0 1.5 -0.0 -0.9 0.2 0.3 -0.1
Headache pain in last month 0.4 0.7 1.6 0.0 0.1 0.1 -0.5 1.3 1.2 -1.2
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 6.5 0.0 -2.5 0.7 1.4 0.1 -0.3 0.0
Glaucoma (self-reported) 1.5 1.8 6.6 0.0 -1.3 -0.1 2.6 1.5 -1.2 -0.7
Gout (self-reported) 0.2 0.3 0.6 0.0 -0.6 0.2 -0.6 -0.7 0.8 0.5
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.7 0.0 1.9 1.6 -0.1 1.8 1.0 0.7
Medication: Amlodipine 0.2 0.3 0.6 0.0 -0.1 0.7 0.5 0.0 -0.8 -0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.0 0.0 1.0 -0.1 -0.9 0.3 0.4 -0.4
Birth weight 0.3 0.7 2.4 0.0 -0.2 -0.3 -1.6 -0.6 0.8 1.0
Chronic bronchitis/emphysema (mother) 0.6 0.7 3.3 0.0 -1.8 0.5 0.0 0.2 0.2 1.0
High blood pressure (siblings) 0.5 0.7 2.9 0.0 -0.2 -0.0 0.9 0.9 -1.7 -0.7
Forced vital capacity (FVC), Best measure 0.7 2.7 14.0 0.0 3.7 -1.2 0.7 1.2 -0.8 -0.8
Body fat percentage 0.3 1.1 5.2 0.0 0.8 2.3 -0.3 0.9 0.7 0.8
Leg fat percentage (right) 0.2 0.7 2.0 0.0 0.9 1.4 -0.6 -0.0 0.6 1.2
Arm fat-free mass (right) 0.2 0.8 2.8 0.0 -0.3 -0.1 1.3 1.0 -1.7 -0.4
Exposure to tobacco smoke outside home 0.6 0.8 2.4 0.0 0.6 1.0 1.0 1.6 -0.2 1.1
Comparative body size at age 10 0.6 1.7 5.9 0.0 -2.4 0.1 0.8 -1.3 -1.9 0.6
Number of full brothers 1.2 1.6 4.9 0.0 -2.2 -1.6 -0.3 -0.7 -1.0 -1.4
Worry too long after embarrassment 1.0 1.6 4.0 0.0 1.0 -2.0 -1.6 -1.6 1.1 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 6.1 0.0 0.2 -0.5 0.5 1.5 -0.6 -2.5
Wheeze or whistling in the chest in last year 1.0 1.7 7.3 0.0 0.9 1.0 -1.3 0.6 2.7 0.8
Number of children fathered 1.2 1.3 7.2 0.0 0.1 -1.3 0.2 0.1 -0.4 -2.7
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 4.4 0.0 -2.1 0.9 -1.2 -0.5 -0.0 2.0
Age at first live birth 0.4 0.6 1.7 0.0 0.5 -1.2 -0.7 -0.3 -0.6 -1.3
Pulse wave peak to peak time 0.6 0.7 1.3 0.0 1.2 1.0 0.8 1.1 0.7 0.0
Health satisfaction 0.3 0.4 0.9 0.0 -0.8 -0.9 -0.5 -0.7 -0.1 -0.9
Shortness of breath walking on level ground 0.3 0.3 0.7 0.0 -0.4 -0.8 -0.7 -0.4 0.1 -0.8
Qualifications: College or University degree 0.5 1.6 4.3 0.0 0.7 -1.8 -2.1 -1.3 -0.3 -1.2
Eye problems/disorders: None of the above 0.9 1.1 2.4 0.0 1.4 -0.8 -1.5 -0.5 1.6 0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.8 3.2 0.0 0.9 -0.7 -0.4 -0.1 0.8 -1.8
