Best TWAS P=4.32e-42 · Best GWAS P=8e-42 conditioned to 0.158
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SLC16A9 | 0.08 | 0.01 | enet | 17 | 0.00 | 4.5e-01 | 13.55 | 12.9 | 7.2e-38 | 0.59 | 0.01 | 0.94 | TRUE |
| 2 | GTEx | Artery Aorta | SLC16A9 | 0.19 | 0.02 | lasso | 7 | 0.05 | 1.0e-03 | 11.43 | 13.6 | 4.3e-42 | 0.90 | 0.00 | 0.98 | TRUE |
| 3 | GTEx | Artery Tibial | CCDC6 | 0.08 | 0.05 | lasso | 4 | 0.06 | 3.8e-05 | 4.34 | 5.6 | 2.7e-08 | 0.09 | 0.89 | 0.01 | FALSE |
| 4 | GTEx | Brain Cerebellum | SLC16A9 | 0.59 | 0.38 | enet | 31 | 0.56 | 1.0e-19 | 0.96 | 5.5 | 2.8e-08 | 0.23 | 0.97 | 0.02 | TRUE |
| 5 | GTEx | Breast Mammary Tissue (Female) | CCDC6 | 0.11 | -0.01 | lasso | 2 | -0.01 | 6.3e-01 | -7.40 | -7.4 | 1.3e-13 | -0.29 | 0.07 | 0.06 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CCDC6 | 0.10 | 0.07 | bslmm | 601 | 0.08 | 5.6e-11 | -2.79 | 5.4 | 8.2e-08 | 0.09 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC16A9 | 0.06 | 0.05 | blup | 83 | 0.04 | 1.6e-04 | 3.62 | 5.6 | 1.7e-08 | 0.29 | 0.36 | 0.04 | FALSE |