Emphysema/chronic bronchitis 0.9 1.0 2.9 0.0 0.3 -0.0 -1.7 -0.8 1.2 1.3
Medication for pain relief, constipation, heartburn 0.9 1.5 4.3 0.0 -1.0 0.1 2.1 0.8 -2.0 -0.4
Neck or shoulder pain in last month 0.7 1.0 3.2 0.0 1.1 -0.5 -1.4 0.4 1.8 -0.7
Medication: Blood pressure 0.6 1.0 3.8 0.0 2.0 -1.0 -1.1 -0.5 1.0 -0.4
Angina (self-reported) 1.0 1.3 3.7 0.0 1.9 0.4 1.0 1.3 1.5 -0.5
Migraine (self-reported) 0.7 0.8 4.0 0.0 1.0 0.0 0.2 0.8 2.0 -0.4
Medication: Ibuprofen 1.2 1.4 3.9 0.0 -2.0 -0.4 -1.2 -1.3 0.7 1.4
Medication: Allopurinol 0.2 0.3 1.3 0.0 0.3 0.4 -0.6 -0.1 1.2 -0.0
Medication: Omeprazole 1.1 1.3 5.1 0.0 -0.3 -1.2 -2.3 -1.5 0.1 -0.5
Medication: Seretide 50 evohaler 0.9 1.0 2.6 0.0 1.6 1.1 -1.4 0.0 1.2 0.4
Mean time to correctly identify matches 0.5 0.9 2.3 0.0 1.0 1.5 -0.3 -0.0 1.5 0.9
Heart disease (mother) 0.7 0.9 3.2 0.0 1.8 0.2 0.9 0.8 1.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 7.7 0.0 -2.8 -1.0 -0.6 -1.3 -0.6 -0.8
Whole body fat mass 0.2 0.9 4.0 0.0 0.4 2.0 0.5 1.3 -0.4 0.4
Leg fat mass (right) 0.1 0.3 1.7 0.0 0.2 1.3 0.0 0.5 -0.1 0.6
Arm predicted mass (right) 0.2 0.9 2.6 0.0 -0.5 -0.2 1.4 1.1 -1.6 -0.3
Pulse rate, automated reading 0.4 1.2 3.5 0.0 -0.8 1.7 0.7 0.6 -1.9 0.6
Alcohol intake frequency. 0.3 0.7 2.1 0.0 0.8 -1.4 -1.0 -0.1 0.8 -0.8
Comparative height size at age 10 0.5 2.8 11.4 0.0 3.4 -2.1 0.1 0.0 -1.0 -1.7
Number of full sisters 0.4 0.5 2.3 0.0 -0.4 -1.5 -0.7 -0.8 -0.2 0.2
Suffer from ‘nerves’ 0.9 1.4 7.6 0.0 2.8 0.1 0.1 1.2 0.8 0.3
Overall health rating 0.3 0.7 3.6 0.0 0.2 -0.0 -1.9 -0.7 0.7 0.8
Chest pain or discomfort 0.2 0.2 1.0 0.0 0.1 0.5 -0.2 0.4 1.0 0.3
Had major operations 0.9 1.0 3.8 0.0 0.3 -1.4 0.2 0.1 -1.9 -1.1
Age at last live birth 0.4 0.6 2.2 0.0 -0.3 -0.2 -1.5 -1.0 0.2 -0.7
Family relationship satisfaction 1.2 1.5 3.6 0.0 -1.7 -0.7 -1.4 -1.9 0.5 1.2
Leg pain on walking 0.6 0.8 2.8 0.0 -0.3 -1.7 -1.2 -0.3 0.6 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.8 0.0 -0.4 0.1 -0.2 -0.7 1.3 1.7
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.7 0.0 1.3 -0.4 0.2 0.0 0.1 -0.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.2 0.0 0.6 -1.0 0.7 0.1 0.1 -1.1
Medication: Aspirin 0.7 0.9 3.2 0.0 1.4 0.6 -0.4 -0.3 1.8 0.6
Supplements: Vitamin C 1.2 1.5 2.9 0.0 1.0 1.4 0.1 1.6 1.4 1.7
Knee pain experienced in last month 0.6 0.9 3.3 0.0 -1.8 -1.2 0.2 -0.7 -0.8 0.6
Hypertension (Self-reported) 0.1 0.2 0.4 0.0 0.6 -0.2 -0.4 -0.6 0.3 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 4.1 0.0 2.0 -0.6 -1.5 -0.5 2.0 1.2
Illnesses of father: Heart disease 0.3 0.4 1.2 0.0 -0.2 -1.1 -0.8 -1.1 0.4 0.1
Illnesses of siblings: Diabetes 1.0 1.2 3.2 0.0 -0.9 -0.9 -1.6 -1.8 0.7 0.9
Smoking status: Previous 0.2 0.3 0.8 0.0 -0.3 0.3 -0.5 -0.3 -0.9 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.4 0.0 1.5 0.6 1.0 1.1 -1.3 0.4
Whole body fat-free mass 0.3 1.6 6.1 0.0 -0.9 -0.2 1.5 1.1 -2.5 -0.8
Leg fat-free mass (right) 0.4 1.9 5.2 0.0 -2.0 0.4 1.6 1.2 -2.3 -0.5
Arm fat percentage (left) 0.3 1.1 5.5 0.0 -1.2 2.3 -0.1 0.3 -0.1 0.9
Average weekly red wine intake 0.9 1.3 3.6 0.0 -1.4 1.3 0.6 1.1 -1.9 0.4
Handedness (chirality/laterality): Left-handed 0.6 0.7 3.4 0.0 -1.0 -0.4 0.6 0.2 -1.8 0.3
Mood swings 0.2 0.3 1.4 0.0 0.0 1.2 -0.1 0.5 0.7 0.6
Loneliness, isolation 0.2 0.2 0.7 0.0 -0.3 -0.0 -0.8 -0.3 0.3 0.8
Long-standing illness, disability or infirmity 1.1 1.7 3.7 0.0 1.1 -1.7 -1.9 -0.4 0.7 -1.9
Ever had bowel cancer screening 1.0 1.1 5.1 0.0 -0.1 -1.3 0.4 0.7 -0.6 -2.2
Diabetes diagnosed by doctor 1.0 1.7 3.4 0.0 1.4 -1.9 -1.6 -1.7 0.8 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 3.0 0.0 0.8 -0.3 -1.7 -0.6 1.4 -0.0
Friendships satisfaction 1.2 1.4 8.3 0.0 -0.3 0.5 -0.6 -1.0 0.0 2.9
Qualifications: nursing, teaching 0.1 0.2 0.5 0.0 0.6 0.5 -0.3 0.7 -0.2 -0.2
Commuting to job workplace: Walk 0.9 1.0 2.7 0.0 0.5 1.6 -0.4 0.6 1.2 1.4
Eye problems/disorders: Cataract 0.3 0.3 1.0 0.0 -0.5 0.3 0.2 -0.9 -0.0 1.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.9 0.0 -0.6 -0.8 -1.7 -1.6 0.2 0.0
Medication for cholesterol 0.5 0.8 2.8 0.0 -0.4 -0.6 1.0 0.8 -1.7 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.0 0.0 0.2 -1.0 -0.6 0.1 0.8 -0.1
Back pain experienced in last month 0.3 0.5 1.7 0.0 -0.1 0.1 -0.4 1.0 1.3 0.7
Mineral and other dietary supplements 0.7 0.9 2.7 0.0 -0.6 -1.6 -0.8 -1.2 -0.1 -1.1
Breast cancer (self-reported) 0.5 0.6 2.5 0.0 -1.6 1.0 0.6 0.1 -0.5 0.3
Asthma (self-reported) 0.3 0.6 1.8 0.0 1.3 0.8 -0.9 0.6 0.9 -0.4
Osteoporosis (self-reported) 0.3 0.4 0.9 0.0 0.8 0.1 -0.9 -0.5 -0.9 0.1
Osteoarthritis (self-reported) 0.8 1.0 4.7 0.0 -2.2 0.4 -0.0 -0.4 -1.4 0.3
Medication: Aspirin 1.4 1.8 6.5 0.0 2.2 0.5 -0.9 -0.2 2.6 0.5
Medication: Gliclazide 1.2 1.4 5.0 0.0 1.3 -0.9 -2.2 -0.5 1.4 0.3
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 0.0 -0.9 0.9 0.4 1.1 -0.6 0.2
Smoking status: Current 0.1 0.1 0.2 0.0 0.0 -0.2 -0.5 0.4 0.5 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.1 0.0 0.2 -1.3 -1.0 -1.5 -0.5 0.6
Whole body water mass 0.3 1.5 5.5 0.0 -0.8 -0.2 1.6 1.2 -2.4 -0.8
Leg predicted mass (right) 0.4 2.0 5.3 0.0 -2.0 0.4 1.6 1.2 -2.3 -0.6
Arm fat mass (left) 0.2 0.9 3.5 0.0 -0.8 1.9 0.7 0.9 -0.6 0.5
Number of self-reported non-cancer illnesses 0.3 0.5 1.6 0.0 0.8 -0.4 -1.3 0.2 0.9 -0.8
Average weekly champagne plus white wine intake 0.6 0.8 2.2 0.0 0.5 -1.1 -0.7 -0.7 1.5 0.9
Miserableness 0.2 0.4 1.2 0.0 0.2 0.8 0.4 1.1 0.2 -0.8
Guilty feelings 0.1 0.2 0.4 0.0 0.0 0.0 -0.6 -0.5 -0.6 0.3
Wears glasses or contact lenses 1.5 1.7 5.7 0.0 -0.7 -1.6 -1.4 -2.4 -1.1 -0.6
Ever taken oral contraceptive pill 0.2 0.2 0.7 0.0 0.8 -0.5 -0.6 -0.4 0.5 -0.1
Hearing aid user 2.5 2.8 7.4 0.0 0.8 -1.7 -2.7 -1.9 1.5 1.6
Mother’s age at death 1.3 1.6 3.9 0.0 -1.8 -0.2 1.4 0.2 -2.0 -1.5
Financial situation satisfaction 1.3 1.6 6.6 0.0 -2.6 1.0 -0.0 -1.0 0.2 1.6
Tinnitus: Yes, now most or all of the time 1.5 1.8 4.9 0.0 1.4 1.7 0.2 2.2 1.4 0.9
Commuting to job workplace: Public transport 0.9 1.1 2.3 0.0 -0.6 1.2 1.0 1.0 -1.2 1.5
Eye problems/disorders: Glaucoma 1.7 2.0 6.0 0.0 -0.6 0.8 2.4 2.1 -1.1 -1.4
Medication: Blood pressure 0.1 0.2 0.8 0.0 -0.2 0.9 0.4 -0.2 0.3 0.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.8 0.0 -0.9 -0.3 -0.4 0.4 0.3 -0.3
Supplements: Fish oil (including cod liver oil) 1.6 2.1 6.2 0.0 0.4 2.5 1.3 1.6 -0.2 2.0
High cholesterol (Self-reported) 0.3 0.5 2.7 0.0 0.6 -0.4 0.0 0.1 -1.6 -0.6
Medication: Bendroflumethiazide 1.0 1.6 5.5 0.0 -0.6 -1.8 -0.9 -2.3 0.3 1.1
Medication: Paracetamol 0.3 0.5 1.4 0.0 1.2 0.3 -0.1 1.1 0.5 -0.8
Medication: Lisinopril 0.4 0.5 1.3 0.0 1.1 0.3 0.3 0.4 1.0 -0.7
Medication: Atorvastatin 1.1 1.3 3.8 0.0 0.1 -1.7 -1.5 -1.9 0.2 -0.4
Illnesses of father: High blood pressure 0.6 0.7 1.4 0.0 0.4 -0.9 -0.3 -1.2 1.1 -1.1
Alcohol drinker status: Never 0.6 0.7 1.9 0.0 1.4 -1.2 -0.9 0.5 0.7 0.4
Ever smoked 0.1 0.2 0.7 0.0 0.8 0.2 -0.2 0.4 0.3 -0.8
Basal metabolic rate 0.2 1.2 4.2 0.0 -0.6 0.1 1.4 1.2 -2.0 -0.6
Leg fat percentage (left) 0.2 0.6 2.3 0.0 0.6 1.5 -0.4 0.4 0.5 1.0
Arm fat-free mass (left) 0.2 1.1 3.3 0.0 0.0 -0.4 1.6 1.1 -1.8 -0.4
Number of operations (self-reported) 0.4 0.5 1.7 0.0 -0.8 -1.0 -0.0 -0.3 -0.6 -1.3
Average weekly beer plus cider intake 0.3 0.5 1.0 0.0 -1.0 0.6 1.0 -0.3 0.3 -0.9
Irritability 0.3 0.5 2.2 0.0 0.9 0.2 -0.6 -0.5 1.5 0.3
Risk taking 0.3 0.4 1.8 0.0 -1.4 0.4 0.4 0.8 -0.3 0.1
Ever had prostate specific antigen (PSA) test 0.5 0.5 2.2 0.0 0.7 -0.8 -1.5 -0.1 -0.1 -0.7
Fractured/broken bones in last 5 years 1.7 2.2 4.5 0.0 -0.4 1.8 2.0 2.1 -1.8 -0.5
Age started oral contraceptive pill 1.1 1.3 3.0 0.0 -0.9 1.1 1.7 1.6 -0.7 1.2
Diastolic blood pressure, automated reading 0.1 0.3 2.0 0.0 0.0 0.2 -1.4 -0.5 -0.1 -0.1
Ever depressed for a whole week 0.3 0.4 1.2 0.0 -1.1 0.5 0.3 0.3 -0.8 0.7
Unable to work because of sickness or disability 0.3 0.4 0.9 0.0 -0.3 0.9 1.0 1.0 -0.1 -0.3
Commuting to job workplace: Cycle 0.3 0.3 1.4 0.0 -0.1 0.4 -0.7 0.0 0.7 1.2
Myopia 0.5 0.8 3.4 0.0 -0.3 0.6 -1.0 -0.6 -0.2 1.8
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.6 0.0 -0.5 0.2 0.8 1.1 -1.3 -0.6
Cholesterol lowering medication 0.3 0.4 1.3 0.0 0.4 0.2 -0.1 -0.7 1.2 1.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.2 0.0 -0.7 -0.8 -1.5 -1.1 -0.1 -0.2
Pain experienced in last month 0.4 0.7 2.5 0.0 0.4 -0.5 -0.0 -1.6 -1.4 0.4
Supplements: Calcium 0.8 0.8 3.7 0.0 -1.9 -0.5 0.2 -0.2 -1.2 0.4
Basal cell carcinoma (self-reported) 0.2 0.3 0.9 0.0 0.3 0.3 0.4 0.1 1.0 0.8
Heart attack/myocardial infarction (self-reported) 2.0 2.6 6.3 0.0 2.3 -0.8 -1.7 -1.5 2.5 0.6
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.7 0.0 -0.0 0.8 -0.0 0.4 0.2 -0.1
Heart disease (siblings) 0.3 0.4 1.9 0.0 -1.4 -0.4 0.2 -0.4 -0.7 -0.1
Alcohol drinker status: Previous 0.9 1.0 3.9 0.0 -0.3 -2.0 -1.1 -1.2 0.3 -0.2
Pack years of smoking 0.5 0.8 3.8 0.0 0.6 -0.4 -0.3 1.0 -0.1 -2.0
Impedance of whole body 1.3 6.8 29.9 0.0 5.5 1.0 -1.1 1.3 3.7 -0.3
Leg fat mass (left) 0.1 0.4 1.9 0.0 0.1 1.4 0.3 0.9 -0.1 0.3
Arm predicted mass (left) 0.2 1.1 3.1 0.0 0.0 -0.4 1.8 1.3 -1.7 -0.5